{"id":"https://openalex.org/W3046136354","doi":"https://doi.org/10.1371/journal.pcbi.1008069","title":"Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics","display_name":"Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics","publication_year":2020,"publication_date":"2020-07-27","ids":{"openalex":"https://openalex.org/W3046136354","doi":"https://doi.org/10.1371/journal.pcbi.1008069","mag":"3046136354","pmid":"https://pubmed.ncbi.nlm.nih.gov/32716940"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008069","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008069","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008069&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008069&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061351670","display_name":"William D. Haselden","orcid":"https://orcid.org/0000-0001-6542-7505"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Davis Haselden","raw_affiliation_strings":["Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, United States of America","Neuroscience Graduate Program, MD/PhD Medical Scientist Training Program, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6542-7505","affiliations":[{"raw_affiliation_string":"Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Neuroscience Graduate Program, MD/PhD Medical Scientist Training Program, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034158635","display_name":"Ravi Teja Kedarasetti","orcid":"https://orcid.org/0000-0003-4226-5683"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Teja Kedarasetti","raw_affiliation_strings":["Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4226-5683","affiliations":[{"raw_affiliation_string":"Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038554858","display_name":"Patrick J. Drew","orcid":"https://orcid.org/0000-0002-7483-7378"},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick J. Drew","raw_affiliation_strings":["Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, United States of America","Departments of Biomedical Engineering and Neurosurgery, Pennsylvania State University, University Park, Pennsylvania, United States of America","Neuroscience Graduate Program, MD/PhD Medical Scientist Training Program, Pennsylvania State University, University Park, Pennsylvania, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-7483-7378","affiliations":[{"raw_affiliation_string":"Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Departments of Biomedical Engineering and Neurosurgery, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Neuroscience Graduate Program, MD/PhD Medical Scientist Training Program, Pennsylvania State University, University Park, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038554858"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.1364,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.92539434,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"16","issue":"7","first_page":"e1008069","last_page":"e1008069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"Nitric oxide","score":0.7012789249420166},{"id":"https://openalex.org/keywords/arteriole","display_name":"Arteriole","score":0.6522811651229858},{"id":"https://openalex.org/keywords/vasodilation","display_name":"Vasodilation","score":0.6518104076385498},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"Hyperoxia","score":0.6045970320701599},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5773769021034241},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"Hemoglobin","score":0.5570390224456787},{"id":"https://openalex.org/keywords/hypoxia","display_name":"Hypoxia (environmental)","score":0.5256337523460388},{"id":"https://openalex.org/keywords/vasomotion","display_name":"Vasomotion","score":0.4962027668952942},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.465526282787323},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.42442014813423157},{"id":"https://openalex.org/keywords/deoxygenated-hemoglobin","display_name":"Deoxygenated Hemoglobin","score":0.4238634407520294},{"id":"https://openalex.org/keywords/microcirculation","display_name":"Microcirculation","score":0.4112699627876282},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4109218120574951},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.35955432057380676},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35551726818084717},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2769711911678314},{"id":"https://openalex.org/keywords/oxygen","display_name":"Oxygen","score":0.16028478741645813},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.15835535526275635}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7012789249420166},{"id":"https://openalex.org/C2779482390","wikidata":"https://www.wikidata.org/wiki/Q501908","display_name":"Arteriole","level":3,"score":0.6522811651229858},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6518104076385498},{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.6045970320701599},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5773769021034241},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5570390224456787},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5256337523460388},{"id":"https://openalex.org/C2777583614","wikidata":"https://www.wikidata.org/wiki/Q7916877","display_name":"Vasomotion","level":3,"score":0.4962027668952942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.465526282787323},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.42442014813423157},{"id":"https://openalex.org/C2910876585","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Deoxygenated