{"id":"https://openalex.org/W3034160782","doi":"https://doi.org/10.1371/journal.pcbi.1007770","title":"A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data","display_name":"A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data","publication_year":2020,"publication_date":"2020-06-09","ids":{"openalex":"https://openalex.org/W3034160782","doi":"https://doi.org/10.1371/journal.pcbi.1007770","mag":"3034160782","pmid":"https://pubmed.ncbi.nlm.nih.gov/32516306"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007770","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007770","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007770&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007770&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069489297","display_name":"David Lamparter","orcid":"https://orcid.org/0000-0002-9216-8825"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Lamparter","raw_affiliation_strings":["Verge Genomics, South San Francisco, CA 94080, USA"],"raw_orcid":"https://orcid.org/0000-0002-9216-8825","affiliations":[{"raw_affiliation_string":"Verge Genomics, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082740748","display_name":"Rajat Bhatnagar","orcid":"https://orcid.org/0000-0002-3676-0293"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajat Bhatnagar","raw_affiliation_strings":["Verge Genomics, South San Francisco, CA 94080, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verge Genomics, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046504926","display_name":"Katja Hebestreit","orcid":"https://orcid.org/0000-0002-6404-9917"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katja Hebestreit","raw_affiliation_strings":["Verge Genomics, South San Francisco, CA 94080, USA"],"raw_orcid":"https://orcid.org/0000-0002-6404-9917","affiliations":[{"raw_affiliation_string":"Verge Genomics, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015059988","display_name":"T. Grant Belgard","orcid":"https://orcid.org/0000-0002-6962-7894"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Grant Belgard","raw_affiliation_strings":["Verge Genomics, South San Francisco, CA 94080, USA"],"raw_orcid":"https://orcid.org/0000-0002-6962-7894","affiliations":[{"raw_affiliation_string":"Verge Genomics, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101634618","display_name":"Alice Zhang","orcid":"https://orcid.org/0000-0003-4593-0466"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice Zhang","raw_affiliation_strings":["Verge Genomics, South San Francisco, CA 94080, USA"],"raw_orcid":"https://orcid.org/0000-0003-4593-0466","affiliations":[{"raw_affiliation_string":"Verge Genomics, South San Francisco, CA 94080, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049507945","display_name":"Victor Hanson-Smith","orcid":"https://orcid.org/0000-0002-1699-8712"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Victor Hanson-Smith","raw_affiliation_strings":["Verge Genomics, South San Francisco, CA 94080, USA"],"raw_orcid":"https://orcid.org/0000-0002-1699-8712","affiliations":[{"raw_affiliation_string":"Verge Genomics, South San Francisco, CA 94080, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5049507945"],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2508,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53645735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"6","first_page":"e1007770","last_page":"e1007770"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/expression-quantitative-trait-loci","display_name":"Expression quantitative trait loci","score":0.8960050344467163},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6865358948707581},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.5247761607170105},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5190939903259277},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5089325904846191},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.4784305691719055},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.478153795003891},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4437934458255768},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.41413414478302},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37540408968925476},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35445141792297363},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.24634969234466553},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.07801064848899841}],"concepts":[{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.8960050344467163},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6865358948707581},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.5247761607170105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5190939903259277},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5089325904846191},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.4784305691719055},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.478153795003891},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4437934458255768},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41413414478302},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37540408968925476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35445141792297363},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.24634969234466553},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.07801064848899841},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007770","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007770","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007770&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32516306","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32516306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007770","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007770","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b49618ed04a2439eb6a5b66f1191dc55","is_oa":true,"landing_page_url":"https://doaj.org/article/b49618ed04a2439eb6a5b66f1191dc55","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 