{"id":"https://openalex.org/W3004771246","doi":"https://doi.org/10.1371/journal.pcbi.1007619","title":"A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells","display_name":"A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells","publication_year":2020,"publication_date":"2020-02-10","ids":{"openalex":"https://openalex.org/W3004771246","doi":"https://doi.org/10.1371/journal.pcbi.1007619","mag":"3004771246"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007619","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007619","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007619&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007619&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019955505","display_name":"Shubham Tripathi","orcid":"https://orcid.org/0000-0002-0141-987X"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubham Tripathi","raw_affiliation_strings":["Center for Theoretical Biological Physics, Rice University, Houston, TX, United States of America","Department of Physics, Northeastern University, Boston, MA, United States of America","PhD Program in Systems, Synthetic, and Physical Biology, Rice University, Houston, TX, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0141-987X","affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Physics, Northeastern University, Boston, MA, United States of America","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"PhD Program in Systems, Synthetic, and Physical Biology, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035785820","display_name":"Priyanka Chakraborty","orcid":null},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Chakraborty","raw_affiliation_strings":["Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036939761","display_name":"Herbert Levine","orcid":"https://orcid.org/0000-0002-8819-9055"},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herbert Levine","raw_affiliation_strings":["Center for Theoretical Biological Physics, Rice University, Houston, TX, United States of America","Department of Physics, Northeastern University, Boston, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Physics, Northeastern University, Boston, MA, United States of America","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083772852","display_name":"Mohit Kumar Jolly","orcid":"https://orcid.org/0000-0002-6631-2109"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mohit Kumar Jolly","raw_affiliation_strings":["Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for BioSystems Science and Engineering, Indian Institute of Science, Bangalore, Karnataka, India","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036939761","https://openalex.org/A5083772852"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I4210145836","https://openalex.org/I59270414","https://openalex.org/I74775410"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.1238,"has_fulltext":true,"cited_by_count":127,"citation_normalized_percentile":{"value":0.98227814,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"16","issue":"2","first_page":"e1007619","last_page":"e1007619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cell","display_name":"Mesenchymal stem cell","score":0.7675021886825562},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6884759664535522},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.681740403175354},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5429948568344116},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.5128769874572754},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4723205268383026},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.461527019739151},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.44794511795043945},{"id":"https://openalex.org/keywords/phenotypic-switching","display_name":"Phenotypic switching","score":0.4132435917854309},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.32084643840789795},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.3207787275314331},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20863077044487},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12430441379547119},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08009472489356995}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7675021886825562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6884759664535522},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.681740403175354},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5429948568344116},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5128769874572754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4723205268383026},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.461527019739151},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.44794511795043945},{"id":"https://openalex.org/C2781011225","wikidata":"https://www.wikidata.org/wiki/Q7181400","display_name":"Phenotypic switching","level":4,"score":0.4132435917854309},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32084643840789795},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3207787275314331},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20863077044487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12430441379547119},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08009472489356995},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007619","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007619","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007619&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai::79307","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401429","display_name":"ePrints@IISc (Indian Institute of Science)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:13cb8ea0afe24adaa1433ae7690dba5d","is_oa":true,"landing_page_url":"https://doaj.org/article/13cb8ea0afe24adaa1433ae7690dba5d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 2, p e1007619 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/11832885","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_mechanism_for_epithelial-mesenchymal_heterogeneity_in_a_population_of_cancer_cells/11832885","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7034928","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7034928","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007619","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007619","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007619&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G5981941460","display_name":null,"funder_award_id":"SB/S2/RJN-049/2018","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G6760746498","display_name":null,"funder_award_id":"PHY-1605817","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7457980591","display_name":"Spatial Patterning in the Progressing Tumor - The Role of Notch","funder_award_id":"1605817","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3004771246.pdf","grobid_xml":"https://content.openalex.org/works/W3004771246.