Hemoglobin","level":3,"score":0.4238634407520294},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.4112699627876282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4109218120574951},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35955432057380676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35551726818084717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2769711911678314},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.16028478741645813},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.15835535526275635},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009991","descriptor_name":"Oscillometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009991","descriptor_name":"Oscillometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009991","descriptor_name":"Oscillometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008069","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008069","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008069&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32716940","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32716940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4bfada81bf9a41fd8be82a787f0b28d3","is_oa":true,"landing_page_url":"https://doaj.org/article/4bfada81bf9a41fd8be82a787f0b28d3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 7, p e1008069 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7410342","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7410342","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008069","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008069","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008069&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5400000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1739514832","display_name":null,"funder_award_id":"R01NS078168","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2562935508","display_name":null,"funder_award_id":"R01NS078168","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5356141008","display_name":null,"funder_award_id":"R01EB021703","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3046136354.pdf","grobid_xml":"https://content.openalex.org/works/W3046136354.grobid-xml"},"referenced_works_count":256,"referenced_works":["https://openalex.org/W71450445","https://openalex.org/W194222363","https://openalex.org/W342717187","https://openalex.org/W1493459002","https://openalex.org/W1505333444","https://openalex.org/W1512746852","https://openalex.org/W1513307848","https://openalex.org/W1528220495","https://openalex.org/W1540025214","https://openalex.org/W1556666116","https://openalex.org/W1576343099","https://openalex.org/W1599476364","https://openalex.org/W1679279522","https://openalex.org/W1749866757","https://openalex.org/W1764308599","https://openalex.org/W1874165754","https://openalex.org/W1884294972","https://openalex.org/W1898022738","https://openalex.org/W1917637813","https://openalex.org/W1918557825","https://openalex.org/W1943267040","https://openalex.org/W1965864545","https://openalex.org/W1966637075","https://openalex.org/W1966883507","https://openalex.org/W1967678843","https://openalex.org/W1968244286","https://openalex.org/W1968370953","https://openalex.org/W1968799061","https://openalex.org/W1970610666","https://openalex.org/W1978204538","https://openalex.org/W1978648371","https://openalex.org/W1979240985","https://openalex.org/W1979404773","https://openalex.org/W1980610697","https://openalex.org/W1982474941","https://openalex.org/W1982861332","https://openalex.org/W1982896936","https://openalex.org/W1984776459","https://openalex.org/W1986547603","https://openalex.org/W1988132388","https://openalex.org/W1988677978","https://openalex.org/W1989283313","https://openalex.org/W1989441555","https://openalex.org/W1991841352","https://openalex.org/W1992184689","https://openalex.org/W1992302461","https://openalex.org/W1993783817","https://openalex.org/W1995267843","https://openalex.org/W1996022954","https://openalex.org/W1997268706","https://openalex.org/W2000075945","https://openalex.org/W2000464328","https://openalex.org/W2001078662","https://openalex.org/W2001552996","https://openalex.org/W2002130713","https://openalex.org/W2003666876","https