{"id":"https://openalex.org/W3033736641","doi":"https://doi.org/10.1371/journal.pcbi.1007925","title":"Detecting differential alternative splicing events in scRNA-seq with or without Unique Molecular Identifiers","display_name":"Detecting differential alternative splicing events in scRNA-seq with or without Unique Molecular Identifiers","publication_year":2020,"publication_date":"2020-06-05","ids":{"openalex":"https://openalex.org/W3033736641","doi":"https://doi.org/10.1371/journal.pcbi.1007925","mag":"3033736641","pmid":"https://pubmed.ncbi.nlm.nih.gov/32502143"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007925","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007925","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007925&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007925&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101707005","display_name":"Yu Hu","orcid":"https://orcid.org/0000-0003-4163-7166"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Hu","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Wang","orcid":"https://orcid.org/0000-0002-5585-982X"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Pennsylvania, United States of America","Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I1335321130"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101408348","display_name":"Mingyao Li","orcid":"https://orcid.org/0000-0001-8180-0621"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mingyao Li","raw_affiliation_strings":["Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101408348"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6716,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84139077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"e1007925","last_page":"e1007925"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6932045221328735},{"id":"https://openalex.org/keywords/identifier","display_name":"Identifier","score":0.6038565635681152},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.6003249883651733},{"id":"https://openalex.org/keywords/differential","display_name":"Differential (mechanical device)","score":0.518043041229248},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.4821319580078125},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44357287883758545},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.40300530195236206},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.36399412155151367},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.33861303329467773},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32233619689941406},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.161454975605011},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.11611780524253845},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10140931606292725}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6932045221328735},{"id":"https://openalex.org/C154504017","wikidata":"https://www.wikidata.org/wiki/Q853614","display_name":"Identifier","level":2,"score":0.6038565635681152},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6003249883651733},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.518043041229248},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.4821319580078125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44357287883758545},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40300530195236206},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36399412155151367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33861303329467773},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32233619689941406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.161454975605011},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11611780524253845},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10140931606292725},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020733","descriptor_name":"RNA, Small Cytoplasmic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020733","descriptor_name":"RNA, Small Cytoplasmic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020733","descriptor_name":"RNA, Small Cytoplasmic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007925","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007925","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007925&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32502143","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32502143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007925","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007925","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:580971b9b8ce46cdaecfd31f9d3cf173","is_oa":true,"landing_page_url":"https://doaj.org/article/580971b9b8ce46cdaecfd31f9d3cf173","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 6, p e1007925 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7299405","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7299405","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007925","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007925","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007925&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1467336784","display_name":null,"funder_award_id":"R01EY030192","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3866040738","display_name":null,"funder_award_id":"R01GM125301","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4115325203","display_name":null,"funder_award_id":"R01HL113147","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7458920704","display_name":null,"funder_award_id":"NIH R01GM108600","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7792070147","display_name":null,"funder_award_id":"R01HL150359","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8548557922","display_name":null,"funder_award_id":"R01GM108600","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3033736641.pdf","grobid_xml":"https://content.openalex.org/works/W3033736641.