{"id":"https://openalex.org/W3014236556","doi":"https://doi.org/10.1371/journal.pcbi.1007708","title":"Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing","display_name":"Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing","publication_year":2020,"publication_date":"2020-04-07","ids":{"openalex":"https://openalex.org/W3014236556","doi":"https://doi.org/10.1371/journal.pcbi.1007708","mag":"3014236556","pmid":"https://pubmed.ncbi.nlm.nih.gov/32255775"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007708","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007708","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1007708","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032207534","display_name":"Jamie L. Nosbisch","orcid":"https://orcid.org/0000-0001-9677-9765"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie L. Nosbisch","raw_affiliation_strings":["Biomathematics Graduate Program, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9677-9765","affiliations":[{"raw_affiliation_string":"Biomathematics Graduate Program, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101563298","display_name":"Anisur Rahman","orcid":"https://orcid.org/0000-0002-5203-8188"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anisur Rahman","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5203-8188","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055598606","display_name":"Krithika Mohan","orcid":null},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krithika Mohan","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002387944","display_name":"Timothy C. Elston","orcid":"https://orcid.org/0000-0002-4601-2117"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy C. Elston","raw_affiliation_strings":["Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4601-2117","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014769824","display_name":"James E. Bear","orcid":"https://orcid.org/0000-0002-8489-996X"},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Bear","raw_affiliation_strings":["Department of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042446847","display_name":"Jason M. Haugh","orcid":"https://orcid.org/0000-0002-2476-4027"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason M. Haugh","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2476-4027","affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5042446847"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4444,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.57643415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"16","issue":"4","first_page":"e1007708","last_page":"e1007708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.7218395471572876},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"Protein kinase C","score":0.6806836128234863},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6747147440910339},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"Phosphatidic acid","score":0.6424622535705566},{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"Lysophosphatidic acid","score":0.6259143352508545},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"Phospholipase D","score":0.6110490560531616},{"id":"https://openalex.org/keywords/diacylglycerol-kinase","display_name":"Diacylglycerol kinase","score":0.5789374113082886},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"Phospholipase C","score":0.5749760866165161},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5041464567184448},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4711636006832123},{"id":"https://openalex.org/keywords/autocrine-signalling","display_name":"Autocrine signalling","score":0.44018206000328064},{"id":"https://openalex.org/keywords/marcks","display_name":"MARCKS","score":0.4262264370918274},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.42580318450927734},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36559736728668213},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3475581109523773},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.16674286127090454},{"id":"https://openalex.org/keywords/phospholipid","display_name":"Phospholipid","score":0.11884540319442749}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.7218395471572876},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.6806836128234863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6747147440910339},{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.6424622535705566},{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.6259143352508545},{"id":"https://openalex.org/C6182249","wikidata":"https://www.wikidata.org/wiki/Q700007","display_name":"Phospholipase D","level":3,"score":0.6110490560531616},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.5789374113082886},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5749760866165161},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5041464567184448},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4711636006832123},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.44018206000328064},{"id":"https://openalex.org/C2780780085","wikidata":"https://www.wikidata.org/wiki/Q18028763","display_name":"MARCKS","level":4,"score":0.4262264370918274},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42580318450927734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36559736728668213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3475581109523773},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16674286127090454},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.11884540319442749},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076250","descriptor_name":"Myristoylated Alanine-Rich C Kinase Substrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076250","descriptor_name":"Myristoylated Alanine-Rich C Kinase Substrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000076250","descriptor_name":"Myristoylated Alanine-Rich C Kinase Substrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007708","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007708","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32255775","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32255775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:38c879e4765f4fdea7a92e4d6401cb93","is_oa":true,"landing_page_url":"https://doaj.org/article/38c879e4765f4fdea7a92e4d6401cb93","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 