{"id":"https://openalex.org/W2961341318","doi":"https://doi.org/10.1371/journal.pcbi.1007214","title":"Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential","display_name":"Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential","publication_year":2019,"publication_date":"2019-07-16","ids":{"openalex":"https://openalex.org/W2961341318","doi":"https://doi.org/10.1371/journal.pcbi.1007214","mag":"2961341318","pmid":"https://pubmed.ncbi.nlm.nih.gov/31310602"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007214","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007214&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007214&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027580418","display_name":"Aleksandra Karolak","orcid":null},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandra Karolak","raw_affiliation_strings":["Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061177589","display_name":"Sharan Poonja","orcid":"https://orcid.org/0000-0002-1682-7980"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharan Poonja","raw_affiliation_strings":["Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003007173","display_name":"Katarzyna A. Rejniak","orcid":"https://orcid.org/0000-0003-2093-2422"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katarzyna A. Rejniak","raw_affiliation_strings":["Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, FL, United States of America","Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2093-2422","affiliations":[{"raw_affiliation_string":"Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I2613432"]},{"raw_affiliation_string":"Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States of America","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003007173"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6234,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.8400732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"15","issue":"7","first_page":"e1007214","last_page":"e1007214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organoid","display_name":"Organoid","score":0.8643890619277954},{"id":"https://openalex.org/keywords/penetration","display_name":"Penetration (warfare)","score":0.5148943662643433},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4952448904514313},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4686037302017212},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33514875173568726},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.18442615866661072},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.09933903813362122},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.06719505786895752}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8643890619277954},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.5148943662643433},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4952448904514313},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4686037302017212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33514875173568726},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18442615866661072},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09933903813362122},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.06719505786895752},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009940","descriptor_name":"Organoids","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007214","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007214&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31310602","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31310602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007214","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007214","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bec47c835d2e4cf7b18c6f703f87eac5","is_oa":true,"landing_page_url":"https://doaj.org/article/bec47c835d2e4cf7b18c6f703f87eac5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 7, p e1007214 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5626725","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6660094","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/8938547","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Morphophenotypic_classification_of_tumor_organoids_as_an_indicator_of_drug_exposure_and_penetration_potential/8938547","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007214","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007214","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007214&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"awards":[{"id":"https://openalex.org/G1860239242","display_name":null,"funder_award_id":"U01 CA202229","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2905170376","display_name":null,"funder_award_id":"U01CA202229","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8185248426","display_name":null,"funder_award_id":"U01 CA202229","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2961341318.pdf","grobid_xml":"https://content.openalex.org/works/W2961341318.