{"id":"https://openalex.org/W3081081198","doi":"https://doi.org/10.1371/journal.pcbi.1008064","title":"Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection","display_name":"Early exposure to broadly neutralizing antibodies may trigger a dynamical switch from progressive disease to lasting control of SHIV infection","publication_year":2020,"publication_date":"2020-08-20","ids":{"openalex":"https://openalex.org/W3081081198","doi":"https://doi.org/10.1371/journal.pcbi.1008064","mag":"3081081198","pmid":"https://pubmed.ncbi.nlm.nih.gov/32817614"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008064","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008064","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008064&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008064&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063962990","display_name":"Rajat Desikan","orcid":"https://orcid.org/0000-0002-0785-8187"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajat Desikan","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0002-0785-8187","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039150326","display_name":"Rubesh Raja","orcid":"https://orcid.org/0000-0002-3204-0061"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rubesh Raja","raw_affiliation_strings":["Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0002-3204-0061","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009087944","display_name":"Narendra M. Dixit","orcid":"https://orcid.org/0000-0002-2145-9828"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Narendra M. Dixit","raw_affiliation_strings":["Centre for Biosystems Science and Engineering, Indian Institute of Science, Bengaluru, India","Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India"],"raw_orcid":"https://orcid.org/0000-0002-2145-9828","affiliations":[{"raw_affiliation_string":"Centre for Biosystems Science and Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]},{"raw_affiliation_string":"Department of Chemical Engineering, Indian Institute of Science, Bengaluru, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009087944","https://openalex.org/A5063962990"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3918,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89527433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"16","issue":"8","first_page":"e1008064","last_page":"e1008064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.984000027179718,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viremia","display_name":"Viremia","score":0.9256591796875},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.6916911602020264},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.6298935413360596},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5231600999832153},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.4914189577102661},{"id":"https://openalex.org/keywords/neutralizing-antibody","display_name":"Neutralizing antibody","score":0.47943609952926636},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4244998097419739},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.39790984988212585},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3356885015964508},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32240432500839233},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.17752787470817566},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14833033084869385}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.9256591796875},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6916911602020264},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6298935413360596},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5231600999832153},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4914189577102661},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.47943609952926636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4244998097419739},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.39790984988212585},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3356885015964508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32240432500839233},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17752787470817566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14833033084869385}],"mesh":[{"descriptor_ui":"D000080908","descriptor_name":"Broadly Neutralizing Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000080908","descriptor_name":"Broadly Neutralizing Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000080908","descriptor_name":"Broadly Neutralizing Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008064","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008064","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008064&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32817614","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32817614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.iisc.ac.in:66602","is_oa":false,"landing_page_url":"http://eprints.iisc.ac.in/66602/8/12837354.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306401429","display_name":"ePrints@IISc (Indian Institute of Science)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7fd34ff8fc544c6c96f0422f739e6b2d","is_oa":true,"landing_page_url":"https://doaj.org/article/7fd34ff8fc544c6c96f0422f739e6b2d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 8, p e1008064 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7462315","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7462315","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008064","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008064","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008064&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G5897988762","display_name":null,"funder_award_id":"Senior Fellowship IA/S/14/1/501307","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3081081198.pdf","grobid_xml":"https://content.openalex.org/works/W3081081198.