{"id":"https://openalex.org/W3012216762","doi":"https://doi.org/10.1371/journal.pcbi.1007671","title":"A simplified modelling framework facilitates more complex representations of plant circadian clocks","display_name":"A simplified modelling framework facilitates more complex representations of plant circadian clocks","publication_year":2020,"publication_date":"2020-03-16","ids":{"openalex":"https://openalex.org/W3012216762","doi":"https://doi.org/10.1371/journal.pcbi.1007671","mag":"3012216762","pmid":"https://pubmed.ncbi.nlm.nih.gov/32176683"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007671","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007671","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007671&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007671&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025432609","display_name":"Mathias Foo","orcid":"https://orcid.org/0000-0003-1400-2659"},"institutions":[{"id":"https://openalex.org/I73417466","display_name":"Coventry University","ror":"https://ror.org/01tgmhj36","country_code":"GB","type":"education","lineage":["https://openalex.org/I73417466"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mathias Foo","raw_affiliation_strings":["School of Mechanical, Aerospace and Automotive Engineering, Coventry University, Coventry, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1400-2659","affiliations":[{"raw_affiliation_string":"School of Mechanical, Aerospace and Automotive Engineering, Coventry University, Coventry, United Kingdom","institution_ids":["https://openalex.org/I73417466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, United Kingdom","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014444761","display_name":"Ozgur E. Akman","orcid":"https://orcid.org/0000-0002-9320-5958"},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ozgur E. Akman","raw_affiliation_strings":["College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9320-5958","affiliations":[{"raw_affiliation_string":"College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014444761","https://openalex.org/A5025432609","https://openalex.org/A5077819322"],"corresponding_institution_ids":["https://openalex.org/I23923803","https://openalex.org/I39555362","https://openalex.org/I73417466"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1391,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.76745942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"e1007671","last_page":"e1007671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"Circadian clock","score":0.6799046993255615},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.653627336025238},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5598402619361877},{"id":"https://openalex.org/keywords/bottleneck","display_name":"Bottleneck","score":0.5387289524078369},{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.5176590085029602},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5054671764373779},{"id":"https://openalex.org/keywords/formalism","display_name":"Formalism (music)","score":0.5004172325134277},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4338505268096924},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4269813299179077},{"id":"https://openalex.org/keywords/network-model","display_name":"Network model","score":0.4131550192832947},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.41149672865867615},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3078327178955078},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.30119261145591736},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.2995242178440094},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22653725743293762},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.219964861869812}],"concepts":[{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6799046993255615},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.653627336025238},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5598402619361877},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.5387289524078369},{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.5176590085029602},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5054671764373779},{"id":"https://openalex.org/C73301696","wikidata":"https://www.wikidata.org/wiki/Q5469984","display_name":"Formalism (music)","level":3,"score":0.5004172325134277},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4338505268096924},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4269813299179077},{"id":"https://openalex.org/C104122410","wikidata":"https://www.wikidata.org/wiki/Q1416406","display_name":"Network model","level":2,"score":0.4131550192832947},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.41149672865867615},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3078327178955078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30119261145591736},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.2995242178440094},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22653725743293762},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.219964861869812},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C558565934","wikidata":"https://www.wikidata.org/wiki/Q2743","display_name":"Musical","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018521","descriptor_name":"Plant Physiological Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018521","descriptor_name":"Plant Physiological Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018521","descriptor_name":"Plant Physiological Phenomena","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056925","descriptor_name":"Circadian Rhythm Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056925","descriptor_name":"Circadian