{"id":"https://openalex.org/W3006177941","doi":"https://doi.org/10.1371/journal.pcbi.1007322","title":"From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy","display_name":"From whole-organ imaging to in-silico blood flow modeling: A new multi-scale network analysis for revisiting tissue functional anatomy","publication_year":2020,"publication_date":"2020-02-14","ids":{"openalex":"https://openalex.org/W3006177941","doi":"https://doi.org/10.1371/journal.pcbi.1007322","mag":"3006177941","pmid":"https://pubmed.ncbi.nlm.nih.gov/32059013"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007322","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007322","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007322/2/pcbi.1007322.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132551Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007322/2/pcbi.1007322.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132551Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063348826","display_name":"Pol Kennel","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210110935","display_name":"Institut de M\u00e9canique des Fluides de Toulouse","ror":"https://ror.org/025nmxp11","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210095849","https://openalex.org/I4210110935","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pol Kennel","raw_affiliation_strings":["Institute of Fluid Mechanics of Toulouse (IMFT), Toulouse University, CNRS, INPT, UPS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fluid Mechanics of Toulouse (IMFT), Toulouse University, CNRS, INPT, UPS, Toulouse, France","institution_ids":["https://openalex.org/I4210110935","https://openalex.org/I205747304","https://openalex.org/I134560555","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075738419","display_name":"Jules Dichamp","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210110935","display_name":"Institut de M\u00e9canique des Fluides de Toulouse","ror":"https://ror.org/025nmxp11","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210095849","https://openalex.org/I4210110935","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jules Dichamp","raw_affiliation_strings":["Institute of Fluid Mechanics of Toulouse (IMFT), Toulouse University, CNRS, INPT, UPS, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fluid Mechanics of Toulouse (IMFT), Toulouse University, CNRS, INPT, UPS, Toulouse, France","institution_ids":["https://openalex.org/I4210110935","https://openalex.org/I205747304","https://openalex.org/I134560555","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052885964","display_name":"Corinne Barreau","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210111455","display_name":"StromaLab","ror":"https://ror.org/01tfttw56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210111455","https://openalex.org/I4210128919"]},{"id":"https://openalex.org/I4210155240","display_name":"Canadian Nautical Research Society","ror":"https://ror.org/04zzdbj59","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210155240"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Corinne Barreau","raw_affiliation_strings":["CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","CNRS 5273","UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210111455"]},{"raw_affiliation_string":"CNRS 5273","institution_ids":["https://openalex.org/I4210155240"]},{"raw_affiliation_string":"UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210111455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047971762","display_name":"Christophe Guissard","orcid":"https://orcid.org/0000-0003-0777-7683"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210111455","display_name":"StromaLab","ror":"https://ror.org/01tfttw56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210111455","https://openalex.org/I4210128919"]},{"id":"https://openalex.org/I4210155240","display_name":"Canadian Nautical Research Society","ror":"https://ror.org/04zzdbj59","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210155240"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Christophe Guissard","raw_affiliation_strings":["CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","CNRS 5273"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210111455"]},{"raw_affiliation_string":"UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210111455"]},{"raw_affiliation_string":"CNRS 5273","institution_ids":["https://openalex.org/I4210155240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026316268","display_name":"Lise Teyssedre","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lise Teyssedre","raw_affiliation_strings":["ITAV, Universit\u00e9 de Toulouse, CNRS, UPS, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITAV, Universit\u00e9 de Toulouse, CNRS, UPS, France","institution_ids":["https://openalex.org/I17866349","https://openalex.org/I134560555","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081949120","display_name":"Jacques Rouquette","orcid":"https://orcid.org/0000-0001-6853-0559"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Rouquette","raw_affiliation_strings":["ITAV, Universit\u00e9 de Toulouse, CNRS, UPS, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITAV, Universit\u00e9 de Toulouse, CNRS, UPS, France","institution_ids":["https://openalex.org/I17866349","https://openalex.org/I134560555","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011037748","display_name":"Julien Colombelli","orcid":"https://orcid.org/0000-0002-2784-4276"},"institutions":[{"id":"https://openalex.org/I4210122345","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/01z1gye03","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122345","https://openalex.org/I4210132884","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Julien Colombelli","raw_affiliation_strings":["Advanced Digital Microscopy Core Facility, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology. C. Baldiri Reixac, 10. E-08028 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Digital Microscopy Core Facility, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology. C. Baldiri Reixac, 10. E-08028 Barcelona, Spain","institution_ids":["https://openalex.org/I4210122345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090670823","display_name":"Anne