{"id":"https://openalex.org/W3015780937","doi":"https://doi.org/10.1371/journal.pcbi.1007197","title":"Modeling cross-regulatory influences on monolignol transcripts and proteins under single and combinatorial gene knockdowns in Populus trichocarpa","display_name":"Modeling cross-regulatory influences on monolignol transcripts and proteins under single and combinatorial gene knockdowns in Populus trichocarpa","publication_year":2020,"publication_date":"2020-04-10","ids":{"openalex":"https://openalex.org/W3015780937","doi":"https://doi.org/10.1371/journal.pcbi.1007197","mag":"3015780937","pmid":"https://pubmed.ncbi.nlm.nih.gov/32275650"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007197","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007197","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007197&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007197&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081127886","display_name":"Megan L. Matthews","orcid":"https://orcid.org/0000-0002-5513-9320"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan L. Matthews","raw_affiliation_strings":["Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5513-9320","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019747315","display_name":"Jack Wang","orcid":"https://orcid.org/0000-0002-5392-0076"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jack P. Wang","raw_affiliation_strings":["Department of Forestry and Environmental Resources, Forest Biotechnology Group, North Carolina State University, Raleigh, North Carolina, United States of America","State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0002-5392-0076","affiliations":[{"raw_affiliation_string":"Department of Forestry and Environmental Resources, Forest Biotechnology Group, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030044722","display_name":"Ronald R. Sederoff","orcid":"https://orcid.org/0000-0001-6819-7047"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Sederoff","raw_affiliation_strings":["Department of Forestry and Environmental Resources, Forest Biotechnology Group, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6819-7047","affiliations":[{"raw_affiliation_string":"Department of Forestry and Environmental Resources, Forest Biotechnology Group, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022046994","display_name":"Vincent L. Chiang","orcid":"https://orcid.org/0000-0002-7152-9601"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Vincent L. Chiang","raw_affiliation_strings":["Department of Forest Biomaterials, North Carolina State University, Raleigh, North Carolina, United States of America","Department of Forestry and Environmental Resources, Forest Biotechnology Group, North Carolina State University, Raleigh, North Carolina, United States of America","State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China"],"raw_orcid":"https://orcid.org/0000-0002-7152-9601","affiliations":[{"raw_affiliation_string":"Department of Forest Biomaterials, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Forestry and Environmental Resources, Forest Biotechnology Group, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, China","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001212028","display_name":"Cranos Williams","orcid":"https://orcid.org/0000-0002-0477-9707"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cranos M. Williams","raw_affiliation_strings":["Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0477-9707","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina, United States of America","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001212028"],"corresponding_institution_ids":["https://openalex.org/I137902535"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9581,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.71976682,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":"4","first_page":"e1007197","last_page":"e1007197"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monolignol","display_name":"Monolignol","score":0.9946169853210449},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7148477435112},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6241944432258606},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6134124994277954},{"id":"https://openalex.org/keywords/populus-trichocarpa","display_name":"Populus trichocarpa","score":0.5926882028579712},{"id":"https://openalex.org/keywords/transgene","display_name":"Transgene","score":0.45157259702682495},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4419018626213074},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3637007474899292},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.1839110255241394},{"id":"https://openalex.org/keywords/biosynthesis","display_name":"Biosynthesis","score":0.07857722043991089}],"concepts":[{"id":"https://openalex.org/C2780678855","wikidata":"https://www.wikidata.org/wiki/Q3025640","display_name":"Monolignol","level":4,"score":0.9946169853210449},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7148477435112},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6241944432258606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6134124994277954},{"id":"https://openalex.org/C2780250286","wikidata":"https://www.wikidata.org/wiki/Q149382","display_name":"Populus trichocarpa","level":4,"score":0.5926882028579712},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.45157259702682495},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4419018626213074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3637007474899292},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1839110255241394},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.07857722043991089}],"mesh":[{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008031","descriptor_name":"Lignin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014934","descriptor_name":"Wood","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014934","descriptor_name":"Wood","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014934","descriptor_name":"Wood","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D032107","descriptor_name":"Populus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D032107","descriptor_name":"Populus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D032107","descriptor_name":"Populus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1007197","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007197","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007197&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32275650","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32275650","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:figshare.com:article/12111729","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Modeling_cross-regulatory_influences_on_monolignol_transcripts_and_proteins_under_single_and_combinatorial_gene_knockdowns_in_i_Populus_trichocarpa_i_/12111729","pdf_url":"https://figshare.com/articles/Modeling_cross-regulatory_influences_on_monolignol_transcripts_and_proteins_under_single_and_combinatorial_gene_knockdowns_in_i_Populus_trichocarpa_i_/12111729","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:doaj.org/article:06360a07c68a46d2a7c3dca8874920dd","is_oa":true,"landing_page_url":"https://doaj.org/article/06360a07c68a46d2a7c3dca8874920dd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 