{"id":"https://openalex.org/W2977723710","doi":"https://doi.org/10.1371/journal.pcbi.1007320","title":"Evolving generalists in switching rugged landscapes","display_name":"Evolving generalists in switching rugged landscapes","publication_year":2019,"publication_date":"2019-10-01","ids":{"openalex":"https://openalex.org/W2977723710","doi":"https://doi.org/10.1371/journal.pcbi.1007320","mag":"2977723710","pmid":"https://pubmed.ncbi.nlm.nih.gov/31574088"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007320","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007320","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007320&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007320&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062453288","display_name":"Shenshen Wang","orcid":"https://orcid.org/0000-0001-9951-2118"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shenshen Wang","raw_affiliation_strings":["Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-9951-2118","affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of California, Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049439879","display_name":"Lei Dai","orcid":"https://orcid.org/0000-0002-5598-5308"},"institutions":[{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Dai","raw_affiliation_strings":["Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I4210145761"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062453288"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.0395,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.95502066,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"10","first_page":"e1007320","last_page":"e1007320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11753","display_name":"Forest Management and Policy","score":0.9768999814987183,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10005","display_name":"Ecology and Vegetation Dynamics Studies","score":0.9743000268936157,"subfield":{"id":"https://openalex.org/subfields/2309","display_name":"Nature and Landscape Conservation"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generalist-and-specialist-species","display_name":"Generalist and specialist species","score":0.736915111541748},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3499135971069336},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.3070105314254761},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2854419946670532},{"id":"https://openalex.org/keywords/habitat","display_name":"Habitat","score":0.12027391791343689}],"concepts":[{"id":"https://openalex.org/C45371612","wikidata":"https://www.wikidata.org/wiki/Q3058587","display_name":"Generalist and specialist species","level":3,"score":0.736915111541748},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3499135971069336},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3070105314254761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2854419946670532},{"id":"https://openalex.org/C185933670","wikidata":"https://www.wikidata.org/wiki/Q52105","display_name":"Habitat","level":2,"score":0.12027391791343689}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007320","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007320","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007320&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31574088","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31574088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1905.01470","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1905.01470","pdf_url":"https://arxiv.org/pdf/1905.01470","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bdb319c5d05446cdaf66e7f4fdc8523e","is_oa":true,"landing_page_url":"https://doaj.org/article/bdb319c5d05446cdaf66e7f4fdc8523e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 10, p e1007320 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5746754","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6771975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/9925361","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Evolving_generalists_in_switching_rugged_landscapes/9925361","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007320","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007320","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007320&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320332500","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463"},{"id":"https://openalex.org/F4320337427","display_name":"Kavli Institute for Theoretical Physics, University of California, Santa Barbara","ror":"https://ror.org/02t274463"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2977723710.pdf","grobid_xml":"https://content.openalex.org/works/W2977723710.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W788080004","https://openalex.org/W843706175","https://openalex.org/W1491150201","https://openalex.org/W1551962532","https://openalex.org/W1644749979","https://openalex.org/W1925318597","https://openalex.org/W1930819378","https://openalex.org/W1954069242","https://openalex.org/W1966234892","https://openalex.org/W1969012077","https://openalex.org/W1969857637","https://openalex.org/W1971541535","https://openalex.org/W1978306704","https://openalex.org/W1979058462","https://openalex.org/W1987908112","https://openalex.org/W1989151765","https://openalex.org/W1998756227","https://openalex.org/W2000492287","https://openalex.org/W2009868245","https://openalex.org/W2010025771","https://openalex.org/W2012977051","https://openalex.org/W2016453064","https://openalex.org/W2016666153","https://openalex.org/W2021562946","https://openalex.org/W2022730625","https://openalex.org/W2031231782","https://openalex.org/W2039184693","https://openalex.org/W2039227019","https://openalex.org/W2041042514","https://openalex.org/W2043484919","https://openalex.org/W2043487490","https://openalex.org/W2044594296","https://openalex.org/W2044775606","https://openalex.org/W2045004708","https://openalex.org/W2046094044","https://openalex.org/W2046200242","https://openalex.org/W2049071730","https://openalex.org/W2054069391","https://openalex.org/W2057239104","https://openalex.org/W2058315195","https://openalex.org/W2059905849","https://openalex.org/W2060588922","https://openalex.org/W2064164319","https://openalex.org/W2070990085","https://openalex.org/W2073171022","https://openalex.org/W2075672121","https://openalex.org/W2081531630","https://openalex.org/W2094795801","https://openalex.org/W2105488715","https://openalex.org/W2108020239","https://openalex.org/W2108076410","https://openalex.org/W2109441358","https://openalex.org/W2111020219","https://openalex.org/W2113557726","https://openalex.org/W2124200870","https://openalex.org/W2126606094","https://openalex.org/W2126643167","https://openalex.org/W2128084896","https://openalex.org/W2129683067","https://openalex.org/W2134735802","https://openalex.org/W2140227530","https://openalex.org/W2142879643","https://openalex.org/W2143528254","https://openalex.org/W2144620146","https://openalex.org/W2145022888","https://openalex.org/W2148364220","https://openalex.org/W2153453530","https://openalex.org/W2155929831","https://openalex.org/W2156477417","https://openalex.org/W2171755502","https://openalex.org/W2184599734","https://openalex.org/W2227467442","https://openalex.org/W2238330501","https://openalex.org/W2266201493","https://openalex.org/W2281246504","https://openalex.org/W2296679604","https://openalex.org/W2381153372","https://openalex.org/W2423210081","https://openalex.org/W2468824386","https://openalex.org/W2483469645","https://openalex.org/W2581400213","https://openalex.org/W2600934334","https://openalex.org/W2615642132","https://openalex.org/W2750459324","https://openalex.org/W2782613909","https://openalex.org/W2907627192","https://openalex.org/W2923497684","https://openalex.org/W2948591459","https://openalex.org/W2949975320","https://openalex.org/W2952277428","https://openalex.org/W3098330097","https://openalex.org/W3098712249","https://openalex.org/W3105906550","https://openalex.org/W4210516060","https://openalex.org/W4210953474","https://openalex.org/W4211017114","https://openalex.org/W4388252848","https://openalex.org/W6665067371"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3135453479","https://openalex.org/W2306541987","https://openalex.org/W2947952289","https://openalex.org/W4322625948","https://openalex.org/W1986194836","https://openalex.org/W2896365120","https://openalex.org/W2937411908"],"abstract_inverted_index":{"Evolving":[0],"systems,":[1],"be":[2,73],"it":[3],"an":[4],"antibody":[5],"repertoire":[6],"in":[7,26,96,112,186],"the":[8,93,107,131,171],"face":[9],"of":[10,83,109,142,156,173],"mutating":[11],"pathogens":[12],"or":[13,203],"a":[14,67,89,97,102,180],"microbial":[15],"population":[16],"exposed":[17],"to":[18,32,70,105,151,165,183],"varied":[19],"antibiotics,":[20],"constantly":[21],"search":[22,132],"for":[23,133,198],"adaptive":[24],"solutions":[25],"time-varying":[27],"fitness":[28,175],"landscapes.":[29,176],"Generalists":[30],"refer":[31],"genotypes":[33],"that":[34,115,125,194],"remain":[35],"fit":[36,134],"across":[37,168],"diverse":[38],"selective":[39],"pressures;":[40],"while":[41],"multi-drug":[42,208],"resistant":[43],"microbes":[44,205],"are":[45,51,116,148],"undesired":[46],"yet":[47],"prevalent,":[48],"broadly-neutralizing":[49],"antibodies":[50,202],"much":[52],"wanted":[53],"but":[54],"rare.":[55],"However,":[56],"little":[57],"is":[58],"known":[59],"about":[60],"under":[61],"what":[62],"conditions":[63],"such":[64],"generalists":[65,111,135],"with":[66],"high":[68,146],"capacity":[69],"adapt":[71],"can":[72,80,128],"efficiently":[74],"discovered":[75],"by":[76,136],"evolution.":[77],"In":[78],"addition,":[79],"epistasis-the":[81],"source":[82],"landscape":[84],"ruggedness":[85,157],"and":[86,119,158,190],"path":[87],"constraints-play":[88],"different":[90],"role,":[91],"if":[92],"environment":[94],"varies":[95],"non-random":[98],"way?":[99],"We":[100,123],"present":[101],"generative":[103],"model":[104],"estimate":[106,166],"propensity":[108],"evolving":[110,207],"rugged":[113],"landscapes":[114],"tunably":[117],"related":[118],"alternating":[120],"relatively":[121],"slowly.":[122],"find":[124],"environmental":[126,159],"cycling":[127],"substantially":[129],"facilitate":[130],"dynamically":[137],"enlarging":[138],"their":[139],"effective":[140],"basins":[141],"attraction.":[143],"Importantly,":[144],"these":[145],"performers":[147],"most":[149],"likely":[150],"emerge":[152],"at":[153],"intermediate":[154],"levels":[155],"relatedness.":[160],"Our":[161,177],"approach":[162],"allows":[163],"one":[164],"correlations":[167],"environments":[169],"from":[170,206],"topography":[172],"experimental":[174],"work":[178],"provides":[179],"conceptual":[181],"framework":[182],"study":[184],"evolution":[185],"time-correlated":[187],"complex":[188],"environments,":[189],"offers":[191],"statistical":[192],"understanding":[193],"suggests":[195],"general":[196],"strategies":[197],"eliciting":[199],"broadly":[200],"neutralizing":[201],"preventing":[204],"resistance.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}