{"id":"https://openalex.org/W2948038588","doi":"https://doi.org/10.1371/journal.pcbi.1007054","title":"Mathematical modelling reveals unexpected inheritance and variability patterns of cell cycle parameters in mammalian cells","display_name":"Mathematical modelling reveals unexpected inheritance and variability patterns of cell cycle parameters in mammalian cells","publication_year":2019,"publication_date":"2019-06-03","ids":{"openalex":"https://openalex.org/W2948038588","doi":"https://doi.org/10.1371/journal.pcbi.1007054","mag":"2948038588","pmid":"https://pubmed.ncbi.nlm.nih.gov/31158226"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007054","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007054","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007054&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007054&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008389298","display_name":"Marzena Mura","orcid":"https://orcid.org/0000-0002-8482-3439"},"institutions":[{"id":"https://openalex.org/I119004910","display_name":"Silesian University of Technology","ror":"https://ror.org/02dyjk442","country_code":"PL","type":"education","lineage":["https://openalex.org/I119004910"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Marzena Mura","raw_affiliation_strings":["Ardigen, Krakow, Poland","System Engineering Group, Silesian University of Technology, Gliwice, Poland"],"affiliations":[{"raw_affiliation_string":"Ardigen, Krakow, Poland","institution_ids":[]},{"raw_affiliation_string":"System Engineering Group, Silesian University of Technology, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071435528","display_name":"C\u00e9line Feillet","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Feillet","raw_affiliation_strings":["Universit\u00e9 C\u00f4te d'Azur, CNRS, INSERM, iBV, Nice, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, CNRS, INSERM, iBV, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105777045","display_name":"Roberto Bertolusso","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Bertolusso","raw_affiliation_strings":["Department of Statistics, Rice University, Houston, TX, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Statistics, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010951327","display_name":"Franck Delaunay","orcid":"https://orcid.org/0000-0003-4927-1701"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Delaunay","raw_affiliation_strings":["Universit\u00e9 C\u00f4te d'Azur, CNRS, INSERM, iBV, Nice, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 C\u00f4te d'Azur, CNRS, INSERM, iBV, Nice, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071222148","display_name":"Marek Kimmel","orcid":"https://orcid.org/0000-0001-8161-890X"},"institutions":[{"id":"https://openalex.org/I119004910","display_name":"Silesian University of Technology","ror":"https://ror.org/02dyjk442","country_code":"PL","type":"education","lineage":["https://openalex.org/I119004910"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["PL","US"],"is_corresponding":true,"raw_author_name":"Marek Kimmel","raw_affiliation_strings":["Department of Bioengineering, Rice University, Houston, TX, United States of America","Department of Statistics, Rice University, Houston, TX, United States of America","System Engineering Group, Silesian University of Technology, Gliwice, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Statistics, Rice University, Houston, TX, United States of America","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"System Engineering Group, Silesian University of Technology, Gliwice, Poland","institution_ids":["https://openalex.org/I119004910"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008389298","https://openalex.org/A5071222148"],"corresponding_institution_ids":["https://openalex.org/I119004910","https://openalex.org/I74775410"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3742,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.81084345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"6","first_page":"e1007054","last_page":"e1007054"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.8093055486679077},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6706986427307129},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.640244722366333},{"id":"https://openalex.org/keywords/inheritance","display_name":"Inheritance (genetic algorithm)","score":0.5993960499763489},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.5265306234359741},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5071852207183838},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.4733835756778717},{"id":"https://openalex.org/keywords/cell-synchronization","display_name":"Cell