Lorsignol","orcid":"https://orcid.org/0000-0001-7662-1872"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210111455","display_name":"StromaLab","ror":"https://ror.org/01tfttw56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210111455","https://openalex.org/I4210128919"]},{"id":"https://openalex.org/I4210155240","display_name":"Canadian Nautical Research Society","ror":"https://ror.org/04zzdbj59","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210155240"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Anne Lorsignol","raw_affiliation_strings":["CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","CNRS 5273"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210111455"]},{"raw_affiliation_string":"UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210111455"]},{"raw_affiliation_string":"CNRS 5273","institution_ids":["https://openalex.org/I4210155240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085708867","display_name":"Louis Casteilla","orcid":"https://orcid.org/0000-0001-9647-3248"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210111455","display_name":"StromaLab","ror":"https://ror.org/01tfttw56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210096427","https://openalex.org/I4210111455","https://openalex.org/I4210128919"]},{"id":"https://openalex.org/I4210155240","display_name":"Canadian Nautical Research Society","ror":"https://ror.org/04zzdbj59","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210155240"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Louis Casteilla","raw_affiliation_strings":["CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","CNRS 5273","UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS 5273; UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210111455"]},{"raw_affiliation_string":"CNRS 5273","institution_ids":["https://openalex.org/I4210155240"]},{"raw_affiliation_string":"UMR STROMALab, BP 84225, F-31 432 Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210111455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015076918","display_name":"Franck Plourabou\u00e9","orcid":"https://orcid.org/0000-0003-0349-4221"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I205747304","display_name":"Institut National Polytechnique de Toulouse","ror":"https://ror.org/033p9g875","country_code":"FR","type":"education","lineage":["https://openalex.org/I205747304","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4210110935","display_name":"Institut de M\u00e9canique des Fluides de Toulouse","ror":"https://ror.org/025nmxp11","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210095849","https://openalex.org/I4210110935","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Franck Plourabou\u00e9","raw_affiliation_strings":["Institute of Fluid Mechanics of Toulouse (IMFT), Toulouse University, CNRS, INPT, UPS, Toulouse, France"],"raw_orcid":"https://orcid.org/0000-0003-0349-4221","affiliations":[{"raw_affiliation_string":"Institute of Fluid Mechanics of Toulouse (IMFT), Toulouse University, CNRS, INPT, UPS, Toulouse, France","institution_ids":["https://openalex.org/I4210110935","https://openalex.org/I205747304","https://openalex.org/I134560555","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5015076918"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I205747304","https://openalex.org/I4210110935"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2166,"currency":"EUR","value_usd":2336},"fwci":1.8101,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.87023666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"2","first_page":"e1007322","last_page":"e1007322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.5215275883674622},{"id":"https://openalex.org/keywords/vascular-network","display_name":"Vascular network","score":0.5182533264160156},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.47962626814842224},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45569390058517456},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.43055087327957153},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.427310585975647},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3563799560070038},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3510913848876953},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3278834819793701},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1490834355354309},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.11580449342727661},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.11229437589645386}],"concepts":[{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.5215275883674622},{"id":"https://openalex.org/C3019347889","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Vascular network","level":2,"score":0.5182533264160156},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.47962626814842224},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45569390058517456},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.43055087327957153},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.427310585975647},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3563799560070038},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3510913848876953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278834819793701},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1490834355354309},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11580449342727661},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.11229437589645386},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001775","descriptor_name":"Blood Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1007322","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007322","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007322/2/pcbi.1007322.