{"id":"https://openalex.org/W2949392907","doi":"https://doi.org/10.1371/journal.pcbi.1007079","title":"A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test","display_name":"A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test","publication_year":2019,"publication_date":"2019-06-17","ids":{"openalex":"https://openalex.org/W2949392907","doi":"https://doi.org/10.1371/journal.pcbi.1007079","mag":"2949392907","pmid":"https://pubmed.ncbi.nlm.nih.gov/31206515"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007079","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007079","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007079&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007079&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063211934","display_name":"David Hasler","orcid":"https://orcid.org/0000-0003-3275-1653"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David Hasler","raw_affiliation_strings":["ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland","Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3275-1653","affiliations":[{"raw_affiliation_string":"ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126","https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000428301","display_name":"Pinelopi Anagnostopoulou","orcid":"https://orcid.org/0000-0003-2597-8016"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Pinelopi Anagnostopoulou","raw_affiliation_strings":["Institute of Anatomy, University of Bern, Bern, Switzerland","Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2597-8016","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126","https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036169554","display_name":"Sylvia Nyilas","orcid":"https://orcid.org/0000-0003-1840-3118"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sylvia Nyilas","raw_affiliation_strings":["Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, Switzerland","Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126","https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018337128","display_name":"Philipp Latzin","orcid":"https://orcid.org/0000-0002-5239-1571"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Philipp Latzin","raw_affiliation_strings":["Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Respiratory Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126","https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063307330","display_name":"Johannes C. Schittny","orcid":"https://orcid.org/0000-0003-4025-3961"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johannes Schittny","raw_affiliation_strings":["Institute of Anatomy, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4025-3961","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045838242","display_name":"Dominik Obrist","orcid":"https://orcid.org/0000-0002-6062-9076"},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominik Obrist","raw_affiliation_strings":["ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6062-9076","affiliations":[{"raw_affiliation_string":"ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000428301"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.9804,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91875919,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"6","first_page":"e1007079","last_page":"e1007079"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/washout","display_name":"Washout","score":0.7162966728210449},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.6641902923583984},{"id":"https://openalex.org/keywords/ventilation","display_name":"Ventilation (architecture)","score":0.6070773005485535},{"id":"https://openalex.org/keywords/nitrogen-washout","display_name":"Nitrogen washout","score":0.5253435969352722},{"id":"https://openalex.org/keywords/functional-residual-capacity","display_name":"Functional residual capacity","score":0.49192023277282715},{"id":"https://openalex.org/keywords/lung-volumes","display_name":"Lung volumes","score":0.4858836531639099},{"id":"https://openalex.org/keywords/expiration","display_name":"Expiration","score":0.47312086820602417},{"id":"https://openalex.org/keywords/inert-gas","display_name":"Inert gas","score":0.4643462300300598},{"id":"https://openalex.org/keywords/airway-resistance","display_name":"Airway resistance","score":0.4554261267185211},{"id":"https://openalex.org/keywords/respiratory-physiology","display_name":"Respiratory physiology","score":0.45332401990890503},{"id":"https://openalex.org/keywords/airway","display_name":"Airway","score":0.446686327457428},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4078353941440582},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.37230217456817627},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.3295954763889313},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.32152843475341797},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.31072402000427246},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2870067358016968},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.2738138437271118},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1451164186000824}],"concepts":[{"id":"https://openalex.org/C71839028","wikidata":"https://www.wikidata.org/wiki/Q7972627","display_name":"Washout","level":2,"score":0.7162966728210449},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6641902923583984},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.6070773005485535},{"id":"https://openalex.org/C2780058330","wikidata":"https://www.wikidata.org/wiki/Q751856","display_name":"Nitrogen