{"id":"https://openalex.org/W3028522379","doi":"https://doi.org/10.1371/journal.pcbi.1007793","title":"Dynamical network analysis reveals key microRNAs in progressive stages of lung cancer","display_name":"Dynamical network analysis reveals key microRNAs in progressive stages of lung cancer","publication_year":2020,"publication_date":"2020-05-19","ids":{"openalex":"https://openalex.org/W3028522379","doi":"https://doi.org/10.1371/journal.pcbi.1007793","mag":"3028522379","pmid":"https://pubmed.ncbi.nlm.nih.gov/32428028"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007793","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007793","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007793&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007793&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103281053","display_name":"Chao Kong","orcid":"https://orcid.org/0000-0003-2685-797X"},"institutions":[{"id":"https://openalex.org/I4210098389","display_name":"Ministry of Civil Affairs","ror":"https://ror.org/00rmvjy83","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210098389","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Kong","raw_affiliation_strings":["Institute of Computational Physics and Complex Systems, School of Physical Science and Technology, Lanzhou University, Lanzhou, China","National Engineering Research Center for Healthcare Devices. Guangzhou, Guangdong, P.R. China","The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, P. R. China"],"raw_orcid":"https://orcid.org/0000-0003-2685-797X","affiliations":[{"raw_affiliation_string":"Institute of Computational Physics and Complex Systems, School of Physical Science and Technology, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"National Engineering Research Center for Healthcare Devices. Guangzhou, Guangdong, P.R. China","institution_ids":[]},{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, P. R. China","institution_ids":["https://openalex.org/I4210098389","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041910942","display_name":"Yuxiang Yao","orcid":"https://orcid.org/0000-0002-4757-6483"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Xiang Yao","raw_affiliation_strings":["Institute of Computational Physics and Complex Systems, School of Physical Science and Technology, Lanzhou University, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computational Physics and Complex Systems, School of Physical Science and Technology, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067690714","display_name":"Z. Bing","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210131271","display_name":"Institute of Modern Physics","ror":"https://ror.org/03x8rhq63","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210131271"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Tong Bing","raw_affiliation_strings":["Department of Computational Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China","Evidence Based Medicine Center, School of Basic Medical Science of Lanzhou University, Lanzhou, China","Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China","institution_ids":["https://openalex.org/I4210131271","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Evidence Based Medicine Center, School of Basic Medical Science of Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089707942","display_name":"Binghui Guo","orcid":"https://orcid.org/0000-0002-0540-3779"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing-Hui Guo","raw_affiliation_strings":["Beijing Advanced Innovation Center for Big Data and Brain Computing, LMIB and School of Mathematics and System Sciences, Beihang University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-0540-3779","affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Center for Big Data and Brain Computing, LMIB and School of Mathematics and System Sciences, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073768295","display_name":"Liang Huang","orcid":"https://orcid.org/0000-0002-3346-339X"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Huang","raw_affiliation_strings":["Institute of Computational Physics and Complex Systems, School of Physical Science and Technology, Lanzhou University, Lanzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3346-339X","affiliations":[{"raw_affiliation_string":"Institute of Computational Physics and Complex Systems, School of Physical Science and Technology, Lanzhou University, Lanzhou, China","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050109554","display_name":"Zi\u2010Gang Huang","orcid":"https://orcid.org/0000-0001-9648-3067"},"institutions":[{"id":"https://openalex.org/I4210098389","display_name":"Ministry of Civil Affairs","ror":"https://ror.org/00rmvjy83","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210098389","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zi-Gang Huang","raw_affiliation_strings":["The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-9648-3067","affiliations":[{"raw_affiliation_string":"The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, The Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, P. R. China","institution_ids":["https://openalex.org/I4210098389","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102995786","display_name":"Ying\u2010Cheng Lai","orcid":"https://orcid.org/0000-0002-0723-733X"},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Cheng Lai","raw_affiliation_strings":["Department of Physics, Arizona State University, Tempe, Arizona, United States of America","School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0723-733X","affiliations":[{"raw_affiliation_string":"Department of Physics, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"School of Electrical, Computer