{"id":"https://openalex.org/W2990732605","doi":"https://doi.org/10.1371/journal.pcbi.1007495","title":"Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization","display_name":"Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization","publication_year":2019,"publication_date":"2019-11-27","ids":{"openalex":"https://openalex.org/W2990732605","doi":"https://doi.org/10.1371/journal.pcbi.1007495","mag":"2990732605","pmid":"https://pubmed.ncbi.nlm.nih.gov/31774808"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007495","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007495","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007495&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007495&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091392935","display_name":"Tyler Cassidy","orcid":"https://orcid.org/0000-0003-0757-0017"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Tyler Cassidy","raw_affiliation_strings":["Department of Mathematics and Statistics, McGill University, Montreal, Quebec, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0757-0017","affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006094579","display_name":"Morgan Craig","orcid":"https://orcid.org/0000-0003-4852-4770"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Morgan Craig","raw_affiliation_strings":["Department of Physiology, McGill University, Montreal, Quebec, Canada","D\u00e9partement de math\u00e9matiques et de statistique, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":"https://orcid.org/0000-0003-4852-4770","affiliations":[{"raw_affiliation_string":"Department of Physiology, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"D\u00e9partement de math\u00e9matiques et de statistique, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006094579","https://openalex.org/A5091392935"],"corresponding_institution_ids":["https://openalex.org/I5023651","https://openalex.org/I70931966"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.1994,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.97444844,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"15","issue":"11","first_page":"e1007495","last_page":"e1007495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-virus","display_name":"Oncolytic virus","score":0.9692450761795044},{"id":"https://openalex.org/keywords/virotherapy","display_name":"Virotherapy","score":0.7143562436103821},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.706047773361206},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5724305510520935},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5529513359069824},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"Combination therapy","score":0.5121290683746338},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4260205030441284},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.39652061462402344},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3526532053947449},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21023917198181152}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9692450761795044},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.7143562436103821},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.706047773361206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5724305510520935},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5529513359069824},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.5121290683746338},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4260205030441284},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39652061462402344},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3526532053947449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21023917198181152}],"mesh":[{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075082","descriptor_name":"Proof of Concept Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007495","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007495","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007495&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31774808","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31774808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:de1571c79cf54ec3bdf9e2c93b016e20","is_oa":true,"landing_page_url":"https://doaj.org/article/de1571c79cf54ec3bdf9e2c93b016e20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 11, p e1007495 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5855434","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6880985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/11286455","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Determinants_of_combination_GM-CSF_immunotherapy_and_oncolytic_virotherapy_success_identified_through_i_in_silico_i_treatment_personalization/11286455","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007495","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007495","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007495&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[{"id":"https://openalex.org/G6397965006","display_name":null,"funder_award_id":"RGPIN-2018-04546","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990732605.pdf","grobid_xml":"https://content.openalex.org/works/W2990732605.