{"id":"https://openalex.org/W2953195626","doi":"https://doi.org/10.1371/journal.pcbi.1007053","title":"Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model","display_name":"Metabolic reprogramming dynamics in tumor spheroids: Insights from a multicellular, multiscale model","publication_year":2019,"publication_date":"2019-06-11","ids":{"openalex":"https://openalex.org/W2953195626","doi":"https://doi.org/10.1371/journal.pcbi.1007053","mag":"2953195626","pmid":"https://pubmed.ncbi.nlm.nih.gov/31185009"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007053","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007053","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007053&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007053&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114043070","display_name":"Mahua Roy","orcid":"https://orcid.org/0000-0001-9226-8044"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahua Roy","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067702764","display_name":"Stacey D. Finley","orcid":"https://orcid.org/0000-0001-6901-3692"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stacey D. Finley","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States of America","Mork Family Department of Chemical Engineering and Materials Science; Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America","Mork Family Department of Chemical Engineering and Materials Science","Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Mork Family Department of Chemical Engineering and Materials Science; Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Mork Family Department of Chemical Engineering and Materials Science","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067702764"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.2048,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.87539936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"15","issue":"6","first_page":"e1007053","last_page":"e1007053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9825999736785889,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.6493771076202393},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.6312813758850098},{"id":"https://openalex.org/keywords/reprogramming","display_name":"Reprogramming","score":0.5952959060668945},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4887964427471161},{"id":"https://openalex.org/keywords/spheroid","display_name":"Spheroid","score":0.4847843050956726},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.47236186265945435},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.43509501218795776},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3787480890750885},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35335761308670044},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.32367587089538574},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.30526697635650635},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3000144958496094},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.26422134041786194},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16462135314941406},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12878203392028809}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6493771076202393},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6312813758850098},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5952959060668945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4887964427471161},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.4847843050956726},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.47236186265945435},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.43509501218795776},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3787480890750885},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35335761308670044},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32367587089538574},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30526697635650635},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3000144958496094},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26422134041786194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16462135314941406},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12878203392028809}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007053","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007053","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007053&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31185009","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31185009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007053","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007053","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:1e57be5f5c294ac1a4d4b937cbcb4aab","is_oa":true,"landing_page_url":"https://doaj.org/article/1e57be5f5c294ac1a4d4b937cbcb4aab","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 6, p e1007053 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8257277","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Metabolic_reprogramming_dynamics_in_tumor_spheroids_Insights_from_a_multicellular_multiscale_model/8257277","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6588258","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6588258","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007053","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007053","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007053&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5299999713897705,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315928","display_name":"Rose Hills Foundation","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953195626.pdf","grobid_xml":"https://content.openalex.org/works/W2953195626.