4, p e1007708 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/12093201","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Mechanistic_models_of_PLC_PKC_signaling_implicate_phosphatidic_acid_as_a_key_amplifier_of_chemotactic_gradient_sensing/12093201","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7164671","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7164671","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007708","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007708","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G167388507","display_name":null,"funder_award_id":"U01-EB018816","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3991758691","display_name":null,"funder_award_id":"U01-EB018816","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W205153889","https://openalex.org/W1512964013","https://openalex.org/W1524441326","https://openalex.org/W1587627449","https://openalex.org/W1931315964","https://openalex.org/W1963793114","https://openalex.org/W1964145620","https://openalex.org/W1964874228","https://openalex.org/W1977885600","https://openalex.org/W1985567519","https://openalex.org/W1997230083","https://openalex.org/W1998597603","https://openalex.org/W1999876918","https://openalex.org/W2000774142","https://openalex.org/W2002243207","https://openalex.org/W2002959031","https://openalex.org/W2005088092","https://openalex.org/W2013329576","https://openalex.org/W2022964566","https://openalex.org/W2027052704","https://openalex.org/W2033724230","https://openalex.org/W2039264500","https://openalex.org/W2040561330","https://openalex.org/W2042277916","https://openalex.org/W2050063896","https://openalex.org/W2052818515","https://openalex.org/W2055360565","https://openalex.org/W2059672480","https://openalex.org/W2062635534","https://openalex.org/W2063220206","https://openalex.org/W2065316235","https://openalex.org/W2065475665","https://openalex.org/W2066482993","https://openalex.org/W2066833882","https://openalex.org/W2068780958","https://openalex.org/W2074561793","https://openalex.org/W2074871030","https://openalex.org/W2076123445","https://openalex.org/W2093253631","https://openalex.org/W2093371001","https://openalex.org/W2094618454","https://openalex.org/W2095176131","https://openalex.org/W2100818194","https://openalex.org/W2101792270","https://openalex.org/W2104608392","https://openalex.org/W2105809801","https://openalex.org/W2109519875","https://openalex.org/W2122519300","https://openalex.org/W2127903487","https://openalex.org/W2134283668","https://openalex.org/W2154781280","https://openalex.org/W2154796814","https://openalex.org/W2161112329","https://openalex.org/W2164495477","https://openalex.org/W2166817392","https://openalex.org/W2188659719","https://openalex.org/W2299806323","https://openalex.org/W2303572581","https://openalex.org/W2325727928","https://openalex.org/W2735509567","https://openalex.org/W2802062281","https://openalex.org/W2885287769","https://openalex.org/W4246002002","https://openalex.org/W4388243180"],"related_works":["https://openalex.org/W1992861540","https://openalex.org/W2005823044","https://openalex.org/W1571266982","https://openalex.org/W1569240903","https://openalex.org/W2075346378","https://openalex.org/W2044564421","https://openalex.org/W2109757013","https://openalex.org/W2077424481","https://openalex.org/W2414179288","https://openalex.org/W2166694325"],"abstract_inverted_index":{"Chemotaxis":[0],"of":[1,21,42,56,63,94,142,159,173,190],"fibroblasts":[2,57],"and":[3,12,103,117,193],"other":[4],"mesenchymal":[5,198],"cells":[6],"is":[7,48,165],"critical":[8],"for":[9,169],"embryonic":[10],"development":[11],"wound":[13,160],"healing.":[14],"Fibroblast":[15],"chemotaxis":[16,170],"directed":[17],"by":[18,96],"a":[19,60],"gradient":[20,62],"platelet-derived":[22],"growth":[23],"factor":[24],"(PDGF)":[25],"requires":[26],"signaling":[27],"through":[28],"the":[29,39,52,69,90,110,120,131,140,176],"phospholipase":[30,118],"C":[31,34,99],"(PLC)/protein":[32],"kinase":[33,100,136],"(PKC)":[35],"pathway.":[36],"Diacylglycerol":[37],"(DAG),":[38],"lipid":[40],"product":[41],"PLC":[43],"that":[44,122,196],"activates":[45],"conventional":[46],"PKCs,":[47],"focally":[49],"enriched":[50],"at":[51],"up-gradient":[53],"leading":[54],"edge":[55],"responding":[58],"to":[59,148,186],"shallow":[61],"PDGF,":[64],"signifying":[65],"polarization.":[66],"To":[67],"explain":[68],"underlying":[70],"mechanisms,":[71],"we":[72],"formulated":[73],"reaction-diffusion":[74,177],"models":[75],"including":[76],"as":[77,79,127],"many":[78],"three":[80],"putative":[81],"feedback":[82,107],"loops":[83,108],"based":[84],"on":[85],"known":[86],"biochemistry.":[87],"These":[88],"include":[89],"previously":[91],"analyzed":[92],"mechanism":[93],"substrate-buffering":[95],"myristoylated":[97],"alanine-rich":[98],"substrate":[101],"(MARCKS)":[102],"two":[104],"newly":[105],"considered":[106],"involving":[109],"lipid,":[111],"phosphatidic":[112],"acid":[113],"(PA).":[114],"DAG":[115,135],"kinases":[116],"D,":[119],"enzymes":[121],"produce":[123],"PA,":[124],"are":[125],"identified":[126],"key":[128],"regulators":[129],"in":[130,157,175],"models.":[132,178],"Paradoxically,":[133],"increasing":[134],"activity":[137],"can":[138],"enhance":[139],"robustness":[141],"DAG/active":[143],"PKC":[144],"polarization":[145,174],"with":[146,167],"respect":[147],"chemoattractant":[149],"concentration":[150],"while":[151],"decreasing":[152],"their":[153],"whole-cell":[154],"levels.":[155],"Finally,":[156],"simulations":[158],"invasion,":[161],"efficient":[162],"collective":[163],"migration":[164],"achieved":[166],"thresholds":[168],"matching":[171],"those":[172],"This":[179],"multi-scale":[180],"modeling":[181],"framework":[182],"offers":[183],"testable":[184],"predictions":[185],"guide":[187],"further":[188],"study":[189],"signal":[191],"transduction":[192],"cell":[194],"behavior":[195],"affect":[197],"chemotaxis.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}