{"id":"https://openalex.org/W3116140574","doi":"https://doi.org/10.1371/journal.pcbi.1007988","title":"Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases","display_name":"Classification and phylogeny for the annotation of novel eukaryotic GNAT acetyltransferases","publication_year":2020,"publication_date":"2020-12-23","ids":{"openalex":"https://openalex.org/W3116140574","doi":"https://doi.org/10.1371/journal.pcbi.1007988","mag":"3116140574","pmid":"https://pubmed.ncbi.nlm.nih.gov/33362253"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007988","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007988","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1007988","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076894902","display_name":"Bojan Krtenic","orcid":null},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Bojan Krtenic","raw_affiliation_strings":["Computational Biology Unit, Department of Informatics, University of Bergen, Norway","Department of Biological Sciences, University of Bergen, Norway"],"affiliations":[{"raw_affiliation_string":"Computational Biology Unit, Department of Informatics, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039132032","display_name":"Adrian Drazic","orcid":"https://orcid.org/0000-0001-9263-5502"},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Adrian Drazic","raw_affiliation_strings":["Department of Biomedicine, University of Bergen, Norway"],"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032682346","display_name":"Thomas Arnesen","orcid":"https://orcid.org/0000-0002-3005-147X"},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Thomas Arnesen","raw_affiliation_strings":["Department of Biological Sciences, University of Bergen, Norway","Department of Biomedicine, University of Bergen, Norway","Department of Surgery, Haukeland University Hospital, Norway"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Biomedicine, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Surgery, Haukeland University Hospital, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090274388","display_name":"Nathalie Reuter","orcid":"https://orcid.org/0000-0002-3649-7675"},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Nathalie Reuter","raw_affiliation_strings":["Computational Biology Unit, Department of Informatics, University of Bergen, Norway","Department of Chemistry, University of Bergen, Norway"],"affiliations":[{"raw_affiliation_string":"Computational Biology Unit, Department of Informatics, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Chemistry, University of Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076894902","https://openalex.org/A5090274388"],"corresponding_institution_ids":["https://openalex.org/I4432739"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5865,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70534969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"16","issue":"12","first_page":"e1007988","last_page":"e1007988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyltransferases","display_name":"Acetyltransferases","score":0.7779743671417236},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7777342796325684},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5190342664718628},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.5159119367599487},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4972672760486603},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.4439306855201721},{"id":"https://openalex.org/keywords/acetyltransferase","display_name":"Acetyltransferase","score":0.41150227189064026},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.37575995922088623},{"id":"https://openalex.org/keywords/acetylation","display_name":"Acetylation","score":0.29934757947921753},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27381837368011475}],"concepts":[{"id":"https://openalex.org/C2910274206","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferases","level":4,"score":0.7779743671417236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7777342796325684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5190342664718628},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.5159119367599487},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4972672760486603},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4439306855201721},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.41150227189064026},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.37575995922088623},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.29934757947921753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27381837368011475}],"mesh":[{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007988","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007988","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33362253","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33362253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ba2c21e0af314c908e0fcdd3570aee64","is_oa":true,"landing_page_url":"https://doaj.org/article/ba2c21e0af314c908e0fcdd3570aee64","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 