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132551Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32059013","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32059013","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:oatao.univ-toulouse.fr:25659","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401987","display_name":"Open Archive Toulouse Archive Ouverte (University of Toulouse)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I17866349","host_organization_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","host_organization_lineage":["https://openalex.org/I17866349"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:HAL:hal-02538402v1","is_oa":false,"landing_page_url":"https://hal.science/hal-02538402","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2020, 16 (2), pp.e1007322. ⟨10.1371/journal.pcbi.1007322⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:69297d3e0d844c5299887ab0bff17379","is_oa":true,"landing_page_url":"https://doaj.org/article/69297d3e0d844c5299887ab0bff17379","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 2, p e1007322 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/11857344","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/From_whole-organ_imaging_to_in-silico_blood_flow_modeling_A_new_multi-scale_network_analysis_for_revisiting_tissue_functional_anatomy/11857344","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7062279","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7062279","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007322","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007322","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007322/2/pcbi.1007322.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132551Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328356","display_name":"R\u00e9gion Occitanie Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3006177941.pdf","grobid_xml":"https://content.openalex.org/works/W3006177941.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W70124717","https://openalex.org/W1481471836","https://openalex.org/W1855830754","https://openalex.org/W1885783202","https://openalex.org/W1944523529","https://openalex.org/W1977409995","https://openalex.org/W1981202432","https://openalex.org/W1986586948","https://openalex.org/W1991430328","https://openalex.org/W1991689521","https://openalex.org/W1994223414","https://openalex.org/W2000558985","https://openalex.org/W2008150005","https://openalex.org/W2054882957","https://openalex.org/W2056944867","https://openalex.org/W2078261317","https://openalex.org/W2080416259","https://openalex.org/W2080499538","https://openalex.org/W2094475932","https://openalex.org/W2097507352","https://openalex.org/W2102916742","https://openalex.org/W2119148266","https://openalex.org/W2123729552","https://openalex.org/W2126410943","https://openalex.org/W2126427858","https://openalex.org/W2127048411","https://openalex.org/W2131681506","https://openalex.org/W2134286344","https://openalex.org/W2138621811","https://openalex.org/W2139528660","https://openalex.org/W2144707317","https://openalex.org/W2160167323","https://openalex.org/W2164382630","https://openalex.org/W2166572577","https://openalex.org/W2167822639","https://openalex.org/W2170568150","https://openalex.org/W2187250072","https://openalex.org/W2190054710","https://openalex.org/W2245458847","https://openalex.org/W2254398499","https://openalex.org/W2257467030","https://openalex.org/W2279530658","https://openalex.org/W2303677943","https://openalex.org/W2341043760","https://openalex.org/W2512571444","https://openalex.org/W2531712355","https://openalex.org/W2589041191","https://openalex.org/W2603975286","https://openalex.org/W2620406790","https://openalex.org/W2700381762","https://openalex.org/W2738546406","https://openalex.org/W2747523767","https://openalex.org/W2750533553","https://openalex.org/W2760605310","https://openalex.org/W2886531179","https://openalex.org/W2943525346","https://openalex.org/W3102641634","https://openalex.org/W6648310377","https://openalex.org/W6679686813"],"related_works":["https://openalex.org/W2365682449","https://openalex.org/W2148903279","https://openalex.org/W2370370239","https://openalex.org/W2439274868","https://openalex.org/W1981214148","https://openalex.org/W2026961173","https://openalex.org/W2139059299","https://openalex.org/W1976370882","https://openalex.org/W1968770722","https://openalex.org/W2061676111"],"abstract_inverted_index":{"We":[0,23],"present":[1],"a":[2,10,65,122,128],"multi-disciplinary":[3],"image-based":[4],"blood":[5,98],"flow":[6],"perfusion":[7,99,187],"modeling":[8,188],"of":[9,28,57,75,81,110,117,138,182],"whole":[11],"organ":[12],"vascular":[13,169,206],"network":[14,55,102],"for":[15,162],"analyzing":[16],"both":[17],"its":[18],"structural":[19,106,192],"and":[20,38,50,107,127,193],"functional":[21,108,168,194],"properties.":[22],"show":[24],"how":[25],"the":[26,52,62,76,89,96,105,158,163,180,205],"use":[27],"Light-Sheet":[29],"Fluorescence":[30],"Microscopy":[31],"(LSFM)":[32],"permits":[33],"whole-organ":[34],"micro-vascular":[35,54],"imaging,":[36],"analysis":[37,103,143],"modelling.":[39],"By":[40],"using":[41],"adapted":[42],"image":[43],"post-treatment":[44],"workflow,":[45],"we":[46],"could":[47],"segment,":[48],"vectorize":[49],"reconstruct":[51],"entire":[53,97],"composed":[56],"1.7":[58],"million":[59],"vessels,":[60],"from":[61,201],"tissue-scale,":[63],"inside":[64],"\u223c":[66],"25":[67],"\u00d7":[68,70],"5":[69],"1":[71],"=":[72],"125mm3":[73],"volume":[74],"mouse":[77],"fat":[78,139],"pad,":[79],"hundreds":[80],"times":[82,157],"larger":[83],"than":[84],"previous":[85],"studies,":[86],"down":[87],"to":[88,154],"cellular":[90,159],"scale":[91],"at":[92],"micron":[93],"resolution,":[94],"with":[95,134],"modeled.":[100],"Adapted":[101],"revealed":[104,145],"organization":[109],"meso-scale":[111,149],"tissue":[112],"as":[113],"strongly":[114,166],"connected":[115,167],"communities":[116,120],"vessels.":[118],"These":[119,171],"share":[121],"distinct":[123,147],"heterogeneous":[124,175],"core":[125],"region":[126],"more":[129],"homogeneous":[130],"peripheral":[131],"region,":[132],"consistently":[133],"known":[135],"biological":[136],"functions":[137],"tissue.":[140],"Graph":[141],"clustering":[142],"also":[144],"two":[146],"robust":[148],"typical":[150],"sizes":[151],"(from":[152],"10":[153],"several":[155],"hundred":[156],"size),":[160],"revealing,":[161],"first":[164],"time,":[165],"communities.":[170],"community":[172,202],"networks":[173],"support":[174],"micro-environments.":[176],"This":[177],"work":[178],"provides":[179],"proof":[181],"concept":[183],"that":[184],"in-silico":[185],"all-tissue":[186],"can":[189],"reveal":[190],"new":[191],"exchanges":[195],"between":[196],"micro-regions":[197],"in":[198,204],"tissues,":[199],"found":[200],"clusters":[203],"graph.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}