{"id":"https://openalex.org/W3119647002","doi":"https://doi.org/10.1371/journal.pcbi.1008055","title":"A multiscale model of complex endothelial cell dynamics in early angiogenesis","display_name":"A multiscale model of complex endothelial cell dynamics in early angiogenesis","publication_year":2021,"publication_date":"2021-01-07","ids":{"openalex":"https://openalex.org/W3119647002","doi":"https://doi.org/10.1371/journal.pcbi.1008055","mag":"3119647002","pmid":"https://pubmed.ncbi.nlm.nih.gov/33411727"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008055","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008055","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021657864","display_name":"Daria Stepanova","orcid":"https://orcid.org/0000-0003-1771-1987"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210122226","display_name":"Centre de Recerca Matem\u00e0tica","ror":"https://ror.org/020s51w82","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210122226","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Daria Stepanova","raw_affiliation_strings":["Centre de Recerca Matem\u00e0tica, Bellaterra (Barcelona), Spain","Departament de Matem\u00e0tiques, Universitat Aut\u00f2noma de Barcelona, Bellaterra (Barcelona), Spain"],"raw_orcid":"https://orcid.org/0000-0003-1771-1987","affiliations":[{"raw_affiliation_string":"Centre de Recerca Matem\u00e0tica, Bellaterra (Barcelona), Spain","institution_ids":["https://openalex.org/I4210122226"]},{"raw_affiliation_string":"Departament de Matem\u00e0tiques, Universitat Aut\u00f2noma de Barcelona, Bellaterra (Barcelona), Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087448925","display_name":"Helen M. Byrne","orcid":"https://orcid.org/0000-0003-1771-5910"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Helen M. Byrne","raw_affiliation_strings":["Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0003-1771-5910","affiliations":[{"raw_affiliation_string":"Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025791169","display_name":"Philip K. Maini","orcid":"https://orcid.org/0000-0002-0146-9164"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Philip K. Maini","raw_affiliation_strings":["Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-0146-9164","affiliations":[{"raw_affiliation_string":"Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079611387","display_name":"Tom\u00e1s Alarc\u00f3n","orcid":"https://orcid.org/0000-0002-8566-3676"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210091183","display_name":"Barcelona Graduate School of Mathematics","ror":"https://ror.org/00d5dd272","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210091183"]},{"id":"https://openalex.org/I4210122226","display_name":"Centre de Recerca Matem\u00e0tica","ror":"https://ror.org/020s51w82","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210122226","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Tom\u00e1s Alarc\u00f3n","raw_affiliation_strings":["Barcelona Graduate School of Mathematics (BGSMath), Barcelona, Spain","Centre de Recerca Matem\u00e0tica, Bellaterra (Barcelona), Spain","Departament de Matem\u00e0tiques, Universitat Aut\u00f2noma de Barcelona, Bellaterra (Barcelona), Spain","Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8566-3676","affiliations":[{"raw_affiliation_string":"Barcelona Graduate School of Mathematics (BGSMath), Barcelona, Spain","institution_ids":["https://openalex.org/I4210091183"]},{"raw_affiliation_string":"Centre de Recerca Matem\u00e0tica, Bellaterra (Barcelona), Spain","institution_ids":["https://openalex.org/I4210122226"]},{"raw_affiliation_string":"Departament de Matem\u00e0tiques, Universitat Aut\u00f2noma de Barcelona, Bellaterra (Barcelona), Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5021657864","https://openalex.org/A5025791169","https://openalex.org/A5079611387","https://openalex.org/A5087448925"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I123044942","https://openalex.org/I40120149","https://openalex.org/I4210091183","https://openalex.org/I4210122226"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.9554,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.91778214,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"e1008055","last_page":"e1008055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.6064162850379944},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5380892157554626},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5030514597892761},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.46167632937431335},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4608030319213867},{"id":"https://openalex.org/keywords/sprouting-angiogenesis","display_name":"Sprouting