{"id":"https://openalex.org/W3040005615","doi":"https://doi.org/10.1371/journal.pcbi.1007982","title":"It\u2019s about time: Analysing simplifying assumptions for modelling multi-step pathways in systems biology","display_name":"It\u2019s about time: Analysing simplifying assumptions for modelling multi-step pathways in systems biology","publication_year":2020,"publication_date":"2020-06-29","ids":{"openalex":"https://openalex.org/W3040005615","doi":"https://doi.org/10.1371/journal.pcbi.1007982","mag":"3040005615","pmid":"https://pubmed.ncbi.nlm.nih.gov/32598362"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007982","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007982","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007982&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007982&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071832881","display_name":"Niklas Korsbo","orcid":"https://orcid.org/0000-0001-9811-3190"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2800011936","display_name":"Sainsbury Laboratory","ror":"https://ror.org/02tdtzx53","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800011936"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Niklas Korsbo","raw_affiliation_strings":["Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom","The Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9811-3190","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"The Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2800011936","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010315204","display_name":"Henrik J\u00f6nsson","orcid":"https://orcid.org/0000-0003-2340-588X"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2800011936","display_name":"Sainsbury Laboratory","ror":"https://ror.org/02tdtzx53","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800011936"]}],"countries":["GB","SE"],"is_corresponding":true,"raw_author_name":"Henrik J\u00f6nsson","raw_affiliation_strings":["Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom","Department of Astronomy and Theoretical Physics, Computational Biology and Biological Physics, Lund University, Lund, Sweden","The Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2340-588X","affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Astronomy and Theoretical Physics, Computational Biology and Biological Physics, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"The Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I2800011936","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010315204"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I241749","https://openalex.org/I2800011936"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5048,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.82361467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"16","issue":"6","first_page":"e1007982","last_page":"e1007982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6662192344665527},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6167252659797668},{"id":"https://openalex.org/keywords/truncation","display_name":"Truncation (statistics)","score":0.5470389723777771},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.4383317828178406},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.432468056678772},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3391195833683014},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.23007887601852417},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.18387609720230103},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18156203627586365},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15075290203094482}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6662192344665527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6167252659797668},{"id":"https://openalex.org/C106195933","wikidata":"https://www.wikidata.org/wiki/Q7847935","display_name":"Truncation (statistics)","level":2,"score":0.5470389723777771},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4383317828178406},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.432468056678772},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3391195833683014},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.23007887601852417},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.18387609720230103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18156203627586365},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15075290203094482},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1007982","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007982","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007982&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32598362","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32598362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/309390","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/309390","pdf_url":"https://www.repository.cam.ac.uk/handle/1810/309390","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1007982","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007982","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8f68c3f37c7241078fda7ae6b707773c","is_oa":true,"landing_page_url":"https://doaj.org/article/8f68c3f37c7241078fda7ae6b707773c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 6, p e1007982 (2020)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:d5529a9f-0d46-4ede-8390-34f5fb5353d2","is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/d5529a9f-0d46-4ede-8390-34f5fb5353d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-734X","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7351226","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7351226","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/307847","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/307847","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.54941","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.54941","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17863/cam.56479","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.56479","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007982","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007982","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007982&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G4488024445","display_name":null,"funder_award_id":"GAT3395-PR4B","funder_id":"https://openalex.org/F4320320033","funder_display_name":"Gatsby Charitable Foundation"},{"id":"https://openalex.org/G6333238847","display_name":null,"funder_award_id":"GAT3395","funder_id":"https://openalex.org/F4320320033","funder_display_name":"Gatsby Charitable Foundation"},{"id":"https://openalex.org/G8562127085","display_name":null,"funder_award_id":"GAT3395-PR4","funder_id":"https://openalex.org/F4320320033","funder_display_name":"Gatsby Charitable Foundation"}],"funders":[{"id":"https://openalex.org/F4320320033","display_name":"Gatsby Charitable Foundation","ror":"https://ror.org/0290hax27"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3040005615.pdf","grobid_xml":"https://content.openalex.org/works/W3040005615.