://openalex.org/W2005007861","https://openalex.org/W2007737411","https://openalex.org/W2007813923","https://openalex.org/W2008242304","https://openalex.org/W2008432587","https://openalex.org/W2008624998","https://openalex.org/W2010723338","https://openalex.org/W2011047569","https://openalex.org/W2012238802","https://openalex.org/W2012562145","https://openalex.org/W2013392475","https://openalex.org/W2015759677","https://openalex.org/W2016483466","https://openalex.org/W2016579905","https://openalex.org/W2017019062","https://openalex.org/W2017094886","https://openalex.org/W2017477972","https://openalex.org/W2019073354","https://openalex.org/W2019443617","https://openalex.org/W2024862570","https://openalex.org/W2026623916","https://openalex.org/W2027180565","https://openalex.org/W2029280791","https://openalex.org/W2030630108","https://openalex.org/W2030903898","https://openalex.org/W2032824516","https://openalex.org/W2033695669","https://openalex.org/W2034188480","https://openalex.org/W2035939231","https://openalex.org/W2036472881","https://openalex.org/W2037159899","https://openalex.org/W2038626115","https://openalex.org/W2039187431","https://openalex.org/W2040398705","https://openalex.org/W2040682193","https://openalex.org/W2042099012","https://openalex.org/W2047545717","https://openalex.org/W2049092760","https://openalex.org/W2049584237","https://openalex.org/W2051106202","https://openalex.org/W2051280251","https://openalex.org/W2051872136","https://openalex.org/W2054041272","https://openalex.org/W2054818418","https://openalex.org/W2055821573","https://openalex.org/W2056109168","https://openalex.org/W2057301370","https://openalex.org/W2057593306","https://openalex.org/W2058062846","https://openalex.org/W2063676471","https://openalex.org/W2063703188","https://openalex.org/W2066649179","https://openalex.org/W2067494203","https://openalex.org/W2067637944","https://openalex.org/W2071417727","https://openalex.org/W2071553717","https://openalex.org/W2072767528","https://openalex.org/W2073849733","https://openalex.org/W2074070767","https://openalex.org/W2076138394","https://openalex.org/W2076286574","https://openalex.org/W2076325817","https://openalex.org/W2077461414","https://openalex.org/W2077837756","https://openalex.org/W2078057998","https://openalex.org/W2078261317","https://openalex.org/W2079637544","https://openalex.org/W2079993632","https://openalex.org/W2080828131","https://openalex.org/W2081597880","https://openalex.org/W2082906925","https://openalex.org/W2086251702","https://openalex.org/W2089447683","https://openalex.org/W2093671016","https://openalex.org/W2094506465","https://openalex.org/W2095371540","https://openalex.org/W2097863354","https://openalex.org/W2098090577","https://openalex.org/W2098284969","https://openalex.org/W2099194780","https://openalex.org/W2099262638","https://openalex.org/W2101195581","https://openalex.org/W2102673550","https://openalex.org/W2102813529","https://openalex.org/W2104402415","https://openalex.org/W2105367624","https://openalex.org/W2107187638","https://openalex.org/W2107950066","https://openalex.org/W2108555819","https://openalex.org/W2109313832","https://openalex.org/W2110457661","https://openalex.org/W2111332033","https://openalex.org/W2111609296","https://openalex.org/W2113565953","https://openalex.org/W2114104729","https://openalex.org/W2115067639","https://openalex.org/W2115146410","https://openalex.org/W2115153703","https://openalex.org/W2115299313","https://openalex.org/W2115492525","https://openalex.org/W2115989686","https://openalex.org/W2116403540","https://openalex.org/W2116802184","https://openalex.org/W2117648196","https://openalex.org/W2117951982","https://openalex.org/W2118621907","https://openalex.org/W2119710618","https://openalex.org/W2119979118","https://openalex.org/W2120182098","https://openalex.org/W2122036831","https://openalex.org/W2122427322","https://openalex.org/W2126315219","https://openalex.org/W2126624423","https://openalex.org/W2127075854","https://openalex.org/W2127265774","https://openalex.org/W2127322546","https://openalex.org/W2129234551","https://openalex.org/W2132211251","https://openalex.org/W2132513225","https://openalex.org/W2132872711","https://openalex.org/W2133824489","https://openalex.org/W2136489607","https://openalex.org/W2138733005","https://openalex.org/W2139123746","https://openalex.org/W2139187788","https://openalex.org/W2144632659","https://openalex.org/W2146190354","https://openalex.org/W2146579431","https://openalex.org/W2148772063","https://openalex.org/W2148949857","https://openalex.org/W2150307341","https://openalex.org/W2150393833","https://openalex.org/W2151035291","https://openalex.org/W2151644715","https://openalex.org/W2151969869","https://openalex.org/W2152299618","https://openalex.org/W2154020722","https://openalex.org/W2159707179","https://openalex.org/W2163219993","https://openalex.org/W2163234334","https://openalex.org/W2164617216","https