washout","level":5,"score":0.5253435969352722},{"id":"https://openalex.org/C56283660","wikidata":"https://www.wikidata.org/wiki/Q1073808","display_name":"Functional residual capacity","level":4,"score":0.49192023277282715},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.4858836531639099},{"id":"https://openalex.org/C2776164194","wikidata":"https://www.wikidata.org/wiki/Q2501440","display_name":"Expiration","level":3,"score":0.47312086820602417},{"id":"https://openalex.org/C55766333","wikidata":"https://www.wikidata.org/wiki/Q11136680","display_name":"Inert gas","level":2,"score":0.4643462300300598},{"id":"https://openalex.org/C33362165","wikidata":"https://www.wikidata.org/wiki/Q754455","display_name":"Airway resistance","level":3,"score":0.4554261267185211},{"id":"https://openalex.org/C163498912","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiratory physiology","level":3,"score":0.45332401990890503},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.446686327457428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4078353941440582},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37230217456817627},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3295954763889313},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32152843475341797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31072402000427246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2870067358016968},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2738138437271118},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1451164186000824},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011659","descriptor_name":"Pulmonary Gas Exchange","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1007079","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007079","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007079&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31206515","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31206515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007079","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007079","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:boris.unibe.ch:131496","is_oa":true,"landing_page_url":"https://boris.unibe.ch/131496/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hasler, David; Anagnostopoulou, Pinelopi; Nyilas, Sylvia; Latzin, Philipp; Schittny, Johannes; Obrist, Dominik (2019). A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test. PLoS computational biology, 15(6), e1007079. Public Library of Science 10.1371/journal.pcbi.1007079 &lt;http://dx.doi.org/10.1371/journal.pcbi.1007079&gt;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3f1396902a8d4d719ed91da3f793c416","is_oa":true,"landing_page_url":"https://doaj.org/article/3f1396902a8d4d719ed91da3f793c416","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 6, p e1007079 (2019)","raw_type":"article"},{"id":"pmh:oai:dora:psi_37399","is_oa":false,"landing_page_url":"https://www.dora.lib4ri.ch/psi/islandora/object/psi%3A37399","pdf_url":null,"source":{"id":"https://openalex.org/S4306402574","display_name":"DORA PSI (Paul Scherrer Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2802229908","host_organization_name":"Paul Scherrer Institute","host_organization_lineage":["https://openalex.org/I2802229908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5577004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6597127","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/8284184","is_oa":true,"landing_page_url":"https://figshare.com/articles/A_multi-scale_model_of_gas_transport_in_the_lung_to_study_heterogeneous_lung_ventilation_during_the_multiple-breath_washout_test/8284184","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007079","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007079","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007079&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2114832140","display_name":null,"funder_award_id":"14435.1 PFLS-LS","funder_id":"https://openalex.org/F4320320998","funder_display_name":"Kommission f\u00fcr Technologie und Innovation"},{"id":"https://openalex.org/G3995681455","display_name":null,"funder_award_id":"310030_175953","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7123936129","display_name":null,"funder_award_id":"18274.1 PFLS-LS","funder_id":"https://openalex.org/F4320320998","funder_display_name":"Kommission f\u00fcr Technologie und Innovation"},{"id":"https://openalex.org/G7317831117","display_name":null,"funder_award_id":"#310030_153468 and #310030_175953","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8113852555","display_name":null,"funder_award_id":"310030_153468","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320320998","display_name":"Kommission f\u00fcr Technologie und Innovation","ror":"https://ror.org/012y9zp98"},{"id":"https://openalex.org/F4320327931","display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung","ror":"https://ror.org/05a2bhn71"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949392907.pdf","grobid_xml":"https://content.openalex.org/works/W2949392907.