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1978817835","https://openalex.org/W1979283544","https://openalex.org/W2102212449","https://openalex.org/W2110768394","https://openalex.org/W2119204091","https://openalex.org/W2135937351","https://openalex.org/W2143787026","https://openalex.org/W2159730169","https://openalex.org/W2169456326","https://openalex.org/W2231058499","https://openalex.org/W2582033455","https://openalex.org/W2616950861","https://openalex.org/W2733002388","https://openalex.org/W2757764553","https://openalex.org/W2793520807","https://openalex.org/W2805888371","https://openalex.org/W2887117829","https://openalex.org/W2911108160","https://openalex.org/W2951506174","https://openalex.org/W2952027905"],"related_works":["https://openalex.org/W2321791250","https://openalex.org/W4213427798","https://openalex.org/W2564462691","https://openalex.org/W2023199111","https://openalex.org/W2065030615","https://openalex.org/W2885403345","https://openalex.org/W2052498125","https://openalex.org/W2094867951","https://openalex.org/W1535548930","https://openalex.org/W2426516634"],"abstract_inverted_index":{"The":[0,283],"emergence":[1],"of":[2,24,28,32,63,115,134,156,185,271,285],"single-cell":[3],"RNA-seq":[4],"(scRNA-seq)":[5],"technology":[6],"has":[7,208],"made":[8],"it":[9,160,169],"possible":[10,170],"to":[11,40,49,140,171,245,263],"measure":[12],"gene":[13],"expression":[14],"variations":[15],"at":[16,76],"cellular":[17],"level.":[18],"This":[19],"breakthrough":[20],"enables":[21],"the":[22,113,146,183,268],"investigation":[23],"a":[25],"wider":[26],"range":[27],"problems":[29],"including":[30,200],"analysis":[31,69,155],"splicing":[33,68,154,173,224,254,281],"heterogeneity":[34],"among":[35],"individual":[36],"cells.":[37],"However,":[38],"compared":[39,196,262],"bulk":[41],"RNA-seq,":[42],"scRNA-seq":[43,86,157,193,248],"data":[44,87,158],"are":[45],"much":[46],"noisier":[47],"due":[48],"high":[50,74],"technical":[51,82,102],"variability":[52],"and":[53,109,125,191,195,202,215,265],"low":[54,77],"sequencing":[55,177],"depth.":[56],"Here":[57],"we":[58,187,273],"propose":[59],"SCATS":[60,84,99,121,135,207,250,275,286],"(Single-Cell":[61],"Analysis":[62],"Transcript":[64],"Splicing)":[65],"for":[66,81,106,118,128,279],"differential":[67,253],"in":[70,137,153],"scRNA-seq,":[71,272],"which":[72],"achieves":[73],"sensitivity":[75],"coverage":[78],"by":[79,104],"accounting":[80,105],"noise.":[83],"models":[85,101,122],"either":[88],"with":[89,197,256],"or":[90],"without":[91],"Unique":[92],"Molecular":[93],"Identifiers":[94],"(UMIs).":[95],"For":[96],"non-UMI":[97],"data,":[98,120],"explicitly":[100],"noise":[103],"capture":[107,123],"efficiency":[108,124],"amplification":[110],"bias":[111],"through":[112],"use":[114],"external":[116],"spike-ins;":[117],"UMI":[119],"further":[126],"accounts":[127],"transcriptional":[129],"burstiness.":[130],"A":[131],"key":[132],"aspect":[133],"lies":[136],"its":[138],"ability":[139],"group":[141],"\"exons\"":[142],"that":[143,206],"originate":[144],"from":[145,232,290],"same":[147],"isoform(s).":[148],"Grouping":[149],"exons":[150],"is":[151,179,216,226,240],"essential":[152],"as":[159],"naturally":[161],"aggregates":[162],"spliced":[163],"reads":[164],"across":[165,259],"different":[166],"exons,":[167],"making":[168],"detect":[172],"events":[174,255],"even":[175],"when":[176,223],"depth":[178],"low.":[180],"To":[181],"evaluate":[182],"performance":[184],"SCATS,":[186],"analyzed":[188],"both":[189],"simulated":[190],"real":[192],"datasets":[194],"existing":[198,220],"methods":[199],"Census":[201,230,264],"DEXSeq.":[203,266],"We":[204],"show":[205],"well":[209],"controlled":[210],"type":[211,234],"I":[212,235],"error":[213,236],"rate,":[214],"more":[217,241,252],"powerful":[218],"than":[219],"methods,":[221],"especially":[222],"difference":[225,258],"small.":[227],"In":[228],"contrast,":[229],"suffers":[231],"severe":[233],"inflation,":[237],"whereas":[238],"DEXSeq":[239],"conservative.":[242],"When":[243],"applied":[244],"mouse":[246],"brain":[247],"datasets,":[249],"identified":[251],"subtle":[257],"cell":[260],"types":[261],"With":[267],"increasing":[269],"adoption":[270],"believe":[274],"will":[276],"be":[277,288],"well-suited":[278],"various":[280],"studies.":[282],"implementation":[284],"can":[287],"downloaded":[289],"https://github.com/huyustats/SCATS.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}