{"id":"https://openalex.org/W2970824372","doi":"https://doi.org/10.1371/journal.pcbi.1007231","title":"Red blood cells stabilize flow in brain microvascular networks","display_name":"Red blood cells stabilize flow in brain microvascular networks","publication_year":2019,"publication_date":"2019-08-30","ids":{"openalex":"https://openalex.org/W2970824372","doi":"https://doi.org/10.1371/journal.pcbi.1007231","mag":"2970824372","pmid":"https://pubmed.ncbi.nlm.nih.gov/31469820"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007231","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007231","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007231&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007231&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023396776","display_name":"Franca Schmid","orcid":"https://orcid.org/0000-0002-0689-9366"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Franca Schmid","raw_affiliation_strings":["Institute of Fluid Dynamics, ETH Zurich, Sonneggstrasse 3, Zurich, Switzerland","Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0689-9366","affiliations":[{"raw_affiliation_string":"Institute of Fluid Dynamics, ETH Zurich, Sonneggstrasse 3, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011385646","display_name":"Matthew Barrett","orcid":"https://orcid.org/0000-0002-5025-0732"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthew J. P. Barrett","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland","Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045838242","display_name":"Dominik Obrist","orcid":"https://orcid.org/0000-0002-6062-9076"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominik Obrist","raw_affiliation_strings":["ARTORG Center for Biomedical Engineering Research, University of Bern, Murtenstrasse 50, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6062-9076","affiliations":[{"raw_affiliation_string":"ARTORG Center for Biomedical Engineering Research, University of Bern, Murtenstrasse 50, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021715204","display_name":"Bruno Weber","orcid":"https://orcid.org/0000-0002-9089-0689"},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bruno Weber","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland","Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Neuroscience Center Zurich, University and ETH Zurich, Winterthurerstrasse 190, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044246430","display_name":"Patrick Jenny","orcid":"https://orcid.org/0000-0002-9571-3104"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Patrick Jenny","raw_affiliation_strings":["Institute of Fluid Dynamics, ETH Zurich, Sonneggstrasse 3, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fluid Dynamics, ETH Zurich, Sonneggstrasse 3, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023396776"],"corresponding_institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2253,"currency":"EUR","value_usd":2429},"fwci":4.4895,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.95393218,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"15","issue":"8","first_page":"e1007231","last_page":"e1007231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.621311604976654},{"id":"https://openalex.org/keywords/hematocrit","display_name":"Hematocrit","score":0.5705161690711975},{"id":"https://openalex.org/keywords/outflow","display_name":"Outflow","score":0.5537211894989014},{"id":"https://openalex.org/keywords/microcirculation","display_name":"Microcirculation","score":0.5257119536399841},{"id":"https://openalex.org/keywords/capillary-action","display_name":"Capillary action","score":0.4971144497394562},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.49639207124710083},{"id":"https://openalex.org/keywords/flow","display_name":"Flow (mathematics)","score":0.4920470416545868},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.48058176040649414},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.47808003425598145},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.43086540699005127},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.43047863245010376},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39731574058532715},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38490426540374756},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.38427066802978516},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.27409741282463074},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16691875457763672},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09341272711753845},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.07790684700012207}],"concepts":[{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.621311604976654},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.5705161690711975},{"id":"https://openalex.org/C86132830","wikidata":"https://www.wikidata.org/wiki/Q3308838","display_name":"Outflow","level":2,"score":0.5537211894989014},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5257119536399841},{"id":"https://openalex.org/C196806460","wikidata":"https://www.wikidata.org/wiki/Q188603","display_name":"Capillary