{"id":"https://openalex.org/W3031121206","doi":"https://doi.org/10.1371/journal.pcbi.1007882","title":"A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma","display_name":"A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma","publication_year":2020,"publication_date":"2020-06-03","ids":{"openalex":"https://openalex.org/W3031121206","doi":"https://doi.org/10.1371/journal.pcbi.1007882","mag":"3031121206","pmid":"https://pubmed.ncbi.nlm.nih.gov/32492067"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007882","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007882","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007882&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007882&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019994627","display_name":"H\u00e9l\u00e8ne Ruffieux","orcid":"https://orcid.org/0000-0002-7113-2540"},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"H\u00e9l\u00e8ne Ruffieux","raw_affiliation_strings":["Chair of Statistics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7113-2540","affiliations":[{"raw_affiliation_string":"Chair of Statistics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383","https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074521518","display_name":"J\u00e9r\u00f4me Carayol","orcid":"https://orcid.org/0000-0002-0049-0244"},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Carayol","raw_affiliation_strings":["Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0049-0244","affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383","https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085810415","display_name":"Radu Popescu","orcid":"https://orcid.org/0000-0002-2224-8985"},"institutions":[{"id":"https://openalex.org/I67311998","display_name":"European Organization for Nuclear Research","ror":"https://ror.org/01ggx4157","country_code":"CH","type":"facility","lineage":["https://openalex.org/I67311998"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Radu Popescu","raw_affiliation_strings":["Experimental Physics, Software Development for Experimental Design (EP-SFT), CERN, Geneva, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2224-8985","affiliations":[{"raw_affiliation_string":"Experimental Physics, Software Development for Experimental Design (EP-SFT), CERN, Geneva, Switzerland","institution_ids":["https://openalex.org/I67311998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014760843","display_name":"Mary\u2010Ellen Harper","orcid":"https://orcid.org/0000-0003-3864-5886"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mary-Ellen Harper","raw_affiliation_strings":["Bioenergetics Laboratory, University of Ottawa, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioenergetics Laboratory, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061378146","display_name":"Robert Dent","orcid":"https://orcid.org/0000-0001-8141-5504"},"institutions":[{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert Dent","raw_affiliation_strings":["Weight Management Clinic, The Ottawa Hospital, Ottawa, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0001-8141-5504","affiliations":[{"raw_affiliation_string":"Weight Management Clinic, The Ottawa Hospital, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I2800722420"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063705490","display_name":"Wim H. M. Saris","orcid":"https://orcid.org/0000-0003-0985-0047"},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wim H. M. Saris","raw_affiliation_strings":["Department of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048067129","display_name":"Arne Astrup","orcid":"https://orcid.org/0000-0001-8968-8996"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Arne Astrup","raw_affiliation_strings":["Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-8968-8996","affiliations":[{"raw_affiliation_string":"Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079364377","display_name":"J\u00f6rg Hager","orcid":"https://orcid.org/0000-0002-6634-9294"},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Hager","raw_affiliation_strings":["Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6634-9294","affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383","https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060421254","display_name":"A. C. Davison","orcid":"https://orcid.org/0000-0002-8537-6191"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anthony C. Davison","raw_affiliation_strings":["Chair of Statistics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8537-6191","affiliations":[{"raw_affiliation_string":"Chair of Statistics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046672994","display_name":"Armand Valsesia","orcid":"https://orcid.org/0000-0003-0746-9664"},"institutions":[{"id":"https://openalex.org/I4210112383","display_name":"Nestl\u00e9 (Switzerland)","ror":"https://ror.org/01v5xwf23","country_code":"CH","type":"company","lineage":["https://openalex.org/I4210112383"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Armand Valsesia","raw_affiliation_strings":["Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0746-9664","affiliations":[{"raw_affiliation_string":"Nestl\u00e9 Research, EPFL Innovation Park, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210112383","https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5019994627","https://openalex.org/A5046672994"],"corresponding_institution_ids":["https://openalex.org/I4210112383","https://openalex.org/I5124864"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.6035,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.9302457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"16","issue":"6","first_page":"e1007882","last_page":"e1007882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abundance","display_name":"Abundance (ecology)","score":0.5788232088088989},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.5704881548881531},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49069416522979736},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.47281351685523987},{"id":"https://openalex.org/keywords/human-plasma","display_name":"Human plasma","score":0.4609096646308899},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.445998877286911},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.4366089105606079},{"id":"https://openalex.org/keywords/locus","display_name":"Locus (genetics)","score":0.4312360882759094},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23728635907173157},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.23083019256591797},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.22755032777786255},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20772024989128113},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2006283402442932},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.09071806073188782},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08455106616020203}],"concepts":[{"id":"https://openalex.org/C77077793","wikidata":"https://www.wikidata.org/wiki/Q336019","display_name":"Abundance (ecology)","level":2,"score":0.5788232088088989},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5704881548881531},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49069416522979736},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.47281351685523987},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.4609096646308899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.445998877286911},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.4366089105606079},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4312360882759094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23728635907173157},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.23083019256591797},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.22755032777786255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20772024989128113},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2006283402442932},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.09071806073188782},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08455106616020203},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1007882","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007882","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007882&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32492067","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32492067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/b041458d-899e-4c70-8d49-1f4d05337244","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/b041458d-899e-4c70-8d49-1f4d05337244","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ruffieux, H, Carayol, J, Popescu, R, Harper, M-E, Dent, R, Saris, W H M, Astrup, A, Hager, J, Davison, A C & Valsesia, A 2020, 'A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma', PLoS Computational Biology, vol. 16, no. 6, 1007882. https://doi.org/10.1371/journal.pcbi.1007882","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:cds.cern.ch:2801432","is_oa":true,"landing_page_url":"http://cds.cern.ch/record/2801432","pdf_url":null,"source":{"id":"https://openalex.org/S4306402195","display_name":"CERN Document Server (European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:doaj.org/article:8fb0cb05d4a441a397fbd8bd462d22f2","is_oa":true,"landing_page_url":"https://doaj.org/article/8fb0cb05d4a441a397fbd8bd462d22f2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 6, p e1007882 (2020)","raw_type":"article"},{"id":"pmh:oai:infoscience.epfl.ch:279483","is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/170983","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"research article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7295243","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7295243","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/4015ce9c-24c4-4900-a044-66d90b34872d","is_oa":true,"landing_page_url":"https://curis.ku.dk/portal/da/publications/a-fully-joint-bayesian-quantitative-trait-locus-mapping-of-human-protein-abundance-in-plasma(4015ce9c-24c4-4900-a044-66d90b34872d).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ruffieux , H , Carayol , J , Popescu , R , Harper , M-E , Dent , R , Saris , W H M , Astrup , A , Hager , J , Davison , A C & Valsesia , A 2020 , ' A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma ' , P L o S Computational Biology (Online) , vol. 16 , no. 6 , e1007882 . https://doi.org/10.1371/journal.pcbi.1007882","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/4015ce9c-24c4-4900-a044-66d90b34872d","is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/4015ce9c-24c4-4900-a044-66d90b34872d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ruffieux , H , Carayol , J , Popescu , R , Harper , M-E , Dent , R , Saris , W H M , Astrup , A , Hager , J , Davison , A C & Valsesia , A 2020 , ' A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma ' , P L o S Computational Biology (Online) , vol. 16 , no. 6 , e1007882 . https://doi.org/10.1371/journal.pcbi.1007882","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007882","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007882","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007882&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.550000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G789023750","display_name":null,"funder_award_id":"FP6-2005- 513946","funder_id":"https://openalex.org/F4320333067","funder_display_name":"Sixth Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320310065","display_name":"Danone","ror":"https://ror.org/00aj77a24"},{"id":"https://openalex.org/F4320322918","display_name":"Nordea-fonden","ror":"https://ror.org/03qadc961"},{"id":"https://openalex.org/F4320333067","display_name":"Sixth Framework Programme","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3031121206.pdf","grobid_xml":"https://content.openalex.org/works/W3031121206.