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W1581655059","https://openalex.org/W1689351220","https://openalex.org/W1903523058","https://openalex.org/W1964847767","https://openalex.org/W1966564846","https://openalex.org/W1975356306","https://openalex.org/W1979302584","https://openalex.org/W1980484515","https://openalex.org/W1980561748","https://openalex.org/W1982396530","https://openalex.org/W1987012261","https://openalex.org/W1992380352","https://openalex.org/W1998728654","https://openalex.org/W2001544973","https://openalex.org/W2002654154","https://openalex.org/W2014691022","https://openalex.org/W2023427658","https://openalex.org/W2029231546","https://openalex.org/W2044692345","https://openalex.org/W2051055358","https://openalex.org/W2055498399","https://openalex.org/W2056822151","https://openalex.org/W2090982381","https://openalex.org/W2109998353","https://openalex.org/W2114154136","https://openalex.org/W2125505694","https://openalex.org/W2129375080","https://openalex.org/W2132980978","https://openalex.org/W2134539328","https://openalex.org/W2139182006","https://openalex.org/W2140937954","https://openalex.org/W2145246556","https://openalex.org/W2148323109","https://openalex.org/W2150322923","https://openalex.org/W2153382986","https://openalex.org/W2155418451","https://openalex.org/W2156162122","https://openalex.org/W2157923000","https://openalex.org/W2164796316","https://openalex.org/W2166374791","https://openalex.org/W2177744475","https://openalex.org/W2189664213","https://openalex.org/W2192807450","https://openalex.org/W2240026504","https://openalex.org/W2273006669","https://openalex.org/W2337546159","https://openalex.org/W2338391827","https://openalex.org/W2352147892","https://openalex.org/W2517303441","https://openalex.org/W2523329479","https://openalex.org/W2589620344","https://openalex.org/W2600259521","https://openalex.org/W2613058366","https://openalex.org/W2623485051","https://openalex.org/W2756978353","https://openalex.org/W2796908592","https://openalex.org/W2797931455","https://openalex.org/W2798231099","https://openalex.org/W2801015129","https://openalex.org/W2810263512","https://openalex.org/W2887784244","https://openalex.org/W2890026694","https://openalex.org/W2891378535","https://openalex.org/W2896851403","https://openalex.org/W2900887954","https://openalex.org/W2905491238","https://openalex.org/W2906049926","https://openalex.org/W2907642042","https://openalex.org/W2917523920","https://openalex.org/W2921110468","https://openalex.org/W2947974585","https://openalex.org/W2949510436","https://openalex.org/W2951377960","https://openalex.org/W2952746001","https://openalex.org/W2953057790","https://openalex.org/W2963383004","https://openalex.org/W3102855742","https://openalex.org/W4211233744","https://openalex.org/W4251104453"],"related_works":["https://openalex.org/W2056146351","https://openalex.org/W2004641081","https://openalex.org/W3088929329","https://openalex.org/W1569572117","https://openalex.org/W2803356986","https://openalex.org/W2167125089","https://openalex.org/W2028864554","https://openalex.org/W4200508458","https://openalex.org/W2139354392","https://openalex.org/W2114628959"],"abstract_inverted_index":{"Epithelial-mesenchymal":[0],"heterogeneity":[1,77,94,188,246,260],"implies":[2],"that":[3,92,197],"cells":[4,70,112,203],"within":[5],"the":[6,63,98,101,114,123,129,144,147,171,180,184,208,218,225,240,255],"same":[7],"tumor":[8,50,214],"can":[9,95,169],"exhibit":[10],"different":[11,132,192],"phenotypes-epithelial,":[12],"mesenchymal,":[13],"or":[14,16],"one":[15],"more":[17],"hybrid":[18,166],"epithelial-mesenchymal":[19,93,151,167],"phenotypes.":[20],"This":[21],"behavior":[22],"has":[23,78],"been":[24],"reported":[25],"across":[26],"cancer":[27,55,69,118,140,251,264],"types,":[28],"both":[29],"in":[30,33,37,100,128,134,146,247,263],"vitro":[31],"and":[32,35,52,74,108,142,189,195,201,242,253,261],"vivo,":[34],"implicated":[36],"multiple":[38],"processes":[39],"associated":[40],"with":[41,58],"metastatic":[42],"aggressiveness":[43],"including":[44],"immune":[45],"evasion,":[46],"collective":[47],"dissemination":[48],"of":[49,54,65,68,103,116,131,137,150,174,186,199,220,228,244,250,258],"cells,":[51,141,252],"emergence":[53],"cell":[56,265],"subpopulations":[57],"stem":[59],"cell-like":[60],"properties.":[61],"However,":[62],"ability":[64],"a":[66,80,86,117,135,165,175,229,235,248],"population":[67,136,249],"to":[71,90,158,163,182,206,224],"generate,":[72],"maintain,":[73],"propagate":[75],"this":[76],"remained":[79],"mystifying":[81],"feature.":[82],"Here,":[83],"we":[84,178],"used":[85,179],"computational":[87],"modeling":[88],"approach":[89],"show":[91],"emerge":[96],"from":[97],"noise":[99],"partitioning":[102],"biomolecules":[104],"(such":[105],"as":[106,234],"RNAs":[107],"proteins)":[109],"among":[110],"daughter":[111],"during":[113],"division":[115],"cell.":[119],"Our":[120],"model":[121,154,181],"captures":[122],"experimentally":[124],"observed":[125],"temporal":[126],"changes":[127],"fractions":[130],"phenotypes":[133],"murine":[138],"prostate":[139],"describes":[143],"hysteresis":[145],"population-level":[148],"dynamics":[149,219],"plasticity.":[152],"The":[153],"is":[155,204],"further":[156],"able":[157],"predict":[159],"how":[160],"factors":[161],"known":[162],"promote":[164],"phenotype":[168],"alter":[170],"phenotypic":[172,187,226,259],"composition":[173,227],"population.":[176],"Finally,":[177],"probe":[183],"implications":[185],"plasticity":[190,262],"for":[191,212],"therapeutic":[193,256],"regimens":[194],"found":[196],"co-targeting":[198],"epithelial":[200],"mesenchymal":[202],"likely":[205],"be":[207],"most":[209],"effective":[210],"strategy":[211],"restricting":[213],"growth.":[215],"By":[216],"connecting":[217],"an":[221],"intracellular":[222],"circuit":[223],"population,":[230],"our":[231],"study":[232],"serves":[233],"first":[236],"step":[237],"towards":[238,254],"understanding":[239],"generation":[241],"maintenance":[243],"non-genetic":[245],"targeting":[257],"populations.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":6}],"updated_date":"2026-04-24T08:23:43.765630","created_date":"2025-10-10T00:00:00"}