synchronization","score":0.4615516662597656},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4192522466182709},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3789987564086914},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3474240303039551},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07822790741920471}],"concepts":[{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.8093055486679077},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6706986427307129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.640244722366333},{"id":"https://openalex.org/C2780902518","wikidata":"https://www.wikidata.org/wiki/Q6033780","display_name":"Inheritance (genetic algorithm)","level":3,"score":0.5993960499763489},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5265306234359741},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5071852207183838},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4733835756778717},{"id":"https://openalex.org/C88254577","wikidata":"https://www.wikidata.org/wiki/Q17113282","display_name":"Cell synchronization","level":4,"score":0.4615516662597656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4192522466182709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3789987564086914},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3474240303039551},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07822790741920471},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1007054","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007054","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007054&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31158226","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31158226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:inserm-02275878v1","is_oa":false,"landing_page_url":"https://inserm.hal.science/inserm-02275878","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2019, 15 (6), pp.e1007054. &#x27E8;10.1371/journal.pcbi.1007054&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1007054","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007054","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:396270e48b514226aa373462281b0da3","is_oa":true,"landing_page_url":"https://doaj.org/article/396270e48b514226aa373462281b0da3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 6, p e1007054 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8219177","is_oa":true,"landing_page_url":"https://figshare.com/articles/Mathematical_modelling_reveals_unexpected_inheritance_and_variability_patterns_of_cell_cycle_parameters_in_mammalian_cells/8219177","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6564046","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6564046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007054","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007054","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007054&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G1301437160","display_name":null,"funder_award_id":"R01HL128173","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3451378258","display_name":null,"funder_award_id":"ANR-14-CE09-0011","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3635314633","display_name":null,"funder_award_id":"11-LABX-0028-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3710251737","display_name":null,"funder_award_id":"-11-LABX-0028-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3807293409","display_name":null,"funder_award_id":"ANR-11-LABX-00","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4385100381","display_name":null,"funder_award_id":"R01HL128173","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G5356259312","display_name":null,"funder_award_id":"DEC-2016/21/B/ST7/02241","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"},{"id":"https://openalex.org/G799220982","display_name":null,"funder_award_id":"ANR-11-LABX-0028-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8533281491","display_name":null,"funder_award_id":"ANR-11-LABX-0028","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G978173046","display_name":null,"funder_award_id":"ANR-11-LABX-0028-0","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2948038588.pdf","grobid_xml":"https://content.openalex.org/works/W2948038588.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W657662949","https://openalex.org/W1523572153","https://openalex.org/W1533862883","https://openalex.org/W1760865464","https://openalex.org/W1891946346","https://openalex.org/W1912710617","https://openalex.org/W1914412773","https://openalex.org/W1932965419","https://openalex.org/W1965766641","https://openalex.org/W1982339431","https://openalex.org/W1982396530","https://openalex.org/W1991216151","https://openalex.org/W1993399361","https://openalex.org/W2009390821","https://openalex.org/W2019078072","https://openalex.org/W2022732247","https://openalex.org/W2026442742","https://openalex.org/W2034001474","https://openalex.org/W2035681961","https://openalex.org/W2044721366","https://openalex.org/W2050826226","https://openalex.org/W2052962361","https://openalex.org/W2055631421","https://openalex.org/W2059053384","https://openalex.org/W2063926640","https://openalex.org/W2064670731","https://openalex.org/W2067598073","https://openalex.org/W2067635