{"id":"https://openalex.org/W3040901290","doi":"https://doi.org/10.1371/journal.pcbi.1008048","title":"Heart failure-induced atrial remodelling promotes electrical and conduction alternans","display_name":"Heart failure-induced atrial remodelling promotes electrical and conduction alternans","publication_year":2020,"publication_date":"2020-07-13","ids":{"openalex":"https://openalex.org/W3040901290","doi":"https://doi.org/10.1371/journal.pcbi.1008048","mag":"3040901290","pmid":"https://pubmed.ncbi.nlm.nih.gov/32658888"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008048","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1008048","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071387519","display_name":"Na Zhao","orcid":"https://orcid.org/0000-0002-3317-1389"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Zhao","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0002-3317-1389","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043556359","display_name":"Qince Li","orcid":"https://orcid.org/0000-0003-3447-7352"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I4210136793","display_name":"Peng Cheng Laboratory","ror":"https://ror.org/03qdqbt06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210136793"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qince Li","raw_affiliation_strings":["Peng Cheng Laboratory, Shenzhen, China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peng Cheng Laboratory, Shenzhen, China","institution_ids":["https://openalex.org/I4210136793"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629174","display_name":"Kevin Zhang","orcid":"https://orcid.org/0000-0001-8074-8008"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Zhang","raw_affiliation_strings":["School of Medicine, Imperial College of London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-8074-8008","affiliations":[{"raw_affiliation_string":"School of Medicine, Imperial College of London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049558861","display_name":"Kuanquan Wang","orcid":"https://orcid.org/0000-0003-1347-3491"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kuanquan Wang","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0003-1347-3491","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101467858","display_name":"Runnan He","orcid":"https://orcid.org/0000-0003-2137-8785"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runnan He","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0003-2137-8785","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107919406","display_name":"Yongfeng Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongfeng Yuan","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"funder","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210136793","display_name":"Peng Cheng Laboratory","ror":"https://ror.org/03qdqbt06","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210136793"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China","Peng Cheng Laboratory, Shenzhen, China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-0863-5807","affiliations":[{"raw_affiliation_string":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Peng Cheng Laboratory, Shenzhen, China","institution_ids":["https://openalex.org/I4210136793"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"School of Physics & Astronomy, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5043271142"],"corresponding_institution_ids":["https://openalex.org/I204983213","https://openalex.org/I28407311","https://openalex.org/I3017480383","https://openalex.org/I4210136793"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7697,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.7480188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"7","first_page":"e1008048","last_page":"e1008048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholamban","display_name":"Phospholamban","score":0.7307897806167603},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.7221605777740479},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.6910681128501892},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.6108421087265015},{"id":"https://openalex.org/keywords/serca","display_name":"SERCA","score":0.6063987612724304},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5192944407463074},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4913017153739929},{"id":"https://openalex.org/keywords/diastole","display_name":"Diastole","score":0.4860387444496155},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"Endoplasmic reticulum","score":0.4736301302909851},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.445904403924942},{"id":"https://openalex.org/keywords/atrial-action-potential","display_name":"Atrial action