{"id":"https://openalex.org/W2954896585","doi":"https://doi.org/10.1371/journal.pcbi.1007162","title":"Cross-species functional modules link proteostasis to human normal aging","display_name":"Cross-species functional modules link proteostasis to human normal aging","publication_year":2019,"publication_date":"2019-07-03","ids":{"openalex":"https://openalex.org/W2954896585","doi":"https://doi.org/10.1371/journal.pcbi.1007162","mag":"2954896585","pmid":"https://pubmed.ncbi.nlm.nih.gov/31269015"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007162","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007162","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007162&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007162&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085717784","display_name":"Andrea Komljenovi\u0107","orcid":"https://orcid.org/0000-0002-8739-748X"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andrea Komljenovic","raw_affiliation_strings":["Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348477","display_name":"Hao Li","orcid":"https://orcid.org/0000-0001-5677-3377"},"institutions":[{"id":"https://openalex.org/I4210124410","display_name":"Swiss Integrative Center for Human Health","ror":"https://ror.org/037xabw57","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210124410"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hao Li","raw_affiliation_strings":["Laboratory of Integrative Systems Physiology, EPFL, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, EPFL, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210124410","https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058108094","display_name":"Vincenzo Sorrentino","orcid":"https://orcid.org/0000-0002-7212-370X"},"institutions":[{"id":"https://openalex.org/I4210124410","display_name":"Swiss Integrative Center for Human Health","ror":"https://ror.org/037xabw57","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210124410"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Vincenzo Sorrentino","raw_affiliation_strings":["Laboratory of Integrative Systems Physiology, EPFL, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, EPFL, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210124410","https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075453835","display_name":"Zolt\u00e1n Kutalik","orcid":"https://orcid.org/0000-0001-8285-7523"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Zolt\u00e1n Kutalik","raw_affiliation_strings":["Swiss Institute of Bioinformatics, Lausanne, Switzerland","University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003154600","display_name":"Johan Auwerx","orcid":"https://orcid.org/0000-0002-5065-5393"},"institutions":[{"id":"https://openalex.org/I4210124410","display_name":"Swiss Integrative Center for Human Health","ror":"https://ror.org/037xabw57","country_code":"CH","type":"facility","lineage":["https://openalex.org/I4210124410"]},{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johan Auwerx","raw_affiliation_strings":["Laboratory of Integrative Systems Physiology, EPFL, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Laboratory of Integrative Systems Physiology, EPFL, Lausanne, Switzerland","institution_ids":["https://openalex.org/I4210124410","https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054250703","display_name":"Marc Robinson\u2010Rechavi","orcid":"https://orcid.org/0000-0002-3437-3329"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Marc Robinson-Rechavi","raw_affiliation_strings":["Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland","Swiss Institute of Bioinformatics, Lausanne, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Swiss Institute of Bioinformatics, Lausanne, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5054250703"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I97565354"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8358,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.69470102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"15","issue":"7","first_page":"e1007162","last_page":"e1007162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.953000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteostasis","display_name":"Proteostasis","score":0.9396454095840454},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.738174319267273},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.4822450578212738},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.47867637872695923},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4785110056400299},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.46967536211013794},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.453576922416687},{"id":"https://openalex.org/keywords/ageing","display_name":"Ageing","score":0.4367442727088928},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4367271363735199},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.41885221004486084},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3218895196914673},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1358427107334137},{"id":"https://openalex.org/keywords/base-sequence","display_name":"Base