and Energy Engineering, Arizona State University, Tempe, Arizona, United States of America","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5050109554"],"corresponding_institution_ids":["https://openalex.org/I4210098389","https://openalex.org/I87445476"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6387,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.61116086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"5","first_page":"e1007793","last_page":"e1007793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"Competing endogenous RNA","score":0.9814903140068054},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8559678196907043},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7105520367622375},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6192606091499329},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.480490118265152},{"id":"https://openalex.org/keywords/endogeny","display_name":"Endogeny","score":0.4312489628791809},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"Long non-coding RNA","score":0.3902961015701294},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3613922595977783},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3087203800678253},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2750755548477173}],"concepts":[{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.9814903140068054},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8559678196907043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7105520367622375},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6192606091499329},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.480490118265152},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4312489628791809},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.3902961015701294},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3613922595977783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3087203800678253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2750755548477173},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1007793","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007793","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007793&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32428028","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32428028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:/ir.lzu.edu.cn/:262010/484020","is_oa":false,"landing_page_url":"https://ir.lzu.edu.cn/handle/262010/484020","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/433692","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/433692","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:/ir.lzu.edu.cn/:262010/406162","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/406162","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:ad81b4c9fc2742f2a39758c1e7a011a3","is_oa":true,"landing_page_url":"https://doaj.org/article/ad81b4c9fc2742f2a39758c1e7a011a3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 5, p e1007793 (2020)","raw_type":"article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/405446","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/405446","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/428670","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/428670","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"pmh:oai:pubmedcentral.nih.gov:7295246","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7295246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007793","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007793","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007793&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5099999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1354763008","display_name":null,"funder_award_id":"11975178","funder_id":"https://openalex.org/F4320327721","funder_display_name":"K. C. Wong Education Foundation"},{"id":"https://openalex.org/G1746118717","display_name":null,"funder_award_id":"sxzd022020012","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G1952072486","display_name":null,"funder_award_id":"2020JM-058","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2267025513","display_name":null,"funder_award_id":"61431012","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G2312138436","display_name":null,"funder_award_id":"11775101","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G2649083763","display_name":null,"funder_award_id":"2020JM-058","funder_id":"https://openalex.org/F4320327721","funder_display_name":"K. C. Wong Education Foundation"},{"id":"https://openalex.org/G3377379845","display_name":null,"funder_award_id":"61431012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3929045888","display_name":null,"funder_award_id":"61431012","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4887830804","display_name":null,"funder_award_id":"N00014-16-1-2828","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"},{"id":"https://openalex.org/G5318827692","display_name":null,"funder_award_id":"11775101","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5813598683","display_name":null,"funder_award_id":"11775101","funder_id":"https://openalex.org/F4320327721","funder_display_name":"K. C. Wong Education Foundation"},{"id":"https://openalex.org/G6040790532","display_name":null,"funder_award_id":"11975178","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6241146787","display_name":null,"funder_award_id":"61431012","funder_id":"https://openalex.org/F4320327721","funder_display_name":"K. C. Wong Education Foundation"},{"id":"https://openalex.org/G8193621245","display_name":null,"funder_award_id":"11775101","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8488240028","display_name":null,"funder_award_id":"11422541","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327721","display_name":"K. C. Wong Education Foundation","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null},{"id":"https://openalex.org/F4320336567","display_name":"Natural Science Basic Research Program of Shaanxi Province","ror":null},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3028522379.pdf","grobid_xml":"https://content.openalex.org/works/W3028522379.