{"id":"https://openalex.org/W2963102852","doi":"https://doi.org/10.1371/journal.pcbi.1007186","title":"Why do eukaryotic proteins contain more intrinsically disordered regions?","display_name":"Why do eukaryotic proteins contain more intrinsically disordered regions?","publication_year":2019,"publication_date":"2019-07-22","ids":{"openalex":"https://openalex.org/W2963102852","doi":"https://doi.org/10.1371/journal.pcbi.1007186","mag":"2963102852","pmid":"https://pubmed.ncbi.nlm.nih.gov/31329574"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007186","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007186","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007186&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007186&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013344030","display_name":"Walter Basile","orcid":"https://orcid.org/0000-0003-1701-222X"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Walter Basile","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","Science for Life Laboratory, Stockholm University, Solna, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1701-222X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm University, Solna, Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020335858","display_name":"Marco Salvatore","orcid":"https://orcid.org/0000-0001-5775-0417"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marco Salvatore","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","Science for Life Laboratory, Stockholm University, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm University, Solna, Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005731296","display_name":"Claudio Bassot","orcid":"https://orcid.org/0000-0001-7161-9028"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Claudio Bassot","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","Science for Life Laboratory, Stockholm University, Solna, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-7161-9028","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm University, Solna, Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072903725","display_name":"Arne Elofsson","orcid":"https://orcid.org/0000-0002-7115-9751"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I4210103991","display_name":"Swedish e-Science Research Centre","ror":"https://ror.org/01e59yk92","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210103991"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Arne Elofsson","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","Science for Life Laboratory, Stockholm University, Solna, Sweden","Swedish e-Science Research Center (SeRC), Stockholm, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-7115-9751","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Science for Life Laboratory, Stockholm University, Solna, Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]},{"raw_affiliation_string":"Swedish e-Science Research Center (SeRC), Stockholm, Sweden","institution_ids":["https://openalex.org/I4210103991"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072903725"],"corresponding_institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495","https://openalex.org/I4210103991"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2073,"currency":"EUR","value_usd":2235},"fwci":4.4283,"has_fulltext":true,"cited_by_count":128,"citation_normalized_percentile":{"value":0.95764855,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"15","issue":"7","first_page":"e1007186","last_page":"e1007186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.6104732155799866},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.6059684753417969},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5478188991546631},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5149653553962708},{"id":"https://openalex.org/keywords/serine","display_name":"Serine","score":0.5126022696495056},{"id":"https://openalex.org/keywords/linker","display_name":"Linker","score":0.5100920796394348},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3243796229362488},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.26570793986320496}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6104732155799866},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6059684753417969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5478188991546631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5149653553962708},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5126022696495056},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5100920796394348},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3243796229362488},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.26570793986320496},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007532","descriptor_name":"Isoleucine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007532","descriptor_name":"Isoleucine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007532","descriptor_name":"Isoleucine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007186","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007186","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007186&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31329574","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31329574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5631641","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6675126","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6675126","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6675126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ac920c71f712460c9d3c7420f9a25c5c","is_oa":true,"landing_page_url":"https://doaj.org/article/ac920c71f712460c9d3c7420f9a25c5c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 7, p e1007186 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8977775","is_oa":true,"landing_page_url":"https://figshare.com/articles/Why_do_eukaryotic_proteins_contain_more_intrinsically_disordered_regions_/8977775","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007186","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007186","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007186&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1449831753","display_name":null,"funder_award_id":"VR\u2010NT 2016\u201003798","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5528404029","display_name":"Towards a complete map of the transmembrane proteome in Yeast and E.Coli","funder_award_id":"2016-03798","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320317161","display_name":"Swedish e-Science Research Centre","ror":"https://ror.org/01e59yk92"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963102852.pdf","grobid_xml":"https://content.openalex.org/works/W2963102852.