angiogenesis","score":0.452456533908844},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3258900046348572},{"id":"https://openalex.org/keywords/neovascularization","display_name":"Neovascularization","score":0.263885498046875},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22239768505096436}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6064162850379944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5380892157554626},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5030514597892761},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.46167632937431335},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4608030319213867},{"id":"https://openalex.org/C2910429298","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Sprouting angiogenesis","level":4,"score":0.452456533908844},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3258900046348572},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.263885498046875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22239768505096436}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008055","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008055","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33411727","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33411727","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:ddd.uab.cat:236221","is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/236221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:6011e689154b41e69bf15c3473e11809","is_oa":true,"landing_page_url":"https://doaj.org/article/6011e689154b41e69bf15c3473e11809","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 17, Iss 1, p e1008055 (2021)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:6748248","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7817011","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7817011","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7817011","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008055","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008055","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1897396192","display_name":null,"funder_award_id":"2017SGR01735","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"}],"funders":[{"id":"https://openalex.org/F4320312058","display_name":"\u201cla Caixa\u201d Foundation","ror":"https://ror.org/03zhx9h04"},{"id":"https://openalex.org/F4320315803","display_name":"Centres de Recerca de Catalunya","ror":null},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W136239046","https://openalex.org/W149822561","https://openalex.org/W643878296","https://openalex.org/W1457711407","https://openalex.org/W1513770217","https://openalex.org/W1562060992","https://openalex.org/W1965130848","https://openalex.org/W1973496993","https://openalex.org/W1973721705","https://openalex.org/W1974341035","https://openalex.org/W1977013517","https://openalex.org/W1978393368","https://openalex.org/W1982903250","https://openalex.org/W1988498168","https://openalex.org/W1990253071","https://openalex.org/W1991797784","https://openalex.org/W1992428669","https://openalex.org/W1993523135","https://openalex.org/W1996860993","https://openalex.org/W2012483332","https://openalex.org/W2014455063","https://openalex.org/W2015274661","https://openalex.org/W2016503463","https://openalex.org/W2018428660","https://openalex.org/W2020089786","https://openalex.org/W2022363275","https://openalex.org/W2022738778","https://openalex.org/W2025280242","https://openalex.org/W2027098947","https://openalex.org/W2034982562","https://openalex.org/W2035663157","https://openalex.org/W2038467979","https://openalex.org/W2038786403","https://openalex.org/W2039097069","https://openalex.org/W2042321087","https://openalex.org/W2043416386","https://openalex.org/W2043854809","https://openalex.org/W2045434770","https://openalex.org/W2048195900","https://openalex.org/W2048588851","https://openalex.org/W2049681345","https://openalex.org/W2049918202","https://openalex.org/W2050302207","https://openalex.org/W2050499474","https://openalex.org/W2064583712","https://openalex.org/W2068072750","https://openalex.org/W2071184715","https://openalex.org/W2073281753","https://openalex.org/W2073551059","https://openalex.org/W2080707454","https://openalex.org/W2090004981","https://openalex.org/W2090144600","https://openalex.org/W2091664424","https://openalex.org/W2096252516","https://openalex.org/W2097668262","https://openalex.org/W2099194598","https://openalex.org/W2112251383","https://openalex.org/W2114848029","https://openalex.org/W2115364696","https://openalex.org/W2122913894","https://openalex.org/W2125505694","https://openalex.org/W2127732571","https://openalex.org/W2132729583","https://openalex.org/W2134648876","https://openalex.org/W2145287259","https://openalex.org/W2150680442","https://openalex.org/W2156713309","https://openalex.org/W2157930949","https://openalex.org/W2160254610","https://openalex.org/W2165673724","https://openalex.org/W2166924155","https://openalex.org/W2167645403","https://openalex.org/W2168957713","