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1659842140","https://openalex.org/W1963747703","https://openalex.org/W1964037688","https://openalex.org/W1970259496","https://openalex.org/W1970368422","https://openalex.org/W1977061115","https://openalex.org/W2044835625","https://openalex.org/W2063114530","https://openalex.org/W2070707240","https://openalex.org/W2076264447","https://openalex.org/W2079990421","https://openalex.org/W2105180873","https://openalex.org/W2109274792","https://openalex.org/W2110390205","https://openalex.org/W2151286180","https://openalex.org/W2160126578","https://openalex.org/W2160874621","https://openalex.org/W2232677792","https://openalex.org/W2252869735","https://openalex.org/W2262707985","https://openalex.org/W2304315762","https://openalex.org/W2315707504","https://openalex.org/W2410099483","https://openalex.org/W2410810535","https://openalex.org/W2429744838","https://openalex.org/W2466689966","https://openalex.org/W2497822529","https://openalex.org/W2508710837","https://openalex.org/W2561037714","https://openalex.org/W2569053280","https://openalex.org/W2619182341","https://openalex.org/W2763265527","https://openalex.org/W2770572337","https://openalex.org/W2792291600","https://openalex.org/W2794045287","https://openalex.org/W2795842962","https://openalex.org/W2801067660","https://openalex.org/W2807944903","https://openalex.org/W2900523842","https://openalex.org/W2904250082","https://openalex.org/W2943774074","https://openalex.org/W2945644530","https://openalex.org/W3101847459","https://openalex.org/W3103689510","https://openalex.org/W3105466232","https://openalex.org/W4211238487","https://openalex.org/W4251104453","https://openalex.org/W6718290252","https://openalex.org/W6814119210"],"related_works":["https://openalex.org/W4381623631","https://openalex.org/W3216836855","https://openalex.org/W1504990586","https://openalex.org/W2981223870","https://openalex.org/W2149161500","https://openalex.org/W2099449322","https://openalex.org/W4225867208","https://openalex.org/W2023793534","https://openalex.org/W3049037119","https://openalex.org/W2079990421"],"abstract_inverted_index":{"Oncolytic":[0],"virotherapies,":[1],"including":[2],"the":[3,28],"modified":[4],"herpes":[5],"simplex":[6],"virus":[7],"talimogene":[8],"laherparepvec":[9],"(T-VEC),":[10],"have":[11],"shown":[12],"great":[13],"promise":[14],"as":[15,34,167],"potent":[16],"instigators":[17],"of":[18,32,43,73,91,141,147,181],"anti-tumour":[19],"immune":[20,64,98],"effects.":[21],"The":[22],"OPTiM":[23],"trial,":[24],"in":[25,104],"particular,":[26],"demonstrated":[27],"superior":[29],"anti-cancer":[30],"effects":[31],"T-VEC":[33,77,151],"compared":[35],"to":[36,81,108,173],"systemic":[37],"immunotherapy":[38,55],"treatment":[39],"using":[40],"exogenous":[41,53],"administration":[42],"granulocyte-macrophage":[44],"colony-stimulating":[45],"factor":[46],"(GM-CSF).":[47],"Theoretically,":[48],"a":[49,87,168],"combined":[50],"approach":[51],"leveraging":[52],"cytokine":[54],"and":[56,66,76,93,97,110,114,118,123,150,177],"oncolytic":[57,121],"virotherapy":[58,122],"would":[59],"elicit":[60],"an":[61,103],"even":[62],"greater":[63],"response":[65],"improve":[67],"patient":[68,130],"outcomes.":[69],"However,":[70],"regimen":[71],"scheduling":[72],"combination":[74,112,120,148,175,185],"immunostimulation":[75],"therapy":[78,152],"has":[79],"yet":[80],"be":[82,155],"established.":[83],"Here,":[84],"we":[85,126,144],"calibrate":[86],"computational":[88],"biology":[89],"model":[90],"sensitive":[92],"resistant":[94],"tumour":[95],"cells":[96],"interactions":[99],"for":[100,132,170],"implementation":[101],"into":[102,157],"silico":[105],"clinical":[106],"trial":[107],"test":[109],"individualize":[111],"immuno-":[113],"virotherapy.":[115,187],"By":[116],"personalizing":[117],"optimizing":[119],"immunostimulatory":[124],"therapy,":[125,176],"show":[127],"improved":[128],"simulated":[129],"outcomes":[131],"individuals":[133],"with":[134],"late-stage":[135],"melanoma.":[136],"More":[137],"crucially,":[138],"through":[139],"evaluation":[140],"individualized":[142],"regimens,":[143],"identified":[145],"determinants":[146],"GM-CSF":[149],"that":[153],"can":[154],"translated":[156],"clinically-actionable":[158],"dosing":[159],"strategies":[160],"without":[161],"further":[162],"personalization.":[163],"Our":[164],"results":[165],"serve":[166],"proof-of-concept":[169],"interdisciplinary":[171],"approaches":[172],"determining":[174],"suggest":[178],"promising":[179],"avenues":[180],"investigation":[182],"towards":[183],"tailored":[184],"immunotherapy/oncolytic":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":12}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}