{"id":"https://openalex.org/W2971586943","doi":"https://doi.org/10.1371/journal.pcbi.1007276","title":"Benchmarking network propagation methods for disease gene identification","display_name":"Benchmarking network propagation methods for disease gene identification","publication_year":2019,"publication_date":"2019-09-03","ids":{"openalex":"https://openalex.org/W2971586943","doi":"https://doi.org/10.1371/journal.pcbi.1007276","mag":"2971586943","pmid":"https://pubmed.ncbi.nlm.nih.gov/31479437"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007276&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023202274","display_name":"Sergio Picart\u2010Armada","orcid":"https://orcid.org/0000-0002-6426-8204"},"institutions":[{"id":"https://openalex.org/I1307323311","display_name":"Hospital Sant Joan de D\u00e9u Barcelona","ror":"https://ror.org/001jx2139","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I1307323311"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Sergio Picart-Armada","raw_affiliation_strings":["B2SLab, Departament d'Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, CIBER-BBN, Barcelona, Spain","Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, Spain","Networking Biomedical Research Centre in the subject area of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"B2SLab, Departament d'Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, CIBER-BBN, Barcelona, Spain","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, Spain","institution_ids":["https://openalex.org/I1307323311"]},{"raw_affiliation_string":"Networking Biomedical Research Centre in the subject area of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063854724","display_name":"Steven J. Barrett","orcid":"https://orcid.org/0000-0002-3570-3131"},"institutions":[{"id":"https://openalex.org/I2800110054","display_name":"Age UK","ror":"https://ror.org/050x9d346","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800110054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven J. Barrett","raw_affiliation_strings":["Research Statistics, GSK, Stevenage, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Research Statistics, GSK, Stevenage, United Kingdom","institution_ids":["https://openalex.org/I2800110054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060179440","display_name":"David Will\u00e9","orcid":"https://orcid.org/0000-0003-0850-2665"},"institutions":[{"id":"https://openalex.org/I2800110054","display_name":"Age UK","ror":"https://ror.org/050x9d346","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800110054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David R. Will\u00e9","raw_affiliation_strings":["Research Statistics, GSK, Stevenage, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Research Statistics, GSK, Stevenage, United Kingdom","institution_ids":["https://openalex.org/I2800110054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041616492","display_name":"Alexandre Perera-Lluna","orcid":"https://orcid.org/0000-0001-6427-851X"},"institutions":[{"id":"https://openalex.org/I1307323311","display_name":"Hospital Sant Joan de D\u00e9u Barcelona","ror":"https://ror.org/001jx2139","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I1307323311"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alexandre Perera-Lluna","raw_affiliation_strings":["B2SLab, Departament d'Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, CIBER-BBN, Barcelona, Spain","Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, Spain","Networking Biomedical Research Centre in the subject area of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"B2SLab, Departament d'Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, CIBER-BBN, Barcelona, Spain","institution_ids":["https://openalex.org/I9617848"]},{"raw_affiliation_string":"Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, Spain","institution_ids":["https://openalex.org/I1307323311"]},{"raw_affiliation_string":"Networking Biomedical Research Centre in the subject area of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain","institution_ids":["https://openalex.org/I4210105141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019146555","display_name":"Alex Gutteridge","orcid":"https://orcid.org/0000-0001-7515-634X"},"institutions":[{"id":"https://openalex.org/I2800110054","display_name":"Age UK","ror":"https://ror.org/050x9d346","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800110054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Gutteridge","raw_affiliation_strings":["Computational Biology and Statistics, GSK, Stevenage, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Statistics, GSK, Stevenage, United Kingdom","institution_ids":["https://openalex.org/I2800110054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001044027","display_name":"Beno\u00eet H. Dessailly","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095529","display_name":"GlaxoSmithKline (Belgium)","ror":"https://ror.org/00n3pea85","country_code":"BE","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210095529"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Benoit