4, p e1007197 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7147730","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7147730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007197","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007197","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007197&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/12","score":0.44999998807907104,"display_name":"Responsible consumption and production"}],"awards":[{"id":"https://openalex.org/G3364844646","display_name":"Regulation and Modeling of Lignin Biosynthesis","funder_award_id":"0922391","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4410756717","display_name":null,"funder_award_id":"DBI-0922391","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320314637","display_name":"National Physical Science Consortium","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015780937.pdf","grobid_xml":"https://content.openalex.org/works/W3015780937.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W146277751","https://openalex.org/W1546590920","https://openalex.org/W1855270143","https://openalex.org/W1973268693","https://openalex.org/W1980942339","https://openalex.org/W1990912589","https://openalex.org/W2006900120","https://openalex.org/W2008109277","https://openalex.org/W2035422475","https://openalex.org/W2046826238","https://openalex.org/W2047401439","https://openalex.org/W2049657685","https://openalex.org/W2053836738","https://openalex.org/W2055234679","https://openalex.org/W2079333568","https://openalex.org/W2086187764","https://openalex.org/W2100192722","https://openalex.org/W2126191743","https://openalex.org/W2126276987","https://openalex.org/W2129651180","https://openalex.org/W2137804544","https://openalex.org/W2145547605","https://openalex.org/W2146512944","https://openalex.org/W2161737052","https://openalex.org/W2170693188","https://openalex.org/W2171724922","https://openalex.org/W2179438025","https://openalex.org/W2288929640","https://openalex.org/W2312465510","https://openalex.org/W2334501944","https://openalex.org/W2491458421","https://openalex.org/W2498761000","https://openalex.org/W2529193769","https://openalex.org/W2611370172","https://openalex.org/W2755755941","https://openalex.org/W2767151325","https://openalex.org/W2794679100","https://openalex.org/W2800729007","https://openalex.org/W2892190497","https://openalex.org/W2914489645","https://openalex.org/W3099018540","https://openalex.org/W6702981980"],"related_works":["https://openalex.org/W2312465510","https://openalex.org/W2566078339","https://openalex.org/W3109058627","https://openalex.org/W3202841546","https://openalex.org/W2522144362","https://openalex.org/W2145547605","https://openalex.org/W2139891953","https://openalex.org/W2895627288","https://openalex.org/W2009071581","https://openalex.org/W2553288622"],"abstract_inverted_index":{"Accurate":[0],"manipulation":[1],"of":[2,30,40,48,56,71,77,100,153,160,189,233,238],"metabolites":[3],"in":[4,145,180,216],"monolignol":[5,41,49,57,72,122,140,155,190,239],"biosynthesis":[6],"is":[7,33,81],"a":[8,129,224],"key":[9],"step":[10],"for":[11,228],"controlling":[12],"lignin":[13,243],"content,":[14],"structure,":[15],"and":[16,24,37,107,142,163,177,187,213,235,244],"other":[17,92,245],"wood":[18,246],"properties":[19],"important":[20],"to":[21,64,86,136,182,206],"the":[22,46,53,98,138,198,230],"bioenergy":[23],"biomaterial":[25],"industries.":[26],"A":[27],"crucial":[28],"component":[29],"this":[31,161],"strategy":[32],"predicting":[34],"how":[35],"single":[36,234],"combinatorial":[38,236],"knockdowns":[39,152],"specific":[42,73,121,154,240],"gene":[43],"transcripts":[44],"influence":[45],"abundance":[47],"proteins,":[50],"which":[51],"are":[52,125],"driving":[54],"mechanisms":[55],"biosynthesis.":[58],"Computational":[59],"models":[60],"have":[61],"been":[62],"developed":[63],"estimate":[65,137],"protein":[66,108,143,178],"abundances":[67,144],"from":[68,197,203],"transcript":[69,106,141,176],"perturbations":[70],"genes.":[74,94,156],"The":[75],"accuracy":[76],"these":[78,101],"models,":[79,184],"however,":[80],"hindered":[82],"by":[83],"their":[84],"inability":[85],"capture":[87],"indirect":[88,102,112],"regulatory":[89,113],"influences":[90,103,114],"on":[91,104,150,242],"pathway":[93,123],"Here,":[95],"we":[96,168],"examine":[97],"manifestation":[99],"transgenic":[105,146],"abundances,":[109,179],"identifying":[110],"putative":[111],"that":[115,170],"occur":[116],"when":[117,185],"one":[118],"or":[119],"more":[120,173],"genes":[124,191,241],"perturbed.":[126,193],"We":[127,194],"created":[128],"computational":[130,226],"model":[131,162,172,205,222],"using":[132],"sparse":[133],"maximum":[134],"likelihood":[135],"resulting":[139],"Populus":[147],"trichocarpa":[148],"based":[149],"targeted":[151],"Using":[157],"in-silico":[158],"simulations":[159],"root":[164],"mean":[165],"square":[166],"error,":[167],"showed":[169],"our":[171,204],"accurately":[174],"estimated":[175],"comparison":[181],"previous":[183],"individual":[186],"families":[188],"were":[192],"leveraged":[195],"insight":[196],"inferred":[199],"network":[200],"structure":[201],"obtained":[202],"identify":[207],"potential":[208],"genes,":[209],"including":[210],"PtrHCT,":[211],"PtrCAD,":[212],"Ptr4CL,":[214],"involved":[215],"post-transcriptional":[217],"and/or":[218],"post-translational":[219],"regulation.":[220],"Our":[221],"provides":[223],"useful":[225],"tool":[227],"exploring":[229],"cascaded":[231],"impact":[232],"modifications":[237],"properties.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}