{"id":"https://openalex.org/W3016218204","doi":"https://doi.org/10.1371/journal.pcbi.1007394","title":"Molecular mechanisms of fentanyl mediated \u03b2-arrestin biased signaling","display_name":"Molecular mechanisms of fentanyl mediated \u03b2-arrestin biased signaling","publication_year":2020,"publication_date":"2020-04-10","ids":{"openalex":"https://openalex.org/W3016218204","doi":"https://doi.org/10.1371/journal.pcbi.1007394","mag":"3016218204","pmid":"https://pubmed.ncbi.nlm.nih.gov/32275713"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007394","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1007394","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082863229","display_name":"Parker W. de Waal","orcid":"https://orcid.org/0000-0001-6922-9768"},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parker W. de Waal","raw_affiliation_strings":["Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6922-9768","affiliations":[{"raw_affiliation_string":"Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan, United States of America","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786358","display_name":"Jingjing Shi","orcid":"https://orcid.org/0000-0001-5640-8687"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Shi","raw_affiliation_strings":["The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Erli You","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erli You","raw_affiliation_strings":["The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719969","display_name":"Xiaoxi Wang","orcid":"https://orcid.org/0000-0002-2232-8504"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxi Wang","raw_affiliation_strings":["The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045460299","display_name":"Karsten Melcher","orcid":"https://orcid.org/0000-0002-9125-4027"},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karsten Melcher","raw_affiliation_strings":["Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9125-4027","affiliations":[{"raw_affiliation_string":"Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan, United States of America","institution_ids":["https://openalex.org/I1317189400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062324518","display_name":"Yi Jiang","orcid":"https://orcid.org/0000-0002-0723-1413"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Jiang","raw_affiliation_strings":["The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-0723-1413","affiliations":[{"raw_affiliation_string":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052217844","display_name":"H. Eric Xu","orcid":"https://orcid.org/0000-0002-6829-8144"},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"H. Eric Xu","raw_affiliation_strings":["Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan, United States of America","The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-6829-8144","affiliations":[{"raw_affiliation_string":"Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, Michigan, United States of America","institution_ids":["https://openalex.org/I1317189400"]},{"raw_affiliation_string":"The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210112820","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038761014","display_name":"Bradley M. Dickson","orcid":"https://orcid.org/0000-0002-4995-9111"},"institutions":[{"id":"https://openalex.org/I1317189400","display_name":"Van Andel Institute","ror":"https://ror.org/00wm07d60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1317189400"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bradley M. Dickson","raw_affiliation_strings":["Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4995-9111","affiliations":[{"raw_affiliation_string":"Center for Epigenetics, Van Andel Research Institute, Grand Rapids, Michigan, United States of America","institution_ids":["https://openalex.org/I1317189400","https://openalex.org/I4210111179"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5038761014","https://openalex.org/A5052217844","https://openalex.org/A5062324518"],"corresponding_institution_ids":["https://openalex.org/I1317189400","https://openalex.org/I19820366","https://openalex.org/I4210111179","https://openalex.org/I4210112820"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.2603,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.93125366,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"16","issue":"4","first_page":"e1007394","last_page":"e1007394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fentanyl","display_name":"Fentanyl","score":0.7688987851142883},{"id":"https://openalex.org/keywords/damgo","display_name":"DAMGO","score":0.6265051364898682},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5885760188102722},{"id":"https://openalex.org/keywords/arrestin","display_name":"Arrestin","score":0.5638400316238403},{"id":"https://openalex.org/keywords/opioid-receptor","display_name":"Opioid receptor","score":0.4630323648452759},{"id":"https://openalex.org/keywords/agonist","display_name":"Agonist","score":0.4617727994918823},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4563579559326172},{"id":"https://openalex.org/keywords/opioid","display_name":"Opioid","score":0.45566147565841675},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.44239795207977295},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.4336608052253723},{"id":"https://openalex.org/keywords/g-protein","display_name":"G protein","score":0.42428457736968994},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.4026634693145752},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.36768171191215515},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3614931106567383},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3347637951374054},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3313360810279846},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19493815302848816},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13496920466423035}],"concepts":[{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.7688987851142883},{"id":"https://openalex.org/C2776401185","wikidata":"https://www.wikidata.org/wiki/Q5204254","display_name":"DAMGO","level":5,"score":0.6265051364898682},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5885760188102722},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.5638400316238403},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.4630323648452759},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4617727994918823},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4563579559326172},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.45566147565841675},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44239795207977295},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4336608052253723},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.42428457736968994},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4026634693145752},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.36768171191215515},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3614931106567383},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3347637951374054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3313360810279846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19493815302848816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13496920466423035}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017450","descriptor_name":"Receptors, Opioid, mu","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007394","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32275713","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32275713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:635dacf284454c0382637012e3d7ad7b","is_oa":true,"landing_page_url":"https://doaj.org/article/635dacf284454c0382637012e3d7ad7b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 