H. Dessailly","raw_affiliation_strings":["GSK Vaccines, Rixensart, Belgium"],"affiliations":[{"raw_affiliation_string":"GSK Vaccines, Rixensart, Belgium","institution_ids":["https://openalex.org/I4210095529"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023202274"],"corresponding_institution_ids":["https://openalex.org/I1307323311","https://openalex.org/I4210105141","https://openalex.org/I9617848"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.8341,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.91676456,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"15","issue":"9","first_page":"e1007276","last_page":"e1007276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7177442908287048},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.590844452381134},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5893605351448059},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.556654691696167},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5046898126602173},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.47581082582473755},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.45701438188552856},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.42672958970069885},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3550299108028412},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3467940092086792},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3466860055923462},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.328643262386322},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31000733375549316},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21821418404579163}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7177442908287048},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.590844452381134},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5893605351448059},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.556654691696167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5046898126602173},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.47581082582473755},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.45701438188552856},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42672958970069885},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3550299108028412},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3467940092086792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3466860055923462},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.328643262386322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31000733375549316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21821418404579163},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1007276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31479437","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31479437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:upcommons.upc.edu:2117/176501","is_oa":true,"landing_page_url":"https://hdl.handle.net/2117/176501","pdf_url":null,"source":{"id":"https://openalex.org/S4210207057","display_name":"QRU Quaderns de Recerca en Urbanisme","issn_l":"2014-9689","issn":["2014-9689","2385-6777"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310322448","host_organization_name":"Q71272178","host_organization_lineage":["https://openalex.org/P4310322448"],"host_organization_lineage_names":["Q71272178"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1007276","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007276","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:01d606f62d954bd9960910aea0304e90","is_oa":true,"landing_page_url":"https://doaj.org/article/01d606f62d954bd9960910aea0304e90","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 9, p e1007276 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5713072","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6743778","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/9764216","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Benchmarking_network_propagation_methods_for_disease_gene_identification/9764216","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.550000011920929,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2640468998","display_name":null,"funder_award_id":"DPI2017-89827-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G5218991717","display_name":null,"funder_award_id":"TEC2014-60337-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320323089","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina","ror":"https://ror.org/01gm5f004"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971586943.pdf","grobid_xml":"https://content.openalex.org/works/W2971586943.