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1533942137","https://openalex.org/W1952660301","https://openalex.org/W1976531401","https://openalex.org/W1980168725","https://openalex.org/W2007463795","https://openalex.org/W2014597082","https://openalex.org/W2017602185","https://openalex.org/W2018617521","https://openalex.org/W2032230252","https://openalex.org/W2078803352","https://openalex.org/W2080183225","https://openalex.org/W2091479034","https://openalex.org/W2102877189","https://openalex.org/W2105673666","https://openalex.org/W2110614590","https://openalex.org/W2116404316","https://openalex.org/W2116868464","https://openalex.org/W2124999415","https://openalex.org/W2125944762","https://openalex.org/W2134555793","https://openalex.org/W2146738944","https://openalex.org/W2152325859","https://openalex.org/W2152438005","https://openalex.org/W2166687066","https://openalex.org/W2259763421","https://openalex.org/W2398690791","https://openalex.org/W2493925084","https://openalex.org/W2511683610","https://openalex.org/W2519420814","https://openalex.org/W2566116513","https://openalex.org/W2599563367","https://openalex.org/W2605261164","https://openalex.org/W2611152592","https://openalex.org/W2774070574","https://openalex.org/W2792436446","https://openalex.org/W2801470635","https://openalex.org/W2805712258","https://openalex.org/W2806375253","https://openalex.org/W2885870007","https://openalex.org/W2886245587","https://openalex.org/W2901443756","https://openalex.org/W2912664120","https://openalex.org/W2934861239","https://openalex.org/W2944540884","https://openalex.org/W2963932270","https://openalex.org/W3099090856","https://openalex.org/W3102526540","https://openalex.org/W4205433696","https://openalex.org/W6988038491"],"related_works":["https://openalex.org/W2379881015","https://openalex.org/W2942351976","https://openalex.org/W47320847","https://openalex.org/W2158717226","https://openalex.org/W2166735118","https://openalex.org/W2803670087","https://openalex.org/W2413302882","https://openalex.org/W3144110022","https://openalex.org/W2072376182","https://openalex.org/W2114496290"],"abstract_inverted_index":{"Molecular":[0],"quantitative":[1],"trait":[2],"locus":[3],"(QTL)":[4],"analyses":[5],"are":[6,124,212,241,261],"increasingly":[7],"popular":[8],"to":[9,163,253,269],"explore":[10],"the":[11,35,86,94,113,145,171,180,194,201,206,235,239,243],"genetic":[12],"architecture":[13],"of":[14,37,89,112,170,196,238,245,280,284],"complex":[15],"traits,":[16],"but":[17],"existing":[18],"studies":[19],"do":[20],"not":[21],"leverage":[22],"shared":[23],"regulatory":[24],"patterns":[25],"and":[26,75,98,106,140,157,186,221,223,282,299,304],"suffer":[27],"from":[28,64,200,264],"a":[29,47,160],"large":[30],"multiplicity":[31],"burden,":[32],"which":[33,90],"hampers":[34],"detection":[36],"weak":[38],"signals":[39],"such":[40],"as":[41,227],"trans":[42,185],"associations.":[43],"Here,":[44],"we":[45],"present":[46],"fully":[48],"multivariate":[49],"proteomic":[50,122],"QTL":[51,134,300],"(pQTL)":[52],"analysis":[53,195],"performed":[54],"with":[55,68,102,131,189,216],"our":[56,246,265],"recently":[57],"proposed":[58],"Bayesian":[59],"method":[60],"LOCUS":[61,150,175,211,275],"on":[62,136,159,234],"data":[63,139,143,147,199],"two":[65,202],"clinical":[66,198,236],"cohorts,":[67],"plasma":[69],"protein":[70,116,155],"levels":[71,156],"quantified":[72,119],"by":[73,120,174,179,210],"mass-spectrometry":[74],"aptamer-based":[76],"assays.":[77,127],"Our":[78,128],"two-stage":[79],"study":[80],"identifies":[81],"136":[82],"pQTL":[83,290],"associations":[84,215],"in":[85,93,214,256],"first":[87],"cohort,":[88],">80%":[91],"replicate":[92],"second":[95],"independent":[96,191],"cohort":[97],"have":[99],"significant":[100],"enrichment":[101],"functional":[103],"genomic":[104],"elements":[105],"disease":[107],"risk":[108],"loci.":[109],"Moreover,":[110],"78%":[111],"pQTLs":[114,172,240],"whose":[115],"abundance":[117],"was":[118],"both":[121],"techniques":[123],"confirmed":[125],"across":[126,153],"thorough":[129],"comparisons":[130],"standard":[132],"univariate":[133,181],"mapping":[135],"(1)":[137],"these":[138,248],"(2)":[141],"synthetic":[142],"emulating":[144],"real":[146],"show":[148],"how":[149],"borrows":[151],"strength":[152],"correlated":[154],"markers":[158],"genome-wide":[161,297],"scale":[162],"effectively":[164],"increase":[165],"statistical":[166],"power.":[167],"Notably,":[168],"15%":[169],"uncovered":[173],"would":[176],"be":[177,254],"missed":[178],"approach,":[182],"including":[183],"several":[184],"pleiotropic":[187],"hits":[188],"successful":[190],"validation.":[192],"Finally,":[193],"extensive":[197],"cohorts":[203],"indicates":[204],"that":[205],"genetically-driven":[207],"proteins":[208],"identified":[209],"enriched":[213],"low-grade":[217],"inflammation,":[218],"insulin":[219],"resistance":[220],"dyslipidemia":[222],"might":[224],"therefore":[225],"act":[226],"endophenotypes":[228],"for":[229,295],"metabolic":[230],"diseases.":[231],"While":[232],"considerations":[233],"role":[237],"beyond":[242,289],"scope":[244],"work,":[247],"findings":[249],"generate":[250],"useful":[251],"hypotheses":[252],"explored":[255],"future":[257],"research;":[258],"all":[259],"results":[260],"accessible":[262],"online":[263],"searchable":[266],"database.":[267],"Thanks":[268],"its":[270],"efficient":[271],"variational":[272],"Bayes":[273],"implementation,":[274],"can":[276],"analyze":[277],"jointly":[278],"thousands":[279],"traits":[281],"millions":[283],"markers.":[285],"Its":[286],"applicability":[287],"goes":[288],"studies,":[291],"opening":[292],"new":[293],"perspectives":[294],"large-scale":[296],"association":[298],"analyses.":[301],"Diet,":[302],"Obesity":[303],"Genes":[305],"(DiOGenes)":[306],"trial":[307],"registration":[308],"number:":[309],"NCT00390637.":[310]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}