{"id":"https://openalex.org/W3014984286","doi":"https://doi.org/10.1371/journal.pcbi.1007750","title":"Robustness of the Dorsal morphogen gradient with respect to morphogen dosage","display_name":"Robustness of the Dorsal morphogen gradient with respect to morphogen dosage","publication_year":2020,"publication_date":"2020-04-06","ids":{"openalex":"https://openalex.org/W3014984286","doi":"https://doi.org/10.1371/journal.pcbi.1007750","mag":"3014984286","pmid":"https://pubmed.ncbi.nlm.nih.gov/32251432"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007750","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007750","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007750&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007750&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081394156","display_name":"Hadel Al Asafen","orcid":"https://orcid.org/0000-0003-0826-9816"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hadel Al Asafen","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025294769","display_name":"Prasad U. Bandodkar","orcid":"https://orcid.org/0000-0002-4955-144X"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prasad U. Bandodkar","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4955-144X","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021359653","display_name":"Sophia Carrell-Noel","orcid":"https://orcid.org/0000-0003-0737-6257"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sophia Carrell-Noel","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0737-6257","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042000995","display_name":"Allison E. Schloop","orcid":"https://orcid.org/0000-0002-2624-9184"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison E. Schloop","raw_affiliation_strings":["Genetics Program, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2624-9184","affiliations":[{"raw_affiliation_string":"Genetics Program, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023975680","display_name":"Jeramey Friedman","orcid":null},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeramey Friedman","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012498470","display_name":"Gregory T. Reeves","orcid":"https://orcid.org/0000-0003-0836-7766"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory T. Reeves","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","Genetics Program, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Genetics Program, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5012498470"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.5852,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.646149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"4","first_page":"e1007750","last_page":"e1007750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9760000109672546,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12832","display_name":"Biocrusts and Microbial Ecology","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphogen","display_name":"Morphogen","score":0.9843964576721191},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6638802886009216},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5961346626281738},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.49611696600914},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.466632217168808},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4634862244129181},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.44248098134994507},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.35133039951324463},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34585508704185486},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33663344383239746}],"concepts":[{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.9843964576721191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6638802886009216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5961346626281738},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.49611696600914},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.466632217168808},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4634862244129181},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.44248098134994507},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35133039951324463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34585508704185486},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33663344383239746}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007750","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007750","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007750&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32251432","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32251432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007750","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007750","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d5b80327cede47099d0f744282889b99","is_oa":true,"landing_page_url":"https://doaj.org/article/d5b80327cede47099d0f744282889b99","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 4, p e1007750 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/12088848","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Robustness_of_the_Dorsal_morphogen_gradient_with_respect_to_morphogen_dosage/12088848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7162545","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7162545","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007750","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007750","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007750&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3268059518","display_name":null,"funder_award_id":"CBET-1254344","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6189523236","display_name":"CAREER: Engineering principles within cell-cell communication networks in animal development","funder_award_id":"1254344","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G664468360","display_name":null,"funder_award_id":"CBET-1254344","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306106","display_name":"U.S. Department of Education","ror":"https://ror.org/021adze67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3014984286.pdf","grobid_xml":"https://content.openalex.org/works/W3014984286.