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W49891529","https://openalex.org/W146076398","https://openalex.org/W229097380","https://openalex.org/W273955616","https://openalex.org/W1504480307","https://openalex.org/W1731081199","https://openalex.org/W1774304772","https://openalex.org/W1831050183","https://openalex.org/W1854214752","https://openalex.org/W1964602337","https://openalex.org/W1966327575","https://openalex.org/W1966716734","https://openalex.org/W1972881673","https://openalex.org/W1973094248","https://openalex.org/W1975875968","https://openalex.org/W1994642659","https://openalex.org/W1995047796","https://openalex.org/W1995683190","https://openalex.org/W1999597013","https://openalex.org/W2028279608","https://openalex.org/W2035753486","https://openalex.org/W2062263714","https://openalex.org/W2066531004","https://openalex.org/W2078622638","https://openalex.org/W2088891952","https://openalex.org/W2095319945","https://openalex.org/W2096173332","https://openalex.org/W2097532544","https://openalex.org/W2101357408","https://openalex.org/W2110065044","https://openalex.org/W2117513900","https://openalex.org/W2117692326","https://openalex.org/W2118822739","https://openalex.org/W2123958887","https://openalex.org/W2124649441","https://openalex.org/W2125118217","https://openalex.org/W2146545950","https://openalex.org/W2157963336","https://openalex.org/W2159267296","https://openalex.org/W2160697532","https://openalex.org/W2165253681","https://openalex.org/W2166468869","https://openalex.org/W2170283814","https://openalex.org/W2206890303","https://openalex.org/W2418684121","https://openalex.org/W2510031061","https://openalex.org/W2537623931","https://openalex.org/W2544745230","https://openalex.org/W2556519015","https://openalex.org/W2557530941","https://openalex.org/W2557833574","https://openalex.org/W2624021832","https://openalex.org/W2626606138","https://openalex.org/W2763172433","https://openalex.org/W2769093805","https://openalex.org/W2772875656","https://openalex.org/W2774245015","https://openalex.org/W2787399209","https://openalex.org/W2794479004","https://openalex.org/W2908246766","https://openalex.org/W2915536738","https://openalex.org/W2950761565","https://openalex.org/W2952588534","https://openalex.org/W2963146150","https://openalex.org/W3122709706","https://openalex.org/W4246413330","https://openalex.org/W4288627274","https://openalex.org/W4399271987","https://openalex.org/W6610017368","https://openalex.org/W6648974641","https://openalex.org/W6728933153"],"related_works":["https://openalex.org/W4238897586","https://openalex.org/W435179959","https://openalex.org/W2619091065","https://openalex.org/W2059640416","https://openalex.org/W1490753184","https://openalex.org/W2284465472","https://openalex.org/W2291782699","https://openalex.org/W1993948687","https://openalex.org/W2000169967","https://openalex.org/W2112883198"],"abstract_inverted_index":{"In-silico":[0],"identification":[1],"of":[2,12,40,80,87,110,170,210,219],"potential":[3],"target":[4,14],"genes":[5,50,154],"for":[6,193],"disease":[7,157,221],"is":[8],"an":[9,212],"essential":[10],"aspect":[11],"drug":[13,133,194],"discovery.":[15],"Recent":[16],"studies":[17],"suggest":[18],"that":[19,51,181],"successful":[20],"targets":[21,144],"can":[22],"be":[23],"found":[24,140],"through":[25,95],"by":[26,55,158],"leveraging":[27],"genetic,":[28],"genomic":[29],"and":[30,76,137,184,198,216],"protein":[31,111,123],"interaction":[32],"information.":[33],"Here,":[34],"we":[35,119],"systematically":[36],"tested":[37],"the":[38,88,108,146,151,207,217],"ability":[39],"12":[41],"varied":[42],"algorithms,":[43],"based":[44],"on":[45,58,166],"network":[46],"propagation,":[47],"to":[48,102,107,115,156,188],"identify":[49],"have":[52],"been":[53],"targeted":[54],"any":[56],"drug,":[57],"gene-disease":[59,82],"data":[60],"from":[61],"22":[62],"common":[63],"non-cancerous":[64],"diseases":[65],"in":[66,91,196],"OpenTargets.":[67],"We":[68,179,204],"considered":[69],"two":[70,78,121],"biological":[71,129],"networks,":[72],"six":[73],"performance":[74,92,104,161],"metrics":[75],"compared":[77],"types":[79],"input":[81],"association":[83],"scores.":[84],"The":[85,168],"impact":[86,209],"design":[89],"factors":[90],"was":[93],"quantified":[94],"additive":[96],"explanatory":[97],"models.":[98],"Standard":[99],"cross-validation":[100,125],"led":[101],"over-optimistic":[103],"estimates":[105],"due":[106],"presence":[109],"complexes.":[112],"In":[113],"order":[114],"obtain":[116],"realistic":[117],"estimates,":[118],"introduced":[120],"novel":[122],"complex-aware":[124],"schemes.":[126],"When":[127],"seeding":[128],"networks":[130,152],"with":[131,153],"known":[132],"targets,":[134],"machine":[135,185],"learning":[136,186],"diffusion-based":[138,182,189],"methods":[139],"around":[141],"2-4":[142],"true":[143,164],"within":[145],"top":[147],"20":[148],"suggestions.":[149],"Seeding":[150],"associated":[155],"genetics":[159],"decreased":[160],"below":[162],"1":[163],"hit":[165],"average.":[167],"use":[169],"a":[171],"larger":[172],"network,":[173],"although":[174],"noisier,":[175],"improved":[176],"overall":[177],"performance.":[178],"conclude":[180],"prioritisers":[183],"applied":[187],"features":[190],"are":[191],"suited":[192],"discovery":[195],"practice":[197],"improve":[199],"over":[200],"simpler":[201],"neighbour-voting":[202],"methods.":[203],"also":[205],"demonstrate":[206],"large":[208],"choosing":[211],"adequate":[213],"validation":[214],"strategy":[215],"definition":[218],"seed":[220],"genes.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":3}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}