737","https://openalex.org/W2077029264","https://openalex.org/W2077046573","https://openalex.org/W2077496900","https://openalex.org/W2088849679","https://openalex.org/W2093470850","https://openalex.org/W2105670702","https://openalex.org/W2108835820","https://openalex.org/W2115596355","https://openalex.org/W2121288817","https://openalex.org/W2126389045","https://openalex.org/W2136714385","https://openalex.org/W2137088684","https://openalex.org/W2144758087","https://openalex.org/W2145246556","https://openalex.org/W2145261392","https://openalex.org/W2146638375","https://openalex.org/W2153777689","https://openalex.org/W2171280873","https://openalex.org/W2177689130","https://openalex.org/W2221403599","https://openalex.org/W2276286733","https://openalex.org/W2300371779","https://openalex.org/W2317397744","https://openalex.org/W2508891881","https://openalex.org/W2509925455","https://openalex.org/W2560439679","https://openalex.org/W2578839378","https://openalex.org/W2579382924","https://openalex.org/W2586808014","https://openalex.org/W2744312029","https://openalex.org/W2760987689","https://openalex.org/W2799002609","https://openalex.org/W2809000676","https://openalex.org/W2979548144","https://openalex.org/W4230641760","https://openalex.org/W4240458502","https://openalex.org/W4247000077","https://openalex.org/W6828211613"],"related_works":["https://openalex.org/W2406488385","https://openalex.org/W2012898143","https://openalex.org/W4253596993","https://openalex.org/W1996121326","https://openalex.org/W4200203052","https://openalex.org/W2623248147","https://openalex.org/W2033498500","https://openalex.org/W4200508235","https://openalex.org/W1568471853","https://openalex.org/W2521560206"],"abstract_inverted_index":{"The":[0],"cell":[1,8,25,63,74,79,102,111,192,222,226,259],"cycle":[2,21,64,193,227],"is":[3,11,27,57,67],"the":[4,53,59,62,73,83,176,179,217,236,240,267],"fundamental":[5],"process":[6],"of":[7,36,52,97,114,124,126,150,154,182,191,219,233,242,246,258,269],"populations,":[9],"it":[10],"regulated":[12],"by":[13,17,29,210],"environmental":[14],"cues":[15],"and":[16,44,75,104,130,152,157,185],"intracellular":[18],"checkpoints.":[19],"Cell":[20],"variability":[22],"in":[23,49,82,107,172,249],"clonal":[24],"population":[26,80,199],"caused":[28],"stochastic":[30],"processes":[31],"such":[32],"as":[33,273,283],"random":[34,45],"partitioning":[35,151],"cellular":[37],"components":[38],"to":[39,69,121,147,163,206,239,265],"progeny":[40,218],"cells":[41,99,117,251,271],"at":[42,61],"division":[43],"interactions":[46],"among":[47,213],"biomolecules":[48],"cells.":[50,214],"One":[51],"important":[54,196,253],"biological":[55],"questions":[56],"how":[58],"dynamics":[60],"scale,":[65],"which":[66,261,278],"related":[68],"family":[70,211],"dependencies":[71],"between":[72],"its":[76],"descendants,":[77],"affects":[78],"behavior":[81],"long-run.":[84],"We":[85,109,201],"address":[86],"this":[87],"question":[88],"using":[89],"a":[90,140,220,224,230],"\"mechanistic\"":[91],"model,":[92,143],"built":[93],"based":[94],"on":[95,135],"observations":[96,113],"single":[98,221],"over":[100],"several":[101],"generations,":[103],"then":[105],"extrapolated":[106],"time.":[108],"used":[110],"pedigree":[112],"NIH":[115],"3T3":[116],"including":[118],"FUCCI":[119],"markers,":[120],"determine":[122],"patterns":[123],"inheritance":[125,153],"cell-cycle":[127,243],"phase":[128],"durations":[129],"single-cell":[131,165],"protein":[132,166],"dynamics.":[133,167],"Based":[134],"that":[136],"information":[137],"we":[138],"developed":[139],"hybrid":[141],"mathematical":[142],"involving":[144],"bifurcating":[145],"autoregression":[146],"describe":[148],"stochasticity":[149],"cell-cycle-phase":[155],"times,":[156],"an":[158,203],"ordinary":[159],"differential":[160],"equation":[161],"system":[162],"capture":[164],"Long-term":[168],"simulations,":[169],"concordant":[170],"with":[171,223],"vitro":[173],"experiments,":[174],"demonstrated":[175],"model":[177],"reproduced":[178],"main":[180],"features":[181],"our":[183],"data":[184],"had":[186,229],"homeostatic":[187],"properties.":[188],"Moreover,":[189],"heterogeneity":[190],"may":[194],"have":[195],"consequences":[197],"during":[198],"development.":[200],"discovered":[202],"effect":[204],"similar":[205],"genetic":[207],"drift,":[208],"amplified":[209],"relationships":[212],"In":[215],"consequence,":[216],"short":[225],"time":[228],"high":[231],"probability":[232],"eventually":[234],"dominating":[235],"population,":[237],"due":[238],"heritability":[241,248],"phases.":[244],"Patterns":[245],"epigenetic":[247],"proliferating":[250,280],"are":[252,262],"for":[254],"understanding":[255],"long-term":[256],"trends":[257],"populations":[260],"either":[263],"required":[264],"provide":[266],"influx":[268],"maturing":[270],"(such":[272,282],"hematopoietic":[274],"stem":[275],"cells)":[276],"or":[277],"started":[279],"uncontrollably":[281],"cancer":[284],"cells).":[285]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}