6, p e1007770 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7332077","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7332077","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007770","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007770","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007770&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3034160782.pdf","grobid_xml":"https://content.openalex.org/works/W3034160782.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W779421447","https://openalex.org/W1663973292","https://openalex.org/W1964963969","https://openalex.org/W1967658333","https://openalex.org/W1971376656","https://openalex.org/W1977104259","https://openalex.org/W1986911601","https://openalex.org/W1988483433","https://openalex.org/W2002888609","https://openalex.org/W2012034410","https://openalex.org/W2012697072","https://openalex.org/W2017165199","https://openalex.org/W2023155906","https://openalex.org/W2025943989","https://openalex.org/W2027455260","https://openalex.org/W2027673579","https://openalex.org/W2058244987","https://openalex.org/W2067673709","https://openalex.org/W2076154138","https://openalex.org/W2081243727","https://openalex.org/W2086132387","https://openalex.org/W2104549677","https://openalex.org/W2107032654","https://openalex.org/W2112051837","https://openalex.org/W2124655419","https://openalex.org/W2136091734","https://openalex.org/W2136204142","https://openalex.org/W2138019504","https://openalex.org/W2149357952","https://openalex.org/W2152885121","https://openalex.org/W2156358825","https://openalex.org/W2198606573","https://openalex.org/W2212528563","https://openalex.org/W2225156818","https://openalex.org/W2259938310","https://openalex.org/W2271281302","https://openalex.org/W2278401009","https://openalex.org/W2345512687","https://openalex.org/W2396213597","https://openalex.org/W2400221198","https://openalex.org/W2511515754","https://openalex.org/W2525152921","https://openalex.org/W2605298444","https://openalex.org/W2774504697","https://openalex.org/W2782454362","https://openalex.org/W2794100731","https://openalex.org/W2811205482","https://openalex.org/W2883945062","https://openalex.org/W2899616402","https://openalex.org/W2942757851","https://openalex.org/W2951325776","https://openalex.org/W2951544440","https://openalex.org/W3101380508","https://openalex.org/W4212863985","https://openalex.org/W6682671827"],"related_works":["https://openalex.org/W2361861616","https://openalex.org/W2164780420","https://openalex.org/W2995716764","https://openalex.org/W2263699433","https://openalex.org/W2377979023","https://openalex.org/W2995369528","https://openalex.org/W2161056048","https://openalex.org/W2218034408","https://openalex.org/W2392921965","https://openalex.org/W2117545158"],"abstract_inverted_index":{"A":[0],"longstanding":[1],"goal":[2],"of":[3,59,84,115,122,146,161,166],"regulatory":[4],"genetics":[5],"is":[6],"to":[7,15,36,48,113,144,169,173],"understand":[8],"how":[9],"variants":[10],"in":[11,17,73,119,138],"genome":[12],"sequences":[13],"lead":[14],"changes":[16],"gene":[18,71],"expression.":[19],"Here":[20],"we":[21,157],"present":[22],"a":[23,32],"method":[24],"named":[25],"Bayesian":[26],"Annotation":[27],"Guided":[28],"eQTL":[29,54,103,127],"Analysis":[30],"(BAGEA),":[31],"variational":[33],"Bayes":[34],"framework":[35],"model":[37],"cis-eQTLs":[38],"using":[39],"directed":[40,50,92,107],"and":[41,76],"undirected":[42],"genomic":[43,51,93,108],"annotations.":[44,94],"We":[45,79],"used":[46],"BAGEA":[47,162],"integrate":[49],"annotations":[52,109,171],"with":[53,124,134],"summary":[55],"statistics":[56],"from":[57],"tissues":[58,75],"various":[60],"origins.":[61],"This":[62,95],"analysis":[63,96,165],"revealed":[64],"epigenetic":[65],"marks":[66],"that":[67,87],"are":[68],"relevant":[69,172],"for":[70,163],"expression":[72,121,148,174],"different":[74],"cell":[77],"types.":[78],"estimated":[80,135],"the":[81,85,101,106,116,120,139,147,159,164],"predictive":[82],"power":[83],"models":[86],"were":[88],"fitted":[89],"based":[90],"on":[91,100,154],"showed":[97],"that,":[98],"depending":[99],"underlying":[102],"data":[104,168],"used,":[105],"could":[110,150],"predict":[111],"up":[112,143],"1.5%":[114],"variance":[117,149],"observed":[118],"genes":[123,133],"top":[125,140],"nominal":[126],"association":[128],"p-values":[129],"<":[130],"10-7.":[131],"For":[132],"effect":[136],"sizes":[137],"25%":[141],"quantile,":[142],"5%":[145],"be":[151],"predicted.":[152],"Based":[153],"our":[155],"results,":[156],"recommend":[158],"use":[160],"cis-eQTL":[167],"reveal":[170],"biology.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}