{"id":"https://openalex.org/W3015686348","doi":"https://doi.org/10.1371/journal.pcbi.1007705","title":"A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract","display_name":"A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract","publication_year":2020,"publication_date":"2020-04-13","ids":{"openalex":"https://openalex.org/W3015686348","doi":"https://doi.org/10.1371/journal.pcbi.1007705","mag":"3015686348","pmid":"https://pubmed.ncbi.nlm.nih.gov/32282797"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007705","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007705","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1007705","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005805170","display_name":"Christian Quirouette","orcid":"https://orcid.org/0000-0002-9461-6660"},"institutions":[{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christian Quirouette","raw_affiliation_strings":["Department of Physics, Ryerson University, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9461-6660","affiliations":[{"raw_affiliation_string":"Department of Physics, Ryerson University, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I530967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020021218","display_name":"Nada P. Younis","orcid":"https://orcid.org/0000-0003-0631-5524"},"institutions":[{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nada P. Younis","raw_affiliation_strings":["Department of Physics, Ryerson University, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0631-5524","affiliations":[{"raw_affiliation_string":"Department of Physics, Ryerson University, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I530967"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054250029","display_name":"Micaela B. Reddy","orcid":"https://orcid.org/0000-0002-2721-3714"},"institutions":[{"id":"https://openalex.org/I4210101899","display_name":"Array BioPharma (United States)","ror":"https://ror.org/018axtd57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210101899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micaela B. Reddy","raw_affiliation_strings":["Array BioPharma Inc., Boulder, Colorado, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2721-3714","affiliations":[{"raw_affiliation_string":"Array BioPharma Inc., Boulder, Colorado, United States of America","institution_ids":["https://openalex.org/I4210101899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024742488","display_name":"Catherine A. A. Beauchemin","orcid":"https://orcid.org/0000-0003-0599-0069"},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA","JP"],"is_corresponding":true,"raw_author_name":"Catherine A. A. Beauchemin","raw_affiliation_strings":["Department of Physics, Ryerson University, Toronto, Ontario, Canada","Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Wako, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0599-0069","affiliations":[{"raw_affiliation_string":"Department of Physics, Ryerson University, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS), RIKEN, Wako, Japan","institution_ids":["https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024742488"],"corresponding_institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I530967"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.2715,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.98020972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"16","issue":"4","first_page":"e1007705","last_page":"e1007705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.7159252166748047},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6308359503746033},{"id":"https://openalex.org/keywords/advection","display_name":"Advection","score":0.5755714774131775},{"id":"https://openalex.org/keywords/respiratory-tract","display_name":"Respiratory tract","score":0.5194413065910339},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4712263345718384},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.45851871371269226},{"id":"https://openalex.org/keywords/nose","display_name":"Nose","score":0.4340376853942871},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.41885384917259216},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.2586606740951538},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10575124621391296}],"concepts":[{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7159252166748047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6308359503746033},{"id":"https://openalex.org/C5072599","wikidata":"https://www.wikidata.org/wiki/Q379788","display_name":"Advection","level":2,"score":0.5755714774131775},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.5194413065910339},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4712263345718384},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.45851871371269226},