4, p e1007394 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/12113733","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Molecular_mechanisms_of_fentanyl_mediated_-arrestin_biased_signaling/12113733","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7176292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7176292","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007394","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007394","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8500000238418579,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2606711600","display_name":null,"funder_award_id":"31770796","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4034949710","display_name":null,"funder_award_id":"2018ZX09711002","funder_id":"https://openalex.org/F4320335960","funder_display_name":"National Major Science and Technology Projects of China"},{"id":"https://openalex.org/G7057204618","display_name":null,"funder_award_id":"2018ZX09711002","funder_id":"https://openalex.org/F4320329860","funder_display_name":"National Science and Technology Major Project"}],"funders":[{"id":"https://openalex.org/F4320308551","display_name":"Van Andel Research Institute","ror":"https://ror.org/00wm07d60"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327721","display_name":"K. C. Wong Education Foundation","ror":null},{"id":"https://openalex.org/F4320329860","display_name":"National Science and Technology Major Project","ror":null},{"id":"https://openalex.org/F4320335960","display_name":"National Major Science and Technology Projects of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1607931568","https://openalex.org/W1655589213","https://openalex.org/W1918796765","https://openalex.org/W1984546455","https://openalex.org/W1988821183","https://openalex.org/W1994388300","https://openalex.org/W1997340548","https://openalex.org/W2015087988","https://openalex.org/W2017663673","https://openalex.org/W2036108598","https://openalex.org/W2041970883","https://openalex.org/W2042572511","https://openalex.org/W2047567287","https://openalex.org/W2049617698","https://openalex.org/W2051746492","https://openalex.org/W2057451466","https://openalex.org/W2063923754","https://openalex.org/W2067973462","https://openalex.org/W2070753604","https://openalex.org/W2075453187","https://openalex.org/W2083725367","https://openalex.org/W2084550263","https://openalex.org/W2086240493","https://openalex.org/W2104477830","https://openalex.org/W2109083102","https://openalex.org/W2110045591","https://openalex.org/W2117762969","https://openalex.org/W2119154997","https://openalex.org/W2120823854","https://openalex.org/W2132629607","https://openalex.org/W2137887442","https://openalex.org/W2146411229","https://openalex.org/W2157205606","https://openalex.org/W2165835468","https://openalex.org/W2226712470","https://openalex.org/W2270756322","https://openalex.org/W2313116527","https://openalex.org/W2332712348","https://openalex.org/W2512819857","https://openalex.org/W2514617502","https://openalex.org/W2529534853","https://openalex.org/W2535112051","https://openalex.org/W2555870966","https://openalex.org/W2581696375","https://openalex.org/W2591997013","https://openalex.org/W2604764539","https://openalex.org/W2617279801","https://openalex.org/W2763609857","https://openalex.org/W2770319189","https://openalex.org/W2791091229","https://openalex.org/W2794587166","https://openalex.org/W2804674424","https://openalex.org/W2807850657","https://openalex.org/W2808215229","https://openalex.org/W2883755802","https://openalex.org/W2897059447","https://openalex.org/W2906591149","https://openalex.org/W3022986877","https://openalex.org/W4230763112","https://openalex.org/W4296309414"],"related_works":["https://openalex.org/W3099352123","https://openalex.org/W1977323674","https://openalex.org/W77586585","https://openalex.org/W2996306092","https://openalex.org/W2479584601","https://openalex.org/W3049722152","https://openalex.org/W4308834482","https://openalex.org/W4221121402","https://openalex.org/W3205509257","https://openalex.org/W3125274977"],"abstract_inverted_index":{"The":[0,58],"development":[1],"of":[2,68,115,157],"novel":[3,122],"analgesics":[4,159],"with":[5,160],"improved":[6,161],"safety":[7,162],"profiles":[8],"to":[9,18,44,92],"combat":[10],"the":[11,54,85,112],"opioid":[12,87],"epidemic":[13],"represents":[14],"a":[15,48,66,121,151],"central":[16],"question":[17],"G":[19,31,101,134],"protein":[20,32,102,135],"coupled":[21],"receptor":[22,56],"structural":[23],"biology":[24],"and":[25,84,106,150],"pharmacology:":[26],"What":[27],"chemical":[28,73],"features":[29],"dictate":[30],"or":[33],"\u03b2-arrestin":[34,50,94,119,147],"signaling?":[35],"Here":[36],"we":[37,80],"use":[38],"adaptively":[39],"biased":[40,51,136,148],"molecular":[41,142],"dynamics":[42],"simulations":[43],"determine":[45],"how":[46],"fentanyl,":[47],"potent":[49],"agonist,":[52],"binds":[53],"\u03bc-opioid":[55],"(\u03bcOR).":[57],"resulting":[59],"fentanyl-bound":[60],"pose":[61],"provides":[62],"rational":[63,152],"insight":[64,143],"into":[65,144],"wealth":[67],"historical":[69],"structure-activity-relationship":[70],"on":[71],"its":[72],"scaffold.":[74],"Following":[75],"an":[76,108],"in-silico":[77],"derived":[78],"hypothesis":[79],"found":[81],"that":[82,129],"fentanyl":[83,116,145],"synthetic":[86],"peptide":[88],"DAMGO":[89],"require":[90],"M153":[91,97,123],"induce":[93],"coupling,":[95],"while":[96],"was":[98],"dispensable":[99],"for":[100,154],"coupling.":[103,137],"We":[104],"propose":[105],"validate":[107],"activation":[109],"mechanism":[110],"where":[111],"n-aniline":[113],"ring":[114],"mediates":[117],"\u03bcOR":[118],"through":[120],"\"microswitch\"":[124],"by":[125],"synthesizing":[126],"fentanyl-based":[127,158],"derivatives":[128],"exhibit":[130],"complete,":[131],"clinically":[132],"desirable,":[133],"Together,":[138],"these":[139],"results":[140],"provide":[141],"mediated":[146],"signaling":[149],"framework":[153],"further":[155],"optimization":[156],"profiles.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}