{"id":"https://openalex.org/W3043434686","doi":"https://doi.org/10.1371/journal.pcbi.1008015","title":"Interactions between calmodulin and neurogranin govern the dynamics of CaMKII as a leaky integrator","display_name":"Interactions between calmodulin and neurogranin govern the dynamics of CaMKII as a leaky integrator","publication_year":2020,"publication_date":"2020-07-17","ids":{"openalex":"https://openalex.org/W3043434686","doi":"https://doi.org/10.1371/journal.pcbi.1008015","mag":"3043434686","pmid":"https://pubmed.ncbi.nlm.nih.gov/32678848"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008015","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008015&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008015&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041274888","display_name":"Mariam Ordyan","orcid":"https://orcid.org/0000-0003-0064-2997"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariam Ordyan","raw_affiliation_strings":["Computational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, California, United States of America","Institute for Neural Computation, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0064-2997","affiliations":[{"raw_affiliation_string":"Computational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Institute for Neural Computation, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112347392","display_name":"Tom Bartol","orcid":null},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Bartol","raw_affiliation_strings":["Computational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048832172","display_name":"Mary B. Kennedy","orcid":"https://orcid.org/0000-0003-1369-0525"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Kennedy","raw_affiliation_strings":["The Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1369-0525","affiliations":[{"raw_affiliation_string":"The Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, United States of America","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044701434","display_name":"Padmini Rangamani","orcid":"https://orcid.org/0000-0001-5953-4347"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Padmini Rangamani","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5953-4347","affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044141636","display_name":"Terrence J. Sejnowski","orcid":"https://orcid.org/0000-0002-0622-7391"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terrence Sejnowski","raw_affiliation_strings":["Computational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, California, United States of America","Institute for Neural Computation, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0622-7391","affiliations":[{"raw_affiliation_string":"Computational Neurobiology Laboratory, Salk Institute for Biological Sciences, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Institute for Neural Computation, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044141636","https://openalex.org/A5044701434"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I36258959"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0828,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.86553436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"16","issue":"7","first_page":"e1008015","last_page":"e1008015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurogranin","display_name":"Neurogranin","score":0.8058911561965942},{"id":"https://openalex.org/keywords/autophosphorylation","display_name":"Autophosphorylation","score":0.7601224184036255},{"id":"https://openalex.org/keywords/calmodulin","display_name":"Calmodulin","score":0.6754224300384521},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.602415919303894},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"Long-term potentiation","score":0.5573921799659729},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5276269316673279},{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.5254442095756531},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"Calcium signaling","score":0.4824000597000122},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.47387003898620605},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46771684288978577},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.4473893344402313},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.41300082206726074},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.37319695949554443},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.35734739899635315},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.30577099323272705},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2944526672363281},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2795320749282837},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.20853456854820251},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"Protein kinase C","score":0.09516388177871704}],"concepts":[{"id":"https://openalex.org/C2780748493","wikidata":"https://www.wikidata.org/wiki/Q22676708","display_name":"Neurogranin","level":4,"score":0.8058911561965942},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.7601224184036255},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.6754224300384521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.602415919303894},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.5573921799659729},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5276269316673279},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5254442095756531},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4824000597000122},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.47387003898620605},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46771684288978577},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.4473893344402313},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.41300082206726074},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37319695949554443},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.35734739899635315},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30577099323272705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2944526672363281},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2795320749282837},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20853456854820251},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.09516388177871704},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017774","descriptor_name":"Long-Term Potentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051579","descriptor_name":"Neurogranin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051579","descriptor_name":"Neurogranin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051579","descriptor_name":"Neurogranin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057907","descriptor_name":"Post-Synaptic Density","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057907","descriptor_name":"Post-Synaptic Density","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057907","descriptor_name":"Post-Synaptic Density","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1008015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008015","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008015&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32678848","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32678848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1008015","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008015","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:246b4eeeaa5f4b8ba208822d4287ea1f","is_oa":true,"landing_page_url":"https://doaj.org/article/246b4eeeaa5f4b8ba208822d4287ea1f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 7, p e1008015 (2020)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8ff3f7g5","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8ff3f7g5","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 16, iss 7","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7390456","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7390456","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008015","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008015","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008015&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4146002358","display_name":null,"funder_award_id":"FA9550-18-1-005","funder_id":"https://openalex.org/F4320332467","funder_display_name":"U.S. Air Force"}],"funders":[{"id":"https://openalex.org/F4320332467","display_name":"U.S. Air Force","ror":"https://ror.org/006gmme17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3043434686.pdf","grobid_xml":"https://content.openalex.org/works/W3043434686.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W924178511","https://openalex.org/W1480101062","https://openalex.org/W1505515840","https://openalex.org/W1523015514","https://openalex.org/W1533227151","https://openalex.org/W1557771190","https://openalex.org/W1565248232","https://openalex.org/W1570784999","https://openalex.org/W1573584522","https://openalex.org/W1599390139","https://openalex.org/W1609834322","https://openalex.org/W1641016126","https://openalex.org/W1957331510","https://openalex.org/W1963881156","https://openalex.org/W1964789490","https://openalex.org/W1975255652","https://openalex.org/W1977679299","https://openalex.org/W1978730538","https://openalex.org/W1978756588","https://openalex.org/W1979318504","https://openalex.org/W1979586675","https://openalex.org/W1985019456","https://openalex.org/W1986291163","https://openalex.org/W1988297823","https://openalex.org/W1989361508","https://openalex.org/W1990402608","https://openalex.org/W1990501032","https://openalex.org/W1994155349","https://openalex.org/W1994923272","https://openalex.org/W1997297151","https://openalex.org/W1998678953","https://openalex.org/W1999912060","https://openalex.org/W2013115334","https://openalex.org/W2017789880","https://openalex.org/W2017836075","https://openalex.org/W2020564163","https://openalex.org/W2021235911","https://openalex.org/W2022174722","https://openalex.org/W2022286642","https://openalex.org/W2022924617","https://openalex.org/W2030890665","https://openalex.org/W2033302498","https://openalex.org/W2033942553","https://openalex.org/W2034424952","https://openalex.org/W2035391953","https://openalex.org/W2035880579","https://openalex.org/W2037069728","https://openalex.org/W2042312855","https://openalex.org/W2042663951","https://openalex.org/W2045194954","https://openalex.org/W2045546690","https://openalex.org/W2046033738","https://openalex.org/W2047966157","https://openalex.org/W2052322593","https://openalex.org/W2054856526","https://openalex.org/W2054975255","https://openalex.org/W2055584624","https://openalex.org/W2059785780","https://openalex.org/W2059901952","https://openalex.org/W2060200435","https://openalex.org/W2060941075","https://openalex.org/W2062090669","https://openalex.org/W2062317659","https://openalex.org/W2067529350","https://openalex.org/W2069118261","https://openalex.org/W2080611091","https://openalex.org/W2080631697","https://openalex.org/W2084010240","https://openalex.org/W2084354745","https://openalex.org/W2084653594","https://openalex.org/W2087436387","https://openalex.org/W2090714277","https://openalex.org/W2095169768","https://openalex.org/W2095421300","https://openalex.org/W2106389606","https://openalex.org/W2113094198","https://openalex.org/W2116153674","https