12, p e1007988 (2020)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:6745358","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7790372","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7790372","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7790372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007988","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007988","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5799999833106995,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1897079340","display_name":null,"funder_award_id":"PR-2009-0222","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G2730210754","display_name":null,"funder_award_id":"F-12540","funder_id":"https://openalex.org/F4320322496","funder_display_name":"Helse Vest"},{"id":"https://openalex.org/G3748656914","display_name":null,"funder_award_id":"Norway","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G3932871164","display_name":null,"funder_award_id":"251247","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G5201527707","display_name":null,"funder_award_id":"912176","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G6222146311","display_name":null,"funder_award_id":"2009-0222","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G7198429319","display_name":null,"funder_award_id":"249843","funder_id":"https://openalex.org/F4320310758","funder_display_name":"Kreftforeningen"},{"id":"https://openalex.org/G728116563","display_name":null,"funder_award_id":"249843","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G8072577569","display_name":null,"funder_award_id":"912176","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"},{"id":"https://openalex.org/G8793371682","display_name":null,"funder_award_id":"288008","funder_id":"https://openalex.org/F4320323299","funder_display_name":"Norges Forskningsr\u00e5d"}],"funders":[{"id":"https://openalex.org/F4320310758","display_name":"Kreftforeningen","ror":"https://ror.org/01925vb10"},{"id":"https://openalex.org/F4320322496","display_name":"Helse Vest","ror":"https://ror.org/001212e83"},{"id":"https://openalex.org/F4320323299","display_name":"Norges Forskningsr\u00e5d","ror":"https://ror.org/00epmv149"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W105392238","https://openalex.org/W107719192","https://openalex.org/W158285355","https://openalex.org/W1563817153","https://openalex.org/W1592870802","https://openalex.org/W1883668892","https://openalex.org/W1954288236","https://openalex.org/W1967363545","https://openalex.org/W1975692560","https://openalex.org/W1980117255","https://openalex.org/W1983415168","https://openalex.org/W1987370810","https://openalex.org/W1989851713","https://openalex.org/W1990425248","https://openalex.org/W1997612055","https://openalex.org/W2002769816","https://openalex.org/W2004500138","https://openalex.org/W2006897037","https://openalex.org/W2007462973","https://openalex.org/W2008206202","https://openalex.org/W2008207297","https://openalex.org/W2014314082","https://openalex.org/W2014652729","https://openalex.org/W2017519756","https://openalex.org/W2019076314","https://openalex.org/W2019710427","https://openalex.org/W2025636361","https://openalex.org/W2026881360","https://openalex.org/W2026965903","https://openalex.org/W2027419223","https://openalex.org/W2029132704","https://openalex.org/W2030663130","https://openalex.org/W2031029779","https://openalex.org/W2032961316","https://openalex.org/W2033750217","https://openalex.org/W2036874847","https://openalex.org/W2038286309","https://openalex.org/W2045131701","https://openalex.org/W2048958290","https://openalex.org/W2059283641","https://openalex.org/W2062018285","https://openalex.org/W2072080280","https://openalex.org/W2073889204","https://openalex.org/W2074597391","https://openalex.org/W2082565035","https://openalex.org/W2083195949","https://openalex.org/W2089130436","https://openalex.org/W2092735199","https://openalex.org/W2096357091","https://openalex.org/W2096525273","https://openalex.org/W2097606916","https://openalex.org/W2100320834","https://openalex.org/W2103123341","https://openalex.org/W2104488123","https://openalex.org/W2107158607","https://openalex.org/W2108211735","https://openalex.org/W2108318453","https://openalex.org/W2109027544","https://openalex.org/W2109640950","https://openalex.org/W2111199460","https://openalex.org/W2112090702","https://openalex.org/W2114874351","https://openalex.org/W2115595474","https://openalex.org/W2115943691","https://openalex.org/W2118520292","https://openalex.org/W2122540435","https://openalex.org/W2123858481","https://openalex.org/W2124790653","https://openalex.org/W2127322768","https://openalex.org/W2127648442","https://openalex.org/W2129039174","https://openalex.org/W2131510173","https://openalex.org/W2132022337","https://openalex.org/W2137955461","https://openalex.org/W2138386513","https://openalex.org/W2139134537","https://openalex.org/W2141052558","https://openalex.org/W2143348980","https://