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W612343255","https://openalex.org/W1525117983","https://openalex.org/W1820723315","https://openalex.org/W1835981532","https://openalex.org/W1967424629","https://openalex.org/W1972892962","https://openalex.org/W1972989638","https://openalex.org/W1979300931","https://openalex.org/W1985400174","https://openalex.org/W1988163167","https://openalex.org/W1991153319","https://openalex.org/W1995082021","https://openalex.org/W2001155312","https://openalex.org/W2016106370","https://openalex.org/W2046387002","https://openalex.org/W2053907825","https://openalex.org/W2054841768","https://openalex.org/W2064039900","https://openalex.org/W2071480068","https://openalex.org/W2071776031","https://openalex.org/W2078564924","https://openalex.org/W2081098333","https://openalex.org/W2084706776","https://openalex.org/W2087377443","https://openalex.org/W2088720324","https://openalex.org/W2097302215","https://openalex.org/W2102304447","https://openalex.org/W2102326716","https://openalex.org/W2105493915","https://openalex.org/W2106787323","https://openalex.org/W2111661781","https://openalex.org/W2115356925","https://openalex.org/W2115530814","https://openalex.org/W2128768066","https://openalex.org/W2130687298","https://openalex.org/W2134118500","https://openalex.org/W2143662314","https://openalex.org/W2145361279","https://openalex.org/W2146512944","https://openalex.org/W2147668950","https://openalex.org/W2153265806","https://openalex.org/W2154551754","https://openalex.org/W2158135353","https://openalex.org/W2159864284","https://openalex.org/W2162674813","https://openalex.org/W2165515236","https://openalex.org/W2168793216","https://openalex.org/W2176018013","https://openalex.org/W2180481128","https://openalex.org/W2182375217","https://openalex.org/W2191329868","https://openalex.org/W2196543065","https://openalex.org/W2246653280","https://openalex.org/W2268565105","https://openalex.org/W2275877493","https://openalex.org/W2288929640","https://openalex.org/W2308318152","https://openalex.org/W2325343629","https://openalex.org/W2405799505","https://openalex.org/W2444348215","https://openalex.org/W2530294125","https://openalex.org/W2587636834","https://openalex.org/W2602656443","https://openalex.org/W2621312652","https://openalex.org/W2741363425","https://openalex.org/W2758499822","https://openalex.org/W2766126935","https://openalex.org/W2768096340","https://openalex.org/W2770715352","https://openalex.org/W2776508475","https://openalex.org/W2781525129","https://openalex.org/W2784207258","https://openalex.org/W2793353518","https://openalex.org/W2883915660","https://openalex.org/W2883963675","https://openalex.org/W2885764767","https://openalex.org/W2887262889","https://openalex.org/W2894860758","https://openalex.org/W2896493977","https://openalex.org/W2905054950","https://openalex.org/W2905101550","https://openalex.org/W2917837889","https://openalex.org/W2972287571","https://openalex.org/W2973056123","https://openalex.org/W3099018540","https://openalex.org/W3145395549","https://openalex.org/W4234236664","https://openalex.org/W4293241248","https://openalex.org/W4298345797"],"related_works":["https://openalex.org/W1998618295","https://openalex.org/W2605415066","https://openalex.org/W2586183753","https://openalex.org/W2400832891","https://openalex.org/W2901590794","https://openalex.org/W2912601922","https://openalex.org/W3162111133","https://openalex.org/W2903735212","https://openalex.org/W3110530940","https://openalex.org/W2905497924"],"abstract_inverted_index":{"Non-coding":[0],"RNAs":[1,41],"are":[2,94],"fundamental":[3],"to":[4],"the":[5,49,70,84,87,104,134],"competing":[6,57,75],"endogenous":[7,58,76],"RNA":[8],"(CeRNA)":[9],"hypothesis":[10],"in":[11,89],"oncology.":[12],"Previous":[13],"work":[14],"focused":[15],"on":[16,35],"static":[17],"CeRNA":[18,24],"networks.":[19],"We":[20,46,100],"construct":[21],"and":[22,44,72,129,149],"analyze":[23],"networks":[25,50,77],"for":[26,152],"four":[27,130],"sequential":[28],"stages":[29,71],"of":[30,38,62,66,83,86],"lung":[31],"adenocarcinoma":[32],"(LUAD)":[33],"based":[34],"multi-omics":[36],"data":[37],"long":[39],"non-coding":[40],"(lncRNAs),":[42],"microRNAs":[43,67,119,131,142],"mRNAs.":[45],"find":[47,102],"that":[48,92,103,122,132],"possess":[51],"a":[52,110,137],"two-level":[53],"bipartite":[54],"structure:":[55],"common":[56],"network":[59],"(CCEN)":[60],"composed":[61],"an":[63],"invariant":[64],"set":[65],"over":[68],"all":[69,127],"stage-dependent,":[73],"unique":[74],"(UCENs).":[78],"A":[79,114],"systematic":[80],"enrichment":[81,112],"analysis":[82],"pathways":[85],"mRNAs":[88,106],"CCEN":[90,121],"reveals":[91],"they":[93],"strongly":[95],"associated":[96],"with":[97],"cancer":[98],"development.":[99],"also":[101],"microRNA-linked":[105],"from":[107,120,136],"UCENs":[108],"have":[109],"higher":[111],"efficiency.":[113],"key":[115],"finding":[116],"is":[117],"six":[118],"impact":[123],"patient":[124],"survival":[125,135],"at":[126],"stages,":[128],"affect":[133],"specific":[138],"stage.":[139],"The":[140],"ten":[141],"can":[143],"then":[144],"serve":[145],"as":[146],"potential":[147],"biomarkers":[148],"prognostic":[150],"tools":[151],"LUAD.":[153]},"counts_by_year":[{"year":2023,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
