{"id":"https://openalex.org/W3032723080","doi":"https://doi.org/10.1371/journal.pcbi.1007930","title":"Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications","display_name":"Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications","publication_year":2020,"publication_date":"2020-05-29","ids":{"openalex":"https://openalex.org/W3032723080","doi":"https://doi.org/10.1371/journal.pcbi.1007930","mag":"3032723080","pmid":"https://pubmed.ncbi.nlm.nih.gov/32469859"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007930","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007930","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1007930","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079349107","display_name":"Mart\u00edn Carballo\u2010Pacheco","orcid":"https://orcid.org/0000-0002-9047-1855"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mart\u00edn Carballo-Pacheco","raw_affiliation_strings":["School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017327074","display_name":"Michael D. Nicholson","orcid":"https://orcid.org/0000-0003-2813-8979"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Michael D. Nicholson","raw_affiliation_strings":["Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America","Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-2813-8979","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084239252","display_name":"Elin Lilja","orcid":"https://orcid.org/0000-0002-3628-2332"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elin E. Lilja","raw_affiliation_strings":["School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030956076","display_name":"Rosalind J. Allen","orcid":"https://orcid.org/0000-0003-4110-2962"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rosalind J. Allen","raw_affiliation_strings":["Centre for Synthetic and Systems Biology, The University of Edinburgh, Edinburgh, United Kingdom","School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4110-2962","affiliations":[{"raw_affiliation_string":"Centre for Synthetic and Systems Biology, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062292279","display_name":"Bart\u0142omiej Waclaw","orcid":"https://orcid.org/0000-0001-5355-7994"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Bartlomiej Waclaw","raw_affiliation_strings":["Centre for Synthetic and Systems Biology, The University of Edinburgh, Edinburgh, United Kingdom","School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5355-7994","affiliations":[{"raw_affiliation_string":"Centre for Synthetic and Systems Biology, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"School of Physics and Astronomy, The University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5062292279"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4414,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82485005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"5","first_page":"e1007930","last_page":"e1007930"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9836999773979187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7410032153129578},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6318157315254211},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6155169606208801},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.57850581407547},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5160598158836365},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.49527493119239807},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.462586373090744},{"id":"https://openalex.org/keywords/mutation-rate","display_name":"Mutation rate","score":0.44916918873786926},{"id":"https://openalex.org/keywords/dilution","display_name":"Dilution","score":0.44285038113594055},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.42840576171875},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"Antibiotic resistance","score":0.4274655878543854},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17312172055244446},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1050981879234314}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7410032153129578},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6318157315254211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6155169606208801},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.57850581407547},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5160598158836365},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49527493119239807},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.462586373090744},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.44916918873786926},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.44285038113594055},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.42840576171875},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4274655878543854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17312172055244446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1050981879234314},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024881","descriptor_name":"Drug Resistance, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007930","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007930","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32469859","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32469859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pure.ed.ac.uk:openaire/88b77a50-2d40-4c9c-a856-2d9e31259d33","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/88b77a50-2d40-4c9c-a856-2d9e31259d33","pdf_url":null,"source":{"id":"https://openalex.org/S4406922455","display_name":"Edinburgh Research Explorer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carballo Pacheco, M, Nicholson, M, Lilja, E, Allen, R & Waclaw, B 2020, 'Phenotypic delay in the evolution of bacterial antibiotic resistance: mechanistic models and their implications', PLoS Computational Biology, vol. 16, no. 5, e1007930. https://doi.org/10.1371/journal.pcbi.1007930","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:1f8bcc62b63a47c292f683920f871c5c","is_oa":true,"landing_page_url":"https://doaj.org/article/1f8bcc62b63a47c292f683920f871c5c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 5, p e1007930 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7307788","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7307788","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.ed.ac.uk:publications/88b77a50-2d40-4c9c-a856-2d9e31259d33","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11820/88b77a50-2d40-4c9c-a856-2d9e31259d33","pdf_url":null,"source":{"id":"https://openalex.org/S4406922455","display_name":"Edinburgh Research