{"id":"https://openalex.org/W3025741173","doi":"https://doi.org/10.1371/journal.pcbi.1007872","title":"iCDA-CGR: Identification of circRNA-disease associations based on Chaos Game Representation","display_name":"iCDA-CGR: Identification of circRNA-disease associations based on Chaos Game Representation","publication_year":2020,"publication_date":"2020-05-18","ids":{"openalex":"https://openalex.org/W3025741173","doi":"https://doi.org/10.1371/journal.pcbi.1007872","mag":"3025741173","pmid":"https://pubmed.ncbi.nlm.nih.gov/32421715"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007872","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007872","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007872&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007872&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032517198","display_name":"Kai Zheng","orcid":"https://orcid.org/0000-0003-1578-1818"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Zheng","raw_affiliation_strings":["School of Computer Science and Engineering, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhu-Hong You","raw_affiliation_strings":["Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China"],"raw_orcid":"https://orcid.org/0000-0003-1266-2696","affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393871","display_name":"Jianqiang Li","orcid":"https://orcid.org/0000-0002-2208-962X"},"institutions":[{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Qiang Li","raw_affiliation_strings":["College of Computer and Software Engineering, Shenzhen University, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer and Software Engineering, Shenzhen University, Shenzhen, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436059","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-0184-307X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210159676","display_name":"Zaozhuang University","ror":"https://ror.org/05x21tp94","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210159676"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Wang","raw_affiliation_strings":["College of Information Science and Engineering, Zaozhuang University, Zaozhuang, China","Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China"],"raw_orcid":"https://orcid.org/0000-0003-0184-307X","affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Zaozhuang University, Zaozhuang, China","institution_ids":["https://openalex.org/I4210159676"]},{"raw_affiliation_string":"Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082017081","display_name":"Zhen-Hao Guo","orcid":"https://orcid.org/0000-0002-1965-6988"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Hao Guo","raw_affiliation_strings":["Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xinjiang Technical Institutes of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China","institution_ids":["https://openalex.org/I4210106108","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017713277","display_name":"Yu\u2010An Huang","orcid":"https://orcid.org/0000-0002-5346-2394"},"institutions":[{"id":"https://openalex.org/I14243506","display_name":"Hong Kong Polytechnic University","ror":"https://ror.org/0030zas98","country_code":"HK","type":"education","lineage":["https://openalex.org/I14243506"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yu-An Huang","raw_affiliation_strings":["Department of Computing, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computing, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China","institution_ids":["https://openalex.org/I14243506"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019805735","https://openalex.org/A5100436059"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108","https://openalex.org/I4210159676"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":6.7714,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.97878911,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"16","issue":"5","first_page":"e1007872","last_page":"e1007872"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6044119000434875},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.45996078848838806},{"id":"https://openalex.org/keywords/nucleic-acid","display_name":"Nucleic acid","score":0.4552208483219147},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4414594769477844},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42718249559402466},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.41535499691963196},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40885359048843384},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.39071670174598694},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2602275013923645},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16514280438423157},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13384413719177246},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10771140456199646}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6044119000434875},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.45996078848838806},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4552208483219147},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4414594769477844},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42718249559402466},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.41535499691963196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40885359048843384},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39071670174598694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2602275013923645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16514280438423157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13384413719177246},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10771140456199646}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007872","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007872","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007872&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32421715","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32421715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007872","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8a09b651d6c7442ebd978189c9d527c5","is_oa":true,"landing_page_url":"https://doaj.org/article/8a09b651d6c7442ebd978189c9d527c5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 5, p e1007872 (2020)","raw_type":"article"},{"id":"pmh:oai:ira.lib.polyu.edu.hk:10397/87857","is_oa":true,"landing_page_url":"http://hdl.handle.net/10397/87857","pdf_url":null,"source":{"id":"https://openalex.org/S4306400205","display_name":"PolyU