://openalex.org/W2118444707","https://openalex.org/W2121490181","https://openalex.org/W2135711165","https://openalex.org/W2136008443","https://openalex.org/W2139045279","https://openalex.org/W2140944550","https://openalex.org/W2143471960","https://openalex.org/W2144948613","https://openalex.org/W2146831587","https://openalex.org/W2147101007","https://openalex.org/W2148923308","https://openalex.org/W2157942605","https://openalex.org/W2161262899","https://openalex.org/W2161448985","https://openalex.org/W2161939122","https://openalex.org/W2163172571","https://openalex.org/W2163493106","https://openalex.org/W2163680039","https://openalex.org/W2163883777","https://openalex.org/W2163978292","https://openalex.org/W2165739257","https://openalex.org/W2170201765","https://openalex.org/W2175715045","https://openalex.org/W2193304014","https://openalex.org/W2195210638","https://openalex.org/W2303100661","https://openalex.org/W2496824318","https://openalex.org/W2498442975","https://openalex.org/W2518269465","https://openalex.org/W2518276547","https://openalex.org/W2616355480","https://openalex.org/W2621892584","https://openalex.org/W2882341351","https://openalex.org/W2884299905","https://openalex.org/W2899549546","https://openalex.org/W2908553168","https://openalex.org/W2912257116","https://openalex.org/W2920899837","https://openalex.org/W2948493777","https://openalex.org/W2951196187","https://openalex.org/W2953864225","https://openalex.org/W2963381503","https://openalex.org/W2967980310","https://openalex.org/W2979293455","https://openalex.org/W2980686459","https://openalex.org/W2983201012","https://openalex.org/W2996447991","https://openalex.org/W3025155896","https://openalex.org/W4245570086"],"related_works":["https://openalex.org/W2767016092","https://openalex.org/W1575693343","https://openalex.org/W3085040917","https://openalex.org/W1987074935","https://openalex.org/W2168494337","https://openalex.org/W1966245166","https://openalex.org/W1505515840","https://openalex.org/W1512908939","https://openalex.org/W2153475422","https://openalex.org/W1991877115"],"abstract_inverted_index":{"Calmodulin-dependent":[0],"kinase":[1],"II":[2],"(CaMKII)":[3],"has":[4,27,229,290],"long":[5,20],"been":[6,28,230,291],"known":[7],"to":[8,46,91,124,225,321,328],"play":[9],"an":[10,117,182],"important":[11,183],"role":[12,59,185],"in":[13,35,66,104,113,157,172,186,234,273,294],"learning":[14],"and":[15,119,130,148,270,316],"memory":[16],"as":[17,19,280],"well":[18],"term":[21],"potentiation":[22],"(LTP).":[23],"More":[24],"recently":[25,292],"it":[26,31],"suggested":[29],"that":[30,179,207,233,272,289,299],"might":[32],"be":[33],"involved":[34],"the":[36,47,58,61,68,87,93,99,105,125,141,161,167,173,210,219,226,235,260,274,300,310,324],"time":[37],"averaging":[38],"of":[39,50,60,70,95,101,127,143,145,163,175,192,201,213,221,237,245,262,276,284,302,312,326],"synaptic":[40,114],"signals,":[41,286],"which":[42,169],"can":[43],"then":[44],"lead":[45],"high":[48,193],"precision":[49],"information":[51],"stored":[52],"at":[53],"a":[54,82,190,198,281,287,319],"single":[55],"synapse.":[56],"However,":[57],"scaffolding":[62,152],"molecule,":[63,153],"neurogranin":[64],"(Ng),":[65],"governing":[67],"dynamics":[69,100,142],"CaMKII":[71,102,146,171,187,216,239,267,278],"is":[72],"not":[73,333],"yet":[74],"fully":[75],"understood.":[76],"In":[77],"this":[78,202,303],"work,":[79],"we":[80,138],"adopt":[81],"rule-based":[83],"modeling":[84],"approach":[85],"through":[86,248,309],"Monte":[88],"Carlo":[89],"method":[90],"study":[92,259],"effect":[94,203,261],"Ca2+":[96,243],"signals":[97,244],"on":[98,204,218,266],"phosphorylation":[103,144,188],"postsynaptic":[106],"density":[107],"(PSD).":[108],"Calcium":[109],"surges":[110],"are":[111,306],"observed":[112,293],"spines":[115],"during":[116],"EPSP":[118],"back-propagating":[120],"action":[121],"potential":[122],"due":[123],"opening":[126],"NMDA":[128],"receptors":[129],"voltage":[131],"dependent":[132],"calcium":[133,194,222,264,285,329],"channels.":[134],"Using":[135],"agent-based":[136],"models,":[137],"computationally":[139],"investigate":[140],"monomers":[147,240],"dodecameric":[149],"holoenzymes.":[150],"The":[151],"Ng,":[154,313],"when":[155],"present":[156],"significant":[158],"concentration,":[159],"limits":[160],"availability":[162],"free":[164],"calmodulin":[165],"(CaM),":[166],"protein":[168],"activates":[170],"presence":[174,275],"calcium.":[176],"We":[177,196,257],"show":[178,271],"Ng":[180],"plays":[181],"modulatory":[184],"following":[189],"surge":[191],"concentration.":[195],"find":[197],"non-intuitive":[199],"dependence":[200],"CaM":[205,214],"concentration":[206],"results":[208],"from":[209],"different":[211],"affinities":[212],"for":[215,335],"depending":[217],"number":[220],"ions":[223],"bound":[224],"former.":[227],"It":[228],"shown":[231],"previously":[232],"absence":[236],"phosphatase,":[238,277],"integrate":[241],"over":[242],"certain":[246],"frequencies":[247],"autophosphorylation":[249],"(Pepke":[250],"et":[251],"al,":[252],"Plos":[253],"Comp.":[254],"Bio.,":[255],"2010).":[256],"also":[258],"multiple":[263],"spikes":[265],"holoenzyme":[268],"autophosphorylation,":[269],"behaves":[279],"leaky":[282,304],"integrator":[283,305],"result":[288],"vivo.":[295],"Our":[296],"models":[297],"predict":[298],"parameters":[301],"finely":[307],"tuned":[308],"interactions":[311],"CaM,":[314],"CaMKII,":[315],"PP1,":[317],"providing":[318],"mechanism":[320],"precisely":[322],"control":[323],"sensitivity":[325],"synapses":[327],"signals.":[330],"Author":[331],"Summary":[332],"valid":[334],"PLOS":[336],"ONE":[337],"submissions.":[338]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}