{"id":"https://openalex.org/W3047475365","doi":"https://doi.org/10.1371/journal.pcbi.1008076","title":"Multiplexing information flow through dynamic signalling systems","display_name":"Multiplexing information flow through dynamic signalling systems","publication_year":2020,"publication_date":"2020-08-03","ids":{"openalex":"https://openalex.org/W3047475365","doi":"https://doi.org/10.1371/journal.pcbi.1008076","mag":"3047475365","pmid":"https://pubmed.ncbi.nlm.nih.gov/32745094"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008076","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008076&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008076&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014057991","display_name":"Giorgos Minas","orcid":"https://orcid.org/0000-0001-7953-706X"},"institutions":[{"id":"https://openalex.org/I16835326","display_name":"University of St Andrews","ror":"https://ror.org/02wn5qz54","country_code":"GB","type":"education","lineage":["https://openalex.org/I16835326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giorgos Minas","raw_affiliation_strings":["School of Mathematics and Statistics, University of St Andrews, St Andrews, Scotland, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7953-706X","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, University of St Andrews, St Andrews, Scotland, United Kingdom","institution_ids":["https://openalex.org/I16835326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023191105","display_name":"Dan J. Woodcock","orcid":"https://orcid.org/0000-0003-0576-044X"},"institutions":[{"id":"https://openalex.org/I2802952180","display_name":"Open Data Institute","ror":"https://ror.org/02hr72y72","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802952180"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dan J. Woodcock","raw_affiliation_strings":["Big Data Institute, University of Oxford, Oxford, England, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Big Data Institute, University of Oxford, Oxford, England, United Kingdom","institution_ids":["https://openalex.org/I2802952180","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078464226","display_name":"Louise Ashall","orcid":null},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louise Ashall","raw_affiliation_strings":["Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, England, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, England, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088793095","display_name":"Claire V. Harper","orcid":null},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire V. Harper","raw_affiliation_strings":["Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, England, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6228-4078","affiliations":[{"raw_affiliation_string":"Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, England, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024893058","display_name":"Michael White","orcid":"https://orcid.org/0000-0002-3617-3232"},"institutions":[{"id":"https://openalex.org/I2799725268","display_name":"Manchester Academic Health Science Centre","ror":"https://ror.org/04rrkhs81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799725268"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael R. H. White","raw_affiliation_strings":["Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, England, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, England, United Kingdom","institution_ids":["https://openalex.org/I2799725268","https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012032003","display_name":"D.A.J. Rand","orcid":"https://orcid.org/0000-0002-2217-3274"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David A. Rand","raw_affiliation_strings":["Mathematics Institute, University of Warwick, Coventry, England, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2217-3274","affiliations":[{"raw_affiliation_string":"Mathematics Institute, University of Warwick, Coventry, England, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012032003"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4879,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62384413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"16","issue":"8","first_page":"e1008076","last_page":"e1008076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9811999797821045,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.949999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiplexing","display_name":"Multiplexing","score":0.868609607219696},{"id":"https://openalex.org/keywords/multiplex","display_name":"Multiplex","score":0.7750188112258911},{"id":"https://openalex.org/keywords/signalling","display_name":"Signalling","score":0.758315920829773},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6758005023002625},{"id":"https://openalex.org/keywords/information-theory","display_name":"Information theory","score":0.5964845418930054},{"id":"https://openalex.org/keywords/information-flow","display_name":"Information flow","score":0.5095584392547607},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4288100302219391},{"id":"https://openalex.org/keywords/scalar","display_name":"Scalar (mathematics)","score":0.42684251070022583},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.3314497470855713},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.1748751997947693},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16678789258003235},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14179959893226624},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.0921945869922638},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07425376772880554}],"concepts":[{"id":"https://openalex.org/C19275194","wikidata":"https://www.wikidata.org/wiki/Q222903","display_name":"Multiplexing","level":2,"score":0.868609607219696},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.7750188112258911},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.758315920829773},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6758005023002625},{"id":"https://openalex.org/C52622258","wikidata":"https://www.wikidata.org/wiki/Q131222","display_name":"Information theory","level":2,"score":0.5964845418930054},{"id":"https://openalex.org/C2779136372","wikidata":"https://www.wikidata.org/wiki/Q10283002","display_name":"Information flow","level":2,"score":0.5095584392547607},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4288100302219391},{"id":"https://openalex.org/C57691317","wikidata":"https://www.wikidata.org/wiki/Q1289248","display_name":"Scalar (mathematics)","level":2,"score":0.42684251070022583},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.3314497470855713},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.1748751997947693},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16678789258003235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14179959893226624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0921945869922638},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07425376772880554},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007257","descriptor_name":"Information Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051766","descriptor_name":"Early Growth Response Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1008076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008076","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008076&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32745094","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32745094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/7ac11a43-5f2b-4ff5-8ef3-021b4044e460","is_oa":true,"landing_page_url":"https://research.edgehill.ac.uk/en/publications/7ac11a43-5f2b-4ff5-8ef3-021b4044e460","pdf_url":null,"source":{"id":"https://openalex.org/S4306402462","display_name":"Edge Hill University Research Information Repository (Edge Hill University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165525304","host_organization_name":"Edge Hill University","host_organization_lineage":["https://openalex.org/I165525304"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minas, G, Woodcock, D J, Ashall, L, Harper, C V, White, M R H & Rand, D A 2020, 'Multiplexing information flow through dynamic signalling systems', PLoS Computational Biology, vol. 16, no. 8, pp. e1008076. https://doi.org/10.1371/journal.pcbi.1008076","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:wrap.warwick.ac.uk:139682","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/7ac11a43-5f2b-4ff5-8ef3-021b4044e460","is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85089618058&partnerID=8YFLogxK","pdf_url":"https://research.edgehill.ac.uk/ws/files/29893259/multiplexing_information_flow_through_dynamic_signalling_systems.pdf","source":{"id":"https://openalex.org/S4306402462","display_name":"Edge Hill University Research Information Repository (Edge Hill University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I165525304","host_organization_name":"Edge Hill University","host_organization_lineage":["https://openalex.org/I165525304"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Minas, G, Woodcock, D J, Ashall, L, Harper, C V, White, M R H & Rand, D A 2020, 'Multiplexing information flow through dynamic signalling systems', PLoS Computational Biology, vol. 16, no. 8, pp. e1008076. https://doi.org/10.1371/journal.pcbi.1008076","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:RePEc:plo:pcbi00:1008076","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008076","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:04ee45a4dd7645fe931ba4f39c34efa6","is_oa":true,"landing_page_url":"https://doaj.org/article/04ee45a4dd7645fe931ba4f39c34efa6","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 8, p e1008076 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7425991","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7425991","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:research-repository.st-andrews.ac.uk:10023/20469","is_oa":true,"landing_page_url":"https://hdl.handle.net/10023/20469","pdf_url":null,"source":{"id":"https://openalex.org/S4306400230","display_name":"St Andrews Research Repository (St Andrews Research Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I16835326","host_organization_name":"University of St Andrews","host_organization_lineage":["https://openalex.org/I16835326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008076","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008076","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008076&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1059042294","display_name":null,"funder_award_id":"BB/K003097/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G1314499027","display_name":"Dynamics and function of the NF-kappaB signalling system","funder_award_id":"BB/F005938/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2123666788","display_name":null,"funder_award_id":"MR/M008908/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2298205076","display_name":null,"funder_award_id":"BB/F005938/2","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3091641778","display_name":"Mathematical Foundations of Information and Decisions in Dynamic Cell