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W20798278","https://openalex.org/W43550982","https://openalex.org/W170003874","https://openalex.org/W609920316","https://openalex.org/W1522043295","https://openalex.org/W1597285101","https://openalex.org/W1603927057","https://openalex.org/W1874133486","https://openalex.org/W1981837287","https://openalex.org/W1985229312","https://openalex.org/W1999900624","https://openalex.org/W2005672672","https://openalex.org/W2011577207","https://openalex.org/W2012459137","https://openalex.org/W2012923056","https://openalex.org/W2023159816","https://openalex.org/W2050114393","https://openalex.org/W2070628727","https://openalex.org/W2085292874","https://openalex.org/W2093259591","https://openalex.org/W2095712753","https://openalex.org/W2098146262","https://openalex.org/W2102585208","https://openalex.org/W2106489270","https://openalex.org/W2108627607","https://openalex.org/W2117937806","https://openalex.org/W2119051178","https://openalex.org/W2132023845","https://openalex.org/W2133230020","https://openalex.org/W2135463668","https://openalex.org/W2136962715","https://openalex.org/W2138042009","https://openalex.org/W2145536313","https://openalex.org/W2146086523","https://openalex.org/W2162500118","https://openalex.org/W2163218659","https://openalex.org/W2175296276","https://openalex.org/W2272024129","https://openalex.org/W2273480019","https://openalex.org/W2296719457","https://openalex.org/W2394835459","https://openalex.org/W2415365950","https://openalex.org/W2422411849","https://openalex.org/W2436132938","https://openalex.org/W2440029493","https://openalex.org/W2498981815","https://openalex.org/W2522098306","https://openalex.org/W2535387116","https://openalex.org/W2581625378","https://openalex.org/W2592958737","https://openalex.org/W2758516060","https://openalex.org/W2766580198","https://openalex.org/W2772546674","https://openalex.org/W2785048783","https://openalex.org/W2790443041","https://openalex.org/W2797846108","https://openalex.org/W2889086504","https://openalex.org/W2894256259","https://openalex.org/W3014699001","https://openalex.org/W3133063912","https://openalex.org/W3141563021","https://openalex.org/W6635877869","https://openalex.org/W6649725072","https://openalex.org/W6718544275","https://openalex.org/W6823580675"],"related_works":["https://openalex.org/W2150135482","https://openalex.org/W2064556624","https://openalex.org/W185871855","https://openalex.org/W827028078","https://openalex.org/W2006124873","https://openalex.org/W2050365681","https://openalex.org/W2428290426","https://openalex.org/W2039876497","https://openalex.org/W2038038404","https://openalex.org/W2339264923"],"abstract_inverted_index":{"The":[0,17,168],"multiple-breath":[1],"washout":[2,85,118],"(MBW)":[3],"is":[4,19,256],"a":[5,88,96,125,221,282],"lung":[6,29,97,109,127,153,187,219,266,287],"function":[7,288],"test":[8,18,43,86],"that":[9,40,99,198],"measures":[10],"the":[11,35,42,62,71,82,101,106,115,131,152,176,182,186,190,206,211,218,231,243,265,274,279],"degree":[12],"of":[13,70,75,108,137,151,175,205,214,245,262,273,286],"ventilation":[14],"inhomogeneity":[15],"(VI).":[16],"used":[20,58],"to":[21,59,94,129,146,172,258,270],"identify":[22],"small":[23],"airway":[24,157],"impairment":[25],"in":[26,79,87,135,200,217,264],"patients":[27],"with":[28,81,166],"diseases":[30],"like":[31],"cystic":[32],"fibrosis.":[33],"However,":[34],"physical":[36],"and":[37,45,67,104,111,148,159,178,188,202,229,267,289],"physiological":[38,68],"factors":[39],"influence":[41,223],"outcomes":[44],"differentiate":[46],"health":[47],"from":[48],"disease":[49],"are":[50],"not":[51],"well":[52,209],"understood.":[53],"Computational":[54],"models":[55],"have":[56,163],"been":[57,164],"better":[60],"understand":[61],"interaction":[63],"between":[64],"anatomical":[65],"structure":[66],"properties":[69,150],"lung,":[72],"but":[73],"none":[74],"them":[76,269],"has":[77],"dealt":[78],"depth":[80],"tracer":[83,116],"gas":[84,117,133,183,191,225],"whole.":[89],"Thus,":[90],"our":[91],"aim":[92],"was":[93],"create":[95],"model":[98,128,154],"simulates":[100],"entire":[102],"MBW":[103,232,275],"investigate":[105],"role":[107],"morphology":[110],"tissue":[112],"mechanics":[113],"on":[114,181,189,224,230,252],"procedure.":[119],"To":[120],"this":[121,215],"end,":[122],"we":[123],"developed":[124],"multi-scale":[126],"simulate":[130],"inert":[132],"transport":[134],"airways":[136,228],"all":[138],"size.":[139],"We":[140,196],"then":[141],"applied":[142,171],"systematically":[143],"different":[144,260],"modifications":[145,169],"geometrical":[147],"mechanical":[149],"(compliance,":[155],"residual":[156,203],"volume":[158,204],"flow":[160,247],"resistance)":[161],"which":[162,277],"associated":[165],"VI.":[167],"were":[170,194,249],"distinct":[173],"parts":[174],"model,":[177],"their":[179],"effects":[180,244],"distribution":[184,213,226],"within":[185],"concentration":[192,237],"profile":[193,238],"assessed.":[195],"found":[197],"variability":[199,216],"compliance":[201],"airways,":[207],"as":[208,210],"spatial":[212],"had":[220],"direct":[222],"among":[227],"pattern":[233],"(washout":[234],"duration,":[235],"characteristic":[236],"during":[239],"each":[240],"expiration),":[241],"while":[242],"variable":[246],"resistance":[248],"negligible.":[250],"Based":[251],"these":[253],"findings,":[254],"it":[255],"possible":[257],"classify":[259],"types":[261],"inhomogeneities":[263],"relate":[268],"specific":[271],"features":[272],"pattern,":[276],"builds":[278],"basis":[280],"for":[281],"more":[283],"detailed":[284],"association":[285],"structure.":[290]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