Institutional Research Archive (Hong Kong Polytechnic University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I14243506","host_organization_name":"Hong Kong Polytechnic University","host_organization_lineage":["https://openalex.org/I14243506"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal/Magazine Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7259804","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7259804","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007872","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007872","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007872&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1472446628","display_name":null,"funder_award_id":"2019M653804","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G3158980518","display_name":null,"funder_award_id":"61572506","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3588239447","display_name":null,"funder_award_id":"61702444","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G53239543","display_name":null,"funder_award_id":"2018-XBQNXZ-B-008","funder_id":"https://openalex.org/F4320328015","funder_display_name":"West Light Foundation of the Chinese Academy of Sciences"},{"id":"https://openalex.org/G670923129","display_name":null,"funder_award_id":"61722212","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G82793888","display_name":null,"funder_award_id":"61722212","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320328015","display_name":"West Light Foundation of the Chinese Academy of Sciences","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3025741173.pdf","grobid_xml":"https://content.openalex.org/works/W3025741173.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1032731786","https://openalex.org/W1874402154","https://openalex.org/W1966411071","https://openalex.org/W1967087625","https://openalex.org/W2054891772","https://openalex.org/W2055493067","https://openalex.org/W2088128227","https://openalex.org/W2100317431","https://openalex.org/W2106029302","https://openalex.org/W2115662330","https://openalex.org/W2127563440","https://openalex.org/W2128049108","https://openalex.org/W2129103781","https://openalex.org/W2158073956","https://openalex.org/W2174483798","https://openalex.org/W2209200250","https://openalex.org/W2313125707","https://openalex.org/W2530008209","https://openalex.org/W2557141539","https://openalex.org/W2606895029","https://openalex.org/W2766950760","https://openalex.org/W2795917193","https://openalex.org/W2800766678","https://openalex.org/W2807602500","https://openalex.org/W2884943532","https://openalex.org/W2889334297","https://openalex.org/W2897712722","https://openalex.org/W2898991725","https://openalex.org/W2899436082","https://openalex.org/W2908043015","https://openalex.org/W2909637325","https://openalex.org/W2913545508","https://openalex.org/W2923922207","https://openalex.org/W2957180077","https://openalex.org/W2964579384","https://openalex.org/W2964951118","https://openalex.org/W2973097270","https://openalex.org/W2988622152","https://openalex.org/W2995337846"],"related_works":["https://openalex.org/W1971444612","https://openalex.org/W1543504406","https://openalex.org/W633173308","https://openalex.org/W2802691951","https://openalex.org/W2003530972","https://openalex.org/W2383750441","https://openalex.org/W1572021523","https://openalex.org/W2061946247","https://openalex.org/W3004967179","https://openalex.org/W2135990064"],"abstract_inverted_index":{"Found":[0],"in":[1,78,166,211],"recent":[2],"research,":[3],"tumor":[4],"cell":[5],"invasion,":[6],"proliferation,":[7],"or":[8],"other":[9,185],"biological":[10,158,251],"processes":[11],"are":[12],"controlled":[13],"by":[14,149,223,230],"circular":[15],"RNA.":[16],"Understanding":[17],"the":[18,30,48,55,82,87,100,110,131,143,157,163,167,172,189,200,212,217],"association":[19],"between":[20,86,113],"circRNAs":[21],"and":[22,35,44,71,91,115,141,198,208,242,244],"diseases":[23,34],"is":[24,95],"an":[25],"important":[26],"way":[27],"to":[28,57,108,129],"explore":[29],"pathogenesis":[31],"of":[32,50,68,102,147,191,203,216],"complex":[33,80,111],"promote":[36],"disease-targeted":[37],"therapy.":[38],"Most":[39],"methods,":[40],"such":[41],"as":[42],"k-mer":[43],"PSSM,":[45],"based":[46,155],"on":[47,156,225],"analysis":[49,101],"high-throughput":[51],"expression":[52,105],"data":[53,193],"have":[54],"tendency":[56],"think":[58],"functionally":[59],"similar":[60],"nucleic":[61,89,93],"acid":[62,90,94],"lack":[63],"direct":[64],"linear":[65],"homology":[66],"regardless":[67],"positional":[69,103],"information":[70,104,140,161],"only":[72],"quantify":[73],"nonlinear":[74,84,145],"sequence":[75,83,139,144,159],"relationships.":[76],"However,":[77],"many":[79],"diseases,":[81],"relationship":[85,146],"pathogenic":[88],"ordinary":[92],"not":[96],"much":[97],"different.":[98],"Therefore,":[99],"can":[106,245],"help":[107],"predict":[109,130],"associations":[112,221],"circRNA":[114,138,148],"disease.":[116],"To":[117],"fill":[118],"up":[119],"this":[120],"gap,":[121],"we":[122,136],"propose":[123],"a":[124],"new":[125],"method,":[126],"named":[127],"iCDA-CGR,":[128],"circRNA-disease":[132,168,220],"associations.":[133],"In":[134,171,188],"particular,":[135],"introduce":[137],"quantifies":[142],"Chaos":[150],"Game":[151],"Representation":[152],"(CGR)":[153],"technology":[154],"position":[160],"for":[162,250],"first":[164],"time":[165],"prediction":[169,201],"model.":[170],"cross-validation":[173],"experiment,":[174],"our":[175],"method":[176],"achieved":[177],"0.8533":[178],"AUC,":[179],"which":[180],"was":[181],"significantly":[182],"higher":[183],"than":[184],"existing":[186],"methods.":[187],"validation":[190],"independent":[192],"sets":[194],"including":[195],"circ2Disease,":[196],"circRNADisease":[197],"CRDD,":[199],"accuracy":[202],"iCDA-CGR":[204,224,238],"reached":[205],"95.18%,":[206],"90.64%":[207],"95.89%.":[209],"Moreover,":[210],"case":[213],"studies,":[214],"19":[215],"top":[218],"30":[219],"predicted":[222],"circRDisease":[226],"dataset":[227],"were":[228],"confirmed":[229],"newly":[231],"published":[232],"literature.":[233],"These":[234],"results":[235],"demonstrated":[236],"that":[237],"has":[239],"outstanding":[240],"robustness":[241],"stability,":[243],"provide":[246],"highly":[247],"credible":[248],"candidates":[249],"experiments.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":22},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}