{"id":"https://openalex.org/W2988652721","doi":"https://doi.org/10.1371/journal.pcbi.1007401","title":"Prediction of PD-L1 inhibition effects for HIV-infected individuals","display_name":"Prediction of PD-L1 inhibition effects for HIV-infected individuals","publication_year":2019,"publication_date":"2019-11-06","ids":{"openalex":"https://openalex.org/W2988652721","doi":"https://doi.org/10.1371/journal.pcbi.1007401","mag":"2988652721","pmid":"https://pubmed.ncbi.nlm.nih.gov/31693657"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007401","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007401&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007401&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078552830","display_name":"\u0412.\u0412. \u0416\u0435\u043b\u0442\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-4452-7328"},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210086928","display_name":"Institute of Numerical Mathematics","ror":"https://ror.org/00520ey40","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210086928","https://openalex.org/I4210124601"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valerya Zheltkova","raw_affiliation_strings":["Faculty of Computational Mathematics and Cybernetics, Lomonosov Moscow State University, Moscow, Russia","Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4452-7328","affiliations":[{"raw_affiliation_string":"Faculty of Computational Mathematics and Cybernetics, Lomonosov Moscow State University, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210086928","https://openalex.org/I1313323035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029661828","display_name":"Jordi Argilaguet","orcid":"https://orcid.org/0000-0001-5924-2774"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Argilaguet","raw_affiliation_strings":["Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5924-2774","affiliations":[{"raw_affiliation_string":"Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068660686","display_name":"Cristina Peligero","orcid":null},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Peligero","raw_affiliation_strings":["Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032433442","display_name":"Gennady Bocharov","orcid":"https://orcid.org/0000-0002-5049-0656"},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]},{"id":"https://openalex.org/I4210086928","display_name":"Institute of Numerical Mathematics","ror":"https://ror.org/00520ey40","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210086928","https://openalex.org/I4210124601"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Gennady Bocharov","raw_affiliation_strings":["Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia","Sechenov First Moscow State Medical University, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-5049-0656","affiliations":[{"raw_affiliation_string":"Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia","institution_ids":["https://openalex.org/I4210086928","https://openalex.org/I1313323035"]},{"raw_affiliation_string":"Sechenov First Moscow State Medical University, Moscow, Russia","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029705489","display_name":"Andreas Meyerhans","orcid":"https://orcid.org/0000-0003-0620-5317"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Andreas Meyerhans","raw_affiliation_strings":["ICREA, Pg. Llu\u00eds Companys 23, Barcelona, Spain","Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0620-5317","affiliations":[{"raw_affiliation_string":"ICREA, Pg. Llu\u00eds Companys 23, Barcelona, Spain","institution_ids":["https://openalex.org/I11932220"]},{"raw_affiliation_string":"Infection Biology Laboratory, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029705489","https://openalex.org/A5032433442"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I1313323035","https://openalex.org/I170486558","https://openalex.org/I17877952","https://openalex.org/I4210086928"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9923,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.73590504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"11","first_page":"e1007401","last_page":"e1007401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctl*","display_name":"CTL*","score":0.8882894515991211},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.700611412525177},{"id":"https://openalex.org/keywords/blockade","display_name":"Blockade","score":0.6977127194404602},{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.6852859258651733},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.6242872476577759},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5178854465484619},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4944291114807129},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.4792644679546356},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.46646416187286377},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.43828386068344116},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.39807233214378357},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.19369369745254517},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11344099044799805},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.10531839728355408}],"concepts":[{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.8882894515991211},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.700611412525177},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6977127194404602},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6852859258651733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6242872476577759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5178854465484619},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4944291114807129},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4792644679546356},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46646416187286377},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.43828386068344116},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39807233214378357},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19369369745254517},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11344099044799805},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10531839728355408},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007401","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007401&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31693657","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31693657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:repositori.upf.edu:10230/42824","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/42824","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:68697bb9dedf4992acff32f8db205f72","is_oa":true,"landing_page_url":"https://doaj.org/article/68697bb9dedf4992acff32f8db205f72","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 11, p e1007401 