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.4340376853942871},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.41885384917259216},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2586606740951538},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10575124621391296},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1007705","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007705","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32282797","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32282797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmid:33137087","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33137087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1908.08482","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1908.08482","pdf_url":"https://arxiv.org/pdf/1908.08482","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:98afc44ee10543f3bacd28f8bda326f8","is_oa":true,"landing_page_url":"https://doaj.org/article/98afc44ee10543f3bacd28f8bda326f8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 4, p e1007705 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/12120513","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_mathematical_model_describing_the_localization_and_spread_of_influenza_A_virus_infection_within_the_human_respiratory_tract/12120513","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7179943","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7179943","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7605629","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7605629","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007705","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007705","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6531749944","display_name":null,"funder_award_id":"ER13-09-040","funder_id":"https://openalex.org/F4320321886","funder_display_name":"Ontario Ministry of Research, Innovation and Science"},{"id":"https://openalex.org/G6728312345","display_name":null,"funder_award_id":"355837-2013","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320309577","display_name":"Array BioPharma","ror":"https://ror.org/018axtd57"},{"id":"https://openalex.org/F4320314607","display_name":"Government of Ontario","ror":"https://ror.org/015pzp858"},{"id":"https://openalex.org/F4320321886","display_name":"Ontario Ministry of Research, Innovation and Science","ror":"https://ror.org/03zr1tg88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"},{"id":"https://openalex.org/F4320337380","display_name":"Division of Mathematical Sciences","ror":"https://ror.org/051fftw81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W69413871","https://openalex.org/W74050426","https://openalex.org/W327711053","https://openalex.org/W919967210","https://openalex.org/W1491283643","https://openalex.org/W1512687697","https://openalex.org/W1514068133","https://openalex.org/W1535081978","https://openalex.org/W1541159444","https://openalex.org/W1554438070","https://openalex.org/W1578831904","https://openalex.org/W1635779336","https://openalex.org/W1921069800","https://openalex.org/W1965004987","https://openalex.org/W1970813805","https://openalex.org/W1973922464","https://openalex.org/W1979128689","https://openalex.org/W1979468527","https://openalex.org/W1979530960","https://openalex.org/W1980462967","https://openalex.org/W1981860686","https://openalex.org/W1986589631","https://openalex.org/W1989233387","https://openalex.org/W1996311210","https://openalex.org/W2005851777","https://openalex.org/W2020755531","https://openalex.org/W2036024310","https://openalex.org/W2046378278","https://openalex.org/W2049281680","https://openalex.org/W2049812311","https://openalex.org/W2053109557","https://openalex.org/W2054519334","https://openalex.org/W2058740609","https://openalex.org/W2059483175","https://openalex.org/W2060982649","https://openalex.org/W2071688420","https://openalex.org/W2072237100","https://openalex.org/W2072658090","https://openalex.org/W2079164297","https://openalex.org/W2082206279","https://openalex.org/W2082728971","https://openalex.org/W2088402140","https://openalex.org/W2089726099","https://openalex.org/W2093983981","https://openalex.org/W2100008240","https://openalex.org/W2101594367","https://openalex.org/W2101665065","https://openalex.org/W2106258444","https://openalex.org/W2109211024","https://openalex.org/W2109977701","https://openalex.org/W2112639149","https://openalex.org/W2113361715","https://openalex.org/W2114508027","https://openalex.org/W2114956308","https://openalex.org/W2119950877","https://openalex.org/W2120113718","https://openalex.org/W2120982899","https://openalex.org/W2121658243","https://openalex.org/W2122399224","https://openalex.org/W2122988122","https://openalex.org/W2125456091","https://openalex.org/W2125806967","https