{"id":"https://openalex.org/W2996378307","doi":"https://doi.org/10.1371/journal.pcbi.1007010","title":"Revealing evolutionary constraints on proteins through sequence analysis","display_name":"Revealing evolutionary constraints on proteins through sequence analysis","publication_year":2019,"publication_date":"2019-04-24","ids":{"openalex":"https://openalex.org/W2996378307","doi":"https://doi.org/10.1371/journal.pcbi.1007010","mag":"2996378307","pmid":"https://pubmed.ncbi.nlm.nih.gov/31017888"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007010","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007010","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007010&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007010&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082415138","display_name":"Shou\u2010Wen Wang","orcid":"https://orcid.org/0000-0003-4569-1194"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210139958","display_name":"Beijing Computational Science Research Center","ror":"https://ror.org/04tavf782","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210139958"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Shou-Wen Wang","raw_affiliation_strings":["Beijing Computational Science Research Center, Beijing, China","Department of Engineering Physics, Tsinghua University, Beijing, China","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4569-1194","affiliations":[{"raw_affiliation_string":"Beijing Computational Science Research Center, Beijing, China","institution_ids":["https://openalex.org/I4210139958"]},{"raw_affiliation_string":"Department of Engineering Physics, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030010662","display_name":"Anne\u2010Florence Bitbol","orcid":"https://orcid.org/0000-0003-1020-494X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210094907","display_name":"Laboratoire Jean Perrin","ror":"https://ror.org/01ghvgs84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I4210094907","https://openalex.org/I4210098836"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne-Florence Bitbol","raw_affiliation_strings":["Sorbonne Universit\u00e9, CNRS, Laboratoire Jean Perrin (UMR 8237), F-75005 Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-1020-494X","affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9, CNRS, Laboratoire Jean Perrin (UMR 8237), F-75005 Paris, France","institution_ids":["https://openalex.org/I4210094907","https://openalex.org/I39804081","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071133192","display_name":"Ned S. Wingreen","orcid":"https://orcid.org/0000-0001-7384-2821"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ned S. Wingreen","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7384-2821","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030010662","https://openalex.org/A5071133192"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I20089843","https://openalex.org/I39804081","https://openalex.org/I4210094907"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6241,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.84373375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"4","first_page":"e1007010","last_page":"e1007010"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.7005674242973328},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.5781744122505188},{"id":"https://openalex.org/keywords/eigenvalues-and-eigenvectors","display_name":"Eigenvalues and eigenvectors","score":0.5744835734367371},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4784655272960663},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.468738853931427},{"id":"https://openalex.org/keywords/covariance","display_name":"Covariance","score":0.45250403881073},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.44242948293685913},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.43429118394851685},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42725273966789246},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4259444773197174},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4258020222187042},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4028816223144531},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2932952046394348},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2688482701778412},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.24689510464668274},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21857014298439026},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13739866018295288},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13217607140541077},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13047119975090027}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.7005674242973328},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.5781744122505188},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.5744835734367371},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4784655272960663},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.468738853931427},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.45250403881073},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.44242948293685913},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.43429118394851685},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42725273966789246},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4259444773197174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4258020222187042},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4028816223144531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2932952046394348},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2688482701778412},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.24689510464668274},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21857014298439026},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13739866018295288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13217607140541077},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13047119975090027},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1007010","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007010","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007010&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31017888","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31017888","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1808.07149","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1808.07149","pdf_url":"https://arxiv.org/pdf/1808.07149","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:HAL:hal-02143851v1","is_oa":false,"landing_page_url":"https://hal.sorbonne-universite.fr/hal-02143851","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2019, 15 (4), pp.e1007010. ⟨10.1371/journal.pcbi.1007010⟩","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1007010","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007010","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:72b06bdc22e64b1db121a801b60a854e","is_oa":true,"landing_page_url":"https://doaj.org/article/72b06bdc22e64b1db121a801b60a854e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 