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W3515766","https://openalex.org/W118179289","https://openalex.org/W1494453148","https://openalex.org/W1938080407","https://openalex.org/W1947046122","https://openalex.org/W1967120404","https://openalex.org/W1967293289","https://openalex.org/W1968001411","https://openalex.org/W1973214660","https://openalex.org/W1981298474","https://openalex.org/W1983690504","https://openalex.org/W1985090392","https://openalex.org/W1993998781","https://openalex.org/W1995713439","https://openalex.org/W1999146612","https://openalex.org/W1999397355","https://openalex.org/W1999857568","https://openalex.org/W2001081297","https://openalex.org/W2005109042","https://openalex.org/W2014630203","https://openalex.org/W2015141629","https://openalex.org/W2016834188","https://openalex.org/W2024466756","https://openalex.org/W2029667189","https://openalex.org/W2032461554","https://openalex.org/W2040163651","https://openalex.org/W2040196588","https://openalex.org/W2074814551","https://openalex.org/W2075839005","https://openalex.org/W2076845623","https://openalex.org/W2079725937","https://openalex.org/W2093208620","https://openalex.org/W2100657340","https://openalex.org/W2112933240","https://openalex.org/W2119975980","https://openalex.org/W2129708422","https://openalex.org/W2130541969","https://openalex.org/W2142772253","https://openalex.org/W2146071146","https://openalex.org/W2149283799","https://openalex.org/W2149569497","https://openalex.org/W2155127143","https://openalex.org/W2165477530","https://openalex.org/W2173417615","https://openalex.org/W2205728554","https://openalex.org/W2236643502","https://openalex.org/W2278029862","https://openalex.org/W2282335838","https://openalex.org/W2286284214","https://openalex.org/W2319156699","https://openalex.org/W2523230276","https://openalex.org/W2526238900","https://openalex.org/W2563494429","https://openalex.org/W2726207009","https://openalex.org/W2742005115","https://openalex.org/W2766024765","https://openalex.org/W2771057425","https://openalex.org/W2773981699","https://openalex.org/W2782780490","https://openalex.org/W2784530807","https://openalex.org/W2784563802","https://openalex.org/W2788035610","https://openalex.org/W2788735115","https://openalex.org/W2794251976","https://openalex.org/W2798184520","https://openalex.org/W2799444748","https://openalex.org/W2808350668","https://openalex.org/W2912771544","https://openalex.org/W2949797623","https://openalex.org/W2951053164","https://openalex.org/W6628910274"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W4386439204","https://openalex.org/W2082860237","https://openalex.org/W4401794395","https://openalex.org/W3033121461","https://openalex.org/W3094248195","https://openalex.org/W2811397904","https://openalex.org/W3047600752","https://openalex.org/W3047590429","https://openalex.org/W4307092668"],"abstract_inverted_index":{"The":[0,54],"dynamics":[1,132],"of":[2,37,57,66,74,83,97,104,144,147,155,168,200],"tumor":[3,16,28,44,58,78,99,127,177,212,228,235],"progression":[4],"is":[5],"driven":[6],"by":[7],"multiple":[8],"factors,":[9],"which":[10],"can":[11,133],"be":[12,61,224],"exogenous":[13],"to":[14,24,63,121,194,208,215],"the":[15,35,64,101,145,152,165,195,198],"(microenvironment)":[17],"or":[18,22,41,197,241],"intrinsic":[19],"(genetic,":[20],"epigenetic":[21],"due":[23],"intercellular":[25],"interactions).":[26],"While":[27],"heterogeneity":[29],"has":[30,47],"been":[31,49],"extensively":[32],"studied":[33],"on":[34,171,227],"level":[36],"cell":[38,115,119],"genetic":[39],"profiles":[40],"cellular":[42,140,242],"composition,":[43],"morphological":[45],"diversity":[46],"not":[48,223],"given":[50],"as":[51,191,238],"much":[52],"attention.":[53],"limited":[55],"analysis":[56],"morphophenotypes":[59],"may":[60,182],"attributed":[62],"lack":[65],"accurate":[67],"models,":[68],"both":[69],"experimental":[70,102],"and":[71,118,137,157],"computational,":[72],"capable":[73],"capturing":[75],"changes":[76],"in":[77,105,184,211],"morphology":[79,240],"with":[80,129,179,187],"fine":[81],"levels":[82],"spatial":[84],"detail.":[85],"Using":[86],"a":[87,95],"three-dimensional,":[88],"agent-based,":[89],"lattice-free":[90],"computational":[91,148],"model,":[92],"we":[93,124,150,174],"generated":[94],"library":[96],"multicellular":[98],"organoids,":[100],"analogues":[103],"vivo":[106],"tumors.":[107],"By":[108],"varying":[109],"three":[110],"biologically":[111],"relevant":[112],"parameters-cell":[113],"radius,":[114],"division":[116],"age":[117],"sensitivity":[120],"contact":[122],"inhibition,":[123],"showed":[125],"that":[126,162,176,219],"organoids":[128,178],"similar":[130,180],"growth":[131],"express":[134],"distinct":[135],"morphologies":[136],"possess":[138],"diverse":[139],"compositions.":[141],"Taking":[142],"advantage":[143],"high-resolution":[146],"modeling,":[149],"applied":[151],"quantitative":[153],"measures":[154],"compactness":[156],"accessible":[158],"surface":[159],"area,":[160],"concepts":[161],"originated":[163],"from":[164],"structural":[166],"biology":[167],"proteins.":[169],"Based":[170],"these":[172,204],"analyses,":[173],"demonstrated":[175],"sizes":[181],"differ":[183],"features":[185],"associated":[186],"drug":[188,196,201],"effectiveness,":[189],"such":[190,237],"potential":[192],"exposure":[193],"extent":[199],"penetration.":[202],"Both":[203],"characteristics":[205],"might":[206],"lead":[207],"major":[209],"differences":[210],"organoid's":[213],"response":[214],"therapy.":[216],"This":[217],"indicates":[218],"therapeutic":[220],"protocols":[221],"should":[222],"based":[225],"solely":[226],"size,":[229],"but":[230],"take":[231],"into":[232],"account":[233],"additional":[234],"features,":[236],"their":[239],"packing":[243],"density.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8}],"updated_date":"2026-05-19T08:33:51.333923","created_date":"2025-10-10T00:00:00"}