https://openalex.org/W2207316926","https://openalex.org/W2233865695","https://openalex.org/W2275202079","https://openalex.org/W2284378488","https://openalex.org/W2338065732","https://openalex.org/W2408546946","https://openalex.org/W2416392622","https://openalex.org/W2470968000","https://openalex.org/W2482374135","https://openalex.org/W2529543999","https://openalex.org/W2552476396","https://openalex.org/W2563055839","https://openalex.org/W2573890585","https://openalex.org/W2577441975","https://openalex.org/W2580413034","https://openalex.org/W2619876526","https://openalex.org/W2750663726","https://openalex.org/W2786789072","https://openalex.org/W2805953717","https://openalex.org/W2811512231","https://openalex.org/W2901217248","https://openalex.org/W2901833413","https://openalex.org/W2941697077","https://openalex.org/W2950714863","https://openalex.org/W2964050834","https://openalex.org/W2989057373","https://openalex.org/W3002923559","https://openalex.org/W3098826600","https://openalex.org/W3103103607","https://openalex.org/W3103754732","https://openalex.org/W3105566970","https://openalex.org/W4211152410","https://openalex.org/W4252519252"],"related_works":["https://openalex.org/W2378478338","https://openalex.org/W4250385566","https://openalex.org/W1499643796","https://openalex.org/W2013631219","https://openalex.org/W4393156627","https://openalex.org/W2742452287","https://openalex.org/W2022810274","https://openalex.org/W4381492488","https://openalex.org/W4307993920","https://openalex.org/W4386215947"],"abstract_inverted_index":{"We":[0,189],"introduce":[1,173],"a":[2,18,33,42,177,215,294],"hybrid":[3],"two-dimensional":[4],"multiscale":[5],"model":[6,55,80,123],"of":[7,45,51,64,84,115,135,146,153,164,202,214,225,236,274],"angiogenesis,":[8],"the":[9,49,61,76,92,106,111,133,136,141,147,151,154,162,168,174,185,191,195,222,226,233,237,243,272],"process":[10],"by":[11,200],"which":[12],"endothelial":[13],"cells":[14,207,210],"(ECs)":[15],"migrate":[16],"from":[17,110],"pre-existing":[19],"vascular":[20,35,137,169,186,197,238],"bed":[21],"in":[22,48,72,252,289],"response":[23,63],"to":[24,31,66,130,160,232,263],"local":[25,77],"environmental":[26],"cues":[27],"and":[28,96,120,150,208,268],"cell-cell":[29],"interactions,":[30],"create":[32],"new":[34],"network.":[36],"Recent":[37],"experimental":[38,125],"studies":[39],"have":[40],"highlighted":[41],"central":[43],"role":[44,251],"cell":[46,70,97,165,182,246,260,280],"rearrangements":[47,166,247],"formation":[50],"angiogenic":[52,85],"networks.":[53],"Our":[54,218],"accounts":[56],"for":[57,194,286,297],"this":[58,275],"phenomenon":[59],"via":[60],"heterogeneous":[62],"ECs":[65,201],"their":[67],"microenvironment.":[68],"These":[69,99],"rearrangements,":[71],"turn,":[73],"dynamically":[74],"remodel":[75],"environment.":[78],"The":[79],"reproduces":[81],"characteristic":[82],"features":[83,235],"sprouting":[86,253],"that":[87,180,221,245,258],"include":[88],"branching,":[89],"chemotactic":[90],"sensitivity,":[91],"brush":[93],"border":[94],"effect,":[95],"mixing.":[98],"properties,":[100],"rather":[101],"than":[102],"being":[103],"hardwired":[104],"into":[105],"model,":[107],"emerge":[108],"naturally":[109],"gene":[112,143],"expression":[113,144,213],"patterns":[114],"individual":[116,279],"cells.":[117],"After":[118],"calibrating":[119],"validating":[121],"our":[122],"against":[124],"data,":[126],"we":[127,172,256],"use":[128],"it":[129,282,293],"predict":[131,257],"how":[132],"structure":[134],"network":[138,170,187],"changes":[139],"as":[140,184],"baseline":[142],"levels":[145],"VEGF-Delta-Notch":[148],"pathway,":[149],"composition":[152],"extracellular":[155],"environment,":[156],"vary.":[157],"In":[158],"order":[159],"investigate":[161],"impact":[163],"on":[167],"structure,":[171],"mixing":[175,183,192,227],"measure,":[176],"scalar":[178],"metric":[179],"quantifies":[181],"grows.":[188],"calculate":[190],"measure":[193,228],"simulated":[196],"networks":[198,287],"generated":[199,288],"different":[203],"lineages":[204],"(wild":[205],"type":[206],"mutant":[209],"with":[211],"impaired":[212],"specific":[216],"receptor).":[217],"results":[219],"show":[220],"time":[223],"evolution":[224],"is":[229],"directly":[230],"correlated":[231],"generic":[234],"branching":[239,267],"pattern,":[240],"thus,":[241],"supporting":[242],"hypothesis":[244],"play":[248],"an":[249,264],"essential":[250],"angiogenesis.":[254,299],"Furthermore,":[255],"lower":[259],"rearrangement":[261],"leads":[262],"imbalance":[265],"between":[266],"sprout":[269],"elongation.":[270],"Since":[271],"computation":[273],"statistic":[276],"requires":[277],"only":[278],"trajectories,":[281],"can":[283],"be":[284],"computed":[285],"biological":[290],"experiments,":[291],"making":[292],"potential":[295],"biomarker":[296],"pathological":[298]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