action","level":2,"score":0.4971144497394562},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.49639207124710083},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.4920470416545868},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48058176040649414},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47808003425598145},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.43086540699005127},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.43047863245010376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39731574058532715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38490426540374756},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38427066802978516},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.27409741282463074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16691875457763672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09341272711753845},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07790684700012207},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1007231","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007231","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007231&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31469820","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31469820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:www.zora.uzh.ch:178390","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Schmid, Franca; Barrett, Matthew J P; Obrist, Dominik; Weber, Bruno; Jenny, Patrick  (2019). Red blood cells stabilize flow in brain microvascular networks.  PLoS Computational Biology, 15(8):e1007231.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:boris.unibe.ch:135507","is_oa":true,"landing_page_url":"https://boris.unibe.ch/135507/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Schmid, Franca; Barrett, Matthew J. P.; Obrist, Dominik; Weber, Bruno; Jenny, Patrick (2019). Red blood cells stabilize flow in brain microvascular networks. PLoS computational biology, 15(8), e1007231. Public Library of Science 10.1371/journal.pcbi.1007231 <http://dx.doi.org/10.1371/journal.pcbi.1007231>","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8f713f3f53554d3ab8df935dd430238b","is_oa":true,"landing_page_url":"https://doaj.org/article/8f713f3f53554d3ab8df935dd430238b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 8, p e1007231 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/9754622","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Red_blood_cells_stabilize_flow_in_brain_microvascular_networks/9754622","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6750893","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6750893","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/367073","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/367073","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 15 (8)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000367073","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000367073","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5167/uzh-178390","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-178390","pdf_url":null,"source":{"id":"https://openalex.org/S7407051291","display_name":"Universit\u00e4t Z\u00fcrich, ZORA","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007231","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007231","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007231&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2300173928","display_name":null,"funder_award_id":"720270","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G398560324","display_name":"Human Brain Project Specific Grant Agreement 1","funder_award_id":"720270","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5524135226","display_name":"Oxygen Transport in the Cerebral Microcirculation","funder_award_id":"140660","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G5766349579","display_name":"Human Brain Project Specific Grant Agreement 2","funder_award_id":"785907","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6276156780","display_name":null,"funder_award_id":"720270","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6754083667","display_name":null,"funder_award_id":"785907","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2970824372.pdf","grobid_xml":"https://content.openalex.org/works/W2970824372.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1973822681","https://openalex.org/W1981634775","https://openalex.org/W1982120171","https://openalex.org/W1985694790","https://openalex.org/W1987169422","https://openalex.org/W1988257057","https://openalex.org/W1999674966","https://openalex.org/W2001552996","https://openalex.org/W2003451497","https://openalex.org/W2003778728","https://openalex.org/W2013392475","https://openalex.org/W2016954114","https://openalex.org/W2024762861","https://openalex.org/W2036472881","https://openalex.org/W2045791149","https://openalex.org/W2049092760","https://openalex.org/W2053019147","https://openalex.org/W2056547814","https://openalex.org/W2071360157","https://openalex.org/W2076793614","https://openalex.org/W2078261317","https://openalex.org