{"id":"https://openalex.org/W3035337008","doi":"https://doi.org/10.1371/journal.pcbi.1007766","title":"Kilohertz waveforms optimized to produce closed-state Na+\u00a0channel inactivation eliminate onset response in nerve conduction block","display_name":"Kilohertz waveforms optimized to produce closed-state Na+\u00a0channel inactivation eliminate onset response in nerve conduction block","publication_year":2020,"publication_date":"2020-06-15","ids":{"openalex":"https://openalex.org/W3035337008","doi":"https://doi.org/10.1371/journal.pcbi.1007766","mag":"3035337008","pmid":"https://pubmed.ncbi.nlm.nih.gov/32542050"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007766","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007766","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007766&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007766&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058690392","display_name":"Guosheng Yi","orcid":"https://orcid.org/0000-0002-9362-6605"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I59028336","display_name":"Pratt Institute","ror":"https://ror.org/007m3p006","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59028336"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Guosheng Yi","raw_affiliation_strings":["Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States of America","School of Electrical and Information Engineering, Tianjin University, Tianjin, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-9362-6605","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I59028336","https://openalex.org/I170897317"]},{"raw_affiliation_string":"School of Electrical and Information Engineering, Tianjin University, Tianjin, People's Republic of China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017539910","display_name":"Warren M. Grill","orcid":"https://orcid.org/0000-0001-5240-6588"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I59028336","display_name":"Pratt Institute","ror":"https://ror.org/007m3p006","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59028336"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Warren M. Grill","raw_affiliation_strings":["Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States of America","Department of Electrical and Computer Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States of America","Department of Neurobiology, School of Medicine, Duke University, Durham, North Carolina, United States of America","Department of Neurosurgery, School of Medicine, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5240-6588","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I59028336","https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Pratt School of Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Neurobiology, School of Medicine, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Neurosurgery, School of Medicine, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017539910"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I59028336"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1456,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.74246146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"e1007766","last_page":"e1007766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waveform","display_name":"Waveform","score":0.7194427251815796},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.538757860660553},{"id":"https://openalex.org/keywords/blocking","display_name":"Blocking (statistics)","score":0.5268627405166626},{"id":"https://openalex.org/keywords/sodium-channel","display_name":"Sodium channel","score":0.49332156777381897},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4653530716896057},{"id":"https://openalex.org/keywords/thermal-conduction","display_name":"Thermal conduction","score":0.4546608626842499},{"id":"https://openalex.org/keywords/nerve-block","display_name":"Nerve block","score":0.4255019426345825},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.37296900153160095},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3060227036476135},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2996935248374939},{"id":"https://openalex.org/keywords/voltage","display_name":"Voltage","score":0.2954179048538208},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21781614422798157},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.1558288335800171},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12336555123329163},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09717264771461487}],"concepts":[{"id":"https://openalex.org/C197424946","wikidata":"https://www.wikidata.org/wiki/Q1165717","display_name":"Waveform","level":3,"score":0.7194427251815796},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.538757860660553},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.5268627405166626},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.49332156777381897},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4653530716896057},{"id":"https://openalex.org/C172100665","wikidata":"https://www.wikidata.org/wiki/Q7465774","display_name":"Thermal conduction","level":2,"score":0.4546608626842499},{"id":"https://openalex.org/C2777197265","wikidata":"https://www.wikidata.org/wiki/Q4379667","display_name":"Nerve block","level":2,"score":0.4255019426345825},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37296900153160095},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3060227036476135},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2996935248374939},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.2954179048538208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21781614422798157},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1558288335800171},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12336555123329163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09717264771461487},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009431","descriptor_name":"Neural Conduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011901","descriptor_name":"Ranvier's Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011901","descriptor_name":"Ranvier's Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011901","descriptor_name":"Ranvier's Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007766","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007766","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007766&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32542050","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32542050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007766","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007766","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:a3694850014b4016981a415b00798801","is_oa":true,"landing_page_url":"https://doaj.org/article/a3694850014b4016981a415b00798801","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 6, p e1007766 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7316353","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7316353","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007766","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007766","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007766&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4025706680","display_name":null,"funder_award_id":"NS040894","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5887015078","display_name":null,"funder_award_id":"61601320","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8263259782","display_name":null,"funder_award_id":"R37 NS040894","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8310365324","display_name":null,"funder_award_id":"R37 NS040894","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3035337008.pdf","grobid_xml":"https://content.openalex.org/works/W3035337008.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1552338815","https://openalex.org/W1743704663","https://openalex.org/W1761785605","https://openalex.org/W1946085648","https://openalex.org/W1964085479","https://openalex.org/W1969696235","https://openalex.org/W1978527529","https://openalex.org/W1979047378","https://openalex.org/W1997220636","https://openalex.org/W2001161050","https://openalex.org/W2001439169","https://openalex.org/W2002568518","https://openalex.org/W2003547231","https://openalex.org/W2004583716","https://openalex.org/W2014800958","https://openalex.org/W2018764168","https://openalex.org/W2033533301","https://openalex.org/W2036297882","https://openalex.org/W2036480814","https://openalex.org/W2040736033","https://openalex.org/W2057925083","https://openalex.org/W2062000549","https://openalex.org/W2083278554","https://openalex.org/W2083836433","https://openalex.org/W2089678783","https://openalex.org/W2089757301","https://openalex.org/W2093875160","https://openalex.org/W2097697084","https://openalex.org/W2098061246","https://openalex.org/W2101656718","https://openalex.org/W2111891642","https://openalex.org/W2113366653","https://openalex.org/W2114575499","https://openalex.org/W2137237108","https://openalex.org/W2141492636","https://openalex.org/W2143199409","https://openalex.org/W2152195021","https://openalex.org/W2153031112","https://openalex.org/W2168779967","https://openalex.org/W2168915250","https://openalex.org/W2255288257","https://openalex.org/W2466231200","https://openalex.org/W2568009389","https://openalex.org/W2599340422","https://openalex.org/W2750632467","https://openalex.org/W2772275065","https://openalex.org/W2793374840","https://openalex.org/W2798214928","https://openalex.org/W2799532100","https://openalex.org/W2807869803","https://openalex.org/W2889908302","https://openalex.org/W2926501182","https://openalex.org/W2955799648","https://openalex.org/W2999245846","https://openalex.org/W4246786133"],"related_works":["https://openalex.org/W1974895211","https://openalex.org/W2176409448","https://openalex.org/W2392835431","https://openalex.org/W2129841057","https://openalex.org/W3040712279","https://openalex.org/W2364769705","https://openalex.org/W2056136368","https://openalex.org/W2374664672","https://openalex.org/W4367555392","https://openalex.org/W2883092465"],"abstract_inverted_index":{"The":[0,99],"delivery":[1],"of":[2,25,31,115,134,137],"kilohertz":[3],"frequency":[4],"alternating":[5],"current":[6,80],"(KHFAC)":[7],"generates":[8],"rapid,":[9],"controlled,":[10],"and":[11,18,68,95,124,145],"reversible":[12],"conduction":[13,84,135],"block":[14,85,111,136],"in":[15,89,131,143],"motor,":[16],"sensory,":[17],"autonomic":[19],"nerves,":[20],"but":[21],"causes":[22],"transient":[23],"activation":[24],"action":[26],"potentials":[27],"at":[28,92],"the":[29,32,48,125],"onset":[30,49,87],"blocking":[33,44,122],"current.":[34],"We":[35,64],"implemented":[36],"a":[37,75],"novel":[38,118],"engineering":[39],"optimization":[40,71],"approach":[41,119],"to":[42,57,73,106],"design":[43,74],"waveforms":[45,123],"that":[46,82,102],"eliminated":[47],"response":[50],"by":[51,112],"moving":[52],"voltage-gated":[53],"Na+":[54],"channels":[55],"(VGSCs)":[56],"closed-state":[58],"inactivation":[59],"(CSI)":[60],"without":[61,86],"first":[62],"opening.":[63],"used":[65],"computational":[66],"models":[67],"particle":[69],"swarm":[70],"(PSO)":[72],"charge-balanced":[76],"10":[77],"kHz":[78],"biphasic":[79],"waveform":[81,127],"produced":[83],"firing":[88],"peripheral":[90,138],"axons":[91],"specific":[93,97],"locations":[94],"with":[96],"diameters.":[98],"results":[100],"indicate":[101],"it":[103],"is":[104],"possible":[105],"achieve":[107],"onset-free":[108],"KHFAC":[109],"nerve":[110,139],"causing":[113],"CSI":[114],"VGSCs.":[116],"Our":[117],"for":[120,141],"designing":[121],"resulting":[126],"may":[128],"have":[129],"utility":[130],"clinical":[132],"applications":[133],"hyperactivity,":[140],"example":[142],"pain":[144],"spasticity.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