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W285114175","https://openalex.org/W1563203616","https://openalex.org/W1592237925","https://openalex.org/W1791388867","https://openalex.org/W1969377792","https://openalex.org/W1975222501","https://openalex.org/W1990056477","https://openalex.org/W1995141949","https://openalex.org/W2003540678","https://openalex.org/W2009505131","https://openalex.org/W2013474582","https://openalex.org/W2016685368","https://openalex.org/W2018755224","https://openalex.org/W2025250036","https://openalex.org/W2034233361","https://openalex.org/W2036247065","https://openalex.org/W2038163496","https://openalex.org/W2051190420","https://openalex.org/W2060147957","https://openalex.org/W2060592742","https://openalex.org/W2066688961","https://openalex.org/W2090047988","https://openalex.org/W2091535494","https://openalex.org/W2094154815","https://openalex.org/W2095650841","https://openalex.org/W2097270746","https://openalex.org/W2097775940","https://openalex.org/W2100022666","https://openalex.org/W2100994694","https://openalex.org/W2102025585","https://openalex.org/W2103017472","https://openalex.org/W2108138353","https://openalex.org/W2112792893","https://openalex.org/W2117731486","https://openalex.org/W2119983891","https://openalex.org/W2120167569","https://openalex.org/W2121520117","https://openalex.org/W2124052876","https://openalex.org/W2127359880","https://openalex.org/W2130581715","https://openalex.org/W2133190161","https://openalex.org/W2137736270","https://openalex.org/W2140628140","https://openalex.org/W2142628689","https://openalex.org/W2145658930","https://openalex.org/W2147610376","https://openalex.org/W2149472608","https://openalex.org/W2161199282","https://openalex.org/W2161974771","https://openalex.org/W2162172965","https://openalex.org/W2163293619","https://openalex.org/W2164461702","https://openalex.org/W2164718466","https://openalex.org/W2165999027","https://openalex.org/W2166834087","https://openalex.org/W2173591891","https://openalex.org/W2224056471","https://openalex.org/W2512618608","https://openalex.org/W2519829400","https://openalex.org/W2561373149","https://openalex.org/W2601961903","https://openalex.org/W2604808360","https://openalex.org/W2621897082","https://openalex.org/W2621916092","https://openalex.org/W2624409632","https://openalex.org/W2625775194","https://openalex.org/W2767649956","https://openalex.org/W2772934464","https://openalex.org/W2806369557","https://openalex.org/W4211208250"],"related_works":["https://openalex.org/W2048490996","https://openalex.org/W2027377285","https://openalex.org/W4247375799","https://openalex.org/W2372005294","https://openalex.org/W2073620476","https://openalex.org/W2080971378","https://openalex.org/W3144105522","https://openalex.org/W2920176150","https://openalex.org/W1582414116","https://openalex.org/W1971404345"],"abstract_inverted_index":{"Intrinsic":[0],"disorder":[1,12,59,98,154,220,253,279,313],"is":[2,158,170,181,254,263],"more":[3,70,82,241,290,301],"abundant":[4],"in":[5,29,41,57,75,97,99,108,144,155,165,168,186,201,209,219,234,259,278,312,319],"eukaryotic":[6,33,48,78,100,127,156,222,235,260,267,281,287,324],"than":[7],"prokaryotic":[8,35,50,123,224,283,326],"proteins.Methods":[9],"predicting":[10],"intrinsic":[11,42,58],"are":[13,80,184,198,240,299],"based":[14],"on":[15],"the":[16,30,38,55,62,77,91,95,106,116,145,152,163,210,217,227,238,245,248,273,276,306,310],"amino":[17,113,214,230,320],"acid":[18,231,321],"sequence":[19],"of":[20,110,195,212,266,275],"a":[21,264,316],"protein.Therefore,":[22],"there":[23],"must":[24],"exist":[25],"an":[26],"underlying":[27,92],"difference":[28,40,56,218,277,311,318],"sequences":[31],"between":[32,221,280,323],"and":[34,49,74,102,133,140,193,203,223,262,282,294,325],"proteins":[36,68,118,124,128,225,288],"causing":[37],"(predicted)":[39],"disorder.By":[43],"comparing":[44],"proteins,":[45],"from":[46,61,315],"complete":[47],"proteomes,":[51],"we":[52,89,103,269,303],"show":[53,285],"that":[54,105,162,207,286,295,309],"emerges":[60],"linker":[63,72,204,292,297],"regions":[64,192,293,298],"connecting":[65],"Pfam":[66],"domains.Eukaryotic":[67],"have":[69,125],"extended":[71,291],"regions,":[73],"addition,":[76],"linkers":[79,236,239],"significantly":[81,300],"disordered,":[83],"38%":[84],"vs.":[85],"12-16%":[86],"disordered":[87,202,242],"residues.Next,":[88],"examined":[90],"reason":[93],"for":[94,179,256,305],"increase":[96,164],"linkers,":[101],"found":[104],"changes":[107],"abundance":[109,211],"only":[111],"three":[112,148,213],"acids":[114,215],"cause":[115,216,247],"increase.Eukaryotic":[117],"contain":[119,130,289],"8.6%":[120],"serine;":[121],"while":[122],"6.5%,":[126],"also":[129],"5.4%":[131],"proline":[132,139],"5.3%":[134],"isoleucine":[135,143],"compared":[136],"with":[137],"4.0%":[138],"\ufffd":[141],"7.5%":[142],"prokaryotes.All":[146],"these":[147,296],"differences":[149,183,208,246],"contribute":[150],"to":[151,160,172,271],"increased":[153,249],"proteins.It":[157],"tempting":[159],"speculate":[161],"serine":[166],"frequencies":[167,232,322],"eukaryotes":[169],"related":[171],"regulation":[173],"by":[174],"kinases,":[175],"but":[176,197],"direct":[177],"evidence":[178],"this":[180],"lacking.The":[182],"observed":[185],"all":[187],"phyla,":[188],"protein":[189,196],"families,":[190],"structural":[191],"type":[194],"most":[199],"pronounced":[200],"regions.The":[205],"observation":[206],"raises":[226],"question:":[228],"Are":[229],"different":[233],"because":[237],"or":[243],"do":[244],"disorder?":[250],"Author":[251],"SummaryIntrinsic":[252],"essential":[255],"various":[257],"functions":[258],"cells":[261],"signature":[265],"proteins.Here,":[268],"try":[270],"understand":[272],"origin":[274],"proteins.We":[284],"disordered.Further,":[302],"show,":[304],"first":[307],"time,":[308],"originates":[314],"systematic":[317]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":2}],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2025-10-10T00:00:00"}