/W2088344008","https://openalex.org/W2098090577","https://openalex.org/W2099656082","https://openalex.org/W2102916742","https://openalex.org/W2106017906","https://openalex.org/W2109250419","https://openalex.org/W2110935910","https://openalex.org/W2123729552","https://openalex.org/W2126427858","https://openalex.org/W2128483447","https://openalex.org/W2132381902","https://openalex.org/W2132513225","https://openalex.org/W2133516781","https://openalex.org/W2134250291","https://openalex.org/W2135780113","https://openalex.org/W2139528660","https://openalex.org/W2151151208","https://openalex.org/W2152250062","https://openalex.org/W2159622299","https://openalex.org/W2162266981","https://openalex.org/W2164617216","https://openalex.org/W2169118010","https://openalex.org/W2190054710","https://openalex.org/W2254454494","https://openalex.org/W2263258819","https://openalex.org/W2270752438","https://openalex.org/W2285828294","https://openalex.org/W2316891120","https://openalex.org/W2376860413","https://openalex.org/W2412437439","https://openalex.org/W2412787090","https://openalex.org/W2491973535","https://openalex.org/W2528381731","https://openalex.org/W2531712355","https://openalex.org/W2559605063","https://openalex.org/W2589041191","https://openalex.org/W2733945808","https://openalex.org/W2761237624","https://openalex.org/W2763985063","https://openalex.org/W2766740357","https://openalex.org/W2776552926","https://openalex.org/W2789420223","https://openalex.org/W2801828694","https://openalex.org/W2802988332","https://openalex.org/W2809129903","https://openalex.org/W2890782722","https://openalex.org/W3101398427","https://openalex.org/W4233946463","https://openalex.org/W6740294058"],"related_works":["https://openalex.org/W2378680487","https://openalex.org/W2019586532","https://openalex.org/W2119988801","https://openalex.org/W297056630","https://openalex.org/W2994410525","https://openalex.org/W2054060818","https://openalex.org/W84640643","https://openalex.org/W2395601063","https://openalex.org/W3049608659","https://openalex.org/W1967086195"],"abstract_inverted_index":{"Capillaries":[0],"are":[1,279],"the":[2,48,70,80,83,94,110,129,135,141,145,182,189,213,216,220,239,243,251,258,271],"prime":[3],"location":[4],"for":[5,90,281],"oxygen":[6,284],"and":[7,21,37,63,120,150,167,242,276,285],"nutrient":[8],"exchange":[9],"in":[10,24,34,41,61,64,131,144,188,265],"all":[11],"tissues.":[12],"Despite":[13],"their":[14,115,121],"fundamental":[15],"role,":[16],"our":[17,154,247,264],"knowledge":[18],"of":[19,50,72,82,134,137,153,172,178,198,253,260,274],"perfusion":[20],"flow":[22,39,142,156,166,183,240],"regulation":[23],"cortical":[25,146],"capillary":[26,88,161,232],"beds":[27],"is":[28,106],"still":[29],"limited.":[30],"Here,":[31],"we":[32,67,92,158,226,268],"use":[33],"vivo":[35,62,132],"measurements":[36],"blood":[38,52,155,275],"simulations":[40,157],"anatomically":[42],"accurate":[43],"microvascular":[44,56],"network":[45],"to":[46,75,209,236,257],"investigate":[47],"impact":[49,71,136],"red":[51],"cells":[53],"(RBCs)":[54],"on":[55,59,123,140,184,201,263],"flow.":[57],"Based":[58,262],"these":[60],"silico":[65,266],"experiments,":[66],"show":[68,159],"that":[69,103,160,228,250,270],"RBCs":[73,199],"leads":[74],"a":[76,175,193,282],"bias":[77],"toward":[78],"equating":[79],"values":[81],"outflow":[84,217,254],"velocities":[85,218,255],"at":[86,118,219,231],"divergent":[87],"bifurcations,":[89],"which":[91],"coin":[93],"term":[95],"\"well-balanced":[96],"bifurcations\".":[97],"Our":[98],"simulation":[99],"results":[100,127,248],"further":[101],"reveal":[102],"hematocrit":[104],"heterogeneity":[105],"directly":[107],"caused":[108],"by":[109,114,186,203],"RBC":[111,138,168,206,244],"dynamics,":[112],"i.e.":[113],"unequal":[116],"partitioning":[117],"bifurcations":[119],"effect":[122],"vessel":[124,176,191],"resistance.":[125],"These":[126],"provide":[128],"first":[130],"evidence":[133],"dynamics":[139],"field":[143,241],"microvasculature.":[147],"By":[148],"structural":[149],"functional":[151],"analyses":[152],"diameter":[162,229],"changes":[163,230],"locally":[164,237],"alter":[165],"distribution.":[169,245],"A":[170],"dilation":[171],"10%":[173],"along":[174],"length":[177],"100":[179],"\u03bcm":[180],"increases":[181],"average":[185,202],"21%":[187],"dilated":[190],"downstream":[192],"well-balanced":[194],"bifurcation.":[195],"The":[196],"number":[197],"rises":[200],"27%.":[204],"Importantly,":[205],"up-regulation":[207],"proves":[208],"be":[210],"more":[211,214],"effective":[212],"balanced":[215],"upstream":[221],"bifurcation":[222],"are.":[223],"Taken":[224],"together,":[225],"conclude":[227],"level":[233],"bear":[234],"potential":[235],"change":[238],"Moreover,":[246],"suggest":[249],"balancing":[252],"contributes":[256],"robustness":[259],"perfusion.":[261],"results,":[267],"anticipate":[269],"bi-phasic":[272],"nature":[273],"small-scale":[277],"regulations":[278],"essential":[280],"well-adjusted":[283],"energy":[286],"substrate":[287],"supply.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7}],"updated_date":"2026-07-09T07:52:08.696243","created_date":"2025-10-10T00:00:00"}