{"id":"https://openalex.org/W2992230292","doi":"https://doi.org/10.1371/journal.pcbi.1007536","title":"Statistical inference in ensemble modeling of cellular metabolism","display_name":"Statistical inference in ensemble modeling of cellular metabolism","publication_year":2019,"publication_date":"2019-12-09","ids":{"openalex":"https://openalex.org/W2992230292","doi":"https://doi.org/10.1371/journal.pcbi.1007536","mag":"2992230292","pmid":"https://pubmed.ncbi.nlm.nih.gov/31815929"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007536","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007536","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007536&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007536&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083840456","display_name":"Hameri Tuure","orcid":"https://orcid.org/0000-0003-3177-4087"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tuure Hameri","raw_affiliation_strings":["Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3177-4087","affiliations":[{"raw_affiliation_string":"Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052548187","display_name":"Marc\u2010Olivier Boldi","orcid":null},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Marc-Olivier Boldi","raw_affiliation_strings":["Department of Operations, Faculty of Business and Economics, Anthropole, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1527-9652","affiliations":[{"raw_affiliation_string":"Department of Operations, Faculty of Business and Economics, Anthropole, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056011141","display_name":"Vassily Hatzimanikatis","orcid":"https://orcid.org/0000-0001-6432-4694"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Vassily Hatzimanikatis","raw_affiliation_strings":["Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6432-4694","affiliations":[{"raw_affiliation_string":"Laboratory of Computational Systems Biotechnology (LCSB), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052548187","https://openalex.org/A5056011141"],"corresponding_institution_ids":["https://openalex.org/I5124864","https://openalex.org/I97565354"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1966,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79315269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"12","first_page":"e1007536","last_page":"e1007536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bonferroni-correction","display_name":"Bonferroni correction","score":0.8402625918388367},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.6343407034873962},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.573371171951294},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5470678210258484},{"id":"https://openalex.org/keywords/normality","display_name":"Normality","score":0.5282154083251953},{"id":"https://openalex.org/keywords/bootstrapping","display_name":"Bootstrapping (finance)","score":0.5276145935058594},{"id":"https://openalex.org/keywords/statistical-inference","display_name":"Statistical inference","score":0.4879128634929657},{"id":"https://openalex.org/keywords/rank","display_name":"Rank (graph theory)","score":0.4743862450122833},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.46310561895370483},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4534391164779663},{"id":"https://openalex.org/keywords/multivariate-normal-distribution","display_name":"Multivariate normal distribution","score":0.42447465658187866},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.4046207070350647},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3289092779159546},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.30925509333610535},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.24691176414489746},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22003737092018127},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18145903944969177}],"concepts":[{"id":"https://openalex.org/C127808970","wikidata":"https://www.wikidata.org/wiki/Q385989","display_name":"Bonferroni correction","level":2,"score":0.8402625918388367},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.6343407034873962},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.573371171951294},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5470678210258484},{"id":"https://openalex.org/C2776157432","wikidata":"https://www.wikidata.org/wiki/Q1375683","display_name":"Normality","level":2,"score":0.5282154083251953},{"id":"https://openalex.org/C207609745","wikidata":"https://www.wikidata.org/wiki/Q4944086","display_name":"Bootstrapping (finance)","level":2,"score":0.5276145935058594},{"id":"https://openalex.org/C134261354","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical inference","level":2,"score":0.4879128634929657},{"id":"https://openalex.org/C164226766","wikidata":"https://www.wikidata.org/wiki/Q7293202","display_name":"Rank (graph theory)","level":2,"score":0.4743862450122833},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.46310561895370483},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4534391164779663},{"id":"https://openalex.org/C177384507","wikidata":"https://www.wikidata.org/wiki/Q1149000","display_name":"Multivariate normal distribution","level":3,"score":0.42447465658187866},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4046207070350647},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3289092779159546},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.30925509333610535},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.24691176414489746},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22003737092018127},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18145903944969177},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1007536","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007536","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007536&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31815929","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31815929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:serval.unil.ch:BIB_BDD720036AF2","is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_BDD720036AF2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology, vol. 