sequence","score":0.07782256603240967},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.07423627376556396}],"concepts":[{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.9396454095840454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.738174319267273},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.4822450578212738},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.47867637872695923},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4785110056400299},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.46967536211013794},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.453576922416687},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4367442727088928},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4367271363735199},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.41885221004486084},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3218895196914673},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1358427107334137},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.07782256603240967},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.07423627376556396},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pcbi.1007162","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007162","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007162&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31269015","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31269015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:serval.unil.ch:BIB_DB3E6C72F674","is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_DB3E6C72F674","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology, vol. 15, no. 7, pp. e1007162","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:infoscience.epfl.ch:269801","is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/160690","pdf_url":"https://infoscience.epfl.ch/record/269801/files/pcbi.1007162.pdf","source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:iris.unil.ch:iris/235538","is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/235538","pdf_url":"https://iris.unil.ch/bitstreams/12bf5a29-de34-4945-9c9d-01aece55c268/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/d62552b2-544f-4247-a47f-60bd39c10272","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/d62552b2-544f-4247-a47f-60bd39c10272","pdf_url":"https://pure.amsterdamumc.nl/files/163492418/Cross-species-functional-modules-link-proteostasis-to-human-normal-aging.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Komljenovic, A, Li, H, Sorrentino, V, Kutalik, Z, Auwerx, J & Robinson-Rechavi, M 2019, 'Cross-species functional modules link proteostasis to human normal aging', PLoS computational biology, vol. 15, no. 7, e1007162. https://doi.org/10.1371/journal.pcbi.1007162","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/247797","is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/247797","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Elements","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:9f35f1687c684456a4c4e99bcfc3af75","is_oa":true,"landing_page_url":"https://doaj.org/article/9f35f1687c684456a4c4e99bcfc3af75","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 7, p e1007162 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8607593","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Cross-species_functional_modules_link_proteostasis_to_human_normal_aging/8607593","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6634426","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6634426","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007162","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007162","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007162&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1044568870","display_name":null,"funder_award_id":"R01AG043930","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2412389395","display_name":null,"funder_award_id":"AG043930","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2945207006","display_name":null,"funder_award_id":"2013/153","funder_id":"https://openalex.org/F4320320915","funder_display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne"},{"id":"https://openalex.org/G3884604626","display_name":null,"funder_award_id":"AgingX","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"},{"id":"https://openalex.org/G5326042306","display_name":null,"funder_award_id":"SystemsX","funder_id":"https://openalex.org/F4320327577","funder_display_name":"SystemsX.ch"}],"funders":[{"id":"https://openalex.org/F4320309607","display_name":"Velux Stiftung","ror":"https://ror.org/00kgf1c95"},{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"},{"id":"https://openalex.org/F4320327577","display_name":"SystemsX.ch","ror":"https://ror.org/02s09gf16"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2954896585.pdf","grobid_xml":"https://content.openalex.org/works/W2954896585.