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W115452890","https://openalex.org/W654451863","https://openalex.org/W1601923831","https://openalex.org/W1970924670","https://openalex.org/W1976144045","https://openalex.org/W1982147183","https://openalex.org/W1986413939","https://openalex.org/W1987012261","https://openalex.org/W1996269383","https://openalex.org/W1998266575","https://openalex.org/W2002785668","https://openalex.org/W2003652177","https://openalex.org/W2009913017","https://openalex.org/W2014768395","https://openalex.org/W2014988241","https://openalex.org/W2017692688","https://openalex.org/W2020644315","https://openalex.org/W2025183054","https://openalex.org/W2028249595","https://openalex.org/W2028897202","https://openalex.org/W2040163651","https://openalex.org/W2043946038","https://openalex.org/W2043967411","https://openalex.org/W2048652043","https://openalex.org/W2049471028","https://openalex.org/W2055683591","https://openalex.org/W2058434720","https://openalex.org/W2066580949","https://openalex.org/W2067256262","https://openalex.org/W2069598084","https://openalex.org/W2075058338","https://openalex.org/W2078355959","https://openalex.org/W2079492355","https://openalex.org/W2082948758","https://openalex.org/W2089362240","https://openalex.org/W2099291727","https://openalex.org/W2100658881","https://openalex.org/W2105054044","https://openalex.org/W2107975811","https://openalex.org/W2113906101","https://openalex.org/W2115124692","https://openalex.org/W2117912210","https://openalex.org/W2125857415","https://openalex.org/W2127225632","https://openalex.org/W2128558411","https://openalex.org/W2128860199","https://openalex.org/W2146839980","https://openalex.org/W2147212734","https://openalex.org/W2148328262","https://openalex.org/W2149006989","https://openalex.org/W2150575159","https://openalex.org/W2154028705","https://openalex.org/W2156289700","https://openalex.org/W2156476088","https://openalex.org/W2165429151","https://openalex.org/W2167537549","https://openalex.org/W2171157655","https://openalex.org/W2241116293","https://openalex.org/W2288284086","https://openalex.org/W2562182278","https://openalex.org/W2568414132","https://openalex.org/W2586972149","https://openalex.org/W2592319176","https://openalex.org/W2598266532","https://openalex.org/W2601780395","https://openalex.org/W2728992026","https://openalex.org/W2729334679","https://openalex.org/W2737046088","https://openalex.org/W2788617782","https://openalex.org/W2789529658","https://openalex.org/W2883266145","https://openalex.org/W2903482389","https://openalex.org/W2949331010","https://openalex.org/W2964182357","https://openalex.org/W3134530972","https://openalex.org/W4211208840","https://openalex.org/W4211215109","https://openalex.org/W4211247063","https://openalex.org/W4255002869","https://openalex.org/W4385374602","https://openalex.org/W6652868496"],"related_works":["https://openalex.org/W2050956753","https://openalex.org/W2184533732","https://openalex.org/W2034330200","https://openalex.org/W3045873720","https://openalex.org/W3046890897","https://openalex.org/W2906127908","https://openalex.org/W2408054456","https://openalex.org/W2906198848","https://openalex.org/W4207051211","https://openalex.org/W1981684516"],"abstract_inverted_index":{"Mathematical":[0],"modeling":[1],"provides":[2,278],"the":[3,8,48,63,85,90,104,110,119,137,143,159,162,176,200,217,220,243,251,254,268,276,282,289,299],"predictive":[4],"ability":[5],"to":[6,29,35,112,121,149,216,237,250,262,294,305],"understand":[7],"metabolic":[9,208,296,308],"reprogramming":[10,284],"and":[11,44,79,114,117,124,167,184,210,266],"complex":[12],"pathways":[13],"that":[14,182,213],"mediate":[15],"cancer":[16,150],"cells'":[17],"proliferation.":[18],"We":[19],"present":[20],"a":[21,25,58,66,95,132,171,207,223,257,302],"mathematical":[22],"model":[23,39,98,158,177,195,244,277,300],"using":[24],"multiscale,":[26],"multicellular":[27,190],"approach":[28,71],"simulate":[30],"avascular":[31,180],"tumor":[32,163,174,181,191,221,255,264,286,312],"growth,":[33,152,265],"applied":[34],"pancreatic":[36],"cancer.":[37],"The":[38,225],"spans":[40],"three":[41],"distinct":[42],"spatial":[43],"temporal":[45],"scales.":[46],"At":[47,62,89],"extracellular":[49],"level,":[50,65,92],"reaction":[51],"diffusion":[52],"equations":[53],"describe":[54],"nutrient":[55],"concentrations":[56,144],"over":[57],"span":[59],"of":[60,87,99,106,136,145,161,173,189,202,219,228,253,270,285],"seconds.":[61],"cellular":[64,73],"lattice-based":[67],"energy":[68,123],"driven":[69],"stochastic":[70],"describes":[72],"phenomena":[74],"including":[75],"adhesion,":[76],"proliferation,":[77],"viability":[78],"cell":[80,128,151],"state":[81],"transitions,":[82],"occurring":[83],"on":[84,103],"timescale":[86,105],"hours.":[88],"sub-cellular":[91],"we":[93,157,197],"incorporate":[94],"detailed":[96],"kinetic":[97],"intracellular":[100,146,204,229,290],"metabolite":[101],"dynamics":[102],"minutes,":[107],"which":[108],"enables":[109],"cells":[111,287],"uptake":[113],"excrete":[115],"metabolites":[116,120,147,230],"use":[118],"generate":[122],"building":[125],"blocks":[126],"for":[127,142,310],"growth.":[129,313],"This":[130],"is":[131,301],"particularly":[133],"novel":[134,247],"aspect":[135],"model.":[138],"Certain":[139],"defined":[140],"criteria":[141],"lead":[148],"proliferation":[153],"or":[154],"death.":[155],"Overall,":[156,298],"evolution":[160],"in":[164,292],"both":[165],"time":[166],"space.":[168],"Starting":[169],"with":[170,239],"cluster":[172],"cells,":[175],"produces":[178],"an":[179],"quantitatively":[183],"qualitatively":[185],"mimics":[186],"experimental":[187,240],"measurements":[188],"spheroids.":[192],"Through":[193],"our":[194],"simulations,":[196],"can":[198,245],"investigate":[199,211],"response":[201,214,218,227,252,293],"individual":[203],"species":[205],"under":[206,231],"perturbation":[209],"how":[212],"contributes":[215],"as":[222,249,256],"whole.":[224],"predicted":[226],"various":[232],"targeted":[233,307],"strategies":[234,309],"are":[235],"difficult":[236],"resolve":[238],"techniques.":[241],"Thus,":[242],"give":[246],"predictions":[248],"whole,":[258],"identifies":[259],"potential":[260],"therapies":[261],"impede":[263],"predicts":[267],"effects":[269],"those":[271],"therapeutic":[272],"strategies.":[273],"In":[274],"particular,":[275],"quantitative":[279],"insight":[280],"into":[281],"dynamic":[283],"at":[288],"level":[291],"specific":[295],"perturbations.":[297],"useful":[303],"framework":[304],"study":[306],"inhibiting":[311]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