openalex.org/W2143526876","https://openalex.org/W2151736966","https://openalex.org/W2151831732","https://openalex.org/W2157009395","https://openalex.org/W2159675211","https://openalex.org/W2160942335","https://openalex.org/W2163627198","https://openalex.org/W2164083634","https://openalex.org/W2170236894","https://openalex.org/W2171707538","https://openalex.org/W2207234187","https://openalex.org/W2238868503","https://openalex.org/W2286962642","https://openalex.org/W2342569995","https://openalex.org/W2394990151","https://openalex.org/W2425379846","https://openalex.org/W2431163235","https://openalex.org/W2492997309","https://openalex.org/W2511106300","https://openalex.org/W2546624599","https://openalex.org/W2558272290","https://openalex.org/W2588714631","https://openalex.org/W2592038517","https://openalex.org/W2597283289","https://openalex.org/W2604603855","https://openalex.org/W2622048161","https://openalex.org/W2751583588","https://openalex.org/W2789605661","https://openalex.org/W2794404825","https://openalex.org/W2797831397","https://openalex.org/W2801900613","https://openalex.org/W2810225090","https://openalex.org/W2883210621","https://openalex.org/W2883652577","https://openalex.org/W2898402099","https://openalex.org/W2901263048","https://openalex.org/W2921660925","https://openalex.org/W2944954872","https://openalex.org/W2947100670","https://openalex.org/W2954851300","https://openalex.org/W2990840521","https://openalex.org/W2996334565","https://openalex.org/W3003943371","https://openalex.org/W3010500909","https://openalex.org/W3015309216","https://openalex.org/W3028665039","https://openalex.org/W3030387578","https://openalex.org/W3039051118","https://openalex.org/W3080133182","https://openalex.org/W3095583226","https://openalex.org/W4251386234","https://openalex.org/W6755752558"],"related_works":["https://openalex.org/W2791562104","https://openalex.org/W4389965776","https://openalex.org/W199740677","https://openalex.org/W4403619505","https://openalex.org/W1978231463","https://openalex.org/W3154850690","https://openalex.org/W2016961165","https://openalex.org/W2914605468","https://openalex.org/W2011862732","https://openalex.org/W1991837357"],"abstract_inverted_index":{"The":[0,55],"enzymes":[1,26,203],"of":[2,17,39,50,58,67,74,91,121,187,232,248],"the":[3,21,72,75,79,136,149,158,175,185,215,233,238],"GCN5-related":[4],"N-acetyltransferase":[5],"(GNAT)":[6],"superfamily":[7,93,101],"count":[8],"more":[9,171],"than":[10,172],"870":[11],"000":[12],"members":[13,90,123],"through":[14],"all":[15,68],"kingdoms":[16],"life":[18],"and":[19,47,52,116,139,190],"share":[20],"same":[22],"structural":[23],"fold.":[24],"GNAT":[25,56,76,82,122,146,160,176,216,249],"transfer":[27],"an":[28],"acyl":[29,32],"moiety":[30],"from":[31],"coenzyme":[33],"A":[34],"to":[35,134,183,220,227,244],"a":[36,65,141,154,229,242],"wide":[37],"range":[38],"substrates":[40,96],"including":[41],"aminoglycosides,":[42],"serotonin,":[43],"glucosamine-6-phosphate,":[44],"protein":[45,59,167,195,206],"N-termini":[46],"lysine":[48],"residues":[49],"histones":[51],"other":[53],"proteins.":[54],"subtype":[57],"N-terminal":[60,207],"acetyltransferases":[61,237],"(NATs)":[62],"alone":[63],"targets":[64],"majority":[66],"eukaryotic":[69,145,236],"proteins":[70],"stressing":[71],"omnipresence":[73],"enzymes.":[77],"Despite":[78],"highly":[80],"conserved":[81],"fold,":[83],"sequence":[84,112,131,137],"similarity":[85,113,132],"is":[86,102,114],"quite":[87],"low":[88],"between":[89,235],"this":[92,100],"even":[94,211],"when":[95],"are":[97],"similar.":[98],"Furthermore,":[99],"phylogenetically":[103],"not":[104],"well":[105],"characterized.":[106],"Thus":[107],"functional":[108,246],"annotation":[109,247],"based":[110],"on":[111,174,214],"unreliable":[115],"strongly":[117],"hampered":[118],"for":[119,144],"thousands":[120],"that":[124,166,197,210],"remain":[125],"biochemically":[126],"uncharacterized.":[127],"Here":[128],"we":[129,152],"used":[130],"networks":[133],"map":[135,231],"space":[138],"propose":[140],"new":[142,150,230],"classification":[143,182,239],"acetyltransferases.":[147,250],"Using":[148],"classification,":[151],"built":[153],"phylogenetic":[155],"tree,":[156],"representing":[157],"entire":[159],"acetyltransferase":[161],"superfamily.":[162],"Our":[163],"results":[164],"show":[165],"NATs":[168],"have":[169],"evolved":[170],"once":[173],"acetylation":[177],"scaffold.":[178],"We":[179],"use":[180],"our":[181],"predict":[184],"function":[186],"uncharacterized":[188],"sequences":[189],"verify":[191],"by":[192],"in":[193,222],"vitro":[194],"assays":[196],"two":[198],"fungal":[199],"genes":[200],"encode":[201],"NAT":[202],"targeting":[204],"specific":[205],"sequences,":[208],"showing":[209],"slight":[212],"changes":[213],"fold":[217],"can":[218],"lead":[219],"change":[221],"substrate":[223],"specificity.":[224],"In":[225],"addition":[226],"providing":[228],"relationship":[234],"proposed":[240],"constitutes":[241],"tool":[243],"improve":[245]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}