Rhythm Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056925","descriptor_name":"Circadian Rhythm Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056925","descriptor_name":"Circadian Rhythm Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056925","descriptor_name":"Circadian Rhythm Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056925","descriptor_name":"Circadian Rhythm Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1007671","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007671","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007671&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32176683","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32176683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007671","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007671","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e0b7b90888674f519ee3b45c98c232f8","is_oa":true,"landing_page_url":"https://doaj.org/article/e0b7b90888674f519ee3b45c98c232f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 3, p e1007671 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/11990664","is_oa":true,"landing_page_url":"https://figshare.com/articles/A_simplified_modelling_framework_facilitates_more_complex_representations_of_plant_circadian_clocks/11990664","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:figshare.com:article/29771309","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/A_simplified_modelling_framework_facilitates_more_complex_representations_of_plant_circadian_clocks/29771309","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ore.exeter.ac.uk:10871/121741","is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/121741","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7098658","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7098658","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/ba614816-0d3b-4042-9efe-9f8da07c72eb","is_oa":true,"landing_page_url":"https://pureportal.coventry.ac.uk/en/publications/ba614816-0d3b-4042-9efe-9f8da07c72eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306402411","display_name":"Pure (Coventry University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I73417466","host_organization_name":"Coventry University","host_organization_lineage":["https://openalex.org/I73417466"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Foo, M, Bates, D & Akman, O 2020, 'A simplified modelling framework facilitates more complex representations of plant circadian clocks', PLoS Computational Biology, vol. 16, no. 3, e1007671. https://doi.org/10.1371/journal.pcbi.1007671","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/ba614816-0d3b-4042-9efe-9f8da07c72eb","is_oa":true,"landing_page_url":"https://pureportal.coventry.ac.uk/en/publications/a-simplified-modelling-framework-facilitates-more-complex-representations-of-plant-circadian-clocks(ba614816-0d3b-4042-9efe-9f8da07c72eb).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402411","display_name":"Pure (Coventry University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I73417466","host_organization_name":"Coventry University","host_organization_lineage":["https://openalex.org/I73417466"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007671","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007671","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007671&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G1436783943","display_name":null,"funder_award_id":"EP/N014391/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2865109628","display_name":null,"funder_award_id":"EP/N017846/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3157446626","display_name":"The Parameter Optimisation Problem: Addressing a Key Challenge in Computational Systems Biology","funder_award_id":"EP/N017846/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3184405124","display_name":null,"funder_award_id":"BB/M017982/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3293224696","display_name":"Warwick Integrative Synthetic Biology Centre","funder_award_id":"BB/M017982/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4122777843","display_name":null,"funder_award_id":"BB/M017982","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G625002215","display_name":null,"funder_award_id":"BB/M017982/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G688401098","display_name":"EPSRC Centre for Predictive Modelling in Healthcare","funder_award_id":"EP/N014391/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8484862371","display_name":null,"funder_award_id":"RGS/R2/180195","funder_id":"https://openalex.org/F4320320006","funder_display_name":"Royal Society"}],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3012216762.pdf","grobid_xml":"https://content.openalex.org/works/W3012216762.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W103156936","https://openalex.org/W178056938","https://openalex.org/W1482637285","https://openalex.org/W1510585142","https://openalex.org/W1581582023","https://openalex.org/W1586554382","https://openalex.org/W1599969036","https://openalex.org/W1621540022","https://openalex.org/W1660761394","https://openalex.org/W1721627070","https://openalex.org/W1965324089","https://openalex.org/W1965717790","https://openalex.org/W1965917681","https://openalex.org/W1968764046","https://openalex.org/W1969482758","https://openalex.org/W1972805592","https://openalex.org/W1987464952","https://openalex.org/W1992749367","https://openalex.org/W2003049033","https://openalex.org/W2006005484","https://openalex.org/W2008133909","https://openalex.org/W2010473850","https://openalex.org/W2017798312","https://openalex.org/W2018088831","https://openalex.org/W2019311512","https://openalex.org/W2024991751","https://openalex.org/W2045529195","https://openalex.org/W2046355391