Signalling","funder_award_id":"EP/P019811/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3468978933","display_name":null,"funder_award_id":"MR/K015885/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4817460009","display_name":null,"funder_award_id":"305564","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5000932253","display_name":null,"funder_award_id":"FP7/2007- 2013","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5663847220","display_name":null,"funder_award_id":"EP/P019811/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6339342330","display_name":null,"funder_award_id":"P019811","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6601167538","display_name":"Systems Biology analysis of biological timers and inflammation","funder_award_id":"BB/K003097/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8152561102","display_name":null,"funder_award_id":"BB/F005938/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8561459807","display_name":null,"funder_award_id":"BB/F005814/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3047475365.pdf","grobid_xml":"https://content.openalex.org/works/W3047475365.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W100464641","https://openalex.org/W135467536","https://openalex.org/W1488435683","https://openalex.org/W1757084193","https://openalex.org/W1804121099","https://openalex.org/W1968916032","https://openalex.org/W1989634457","https://openalex.org/W1991923258","https://openalex.org/W1992182416","https://openalex.org/W1998463022","https://openalex.org/W1999982643","https://openalex.org/W2021058886","https://openalex.org/W2021387539","https://openalex.org/W2043368187","https://openalex.org/W2047149512","https://openalex.org/W2055003617","https://openalex.org/W2056406543","https://openalex.org/W2062546738","https://openalex.org/W2071359806","https://openalex.org/W2071941388","https://openalex.org/W2089068724","https://openalex.org/W2090300920","https://openalex.org/W2097651998","https://openalex.org/W2099029060","https://openalex.org/W2108957075","https://openalex.org/W2115281458","https://openalex.org/W2125937596","https://openalex.org/W2128657634","https://openalex.org/W2135078277","https://openalex.org/W2136120517","https://openalex.org/W2139900107","https://openalex.org/W2142362541","https://openalex.org/W2155418451","https://openalex.org/W2156541178","https://openalex.org/W2160845585","https://openalex.org/W2161304688","https://openalex.org/W2228666292","https://openalex.org/W2302524766","https://openalex.org/W2371219959","https://openalex.org/W2411288489","https://openalex.org/W2566910492","https://openalex.org/W2574819148","https://openalex.org/W2604169508","https://openalex.org/W2604482202","https://openalex.org/W2613782315","https://openalex.org/W2613783344","https://openalex.org/W2767212349","https://openalex.org/W2770554646","https://openalex.org/W2770718418","https://openalex.org/W2803828993","https://openalex.org/W2943786253","https://openalex.org/W2949913358","https://openalex.org/W2950938986","https://openalex.org/W2962918658","https://openalex.org/W2963114865","https://openalex.org/W4211216658","https://openalex.org/W4246840991"],"related_works":["https://openalex.org/W2105336199","https://openalex.org/W4386783876","https://openalex.org/W4285192699","https://openalex.org/W2994465778","https://openalex.org/W3047475365","https://openalex.org/W3032013634","https://openalex.org/W2082484220","https://openalex.org/W1582638358","https://openalex.org/W2394399162","https://openalex.org/W3040099050"],"abstract_inverted_index":{"We":[0,19,70,165],"consider":[1],"how":[2,30,82],"a":[3,83,159],"signalling":[4,93],"system":[5,84,177],"can":[6,27,33,62,99],"act":[7],"as":[8,148,172],"an":[9],"information":[10,14,64,105,145],"hub":[11],"by":[12,109],"multiplexing":[13,163],"arising":[15],"from":[16],"multiple":[17,68],"signals.":[18,69,114],"formally":[20],"define":[21],"multiplexing,":[22,49],"mathematically":[23],"characterise":[24],"which":[25],"systems":[26],"multiplex":[28,63,179],"and":[29,91,133,151,154,181],"well":[31],"they":[32],"do":[34],"it.":[35],"While":[36],"the":[37,46,58,78,103,125,139,175],"results":[38,75],"of":[39,48,81,127,141,144,174],"this":[40,186],"paper":[41],"are":[42],"theoretical,":[43],"to":[44,96,101,158],"motivate":[45],"idea":[47],"we":[50,120],"provide":[51,182],"experimental":[52],"evidence":[53],"that":[54,57,72,87,137,167,184],"tentatively":[55],"suggests":[56],"NF-\u03baB":[59,86,176],"transcription":[60],"factor":[61],"about":[65,162],"changes":[66],"in":[67,94],"believe":[71],"our":[73,118],"theoretical":[74],"may":[76],"resolve":[77],"apparent":[79],"paradox":[80],"like":[85],"regulates":[88],"cell":[89],"fate":[90],"inflammatory":[92],"response":[95],"diverse":[97],"stimuli":[98],"appear":[100],"have":[102],"low":[104],"carrying":[106,116],"capacity":[107],"suggested":[108],"recent":[110],"studies":[111],"on":[112],"scalar":[113],"In":[115],"out":[117],"study,":[119],"introduce":[121],"new":[122,160],"methods":[123,157],"for":[124],"analysis":[126],"large,":[128],"nonlinear":[129],"stochastic":[130],"dynamic":[131],"models,":[132],"develop":[134],"computational":[135],"algorithms":[136],"facilitate":[138],"calculation":[140],"fundamental":[142],"constructs":[143],"theory":[146,161],"such":[147,171],"Kullback-Leibler":[149],"divergences":[150],"sensitivity":[152],"matrices,":[153],"link":[155],"these":[156],"information.":[164],"show":[166],"many":[168],"current":[169],"models":[170,183],"those":[173],"cannot":[178],"effectively":[180],"overcome":[185],"limitation":[187],"using":[188],"post-transcriptional":[189],"modifications.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}