15, no. 12, pp. e1007536","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:iris.unil.ch:iris/204290","is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/204290","pdf_url":"https://iris.unil.ch/bitstreams/defe46bf-8223-43f0-8b3d-3c7ee21eec53/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1007536","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007536","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:05464d932aa040ed8b0a230710f2d813","is_oa":true,"landing_page_url":"https://doaj.org/article/05464d932aa040ed8b0a230710f2d813","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 12, p e1007536 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5901278","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6922442","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/11343392","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Statistical_inference_in_ensemble_modeling_of_cellular_metabolism/11343392","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:infoscience.epfl.ch:273626","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/273626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007536","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007536","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007536&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6426235293","display_name":null,"funder_award_id":"315230_163423","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2992230292.pdf","grobid_xml":"https://content.openalex.org/works/W2992230292.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1990284034","https://openalex.org/W1993854668","https://openalex.org/W2002420618","https://openalex.org/W2034961255","https://openalex.org/W2035126508","https://openalex.org/W2064819126","https://openalex.org/W2066382523","https://openalex.org/W2094305273","https://openalex.org/W2111652881","https://openalex.org/W2113282000","https://openalex.org/W2124737787","https://openalex.org/W2126843316","https://openalex.org/W2161227644","https://openalex.org/W2164898811","https://openalex.org/W2412645763","https://openalex.org/W2561960911","https://openalex.org/W2594933406","https://openalex.org/W2737180538","https://openalex.org/W2738840671","https://openalex.org/W2755275228","https://openalex.org/W2951480779"],"related_works":["https://openalex.org/W2390064908","https://openalex.org/W2917228042","https://openalex.org/W1534274833","https://openalex.org/W1997764341","https://openalex.org/W2071289071","https://openalex.org/W2019273819","https://openalex.org/W1985128975","https://openalex.org/W4300543528","https://openalex.org/W3043726481","https://openalex.org/W4252444374"],"abstract_inverted_index":{"Kinetic":[0],"models":[1,57,70,90],"of":[2,56,68,88,122,166,272],"metabolism":[3,169],"can":[4,71,175,215,234,281],"be":[5,283],"constructed":[6],"to":[7,30,39,119,146,156,170,177,202,285,290],"predict":[8],"cellular":[9,76],"regulation":[10],"and":[11,16,53,91,180,197,229,237],"devise":[12],"metabolic":[13,64],"engineering":[14],"strategies,":[15],"various":[17],"promising":[18],"computational":[19,264],"workflows":[20,44,129],"have":[21],"been":[22],"developed":[23],"in":[24,33],"recent":[25],"years":[26],"for":[27,51,102,138,150,240],"this.":[28],"Due":[29],"the":[31,34,151,195,198,207,227,230,245,251,254,278],"uncertainty":[32],"kinetic":[35,41,69,89,164],"parameter":[36],"values":[37],"required":[38,287],"build":[40,203],"models,":[42],"these":[43],"rely":[45],"on":[46],"ensemble":[47],"modeling":[48],"(EM)":[49],"principles":[50],"sampling":[52],"building":[54],"populations":[55,87,121],"describing":[58],"observed":[59],"physiologies.":[60],"Sensitivity":[61],"coefficients":[62],"from":[63,108],"control":[65,77],"analysis":[66],"(MCA)":[67],"provide":[72,99,235],"important":[73,145],"insight":[74],"about":[75],"around":[78],"a":[79,183,292],"given":[80],"physiological":[81],"steady":[82],"state.":[83],"However,":[84],"despite":[85,260],"considering":[86],"their":[92],"model":[93,109,165],"outputs,":[94,110],"current":[95],"approaches":[96],"do":[97],"not":[98],"adequate":[100],"tools":[101],"statistical":[103,191],"inference.":[104],"To":[105],"derive":[106,147],"conclusions":[107],"such":[111],"as":[112],"MCA":[113],"sensitivity":[114],"coefficients,":[115],"it":[116,143],"is":[117,144,266],"necessary":[118],"rank/compare":[120],"variables":[123,152,256],"with":[124,244],"each":[125,139],"other.":[126],"Currently":[127],"existing":[128,162],"consider":[130],"confidence":[131],"intervals":[132],"(CIs)":[133],"that":[134,153,186,226],"are":[135],"derived":[136],"independently":[137],"comparable":[140],"variable.":[141],"Hence,":[142],"simultaneous":[148],"CIs":[149,174,205,218],"we":[154,159,181,275],"wish":[155],"rank/compare.":[157],"Herein,":[158],"used":[160,284],"an":[161],"large-scale":[163],"Escherichia":[167],"Coli":[168],"present":[171,182,257],"how":[172,213,277],"univariate":[173],"lead":[176],"incorrect":[178],"conclusions,":[179],"new":[184],"workflow":[185],"applies":[187],"three":[188],"different":[189],"multivariate":[190],"approaches.":[192],"We":[193,210,224],"use":[194],"Bonferroni":[196,228,252,279],"exact":[199,231,246],"normal":[200,232,247],"methods":[201,233],"symmetric":[204],"using":[206],"normality":[208,222],"assumptions.":[209],"then":[211],"suggest":[212],"bootstrapping":[214],"compute":[216],"asymmetric":[217],"whilst":[219],"relaxing":[220],"this":[221],"assumption.":[223],"conclude":[225],"simple":[236],"efficient":[238],"ways":[239],"constructing":[241],"reliable":[242],"CIs,":[243],"method":[248,280],"favored":[249],"over":[250],"when":[253,268],"compared":[255],"dependencies.":[258],"Bootstrapping,":[259],"its":[261],"significantly":[262],"higher":[263],"cost,":[265],"recommended":[267],"comparing":[269],"non-normal":[270],"distributions":[271],"variables.":[273],"Additionally,":[274],"show":[276],"readily":[282],"estimate":[286],"sample":[288],"numbers":[289],"attain":[291],"certain":[293],"CI":[294],"size.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}