://openalex.org/W2130017811","https://openalex.org/W2131420725","https://openalex.org/W2145825913","https://openalex.org/W2149658463","https://openalex.org/W2155121918","https://openalex.org/W2157493963","https://openalex.org/W2161230104","https://openalex.org/W2162384187","https://openalex.org/W2163262195","https://openalex.org/W2165316954","https://openalex.org/W2168573378","https://openalex.org/W2169343004","https://openalex.org/W2171405797","https://openalex.org/W2171737176","https://openalex.org/W2181350890","https://openalex.org/W2335500481","https://openalex.org/W2340962389","https://openalex.org/W2395520831","https://openalex.org/W2570416398","https://openalex.org/W2735505316","https://openalex.org/W2736661311","https://openalex.org/W2747539919","https://openalex.org/W2800144652","https://openalex.org/W2806022580","https://openalex.org/W2888041009","https://openalex.org/W2895844692","https://openalex.org/W2920472362","https://openalex.org/W2954376662","https://openalex.org/W2959675886","https://openalex.org/W3086400475","https://openalex.org/W3212809170","https://openalex.org/W4230115907","https://openalex.org/W4254020717","https://openalex.org/W4313311491"],"related_works":["https://openalex.org/W3036101264","https://openalex.org/W2163151373","https://openalex.org/W1986676657","https://openalex.org/W4253521710","https://openalex.org/W4245458501","https://openalex.org/W2000378123","https://openalex.org/W2418383432","https://openalex.org/W2431304738","https://openalex.org/W3209983300","https://openalex.org/W1987715131"],"abstract_inverted_index":{"Within":[0],"the":[1,9,14,22,27,33,38,50,61,74,82,87,93,101,105,122,131,145,180,196,200,211,214,222,246,284,293],"human":[2],"respiratory":[3,289],"tract":[4],"(HRT),":[5],"virus":[6,17,42,66,149,153,173,184],"diffuses":[7],"through":[8],"periciliary":[10],"fluid":[11],"(PCF)":[12],"bathing":[13],"epithelium.":[15],"But":[16],"also":[18,45,244],"undergoes":[19],"advection:":[20],"as":[21,95,206,217],"mucus":[23],"layer":[24],"sitting":[25],"atop":[26],"PCF":[28,39],"is":[29,174,225],"pushed":[30,46],"along":[31,119],"by":[32],"ciliated":[34],"cell's":[35],"beating":[36],"cilia,":[37],"and":[40,52,79,84,118,170,192,231,250,277,286],"its":[41],"content":[43],"are":[44,157],"along,":[47],"upwards":[48],"towards":[49,104,213],"nose":[51,102],"mouth.":[53],"While":[54],"many":[55],"mathematical":[56],"models":[57],"(MMs)":[58],"have":[59,72],"described":[60],"course":[62],"of":[63,76,86,133,179,248,266,288],"influenza":[64],"A":[65],"(IAV)":[67],"infections":[68,291],"in":[69,130,195,199,219,241],"vivo,":[70],"none":[71],"considered":[73],"impact":[75],"both":[77],"diffusion":[78],"advection":[80,134,161],"on":[81],"kinetics":[83,247],"localization":[85,285],"infection.":[88],"The":[89],"MM":[90,224,273],"herein":[91],"represents":[92],"HRT":[94,181],"a":[96,275],"one-dimensional":[97],"track":[98],"extending":[99],"from":[100,142,210,280],"down":[103],"lower":[106,186,201,215],"HRT,":[107,202,216],"wherein":[108],"stationary":[109],"cells":[110],"interact":[111],"with":[112,120,258,269],"IAV":[113,252],"which":[114,135,148,281],"moves":[115],"within":[116,292],"(diffusion)":[117],"(advection)":[121],"PCF.":[123],"Diffusion":[124],"was":[125],"found":[126],"to":[127,165,227,282],"be":[128],"negligible":[129],"presence":[132],"effectively":[136],"sweeps":[137],"away":[138],"IAV,":[139],"preventing":[140],"infection":[141,168,190,208],"disseminating":[143],"below":[144],"depth":[146],"at":[147,159],"first":[150],"deposits.":[151],"Higher":[152],"production":[154],"rates":[155],"(10-fold)":[156],"required":[158],"higher":[160],"speeds":[162],"(40":[163],"\u03bcm/s)":[164],"maintain":[166],"equivalent":[167],"severity":[169],"timing.":[171],"Because":[172],"entrained":[175],"upwards,":[176],"upper":[177,197,212],"parts":[178],"see":[182],"more":[183],"than":[185,198],"parts.":[187],"As":[188],"such,":[189],"peaks":[191],"resolves":[193],"faster":[194],"making":[203],"it":[204,235],"appear":[205],"though":[207],"progresses":[209],"reported":[218,240,259],"mice.":[220],"When":[221],"spatial":[223],"expanded":[226],"include":[228],"cellular":[229],"regeneration":[230],"an":[232],"immune":[233],"response,":[234],"reproduces":[236],"tissue":[237],"damage":[238],"levels":[239],"patients.":[242],"It":[243],"captures":[245],"seasonal":[249],"avian":[251],"infections,":[253],"via":[254],"parameter":[255],"changes":[256],"consistent":[257],"differences":[260],"between":[261],"these":[262],"strains,":[263],"enabling":[264],"comparison":[265],"their":[267],"treatment":[268],"antivirals.":[270],"This":[271],"new":[272],"offers":[274],"convenient":[276],"unique":[278],"platform":[279],"study":[283],"spread":[287],"viral":[290],"HRT.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2020-04-17T00:00:00"}