{"id":"https://openalex.org/W2948866156","doi":"https://doi.org/10.1371/journal.pcbi.1007034","title":"Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance","display_name":"Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance","publication_year":2019,"publication_date":"2019-06-05","ids":{"openalex":"https://openalex.org/W2948866156","doi":"https://doi.org/10.1371/journal.pcbi.1007034","mag":"2948866156","pmid":"https://pubmed.ncbi.nlm.nih.gov/31166947"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007034","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007034","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1007034","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073047339","display_name":"Yapeng Su","orcid":"https://orcid.org/0000-0002-6305-8467"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yapeng Su","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","Institute for Systems Biology, Seattle, Washington, United State of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, Washington, United State of America","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061126135","display_name":"Marcus Bintz","orcid":"https://orcid.org/0000-0002-4548-3953"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Bintz","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America"],"raw_orcid":"https://orcid.org/0000-0002-4548-3953","affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529","https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005560079","display_name":"Yezi Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yezi Yang","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529","https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113880034","display_name":"L\u00eddia Robert","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lidia Robert","raw_affiliation_strings":["Department of Medicine, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Medicine, University of California \u2013 Los Angeles, Los Angeles, California, United State of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529"]},{"raw_affiliation_string":"Department of Medicine, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013465269","display_name":"Alphonsus H. C. Ng","orcid":"https://orcid.org/0000-0003-0074-4598"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alphonsus H. C. Ng","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","Institute for Systems Biology, Seattle, Washington, United State of America"],"raw_orcid":"https://orcid.org/0000-0003-0074-4598","affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, Washington, United State of America","institution_ids":["https://openalex.org/I3148997608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473306","display_name":"Victoria Liu","orcid":"https://orcid.org/0000-0003-1845-2497"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Liu","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America"],"raw_orcid":"https://orcid.org/0000-0003-1845-2497","affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083745558","display_name":"Antoni Ribas","orcid":"https://orcid.org/0000-0003-3669-8458"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antoni Ribas","raw_affiliation_strings":["Department of Medicine, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Surgery, Division of Surgical-Oncology, University of California - Los Angeles, Los Angeles, California, United State of America","Jonsson Comprehensive Cancer Center, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","Department of Medicine, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","Department of Surgery, Division of Surgical-Oncology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","Jonsson Comprehensive Cancer Center, University of California \u2013 Los Angeles, Los Angeles, California, United State of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529","https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Department of Surgery, Division of Surgical-Oncology, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Surgery, Division of Surgical-Oncology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032990625","display_name":"James R. Heath","orcid":"https://orcid.org/0000-0001-5356-4385"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James R. Heath","raw_affiliation_strings":["Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","Institute for Systems Biology, Seattle, Washington, United State of America","Jonsson Comprehensive Cancer Center, University of California - Los Angeles, Los Angeles, California, United State of America","Jonsson Comprehensive Cancer Center, University of California \u2013 Los Angeles, Los Angeles, California, United State of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United State of America","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, Washington, United State of America","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100323681","display_name":"Wei Wei","orcid":"https://orcid.org/0000-0002-1018-7708"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I27825529","display_name":"California State University Los Angeles","ror":"https://ror.org/0294hxs80","country_code":"US","type":"education","lineage":["https://openalex.org/I27825529"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4210096972","display_name":"Los Angeles Medical Center","ror":"https://ror.org/00spys463","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210096972"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Wei","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","Institute