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/10261427","is_oa":true,"landing_page_url":"https://figshare.com/articles/Prediction_of_PD-L1_inhibition_effects_for_HIV-infected_individuals/10261427","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6834253","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6834253","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007401","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007401","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007401&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"awards":[{"id":"https://openalex.org/G1373285316","display_name":null,"funder_award_id":"SAF2016-75505-R","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G2481904932","display_name":null,"funder_award_id":"00171","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G2509000725","display_name":null,"funder_award_id":"MDM-2014-0370","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G3610282239","display_name":null,"funder_award_id":"MDM-2014-0370","funder_id":"https://openalex.org/F4320326262","funder_display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a"},{"id":"https://openalex.org/G4338553329","display_name":null,"funder_award_id":"-11-00171","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G5037603606","display_name":null,"funder_award_id":"18-11-00171","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G7089115150","display_name":null,"funder_award_id":"SAF2016-75505-R","funder_id":"https://openalex.org/F4320335204","funder_display_name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n"},{"id":"https://openalex.org/G7736590058","display_name":null,"funder_award_id":"SAF2016-75505-R","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320326262","display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","ror":"https://ror.org/03sv46s19"},{"id":"https://openalex.org/F4320335204","display_name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2988652721.pdf","grobid_xml":"https://content.openalex.org/works/W2988652721.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1607348270","https://openalex.org/W1910012553","https://openalex.org/W1963963990","https://openalex.org/W1965755933","https://openalex.org/W1966478716","https://openalex.org/W1971931476","https://openalex.org/W1976632658","https://openalex.org/W1978436252","https://openalex.org/W1991216151","https://openalex.org/W2001815433","https://openalex.org/W2003051762","https://openalex.org/W2013324823","https://openalex.org/W2023714686","https://openalex.org/W2027054583","https://openalex.org/W2029444376","https://openalex.org/W2035852466","https://openalex.org/W2037343680","https://openalex.org/W2046763569","https://openalex.org/W2058798829","https://openalex.org/W2063396456","https://openalex.org/W2066671159","https://openalex.org/W2066756933","https://openalex.org/W2069146497","https://openalex.org/W2081061234","https://openalex.org/W2083331853","https://openalex.org/W2095387359","https://openalex.org/W2097855813","https://openalex.org/W2110305039","https://openalex.org/W2117280652","https://openalex.org/W2125255512","https://openalex.org/W2128401657","https://openalex.org/W2133919033","https://openalex.org/W2139213642","https://openalex.org/W2147134928","https://openalex.org/W2147954548","https://openalex.org/W2148035653","https://openalex.org/W2149792264","https://openalex.org/W2152803686","https://openalex.org/W2159859837","https://openalex.org/W2183318491","https://openalex.org/W2323626307","https://openalex.org/W2560367415","https://openalex.org/W2626808986","https://openalex.org/W2739076307","https://openalex.org/W2791483720","https://openalex.org/W2808746201","https://openalex.org/W2901185593","https://openalex.org/W2938889495","https://openalex.org/W2949194343","https://openalex.org/W7037695443"],"related_works":["https://openalex.org/W1971118974","https://openalex.org/W2133374731","https://openalex.org/W1782288177","https://openalex.org/W2139048705","https://openalex.org/W1546513461","https://openalex.org/W2023919916","https://openalex.org/W2054101033","https://openalex.org/W2158917805","https://openalex.org/W2162334966","https://openalex.org/W2340237593"],"abstract_inverted_index":{"The":[0,165],"novel":[1],"therapies":[2],"with":[3,12],"immune":[4],"checkpoint":[5],"inhibitors":[6],"hold":[7],"great":[8],"promises":[9],"for":[10,73,94,142,161,201,292],"patients":[11],"chronic":[13],"virus":[14,186],"infections":[15],"and":[16,118,127,130,146,154,216,227,257,268],"cancers.":[17],"This":[18,245],"is":[19,210,286],"based":[20],"mainly":[21],"on":[22,50,125,149,218,241,254,263],"the":[23,27,42,51,74,120,147,176,182,233,251,264],"partial":[24],"reversal":[25],"of":[26,30,44,55,122,178,204,213,236,271,280],"exhausted":[28],"phenotype":[29],"antigen-specific":[31],"cytotoxic":[32],"CD8":[33,110,242],"T":[34,46,111,156,171,225,243,259],"cells":[35,226],"(CTL).":[36],"Recently,":[37],"we":[38,60,105,230],"have":[39],"shown":[40],"that":[41,250],"restoration":[43],"HIV-specific":[45,75],"cell":[47,112,157,172,260],"function":[48],"depends":[49,262],"HIV":[52,144,255],"infection":[53,99,163],"stage":[54],"an":[56],"infected":[57],"individual.":[58],"Here":[59],"aimed":[61],"to":[62,90,288],"answer":[63,102],"two":[64],"fundamental":[65],"questions:":[66],"(i)":[67],"Can":[68,84],"one":[69,85],"estimate":[70],"growth":[71],"parameters":[72],"proliferative":[76],"responsiveness":[77],"upon":[78],"PD-L1":[79,123,284],"blockade":[80,124,238,285],"ex":[81],"vivo?":[82],"(ii)":[83],"use":[86],"these":[87,103],"parameter":[88],"estimates":[89],"predict":[91],"clinical":[92,198],"benefit":[93,199],"HIV-infected":[95,205,293],"individuals":[96],"displaying":[97],"diverse":[98],"phenotypes?":[100],"To":[101],"questions,":[104],"first":[106],"analyzed":[107],"HIV-1":[108],"Gag-specific":[109],"proliferation":[113],"by":[114],"time-resolved":[115],"CFSE":[116],"assays":[117],"estimated":[119],"effect":[121,253],"division":[126],"death":[128],"rates,":[129],"specific":[131],"precursor":[132],"frequencies.":[133],"These":[134,193],"values":[135],"were":[136,159],"then":[137,248],"incorporated":[138],"into":[139],"a":[140,196,202,211,276],"model":[141,247,282],"CTL-mediated":[143],"control":[145],"effects":[148,235,270],"CTL":[150],"frequencies,":[151],"viral":[152],"loads":[153,187],"CD4":[155,170,224,258],"counts":[158,173],"predicted":[160],"different":[162],"phenotypes.":[164],"biggest":[166],"absolute":[167],"increase":[168],"in":[169,175,185,190],"was":[174,188],"group":[177],"slow":[179],"progressors":[180],"while":[181],"strongest":[183],"reduction":[184],"observed":[189],"progressor":[191],"patients.":[192],"results":[194],"suggest":[195],"significant":[197],"only":[200],"subgroup":[203],"individuals.":[206,294],"However,":[207],"as":[208],"PD1":[209],"marker":[212],"lymphocyte":[214,220,272],"activation":[215],"expressed":[217],"several":[219],"subsets":[221],"including":[222],"also":[223],"B":[228],"cells,":[229],"subsequently":[231],"examined":[232],"multiple":[234],"anti-PD-L1":[237],"beyond":[239],"those":[240],"cells.":[244],"extended":[246],"predicts":[249],"net":[252],"load":[256],"number":[261],"interplay":[265],"between":[266],"positive":[267],"negative":[269],"subset":[273],"activation.":[274],"For":[275],"physiologically":[277],"relevant":[278],"range":[279],"affected":[281],"parameters,":[283],"likely":[287],"be":[289],"overall":[290],"beneficial":[291]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}