potential","score":0.4444517493247986},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3225308060646057},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3223772346973419},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.19646099209785461},{"id":"https://openalex.org/keywords/atpase","display_name":"ATPase","score":0.126509428024292},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06558060646057129},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.06498497724533081}],"concepts":[{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.7307897806167603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7221605777740479},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6910681128501892},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6108421087265015},{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.6063987612724304},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5192944407463074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4913017153739929},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4860387444496155},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.4736301302909851},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.445904403924942},{"id":"https://openalex.org/C87520248","wikidata":"https://www.wikidata.org/wiki/Q4817540","display_name":"Atrial action potential","level":4,"score":0.4444517493247986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3225308060646057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3223772346973419},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.19646099209785461},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.126509428024292},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06558060646057129},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06498497724533081},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099211","descriptor_name":"Phospholamban","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002135","descriptor_name":"Calcium-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064752","descriptor_name":"Atrial Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064752","descriptor_name":"Atrial Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064752","descriptor_name":"Atrial Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1008048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008048","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32658888","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32658888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008048","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008048","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:777b3cabe5494bd1bd98de5e6501d968","is_oa":true,"landing_page_url":"https://doaj.org/article/777b3cabe5494bd1bd98de5e6501d968","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 7, p e1008048 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7402519","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7402519","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008048","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3117828192","display_name":"\u4ee3\u8c22\u529f\u80fd\u5931\u5e38\u60c5\u51b5\u4e0b\u6c27\u5316\u5e94\u6fc0\u5f15\u8d77\u5fc3\u810f\u4ea4\u66ff\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"61601143","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G346406294","display_name":null,"funder_award_id":"2015M581448","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G4381733","display_name":"TRPV4\u5728\u5fc3\u623f\u98a4\u52a8\u53d1\u75c5\u4e2d\u7684\u4f5c\u7528\u53ca\u5176\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"81770328","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8882164163","display_name":"\u57fa\u4e8e3D\u7535-\u529b\u8026\u5408\u4eba\u5fc3\u5ba4\u6a21\u578b\u7684\u751f\u7269\u8d77\u640f\u5668\u673a\u5236\u7814\u7a76","funder_award_id":"61572152","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G903721460","display_name":"\u4e2a\u4f53\u5316\u7684\u865a\u62df\u751f\u7406\u5fc3\u5ba4\u5efa\u6a21\u4e0e\u4eff\u771f\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61571165","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W20074729","https://openalex.org/W1018973536","https://openalex.org/W1965139977","https://openalex.org/W1966730613","https://openalex.org/W1973228369","https://openalex.org/W1977252918","https://openalex.org/W1991074270","https://openalex.org/W1998489509","https://openalex.org/W1998730638","https://openalex.org/W2004135099","https://openalex.org/W2021597262","https://openalex.org/W2036437780","https://openalex.org/W2045787555","https://openalex.org/W2045797610","https://openalex.org/W2056622908","https://openalex.org/W2064757035","https://openalex.org/W2067313061","https://openalex.org/W2078242986","https://openalex.org/W2079418868","https://openalex.org/W2079656921","https://openalex.org/W2079763132","https://openalex.org/W2088624984","https://openalex.org/W2090003238","https://openalex.org/W2092541823","https://openalex.org/W2095702602","https://openalex.org/W2100635982","https://openalex.org/W2101482473","https://openalex.org/W2103105155","https://openalex.org/W2105454146","https://openalex.org/W2110222991","https://