for Systems Biology, Seattle, Washington, United State of America","Jonsson Comprehensive Cancer Center, University of California - Los Angeles, Los Angeles, California, United State of America","Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","Jonsson Comprehensive Cancer Center, University of California \u2013 Los Angeles, Los Angeles, California, United State of America"],"raw_orcid":"https://orcid.org/0000-0002-1018-7708","affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529","https://openalex.org/I4210096972"]},{"raw_affiliation_string":"Institute for Systems Biology, Seattle, Washington, United State of America","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California - Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I27825529"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California \u2013 Los Angeles, Los Angeles, California, United State of America","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5032990625","https://openalex.org/A5100323681"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I161318765","https://openalex.org/I27825529","https://openalex.org/I3148997608","https://openalex.org/I4210096972","https://openalex.org/I4390039293"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.0771,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.92504374,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"15","issue":"6","first_page":"e1007034","last_page":"e1007034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7268355488777161},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6498323082923889},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5995897650718689},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5818547010421753},{"id":"https://openalex.org/keywords/reprogramming","display_name":"Reprogramming","score":0.5475072860717773},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5288007259368896},{"id":"https://openalex.org/keywords/phenotypic-plasticity","display_name":"Phenotypic plasticity","score":0.5094910264015198},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4542461335659027},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.44989436864852905},{"id":"https://openalex.org/keywords/somatic-evolution-in-cancer","display_name":"Somatic evolution in cancer","score":0.42571714520454407},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42295798659324646},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.31862592697143555},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.14187148213386536},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.0989348292350769},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08188784122467041}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7268355488777161},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6498323082923889},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5995897650718689},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5818547010421753},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5475072860717773},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5288007259368896},{"id":"https://openalex.org/C62277055","wikidata":"https://www.wikidata.org/wiki/Q295130","display_name":"Phenotypic plasticity","level":2,"score":0.5094910264015198},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4542461335659027},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.44989436864852905},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.42571714520454407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42295798659324646},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31862592697143555},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14187148213386536},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0989348292350769},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08188784122467041},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1007034","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007034","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31166947","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31166947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:authors.library.caltech.edu:96227","is_oa":true,"landing_page_url":"https://resolver.caltech.edu/CaltechAUTHORS:20190610-083058080","pdf_url":null,"source":{"id":"https://openalex.org/S4306402161","display_name":"CaltechAUTHORS (California Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122411786","host_organization_name":"California Institute of Technology","host_organization_lineage":["https://openalex.org/I122411786"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:ark:/13030/qt93p3426s","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:224b492597864332a110e718ba95968a","is_oa":true,"landing_page_url":"https://doaj.org/article/224b492597864332a110e718ba95968a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 6, p e1007034 (2019)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt93p3426s","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/93p3426s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 15, iss 6","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8231387","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Phenotypic_heterogeneity_and_evolution_of_melanoma_cells_associated_with_targeted_therapy_resistance/8231387","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6576794","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6576794","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007034","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007034","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3694405428","display_name":null,"funder_award_id":"R35 