Explorer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007930","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007930","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"awards":[{"id":"https://openalex.org/G4107433587","display_name":null,"funder_award_id":"BB/R012415/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5715339698","display_name":null,"funder_award_id":"682237","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320041","display_name":"Royal Society of Edinburgh","ror":"https://ror.org/03kx2pj14"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W126264051","https://openalex.org/W1481170590","https://openalex.org/W1552342234","https://openalex.org/W1569605331","https://openalex.org/W1600786531","https://openalex.org/W1807366173","https://openalex.org/W1874782934","https://openalex.org/W1875633444","https://openalex.org/W1897359304","https://openalex.org/W1897512913","https://openalex.org/W1914267757","https://openalex.org/W1977321171","https://openalex.org/W1979152503","https://openalex.org/W1988691705","https://openalex.org/W1990818876","https://openalex.org/W1991601642","https://openalex.org/W2003470745","https://openalex.org/W2007452808","https://openalex.org/W2012977051","https://openalex.org/W2013116070","https://openalex.org/W2013735712","https://openalex.org/W2014268112","https://openalex.org/W2018591582","https://openalex.org/W2019385975","https://openalex.org/W2024835565","https://openalex.org/W2028553878","https://openalex.org/W2031223726","https://openalex.org/W2034254026","https://openalex.org/W2037212291","https://openalex.org/W2039685044","https://openalex.org/W2040889971","https://openalex.org/W2042619042","https://openalex.org/W2056335856","https://openalex.org/W2059905849","https://openalex.org/W2063558597","https://openalex.org/W2063563543","https://openalex.org/W2065554842","https://openalex.org/W2079762396","https://openalex.org/W2087875068","https://openalex.org/W2090232842","https://openalex.org/W2090664858","https://openalex.org/W2096650678","https://openalex.org/W2097571872","https://openalex.org/W2104187897","https://openalex.org/W2108748905","https://openalex.org/W2109042184","https://openalex.org/W2116416291","https://openalex.org/W2116427781","https://openalex.org/W2118015073","https://openalex.org/W2119404698","https://openalex.org/W2121581360","https://openalex.org/W2122404311","https://openalex.org/W2126643167","https://openalex.org/W2129026291","https://openalex.org/W2129361946","https://openalex.org/W2132697669","https://openalex.org/W2135532205","https://openalex.org/W2140080780","https://openalex.org/W2142612394","https://openalex.org/W2146370523","https://openalex.org/W2147455202","https://openalex.org/W2147706925","https://openalex.org/W2148364220","https://openalex.org/W2154279044","https://openalex.org/W2157898081","https://openalex.org/W2159859422","https://openalex.org/W2164578658","https://openalex.org/W2166576018","https://openalex.org/W2170343590","https://openalex.org/W2171197491","https://openalex.org/W2179429273","https://openalex.org/W2195802432","https://openalex.org/W2300011769","https://openalex.org/W2320526527","https://openalex.org/W2399952372","https://openalex.org/W2401957325","https://openalex.org/W2529657394","https://openalex.org/W2531758255","https://openalex.org/W2593835589","https://openalex.org/W2607462092","https://openalex.org/W2610250630","https://openalex.org/W2765821397","https://openalex.org/W2767150039","https://openalex.org/W2775498852","https://openalex.org/W2787533914","https://openalex.org/W2885043619","https://openalex.org/W2885985538","https://openalex.org/W2905349247","https://openalex.org/W2936652663","https://openalex.org/W2950480279","https://openalex.org/W2952558578","https://openalex.org/W2963402579","https://openalex.org/W2963667930","https://openalex.org/W2964137854","https://openalex.org/W2994704341","https://openalex.org/W3026026050","https://openalex.org/W3037965392","https://openalex.org/W3099635483","https://openalex.org/W3100301220","https://openalex.org/W3100889652","https://openalex.org/W3103796768","https://openalex.org/W4233875887","https://openalex.org/W4242285942","https://openalex.org/W4251566758","https://openalex.org/W4253991977","https://openalex.org/W4291718509","https://openalex.org/W6676279030"],"related_works":["https://openalex.org/W2146397496","https://openalex.org/W2076383445","https://openalex.org/W2592888218","https://openalex.org/W2804435636","https://openalex.org/W2136281516","https://openalex.org/W2025340064","https://openalex.org/W4384665577","https://openalex.org/W4231831369","https://openalex.org/W2097774084","https://openalex.org/W2606677068"],"abstract_inverted_index":{"Phenotypic":[0],"delay-the":[1],"time":[2],"delay":[3,44,103],"between":[4],"genetic":[5],"mutation":[6,129,164],"and":[7,36,69,97,123,161,183],"expression":[8],"of":[9,42,48,66,71,79,94,108,148,156,163,176,180],"the":[10,40,46,77,92,137,146,174,177],"corresponding":[11],"phenotype-is":[12],"generally":[13],"neglected":[14],"in":[15,128,166],"evolutionary":[16],"models,":[17],"yet":[18],"recent":[19],"work":[20],"suggests":[21],"that":[22,76,186],"it":[23],"may":[24],"be":[25],"more":[26],"common":[27],"than":[28],"previously":[29,195],"assumed.":[30],"Here,":[31],"we":[32,184],"use":[33],"computer":[34],"simulations":[35],"theory":[37],"to":[38,51,153,194],"investigate":[39,112],"significance":[41],"phenotypic":[43,61,102],"for":[45],"evolution":[47],"bacterial":[49],"resistance":[50],"antibiotics.":[52],"We":[53,74,110],"consider":[54],"three":[55],"mechanisms":[56,115],"which":[57],"could":[58,116],"potentially":[59],"cause":[60,101],"delay:":[62],"effective":[63,98,138],"polyploidy,":[64],"dilution":[65,93,147,170],"antibiotic-sensitive":[67],"molecules":[68,81,96,150],"accumulation":[70,78],"resistance-enhancing":[72],"molecules.":[73],"find":[75],"resistant":[80],"is":[82],"relevant":[83],"only":[84],"within":[85],"a":[86,105],"narrow":[87],"parameter":[88],"range,":[89],"but":[90],"both":[91,152],"sensitive":[95,149],"polyploidy":[99,139],"can":[100],"over":[104],"wide":[106],"range":[107],"parameters.":[109],"further":[111],"whether":[113],"these":[114],"affect":[117,143],"population":[118,144],"survival":[119,157],"under":[120,158],"drug":[121,159],"treatment":[122,160],"thereby":[124],"explain":[125],"observed":[126],"discrepancies":[127],"rates":[130,165],"estimated":[131],"by":[132],"Luria-Delbr\u00fcck":[133,178],"fluctuation":[134,167],"tests.":[135,168],"While":[136],"mechanism":[140,171],"does":[141],"not":[142],"survival,":[145],"leads":[151],"decreased":[154],"probability":[155],"underestimation":[162],"The":[169],"also":[172],"changes":[173],"shape":[175],"distribution":[179,189],"mutant":[181],"numbers,":[182],"show":[185],"this":[187],"modified":[188],"provides":[190],"an":[191],"improved":[192],"fit":[193],"published":[196],"experimental":[197],"data.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}