openalex.org/W2110258428","https://openalex.org/W2110368377","https://openalex.org/W2111174244","https://openalex.org/W2111773661","https://openalex.org/W2112713043","https://openalex.org/W2113493519","https://openalex.org/W2115928923","https://openalex.org/W2119159332","https://openalex.org/W2119340816","https://openalex.org/W2141247592","https://openalex.org/W2145264435","https://openalex.org/W2147537230","https://openalex.org/W2150921421","https://openalex.org/W2153042674","https://openalex.org/W2156393131","https://openalex.org/W2158133158","https://openalex.org/W2159614581","https://openalex.org/W2165168573","https://openalex.org/W2166325927","https://openalex.org/W2175513192","https://openalex.org/W2191722017","https://openalex.org/W2197690315","https://openalex.org/W2219147369","https://openalex.org/W2341374042","https://openalex.org/W2537707689","https://openalex.org/W2546952747","https://openalex.org/W2557294840","https://openalex.org/W2594925144","https://openalex.org/W2604389867","https://openalex.org/W2605951782","https://openalex.org/W2609605008","https://openalex.org/W2622208318","https://openalex.org/W2745546719","https://openalex.org/W2752530775","https://openalex.org/W2773785061","https://openalex.org/W2886678431","https://openalex.org/W2893721043","https://openalex.org/W2897630776","https://openalex.org/W2902576139","https://openalex.org/W2913705661","https://openalex.org/W3000616331","https://openalex.org/W4238907867","https://openalex.org/W4239881443"],"related_works":["https://openalex.org/W2020586759","https://openalex.org/W1965138828","https://openalex.org/W2071619191","https://openalex.org/W2162855904","https://openalex.org/W2064263971","https://openalex.org/W2022543170","https://openalex.org/W2070547207","https://openalex.org/W1972301114","https://openalex.org/W1972357381","https://openalex.org/W2167564898"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"(HF)":[2],"is":[3,22,288],"associated":[4],"with":[5,302],"an":[6,93,128,281],"increased":[7,53,129,147,156,165,185,267,282],"propensity":[8],"for":[9],"atrial":[10,28,37,56,73,88,99,118,144,150,298,303],"fibrillation":[11],"(AF),":[12],"causing":[13],"higher":[14],"mortality":[15],"than":[16],"AF":[17],"or":[18],"HF":[19,59,296],"alone.":[20],"It":[21],"hypothesized":[23],"that":[24,45,116,142,183,249],"HF-induced":[25,72,117,143,254],"remodelling":[26,90,120,146,257],"of":[27,36,70,98,203,243,253,275],"cellular":[29,74,107],"and":[30,42,80,102,108,135,169,189,212,223,226,231,238,258],"tissue":[31,81,111,246],"properties":[32],"promotes":[33,297],"the":[34,49,52,68,96,106,155,170,184,201,215,250,268,273],"genesis":[35],"action":[38,252],"potential":[39],"(AP)":[40],"alternans":[41,44,57,101,151,222,230,234],"conduction":[43,104],"perpetuate":[46],"AF.":[47],"However,":[48],"mechanism":[50,179],"underlying":[51,178],"susceptibility":[54,148,271],"to":[55,149,154,196,265,272],"in":[58,206,214,261,280,300],"remains":[60],"incompletely":[61],"elucidated.":[62],"In":[63],"this":[64],"study,":[65],"we":[66],"investigated":[67],"effects":[69],"how":[71,295],"electrophysiological":[75],"(with":[76],"prolonged":[77,121,190],"AP":[78,100,122,191,213,224,229,284],"duration)":[79],"structural":[82],"(reduced":[83],"cell-to-cell":[84,262],"coupling":[85,237,263],"caused":[86,228],"by":[87,127,164],"fibrosis)":[89],"can":[91],"have":[92],"effect":[94],"on":[95],"generation":[97],"their":[103,197],"at":[105,200],"one-dimensional":[109],"(1D)":[110],"levels.":[112],"Simulation":[113,242],"results":[114],"showed":[115,248],"electrical":[119,145],"duration,":[123],"which":[124,287],"was":[125],"accompanied":[126],"sarcoplasmic":[130,157],"reticulum":[131,158],"(SR)":[132],"Ca2+":[133,136,161,187,210,220,232],"content":[134,188],"transient":[137,172,221,233],"amplitude.":[138],"Further":[139],"analysis":[140],"demonstrated":[141],"mainly":[152],"due":[153,264],"Ca2+-ATPase":[159],"(SERCA)":[160],"reuptake,":[162],"modulated":[163],"phospholamban":[166],"(PLB)":[167],"phosphorylation,":[168],"decreased":[171],"outward":[173],"K+":[174],"current":[175],"(Ito).":[176],"The":[177],"has":[180],"been":[181],"suggested":[182],"SR":[186,209],"did":[192],"not":[193],"fully":[194],"recover":[195],"previous":[198],"levels":[199],"end":[202],"diastole,":[204],"resulting":[205,279],"a":[207,244,259],"smaller":[208],"release":[211],"next":[216],"beat.":[217],"These":[218,290],"produced":[219],"alternans,":[225,278],"further":[227],"through":[235],"Ca2+\u2192AP":[236],"AP\u2192Ca2+":[239],"coupling,":[240],"respectively.":[241],"1D":[245],"model":[247],"combined":[251],"ion":[255],"channel":[256],"decrease":[260],"fibrosis":[266],"heart":[269],"tissue's":[270],"formation":[274],"spatially":[276],"discordant":[277],"functional":[283],"propagation":[285],"dispersion,":[286],"pro-arrhythmic.":[289],"findings":[291],"provide":[292],"insights":[293],"into":[294],"arrhythmia":[299],"association":[301],"alternans.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}