{"id":"https://openalex.org/W2965204273","doi":"https://doi.org/10.1371/journal.pcbi.1007243","title":"Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data","display_name":"Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data","publication_year":2019,"publication_date":"2019-07-29","ids":{"openalex":"https://openalex.org/W2965204273","doi":"https://doi.org/10.1371/journal.pcbi.1007243","mag":"2965204273","pmid":"https://pubmed.ncbi.nlm.nih.gov/31356595"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007243","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007243","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007243&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007243&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038360462","display_name":"Ketevan Chkhaidze","orcid":null},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ketevan Chkhaidze","raw_affiliation_strings":["Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060206529","display_name":"Timon Heide","orcid":"https://orcid.org/0000-0002-1386-7469"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Timon Heide","raw_affiliation_strings":["Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-1386-7469","affiliations":[{"raw_affiliation_string":"Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069836964","display_name":"Benjamin Werner","orcid":"https://orcid.org/0000-0002-6857-8699"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin Werner","raw_affiliation_strings":["Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087048312","display_name":"Marc Williams","orcid":"https://orcid.org/0000-0001-5524-4174"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc J. Williams","raw_affiliation_strings":["Evolution and Cancer Lab, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution and Cancer Lab, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082497527","display_name":"Weini Huang","orcid":"https://orcid.org/0000-0002-9016-2665"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Weini Huang","raw_affiliation_strings":["Evolution and Cancer Lab, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution and Cancer Lab, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033643165","display_name":"Giulio Caravagna","orcid":"https://orcid.org/0000-0003-4240-3265"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giulio Caravagna","raw_affiliation_strings":["Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4240-3265","affiliations":[{"raw_affiliation_string":"Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038131018","display_name":"Trevor A. Graham","orcid":"https://orcid.org/0000-0001-9582-1597"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Trevor A. Graham","raw_affiliation_strings":["Evolution and Cancer Lab, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9582-1597","affiliations":[{"raw_affiliation_string":"Evolution and Cancer Lab, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038260194","display_name":"Andrea Sottoriva","orcid":"https://orcid.org/0000-0001-6709-9533"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andrea Sottoriva","raw_affiliation_strings":["Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6709-9533","affiliations":[{"raw_affiliation_string":"Evolutionary Genomics and Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, United Kingdom","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5038131018","https://openalex.org/A5038260194"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I166337079"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2153,"currency":"EUR","value_usd":2322},"fwci":4.0186,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.95450268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"15","issue":"7","first_page":"e1007243","last_page":"e1007243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.565708339214325},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.55598384141922},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5405122637748718},{"id":"https://openalex.org/keywords/spatial-analysis","display_name":"Spatial analysis","score":0.5331928730010986},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.5130916833877563},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4894162714481354},{"id":"https://openalex.org/keywords/sampling-bias","display_name":"Sampling bias","score":0.46870726346969604},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46714043617248535},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44451791048049927},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32802096009254456},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.27124491333961487},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23127850890159607},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.16913646459579468},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13862532377243042}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.565708339214325},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.55598384141922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5405122637748718},{"id":"https://openalex.org/C159620131","wikidata":"https://www.wikidata.org/wiki/Q1938983","display_name":"Spatial analysis","level":2,"score":0.5331928730010986},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.5130916833877563},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4894162714481354},{"id":"https://openalex.org/C75917345","wikidata":"https://www.wikidata.org/wiki/Q2725298","display_name":"Sampling bias","level":3,"score":0.46870726346969604},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46714043617248535},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44451791048049927},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32802096009254456},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.27124491333961487},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23127850890159607},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.16913646459579468},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13862532377243042},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040961","descriptor_name":"Genetic Drift","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060965","descriptor_name":"Clonal Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060965","descriptor_name":"Clonal Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060965","descriptor_name":"Clonal Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060965","descriptor_name":"Clonal Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060965","descriptor_name":"Clonal Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1007243","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007243","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007243&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31356595","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31356595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007243","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007243","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:arts.units.it:11368/2969984","is_oa":true,"landing_page_url":"http://hdl.handle.net/11368/2969984","pdf_url":null,"source":{"id":"https://openalex.org/S4306402362","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3e188ccc5e124ed7ae1596ad08c87868","is_oa":true,"landing_page_url":"https://doaj.org/article/3e188ccc5e124ed7ae1596ad08c87868","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 7, p e1007243 