CA197633","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5747086419","display_name":null,"funder_award_id":"U54 CA199090","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8672857517","display_name":null,"funder_award_id":"U01 CA217655","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306536","display_name":"V Foundation for Cancer Research","ror":"https://ror.org/00kbbk236"},{"id":"https://openalex.org/F4320310863","display_name":"Jean Perkins Foundation","ror":null},{"id":"https://openalex.org/F4320311870","display_name":"Banting Research Foundation","ror":"https://ror.org/05xe9t676"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1818450144","https://openalex.org/W1970283086","https://openalex.org/W1977776332","https://openalex.org/W1985928174","https://openalex.org/W1987681742","https://openalex.org/W1989696946","https://openalex.org/W1999327554","https://openalex.org/W2008322756","https://openalex.org/W2009888774","https://openalex.org/W2017277760","https://openalex.org/W2020685534","https://openalex.org/W2023396760","https://openalex.org/W2026679218","https://openalex.org/W2032558547","https://openalex.org/W2081820338","https://openalex.org/W2090432229","https://openalex.org/W2096027620","https://openalex.org/W2097948046","https://openalex.org/W2099257129","https://openalex.org/W2106391833","https://openalex.org/W2106507796","https://openalex.org/W2114592888","https://openalex.org/W2114903025","https://openalex.org/W2116376943","https://openalex.org/W2125505694","https://openalex.org/W2128542677","https://openalex.org/W2129375080","https://openalex.org/W2130410032","https://openalex.org/W2132853353","https://openalex.org/W2135523574","https://openalex.org/W2140729960","https://openalex.org/W2141458291","https://openalex.org/W2141545875","https://openalex.org/W2148541040","https://openalex.org/W2159675211","https://openalex.org/W2160879045","https://openalex.org/W2163530638","https://openalex.org/W2176599823","https://openalex.org/W2255670428","https://openalex.org/W2318400076","https://openalex.org/W2338391827","https://openalex.org/W2522954633","https://openalex.org/W2561012755","https://openalex.org/W2569342357","https://openalex.org/W2618841642","https://openalex.org/W2737272162","https://openalex.org/W2773011778","https://openalex.org/W2797906965","https://openalex.org/W2952938648","https://openalex.org/W2964314979","https://openalex.org/W3137661843","https://openalex.org/W6690348048"],"related_works":["https://openalex.org/W1631979401","https://openalex.org/W2395945797","https://openalex.org/W1497716427","https://openalex.org/W2129470469","https://openalex.org/W2368295610","https://openalex.org/W1543102035","https://openalex.org/W2946692299","https://openalex.org/W3014941007","https://openalex.org/W2183075003","https://openalex.org/W2990520546"],"abstract_inverted_index":{"Phenotypic":[0],"plasticity":[1,12],"is":[2,25],"associated":[3,73],"with":[4,74,127],"non-genetic":[5],"drug":[6,46,77,151],"tolerance":[7,152],"in":[8,32,40,158],"several":[9],"cancers.":[10],"Such":[11],"can":[13,42,198],"arise":[14],"from":[15],"chromatin":[16],"remodeling,":[17],"transcriptomic":[18],"reprogramming,":[19],"and/or":[20],"protein":[21],"signaling":[22],"rewiring,":[23],"and":[24,48,65,165,184],"characterized":[26],"as":[27,56,93],"a":[28,62,128,137],"cell":[29,54,91,168,186],"state":[30],"transition":[31,71],"response":[33],"to":[34,88],"molecular":[35],"or":[36],"physical":[37],"perturbations.":[38],"This,":[39],"turn,":[41],"confound":[43],"interpretations":[44],"of":[45,68,83,101,108,121,150,167,179,203],"responses":[47],"resistance":[49],"development.":[50,153],"Using":[51],"BRAF-mutant":[52],"melanoma":[53],"lines":[55],"the":[57,69,90,99,106,122,143,148,162,176,180,201],"prototype,":[58],"we":[59],"report":[60],"on":[61],"joint":[63],"theoretical":[64],"experimental":[66],"investigation":[67],"cell-state":[70],"dynamics":[72],"BRAF":[75],"inhibitor":[76],"tolerance.":[78],"Thermodynamically":[79],"motivated":[80],"surprisal":[81],"analysis":[82],"transcriptome":[84],"data":[85,120],"was":[86],"used":[87],"treat":[89],"population":[92,163],"an":[94,109],"entropy":[95],"maximizing":[96],"system":[97,124],"under":[98],"influence":[100],"time-dependent":[102],"constraints.":[103],"This":[104],"permits":[105,192],"extraction":[107],"epigenetic":[110,181],"potential":[111,182],"landscape":[112,183],"for":[113,142,175,189],"drug-induced":[114],"phenotypic":[115,144],"evolution.":[116],"Single-cell":[117],"flow":[118],"cytometry":[119],"same":[123],"were":[125],"modeled":[126],"modified":[129],"Fokker-Planck-type":[130],"kinetic":[131],"model.":[132],"The":[133,154],"two":[134],"approaches":[135],"yield":[136],"consistent":[138],"picture":[139],"that":[140,197],"accounts":[141],"heterogeneity":[145,164],"observed":[146],"over":[147],"course":[149],"results":[155],"reveal":[156],"that,":[157],"certain":[159],"plastic":[160],"cancers,":[161],"evolution":[166],"phenotypes":[169],"may":[170],"be":[171],"understood":[172],"by":[173],"accounting":[174],"competing":[177],"interactions":[178],"state-dependent":[185],"proliferation.":[187],"Accounting":[188],"such":[190],"competition":[191],"accurate,":[193],"experimentally":[194],"verifiable":[195],"predictions":[196],"potentially":[199],"guide":[200],"design":[202],"effective":[204],"treatment":[205],"strategies.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}