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1480587565","https://openalex.org/W1969499963","https://openalex.org/W1985207173","https://openalex.org/W2023121697","https://openalex.org/W2024021877","https://openalex.org/W2026610875","https://openalex.org/W2037921918","https://openalex.org/W2055298283","https://openalex.org/W2057120350","https://openalex.org/W2059398070","https://openalex.org/W2066715151","https://openalex.org/W2067518921","https://openalex.org/W2071238751","https://openalex.org/W2072511250","https://openalex.org/W2073881036","https://openalex.org/W2078760251","https://openalex.org/W2082988779","https://openalex.org/W2088812276","https://openalex.org/W2095847153","https://openalex.org/W2097893691","https://openalex.org/W2099257830","https://openalex.org/W2100885642","https://openalex.org/W2101081847","https://openalex.org/W2116120836","https://openalex.org/W2122761286","https://openalex.org/W2130006359","https://openalex.org/W2134887638","https://openalex.org/W2136481271","https://openalex.org/W2144762520","https://openalex.org/W2145707773","https://openalex.org/W2159330544","https://openalex.org/W2163569157","https://openalex.org/W2419588813","https://openalex.org/W2477481222","https://openalex.org/W2735527928"],"related_works":["https://openalex.org/W2097901077","https://openalex.org/W2981069493","https://openalex.org/W2108193392","https://openalex.org/W4235176448","https://openalex.org/W4256215825","https://openalex.org/W2009651971","https://openalex.org/W2008061069","https://openalex.org/W3098890656","https://openalex.org/W2015805923","https://openalex.org/W2065390575"],"abstract_inverted_index":{"In":[0,80,134],"multicellular":[1],"organisms,":[2],"the":[3,15,21,48,85,88,97,108,112,124,147,172,186,203,206,214,225,232,248,261,266,280],"timing":[4],"and":[5,39,116,190,263],"placement":[6],"of":[7,17,29,37,50,53,57,87,99,111,123,149,185,228,231,237,242,247,265,285,288],"gene":[8,58,72,140,166,275],"expression":[9,59,73,141,167],"in":[10,20,23,65,156,171,202,291],"a":[11,26,34,182,194],"developing":[12],"tissue":[13],"assigns":[14],"fate":[16],"each":[18],"cell":[19],"embryo":[22],"order":[24,292],"for":[25,197,205,253,273,282],"uniform":[27],"field":[28],"cells":[30],"to":[31,63,77,94,96,130,163,169,208,259,293],"differentiate":[32],"into":[33],"reproducible":[35],"pattern":[36],"organs":[38],"tissues.":[40],"This":[41],"positional":[42],"information":[43],"is":[44,127,161,176,271],"often":[45],"achieved":[46],"through":[47],"action":[49],"spatial":[51],"gradients":[52,290],"morphogens.":[54],"Spatial":[55],"patterns":[56,107,142,168],"are":[60,143,251],"paradoxically":[61],"robust":[62,165,229,274],"variations":[64,170],"morphogen":[66,78,105,289],"dosage,":[67],"given":[68],"that,":[69],"by":[70,239],"definition,":[71],"must":[74,199,221],"be":[75,200,209,222],"sensitive":[76,129],"concentration.":[79],"this":[81,150],"work":[82,278],"we":[83,117,136,180],"investigate":[84],"robustness":[86],"Dorsal/NF-\u03baB":[89],"signaling":[90,151,188],"module":[91,152,189,250],"with":[92],"respect":[93],"perturbations":[95],"dosage":[98,175],"maternally-expressed":[100],"dorsal":[101,132,173],"mRNA.":[102],"The":[103],"Dorsal":[104,125,187,238,249,268],"gradient":[106,126],"dorsal-ventral":[109],"axis":[110],"early":[113],"Drosophila":[114],"embryo,":[115],"found":[118,137,191],"that":[119,139,192,216],"an":[120],"empirical":[121],"description":[122],"highly":[128,144],"maternal":[131,174],"dosage.":[133],"contrast,":[135],"experimentally":[138],"robust.":[145,210],"Although":[146],"components":[148],"have":[153],"been":[154],"characterized":[155],"detail,":[157],"how":[158],"their":[159],"function":[160],"integrated":[162],"produce":[164],"still":[177],"unclear.":[178],"Therefore,":[179],"analyzed":[181],"mechanistic":[183],"model":[184],"Cactus,":[193],"cytoplasmic":[195],"inhibitor":[196],"Dorsal,":[198,220],"present":[201],"nucleus":[204],"system":[207,233],"Furthermore,":[211],"active":[212,267],"Toll,":[213],"receptor":[215],"dissociates":[217],"Cactus":[218],"from":[219],"saturated.":[223],"Finally,":[224],"vast":[226],"majority":[227],"descriptions":[230],"require":[234],"facilitated":[235],"diffusion":[236],"Cactus.":[240],"Each":[241],"these":[243],"three":[244],"recently-discovered":[245],"mechanisms":[246,256,287],"critical":[252],"robustness.":[254,299],"These":[255],"synergistically":[257],"contribute":[258],"changing":[260],"amplitude":[262],"shape":[264],"gradient,":[269],"which":[270],"required":[272],"expression.":[276],"Our":[277],"highlights":[279],"need":[281],"quantitative":[283],"understanding":[284],"biophysical":[286],"understand":[294],"emergent":[295],"phenotypes,":[296],"such":[297],"as":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}