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/9160226","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Spatially_constrained_tumour_growth_affects_the_patterns_of_clonal_selection_and_neutral_drift_in_cancer_genomic_data/9160226","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6687187","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6687187","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/59520","is_oa":true,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/59520","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007243","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007243","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007243&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G100879096","display_name":null,"funder_award_id":"MR/P000789/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1764744551","display_name":null,"funder_award_id":"202778/Z/16/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G1947269863","display_name":null,"funder_award_id":"A22909","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2464946330","display_name":null,"funder_award_id":"105104/Z/14/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G2594712584","display_name":null,"funder_award_id":"U54 CA217376","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2675153124","display_name":"Identifying emerging subclones in individual colorectal cancer patients by mapping the spatio-temporal evolution of the tumour phenotype","funder_award_id":"MR/P000789/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2847171857","display_name":null,"funder_award_id":"202778/B/16/Z","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G3668455068","display_name":null,"funder_award_id":"202778/B/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4351610790","display_name":null,"funder_award_id":"A19771","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G4707900444","display_name":null,"funder_award_id":"202778/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4722652232","display_name":null,"funder_award_id":"105104/Z/14/Z","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5564483224","display_name":null,"funder_award_id":"CA217376","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5978310411","display_name":null,"funder_award_id":"105104/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6692431212","display_name":null,"funder_award_id":"202778/B/16/Z","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6775184743","display_name":null,"funder_award_id":"A22909","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6955858463","display_name":null,"funder_award_id":"202778/B/16/Z","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7036909376","display_name":null,"funder_award_id":"NCI U54 CA217376","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G749071514","display_name":null,"funder_award_id":"202778/B/16/Z","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7599057251","display_name":null,"funder_award_id":"U54 CA217376","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8753257735","display_name":null,"funder_award_id":"A22909","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2965204273.pdf","grobid_xml":"https://content.openalex.org/works/W2965204273.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1566107011","https://openalex.org/W1964154017","https://openalex.org/W1973568247","https://openalex.org/W1982669163","https://openalex.org/W2003652177","https://openalex.org/W2006664445","https://openalex.org/W2010873488","https://openalex.org/W2012294035","https://openalex.org/W2023560061","https://openalex.org/W2026549522","https://openalex.org/W2035082999","https://openalex.org/W2043683964","https://openalex.org/W2045486139","https://openalex.org/W2045854741","https://openalex.org/W2052975116","https://openalex.org/W2082850612","https://openalex.org/W2083337908","https://openalex.org/W2088323760","https://openalex.org/W2097455931","https://openalex.org/W2100640599","https://openalex.org/W2104750097","https://openalex.org/W2105054044","https://openalex.org/W2109860416","https://openalex.org/W2109991075","https://openalex.org/W2111512277","https://openalex.org/W2111874706","https://openalex.org/W2116416291","https://openalex.org/W2123303153","https://openalex.org/W2136758725","https://openalex.org/W2140080780","https://openalex.org/W2145980885","https://openalex.org/W2152246075","https://openalex.org/W2153938747","https://openalex.org/W2155418451","https://openalex.org/W2159010139","https://openalex.org/W2167030304","https://openalex.org/W2177689130","https://openalex.org/W2179429273","https://openalex.org/W2260951263","https://openalex.org/W2272546316","https://openalex.org/W2339922023","https://openalex.org/W2346273585","https://openalex.org/W2529657394","https://openalex.org/W2586629973","https://openalex.org/W2588969809","https://openalex.org/W2592257068","https://openalex.org/W2609243345","https://openalex.org/W2611387862","https://openalex.org/W2624281239","https://openalex.org/W2735315721","https://openalex.org/W2748313043","https://openalex.org/W2760143502","https://openalex.org/W2761263651","https://openalex.org/W2798041799","https://openalex.org/W2806991293","https://openalex.org/W2886062391","https://openalex.org/W2888063818","https://openalex.org/W2902524594","https://openalex.org/W2922455135","https://openalex.org/W2949797623","https://openalex.org/W2950015635","https://openalex.org/W2951391875","https://openalex.org/W4210516674","https://openalex.org/W6680003913","https://openalex.org/W6704892621","https://openalex.org/W6804563512"],"related_works":["https://openalex.org/W347387106","https://openalex.org/W4400127305","https://openalex.org/W2299309501","https://openalex.org/W2793350933","https://openalex.org/W2072676583","https://openalex.org/W1997937452","https://openalex.org/W2970859251","https://openalex.org/W3083491872","https://openalex.org/W2052665155","https://openalex.org/W3193874062"],"abstract_inverted_index":{"Quantification":[0],"of":[1,4,11,30,52,61,72,113,117,145,181],"the":[2,9,58,70,111,114,143,164,175,179,186],"effect":[3],"spatial":[5,25,41,50,59,89,129],"tumour":[6,31,134],"sampling":[7,51,94,100],"on":[8,69],"patterns":[10],"mutations":[12],"detected":[13],"in":[14,142],"next-generation":[15,159],"sequencing":[16,46,83,160],"data":[17,47],"is":[18],"largely":[19],"lacking.":[20],"Here":[21],"we":[22],"use":[23],"a":[24,53,62,66,106,123,132,138],"stochastic":[26],"cellular":[27],"automaton":[28],"model":[29],"growth":[32],"that":[33,57,88,102,127,154],"accounts":[34],"for":[35,110,163],"somatic":[36],"mutations,":[37],"selection,":[38],"drift":[39,77],"and":[40,75,81,101,135,183],"constraints,":[42],"to":[43,177],"simulate":[44],"multi-region":[45,98],"derived":[48],"from":[49,78,148],"neoplasm.":[54],"We":[55,120],"show":[56],"structure":[60],"solid":[63],"cancer":[64,156],"has":[65],"major":[67,107],"impact":[68],"detection":[71],"clonal":[73],"selection":[74],"genetic":[76],"both":[79],"bulk":[80,99],"single-cell":[82],"data.":[84,150,187],"Our":[85,151],"results":[86],"indicate":[87],"constrains":[90],"can":[91],"introduce":[92],"significant":[93],"biases":[95],"when":[96],"performing":[97],"such":[103],"bias":[104],"becomes":[105],"confounding":[108,166],"factor":[109],"measurement":[112],"evolutionary":[115,146],"dynamics":[116,147],"human":[118],"tumours.":[119],"also":[121],"propose":[122],"statistical":[124],"inference":[125,144],"framework":[126],"incorporates":[128],"effects":[130],"within":[131],"growing":[133],"so":[136],"represents":[137],"further":[139],"step":[140],"forwards":[141],"genomic":[149],"analysis":[152],"shows":[153],"measuring":[155],"evolution":[157],"using":[158],"while":[161],"accounting":[162],"numerous":[165],"factors":[167],"remains":[168],"challenging.":[169],"However,":[170],"mechanistic":[171],"model-based":[172],"approaches":[173],"have":[174],"potential":[176],"capture":[178],"sources":[180],"noise":[182],"better":[184],"interpret":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}