://openalex.org/W2166298425","https://openalex.org/W2166509587","https://openalex.org/W2166803674","https://openalex.org/W2167541011","https://openalex.org/W2168827635","https://openalex.org/W2169118010","https://openalex.org/W2169182236","https://openalex.org/W2169699497","https://openalex.org/W2198668039","https://openalex.org/W2199359912","https://openalex.org/W2263258819","https://openalex.org/W2321989207","https://openalex.org/W2340249672","https://openalex.org/W2341223505","https://openalex.org/W2396292535","https://openalex.org/W2409838560","https://openalex.org/W2413335445","https://openalex.org/W2420221129","https://openalex.org/W2461148724","https://openalex.org/W2495803895","https://openalex.org/W2509400647","https://openalex.org/W2513508797","https://openalex.org/W2515433320","https://openalex.org/W2536398251","https://openalex.org/W2537505808","https://openalex.org/W2554706792","https://openalex.org/W2572331813","https://openalex.org/W2585661445","https://openalex.org/W2589041191","https://openalex.org/W2602561729","https://openalex.org/W2738996050","https://openalex.org/W2759050422","https://openalex.org/W2761818916","https://openalex.org/W2765135072","https://openalex.org/W2766937272","https://openalex.org/W2770554753","https://openalex.org/W2773821492","https://openalex.org/W2801883343","https://openalex.org/W2809129903","https://openalex.org/W2898388655","https://openalex.org/W2898625779","https://openalex.org/W2900697639","https://openalex.org/W2904698139","https://openalex.org/W2914517813","https://openalex.org/W2946229783","https://openalex.org/W2947689181","https://openalex.org/W2953093286","https://openalex.org/W2958522695","https://openalex.org/W2962791731","https://openalex.org/W2963123582","https://openalex.org/W2968274508","https://openalex.org/W2990571127","https://openalex.org/W2994486456","https://openalex.org/W3024184732","https://openalex.org/W3142410596","https://openalex.org/W4234401654","https://openalex.org/W4241694836","https://openalex.org/W6630644015","https://openalex.org/W7074187229"],"related_works":["https://openalex.org/W2413889807","https://openalex.org/W2372214266","https://openalex.org/W2416919898","https://openalex.org/W3159504814","https://openalex.org/W2208064417","https://openalex.org/W2072548897","https://openalex.org/W4223954720","https://openalex.org/W4211104393","https://openalex.org/W263489676","https://openalex.org/W4205734662"],"abstract_inverted_index":{"Nitric":[0],"oxide":[1],"(NO)":[2],"is":[3,38,55],"a":[4,78],"gaseous":[5],"signaling":[6,53],"molecule":[7],"that":[8,85,161,193,215],"plays":[9],"an":[10,100],"important":[11,101],"role":[12,102],"in":[13,36,44,81,103,120,172,177,195,209],"neurovascular":[14],"coupling.":[15],"NO":[16,34,52,71,90,114,119,146,207,226],"produced":[17],"by":[18,137,141,147,167,205,225,228],"neurons":[19],"diffuses":[20],"into":[21],"the":[22,31,65,86,93,96,121,125,142,148,173,210,229],"smooth":[23],"muscle":[24],"surrounding":[25],"cerebral":[26],"arterioles,":[27],"driving":[28],"vasodilation.":[29],"However,":[30],"rate":[32,112],"of":[33,40,70,77,89,95,113,118,145,169],"degradation":[35,74,115,144,208,227],"hemoglobin":[37,171],"orders":[39],"magnitude":[41],"higher":[42,111],"than":[43],"brain":[45],"tissue,":[46],"though":[47],"how":[48,64],"this":[49],"might":[50],"impact":[51],"dynamics":[54,163,219],"not":[56],"completely":[57],"understood.":[58],"We":[59,83,159],"used":[60],"simulations":[61,213],"to":[62,107,124],"investigate":[63],"spatial":[66,87],"and":[67,73,92,116,150,182],"temporal":[68],"patterns":[69],"generation":[72],"impacted":[75],"dilation":[76],"penetrating":[79],"arteriole":[80],"cortex.":[82],"found":[84,160],"location":[88],"production":[91],"size":[94],"vessel":[97],"both":[98],"played":[99],"determining":[104],"its":[105],"responsiveness":[106],"NO.":[108],"The":[109],"much":[110],"scavenging":[117],"blood":[122,188,196,230],"relative":[123],"tissue":[126],"drove":[127],"emergent":[128,222],"vascular":[129,218],"dynamics.":[130],"Large":[131],"vasodilation":[132],"events":[133],"could":[134,155,164,202],"be":[135,157,165,203,221],"followed":[136],"post-stimulus":[138],"constrictions":[139],"driven":[140],"increased":[143],"blood,":[149],"vasomotion-like":[151],"0.1-0.3":[152],"Hz":[153],"oscillations":[154],"also":[156],"generated.":[158],"these":[162],"enhanced":[166],"elevation":[168],"free":[170],"plasma,":[174],"which":[175],"occurs":[176],"diseases":[178],"such":[179],"as":[180],"malaria":[181],"sickle":[183],"cell":[184],"anemia,":[185],"or":[186,200,231],"following":[187],"transfusions.":[189],"Finally,":[190],"we":[191],"show":[192],"changes":[194],"flow":[197],"during":[198],"hypoxia":[199],"hyperoxia":[201],"explained":[204],"altered":[206],"parenchyma.":[211,232],"Our":[212],"suggest":[214],"many":[216],"common":[217],"may":[220],"phenomena":[223],"generated":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}