","https://openalex.org/W2046445269","https://openalex.org/W2046879305","https://openalex.org/W2046971770","https://openalex.org/W2047279254","https://openalex.org/W2048792111","https://openalex.org/W2055531437","https://openalex.org/W2055699557","https://openalex.org/W2059746610","https://openalex.org/W2063346607","https://openalex.org/W2078955035","https://openalex.org/W2081409037","https://openalex.org/W2085113253","https://openalex.org/W2086490888","https://openalex.org/W2089522577","https://openalex.org/W2099795802","https://openalex.org/W2100169396","https://openalex.org/W2101122984","https://openalex.org/W2101553880","https://openalex.org/W2101682056","https://openalex.org/W2112183540","https://openalex.org/W2112542744","https://openalex.org/W2128588809","https://openalex.org/W2130431253","https://openalex.org/W2135694744","https://openalex.org/W2138190671","https://openalex.org/W2140688829","https://openalex.org/W2141239733","https://openalex.org/W2147948709","https://openalex.org/W2150998297","https://openalex.org/W2155229070","https://openalex.org/W2156444576","https://openalex.org/W2158196600","https://openalex.org/W2158706468","https://openalex.org/W2159130719","https://openalex.org/W2160521086","https://openalex.org/W2163597546","https://openalex.org/W2164965140","https://openalex.org/W2172001413","https://openalex.org/W2186892520","https://openalex.org/W2225816887","https://openalex.org/W2255993693","https://openalex.org/W2274818760","https://openalex.org/W2274956278","https://openalex.org/W2618483832","https://openalex.org/W2761856395","https://openalex.org/W2767353815","https://openalex.org/W2903650961","https://openalex.org/W2971303336","https://openalex.org/W3101174921","https://openalex.org/W6694700227"],"related_works":["https://openalex.org/W2949927938","https://openalex.org/W2029387041","https://openalex.org/W2135896045","https://openalex.org/W1973268559","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W2031892952","https://openalex.org/W3108451992","https://openalex.org/W2171763327","https://openalex.org/W207829213"],"abstract_inverted_index":{"The":[0,177],"circadian":[1,57],"clock":[2,81,142,167,250],"orchestrates":[3],"biological":[4],"processes":[5],"so":[6],"that":[7,159,258,267],"they":[8],"occur":[9],"at":[10],"specific":[11],"times":[12],"of":[13,42,56,71,105,187,198,206,222,243,261],"the":[14,43,49,69,93,102,139,146,173,196,204,220,232,240,253,262,278],"day,":[15],"thereby":[16,209],"facilitating":[17,68,203],"adaptation":[18],"to":[19,36,74,111,118,172,213,231],"diurnal":[20],"and":[21,190],"seasonal":[22],"environmental":[23],"changes.":[24],"In":[25,192],"plants,":[26],"mathematical":[27],"modelling":[28,288],"has":[29],"been":[30],"comprehensively":[31],"integrated":[32],"with":[33,52,96,115,169],"experimental":[34,119],"studies":[35],"gain":[37],"a":[38,63,112,272,286],"better":[39],"mechanistic":[40],"understanding":[41],"complex":[44],"genetic":[45],"regulatory":[46],"network":[47,214],"comprising":[48],"clock.":[50],"However,":[51,92],"an":[53],"increasing":[54],"number":[55],"genes":[58],"being":[59],"discovered,":[60],"there":[61],"is":[62],"pressing":[64],"need":[65],"for":[66,125,153,239,275,290],"methods":[67],"expansion":[70],"computational":[72],"models":[73,82,126,143,168,218,233],"incorporate":[75],"these":[76,135],"newly-discovered":[77],"components.":[78],"Conventionally,":[79],"plant":[80,141,249],"have":[83],"comprised":[84],"differential":[85],"equation":[86],"systems":[87,229],"based":[88,144],"on":[89,145],"Michaelis-Menten":[90,175],"kinetics.":[91],"difficulties":[94],"associated":[95],"modifying":[97],"interactions":[98],"using":[99],"this":[100,164],"approach-and":[101],"concomitant":[103],"problem":[104],"robustly":[106],"identifying":[107],"regulation":[108,207],"types-has":[109],"contributed":[110],"complexity":[113],"bottleneck,":[114],"quantitative":[116],"fits":[117],"data":[120],"rapidly":[121],"becoming":[122],"computationally":[123],"intractable":[124],"possessing":[127],"more":[128],"than":[129],"\u224850":[130],"parameters.":[131],"Here,":[132],"we":[133,235],"address":[134],"issues":[136],"by":[137,151,226],"constructing":[138],"first":[140],"S-System":[147,178,217,279],"formalism":[148,280],"originally":[149],"developed":[150],"Savageau":[152],"analysing":[154],"biochemical":[155],"networks.":[156],"We":[157,265],"show":[158],"despite":[160],"its":[161],"relative":[162],"simplicity,":[163],"approach":[165],"yields":[166],"comparable":[170],"accuracy":[171],"conventional":[174],"formalism.":[176],"formulation":[179],"also":[180,202,281],"confers":[181],"several":[182],"key":[183],"advantages":[184],"in":[185,247],"terms":[186],"model":[188,276],"construction":[189],"expansion.":[191],"particular,":[193],"it":[194,211],"simplifies":[195],"inclusion":[197],"new":[199],"interactions,":[200],"whilst":[201],"modification":[205],"types,":[208],"making":[210],"well-suited":[212],"inference.":[215],"Furthermore,":[216],"mitigate":[219],"issue":[221],"parameter":[223],"identifiability.":[224],"Finally,":[225],"applying":[227],"linear":[228],"theory":[230],"considered,":[234],"provide":[236],"some":[237],"justification":[238],"increased":[241],"use":[242],"aggregated":[244],"protein":[245,256],"equations":[246],"recent":[248],"modelling,":[251],"replacing":[252],"separate":[254],"cytoplasmic/nuclear":[255],"compartments":[257],"were":[259],"characteristic":[260],"earlier":[263],"models.":[264],"conclude":[266],"as":[268,270,285],"well":[269],"providing":[271],"simplified":[273],"framework":[274],"development,":[277],"possesses":[282],"significant":[283],"potential":[284],"robust":[287],"method":[289],"designing":[291],"synthetic":[292],"gene":[293],"circuits.":[294]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}