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W614012683","https://openalex.org/W1595159159","https://openalex.org/W1599969036","https://openalex.org/W1645305843","https://openalex.org/W1847315806","https://openalex.org/W1882584705","https://openalex.org/W1953008475","https://openalex.org/W1975507400","https://openalex.org/W1980396134","https://openalex.org/W1980875771","https://openalex.org/W1982147469","https://openalex.org/W1985261712","https://openalex.org/W1985911638","https://openalex.org/W1990065094","https://openalex.org/W2002045347","https://openalex.org/W2004566760","https://openalex.org/W2006583270","https://openalex.org/W2023651881","https://openalex.org/W2028996974","https://openalex.org/W2030945597","https://openalex.org/W2033474977","https://openalex.org/W2039006574","https://openalex.org/W2042321087","https://openalex.org/W2042831535","https://openalex.org/W2057364858","https://openalex.org/W2063386545","https://openalex.org/W2067414977","https://openalex.org/W2072665520","https://openalex.org/W2076420009","https://openalex.org/W2080757588","https://openalex.org/W2082516483","https://openalex.org/W2085722235","https://openalex.org/W2090297178","https://openalex.org/W2096492216","https://openalex.org/W2101682056","https://openalex.org/W2112913709","https://openalex.org/W2116055501","https://openalex.org/W2117056464","https://openalex.org/W2117453669","https://openalex.org/W2120575449","https://openalex.org/W2121295901","https://openalex.org/W2123333705","https://openalex.org/W2134759932","https://openalex.org/W2136969641","https://openalex.org/W2138190671","https://openalex.org/W2140677435","https://openalex.org/W2142507929","https://openalex.org/W2143113504","https://openalex.org/W2145274928","https://openalex.org/W2149644313","https://openalex.org/W2156413023","https://openalex.org/W2209554446","https://openalex.org/W2282990569","https://openalex.org/W2479540212","https://openalex.org/W2589812846","https://openalex.org/W2607363868","https://openalex.org/W2608169504","https://openalex.org/W2619381903","https://openalex.org/W2748637762","https://openalex.org/W2790723981","https://openalex.org/W2902773595","https://openalex.org/W2903650961","https://openalex.org/W2909620196","https://openalex.org/W2953025957","https://openalex.org/W2970528191","https://openalex.org/W3099650222","https://openalex.org/W4362196385"],"related_works":["https://openalex.org/W1974935850","https://openalex.org/W2074350688","https://openalex.org/W3158981924","https://openalex.org/W2042589464","https://openalex.org/W4252883813","https://openalex.org/W2346128247","https://openalex.org/W2078650164","https://openalex.org/W3047214821","https://openalex.org/W2012531322","https://openalex.org/W2158562798"],"abstract_inverted_index":{"Thoughtful":[0],"use":[1,132],"of":[2,16,28,65,97,126,138,151,212],"simplifying":[3,117],"assumptions":[4],"is":[5,114,144],"crucial":[6],"to":[7,81,90,101,131],"make":[8],"systems":[9],"biology":[10],"models":[11,69,87,211],"tractable":[12],"while":[13],"still":[14],"representative":[15],"the":[17,25,76,133,136,142,149,152,202],"underlying":[18],"biology.":[19],"A":[20,31],"useful":[21],"simplification":[22],"can":[23,48],"elucidate":[24],"core":[26],"dynamics":[27,106],"a":[29,39,62,98,123,155,179,189,218],"system.":[30],"poorly":[32],"chosen":[33],"assumption":[34,113,134,176,204],"can,":[35],"however,":[36],"either":[37],"render":[38],"model":[40,53,105,181,225],"too":[41],"complicated":[42],"for":[43,116,206,220],"making":[44,223],"conclusions":[45],"or":[46],"it":[47],"prevent":[49],"an":[50],"otherwise":[51],"accurate":[52],"from":[54],"describing":[55],"experimentally":[56],"observed":[57,196],"dynamics.":[58,197],"Here,":[59],"we":[60,129,172],"perform":[61],"computational":[63],"investigation":[64],"sequential":[66,166],"multi-step":[67],"pathway":[68,73,99,127,143,153],"that":[70,135,164,182],"contain":[71],"fewer":[72],"steps":[74],"than":[75,121],"system":[77],"they":[78],"are":[79,165],"designed":[80],"emulate.":[82],"We":[83,158,198],"demonstrate":[84],"when":[85],"such":[86,118],"will":[88],"fail":[89],"reproduce":[91],"data":[92],"and":[93,107,167,171,188,209],"how":[94,174,201],"detrimental":[95],"truncation":[96],"leads":[100],"detectable":[102],"signatures":[103],"in":[104,178,194],"its":[108,185],"optimised":[109],"parameters.":[110],"An":[111],"alternative":[112,193],"suggested":[115],"pathways.":[119,214],"Rather":[120],"assuming":[122],"truncated":[124,186],"number":[125],"steps,":[128],"propose":[130],"rates":[137],"information":[139],"propagation":[140],"along":[141],"homogeneous":[145],"and,":[146],"instead,":[147],"letting":[148],"length":[150],"be":[154],"free":[156],"parameter.":[157],"first":[159],"focus":[160],"on":[161],"linear":[162],"pathways":[163],"have":[168],"first-order":[169],"kinetics,":[170],"show":[173,200],"this":[175],"results":[177,216],"three-parameter":[180],"consistently":[183],"outperforms":[184],"rival":[187],"delay":[190],"differential":[191],"equation":[192],"recapitulating":[195],"then":[199],"proposed":[203],"allows":[205],"similarly":[207],"terse":[208],"effective":[210],"non-linear":[213],"Our":[215],"provide":[217],"foundation":[219],"well-informed":[221],"decision":[222],"during":[224],"simplifications.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}