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1495576644","https://openalex.org/W1496703419","https://openalex.org/W1497870368","https://openalex.org/W1507548252","https://openalex.org/W1507800008","https://openalex.org/W1522687244","https://openalex.org/W1531756347","https://openalex.org/W1596437242","https://openalex.org/W1817014772","https://openalex.org/W1910012553","https://openalex.org/W1969577199","https://openalex.org/W1971931476","https://openalex.org/W1979058462","https://openalex.org/W1989174077","https://openalex.org/W1994500037","https://openalex.org/W2014903591","https://openalex.org/W2015776459","https://openalex.org/W2025366506","https://openalex.org/W2026814484","https://openalex.org/W2031473244","https://openalex.org/W2045550107","https://openalex.org/W2046974680","https://openalex.org/W2061536824","https://openalex.org/W2065638217","https://openalex.org/W2073692798","https://openalex.org/W2082667869","https://openalex.org/W2092524383","https://openalex.org/W2093889144","https://openalex.org/W2101516953","https://openalex.org/W2107941528","https://openalex.org/W2111538023","https://openalex.org/W2112391961","https://openalex.org/W2115580899","https://openalex.org/W2117367044","https://openalex.org/W2120389910","https://openalex.org/W2124114936","https://openalex.org/W2126515754","https://openalex.org/W2126603527","https://openalex.org/W2130446440","https://openalex.org/W2146537140","https://openalex.org/W2147590006","https://openalex.org/W2152534166","https://openalex.org/W2152803686","https://openalex.org/W2156075763","https://openalex.org/W2158562498","https://openalex.org/W2163779744","https://openalex.org/W2164250779","https://openalex.org/W2165871546","https://openalex.org/W2168736565","https://openalex.org/W2169404894","https://openalex.org/W2205248131","https://openalex.org/W2294780401","https://openalex.org/W2323113896","https://openalex.org/W2343862396","https://openalex.org/W2346116821","https://openalex.org/W2347047438","https://openalex.org/W2412909330","https://openalex.org/W2506616866","https://openalex.org/W2508401215","https://openalex.org/W2512010774","https://openalex.org/W2556485149","https://openalex.org/W2597074085","https://openalex.org/W2734230971","https://openalex.org/W2743105554","https://openalex.org/W2761099324","https://openalex.org/W2766842037","https://openalex.org/W2802298459","https://openalex.org/W2810189589","https://openalex.org/W2884312175","https://openalex.org/W2884491201","https://openalex.org/W2890205877","https://openalex.org/W2892592159","https://openalex.org/W2892753696","https://openalex.org/W2895775323","https://openalex.org/W2899779910","https://openalex.org/W2904106640","https://openalex.org/W2916757324","https://openalex.org/W2917986762","https://openalex.org/W2917990512","https://openalex.org/W2928603026","https://openalex.org/W2945002674","https://openalex.org/W2967649901","https://openalex.org/W2979774896","https://openalex.org/W2995826607","https://openalex.org/W2999692731"],"related_works":["https://openalex.org/W2002753371","https://openalex.org/W2086616853","https://openalex.org/W1982643583","https://openalex.org/W1547966308","https://openalex.org/W2363693236","https://openalex.org/W4313308334","https://openalex.org/W2046448593","https://openalex.org/W2003627888","https://openalex.org/W3176239880","https://openalex.org/W391733525"],"abstract_inverted_index":{"Antiretroviral":[0],"therapy":[1,9,132,153,235,243],"(ART)":[2],"for":[3],"HIV-1":[4,45,68,87],"infection":[5,16,71,107,127],"is":[6],"life-long.":[7],"Stopping":[8],"typically":[10,108],"leads":[11,109],"to":[12,35,75,110,137,157,289,294],"the":[13,97,126,165,185],"reignition":[14],"of":[15,31,39,43,56,67,82,125,148,194],"and":[17,128,154,205,220,272],"progressive":[18,111,210],"disease.":[19,112,211],"In":[20],"a":[21,53,80,134,146,268],"major":[22],"breakthrough,":[23],"recent":[24],"studies":[25],"have":[26],"shown":[27],"that":[28,86,115,129,173,184,232],"early":[29,69,130,233],"initiation":[30],"ART":[32,276],"can":[33,254],"lead":[34],"sustained":[36],"post-treatment":[37,50,291],"control":[38,51,78,98,117,238,292],"viremia,":[40,200,216,245],"raising":[41],"hopes":[42],"long-term":[44,77],"remission.":[46],"ART,":[47],"however,":[48,103],"elicits":[49],"in":[52,70,79],"small":[54],"fraction":[55],"individuals":[57],"treated.":[58],"Strikingly,":[59],"passive":[60],"immunization":[61],"with":[62,151,181],"broadly":[63],"neutralizing":[64],"antibodies":[65],"(bNAbs)":[66],"was":[72],"found":[73],"recently":[74],"elicit":[76,290],"majority":[81],"SHIV-infected":[83],"macaques,":[84],"suggesting":[85],"remission":[88],"may":[89,262],"be":[90],"more":[91],"widely":[92],"achievable.":[93],"The":[94,161,177,196,212],"mechanisms":[95],"underlying":[96,186],"elicited":[99,236],"by":[100],"bNAb":[101,131,152,234,242,295],"therapy,":[102],"remain":[104],"unclear.":[105],"Untreated":[106],"We":[113],"hypothesized":[114],"viremic":[116,226],"represents":[118],"an":[119],"alternative":[120],"but":[121,265,279],"rarely":[122],"realized":[123],"outcome":[124],"triggers":[133],"dynamical":[135],"switch":[136],"this":[138,142],"outcome.":[139],"To":[140],"test":[141],"hypothesis,":[143,183],"we":[144],"constructed":[145],"model":[147,162,178,229],"viral":[149,168],"dynamics":[150],"applied":[155],"it":[156,253],"analyse":[158],"clinical":[159],"data.":[160],"fit":[163],"quantitatively":[164],"complex":[166],"longitudinal":[167],"load":[169],"data":[170],"from":[171],"macaques":[172],"achieved":[174],"lasting":[175,225,237],"control.":[176,227],"predicted,":[179],"consistently":[180],"our":[182],"system":[187],"exhibited":[188],"bistability,":[189],"indicating":[190,224],"two":[191],"potential":[192],"outcomes":[193],"infection.":[195],"first":[197],"had":[198,214],"high":[199,206],"weak":[201],"cytotoxic":[202],"effector":[203,207,218,222,256,270,283],"responses,":[204,219],"exhaustion,":[208,223],"marking":[209],"second":[213],"low":[215,221],"strong":[217],"Further,":[228],"predictions":[230],"suggest":[231],"via":[239,258],"pleiotropic":[240],"effects.":[241],"lowers":[244],"which":[246],"would":[247,266],"also":[248],"limit":[249],"immune":[250],"exhaustion.":[251],"Simultaneously,":[252],"improve":[255],"stimulation":[257],"cross-presentation.":[259],"Consequently,":[260],"viremia":[261,278],"resurge":[263],"post-therapy,":[264],"encounter":[267],"primed":[269],"population":[271],"eventually":[273],"get":[274],"controlled.":[275],"suppresses":[277],"does":[280],"not":[281],"enhance":[282],"stimulation,":[284],"explaining":[285],"its":[286],"limited":[287],"ability":[288],"relative":[293],"therapy.":[296]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}