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W94412592","https://openalex.org/W229097380","https://openalex.org/W1581119831","https://openalex.org/W1816176398","https://openalex.org/W1967170554","https://openalex.org/W1976948056","https://openalex.org/W1985966076","https://openalex.org/W1986423048","https://openalex.org/W1986911601","https://openalex.org/W2004707197","https://openalex.org/W2007056893","https://openalex.org/W2009487345","https://openalex.org/W2014440105","https://openalex.org/W2018838463","https://openalex.org/W2020431992","https://openalex.org/W2029639109","https://openalex.org/W2058238065","https://openalex.org/W2061756062","https://openalex.org/W2063508090","https://openalex.org/W2065917729","https://openalex.org/W2080094749","https://openalex.org/W2091546930","https://openalex.org/W2097489988","https://openalex.org/W2100577029","https://openalex.org/W2103017472","https://openalex.org/W2103914828","https://openalex.org/W2104438296","https://openalex.org/W2105105960","https://openalex.org/W2106655937","https://openalex.org/W2108700752","https://openalex.org/W2109972881","https://openalex.org/W2116041602","https://openalex.org/W2117826519","https://openalex.org/W2118258530","https://openalex.org/W2124208364","https://openalex.org/W2125202929","https://openalex.org/W2125972459","https://openalex.org/W2126525177","https://openalex.org/W2128049108","https://openalex.org/W2130410032","https://openalex.org/W2130682212","https://openalex.org/W2131681506","https://openalex.org/W2136183044","https://openalex.org/W2137499573","https://openalex.org/W2137526110","https://openalex.org/W2146511318","https://openalex.org/W2151893314","https://openalex.org/W2152231829","https://openalex.org/W2153312037","https://openalex.org/W2156499012","https://openalex.org/W2158674901","https://openalex.org/W2162142896","https://openalex.org/W2164802216","https://openalex.org/W2166682872","https://openalex.org/W2168921092","https://openalex.org/W2169353806","https://openalex.org/W2192658008","https://openalex.org/W2194304382","https://openalex.org/W2197124664","https://openalex.org/W2212393023","https://openalex.org/W2254879037","https://openalex.org/W2280991339","https://openalex.org/W2295275561","https://openalex.org/W2323326409","https://openalex.org/W2436467819","https://openalex.org/W2439659817","https://openalex.org/W2464717012","https://openalex.org/W2497752945","https://openalex.org/W2513896837","https://openalex.org/W2553200397","https://openalex.org/W2577490495","https://openalex.org/W2577597748","https://openalex.org/W2581238721","https://openalex.org/W2599323298","https://openalex.org/W2604808360","https://openalex.org/W2611138580","https://openalex.org/W2619058331","https://openalex.org/W2621065022","https://openalex.org/W2740078953","https://openalex.org/W2753159783","https://openalex.org/W2775174939","https://openalex.org/W2801266108","https://openalex.org/W2883573930","https://openalex.org/W2905045831","https://openalex.org/W2924950986","https://openalex.org/W3099768174","https://openalex.org/W3104267360","https://openalex.org/W4242622626","https://openalex.org/W4297900044"],"related_works":["https://openalex.org/W4252872000","https://openalex.org/W2086646706","https://openalex.org/W2136597136","https://openalex.org/W4388298820","https://openalex.org/W4309510473","https://openalex.org/W2797719377","https://openalex.org/W2529741867","https://openalex.org/W4312475162","https://openalex.org/W2560706264","https://openalex.org/W2911514179"],"abstract_inverted_index":{"The":[0],"evolutionarily":[1,76],"conserved":[2,77,91],"nature":[3],"of":[4,47,59,79,138],"the":[5,48,136],"few":[6],"well-known":[7],"anti-aging":[8],"interventions":[9],"that":[10,18,98,127],"affect":[11],"lifespan,":[12],"such":[13],"as":[14],"caloric":[15,122],"restriction,":[16],"suggests":[17],"aging-related":[19],"research":[20],"in":[21,92],"model":[22,65],"organisms":[23,66],"is":[24,33],"directly":[25],"relevant":[26,144],"to":[27,42,89,101,121,145],"human":[28,31,63,117,146],"aging.":[29,94,148],"Since":[30],"lifespan":[32],"a":[34,37,43,128],"complex":[35],"trait,":[36],"systems-level":[38,129],"approach":[39],"will":[40],"contribute":[41],"more":[44],"comprehensive":[45],"understanding":[46],"underlying":[49],"aging":[50,61,81,140],"landscape.":[51],"Here,":[52],"we":[53,96],"integrate":[54],"evolutionary":[55,133],"and":[56,64,72,85,119,142],"functional":[57],"information":[58],"normal":[60,80,93,147],"across":[62,82],"at":[67],"three":[68],"levels:":[69],"gene-level,":[70],"process-level,":[71],"network-level.":[73],"We":[74],"identify":[75],"modules":[78],"diverse":[83],"taxa,":[84],"notably":[86],"show":[87],"proteostasis":[88],"be":[90],"Additionally,":[95],"find":[97],"mechanisms":[99],"related":[100],"protein":[102],"quality":[103],"control":[104],"network":[105],"are":[106],"enriched":[107],"for":[108],"genes":[109,141],"harboring":[110],"genetic":[111],"variants":[112],"associated":[113,120],"with":[114,132],"22":[115],"age-related":[116],"traits":[118],"restriction.":[123],"These":[124],"results":[125],"demonstrate":[126],"approach,":[130],"combined":[131],"conservation,":[134],"allows":[135],"detection":[137],"candidate":[139],"pathways":[143]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