4, p e1007010 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8036279","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Revealing_evolutionary_constraints_on_proteins_through_sequence_analysis/8036279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400572","display_name":"OPAL (Open@LaTrobe) (La Trobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I196829312","host_organization_name":"La Trobe University","host_organization_lineage":["https://openalex.org/I196829312"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:infoscience.epfl.ch:276041","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/276041","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6502352","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6502352","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007010","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007010","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007010&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1436049641","display_name":null,"funder_award_id":"GM082938","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1716165675","display_name":"INSPIRE Track 1: Resolving and optogenetically perturbing biofilms at the single-cell level","funder_award_id":"1344191","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1926959221","display_name":null,"funder_award_id":"MCB-1344191","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2432923657","display_name":null,"funder_award_id":"1607611","funder_id":"https://openalex.org/F4320310042","funder_display_name":"Aspen Center for Physics"},{"id":"https://openalex.org/G3241809954","display_name":null,"funder_award_id":"1734030","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4065940845","display_name":null,"funder_award_id":"U1430237","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5812093873","display_name":null,"funder_award_id":"PHY-1734030","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6691923362","display_name":null,"funder_award_id":"PHY-1607611","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6770437020","display_name":null,"funder_award_id":"PHY-1734030","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6991164143","display_name":null,"funder_award_id":"PHY-1607611","funder_id":"https://openalex.org/F4320310042","funder_display_name":"Aspen Center for Physics"},{"id":"https://openalex.org/G7415471491","display_name":null,"funder_award_id":"R01 GM082938","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7751617623","display_name":null,"funder_award_id":"1607611","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8537064970","display_name":"\u6d3b\u6027\u7cfb\u7edf\u7684\u70ed\u8017\u6563\u53ca\u957f\u65f6\u52a8\u529b\u5b66","funder_award_id":"11635002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309292","display_name":"Princeton University","ror":"https://ror.org/00hx57361"},{"id":"https://openalex.org/F4320310042","display_name":"Aspen Center for Physics","ror":"https://ror.org/05gqcbq50"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996378307.pdf","grobid_xml":"https://content.openalex.org/works/W2996378307.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1501210482","https://openalex.org/W1548802052","https://openalex.org/W1575279605","https://openalex.org/W1792645488","https://openalex.org/W1861406683","https://openalex.org/W1979762151","https://openalex.org/W1987704449","https://openalex.org/W1990755770","https://openalex.org/W1995924392","https://openalex.org/W1999824974","https://openalex.org/W2001438084","https://openalex.org/W2008545402","https://openalex.org/W2009123297","https://openalex.org/W2014706477","https://openalex.org/W2024173659","https://openalex.org/W2039092135","https://openalex.org/W2048310584","https://openalex.org/W2053671774","https://openalex.org/W2053937911","https://openalex.org/W2054966400","https://openalex.org/W2061042699","https://openalex.org/W2065989745","https://openalex.org/W2069097920","https://openalex.org/W2080655845","https://openalex.org/W2085211779","https://openalex.org/W2092006899","https://openalex.org/W2092189458","https://openalex.org/W2092572492","https://openalex.org/W2096915408","https://openalex.org/W2108823152","https://openalex.org/W2111628752","https://openalex.org/W2115928493","https://openalex.org/W2121444044","https://openalex.org/W2134528197","https://openalex.org/W2137566700","https://openalex.org/W2142595184","https://openalex.org/W2145142882","https://openalex.org/W2147650094","https://openalex.org/W2151457629","https://openalex.org/W2245592118","https://openalex.org/W2308552187","https://openalex.org/W2342766640","https://openalex.org/W2378867027","https://openalex.org/W2402027820","https://openalex.org/W2471654536","https://openalex.org/W2485975781","https://openalex.org/W2519253539","https://openalex.org/W2592980396","https://openalex.org/W2596090231","https://openalex.org/W2744309759","https://openalex.org/W2769965731","https://openalex.org/W2772248591","https://openalex.org/W2790509526","https://openalex.org/W2798859743","https://openalex.org/W2806624193","https://openalex.org/W2883984694","https://openalex.org/W2949413139","https://openalex.org/W2949558459","https://openalex.org/W2949706399","https://openalex.org/W2950410860","https://openalex.org/W2951846698","https://openalex.org/W2952137452","https://openalex.org/W2952277428","https://openalex.org/W2952416773","https://openalex.org/W3099604145","https://openalex.org/W3102341076","https://openalex.org/W3103874809","https://openalex.org/W4211083646","https://openalex.org/W4297845480","https://openalex.org/W6785437593"],"related_works":["https://openalex.org/W2804480386","https://openalex.org/W2121560377","https://openalex.org/W2053803793","https://openalex.org/W2140187548","https://openalex.org/W3186624150","https://openalex.org/W1936662467","https://openalex.org/W2008335091","https://openalex.org/W2070753511","https://openalex.org/W2103210188","https://openalex.org/W4289175812"],"abstract_inverted_index":{"Statistical":[0],"analysis":[1],"of":[2,4,7,13,32,50,59,96,104,108,115,145,156,163,168,174],"alignments":[3],"large":[5],"numbers":[6],"protein":[8,20],"sequences":[9],"has":[10],"revealed":[11],"\"sectors\"":[12],"collectively":[14],"coevolving":[15],"amino":[16],"acids":[17],"in":[18,100,121],"several":[19],"families.":[21],"Here,":[22],"we":[23,54,70,90],"show":[24,71],"that":[25,72,92],"selection":[26,73],"acting":[27,74],"on":[28,75],"any":[29],"functional":[30,97,117,139,158],"property":[31],"a":[33,45,51,134],"protein,":[34],"represented":[35],"by":[36],"an":[37,48,60,65],"additive":[38],"trait,":[39,53],"can":[40],"give":[41],"rise":[42],"to":[43,79,132,137,160,171],"such":[44],"sector.":[46],"As":[47],"illustration":[49],"selected":[52,110,176],"consider":[55],"the":[56,93,101,105,109,122,143,154,166,172],"elastic":[57,66],"energy":[58,77],"important":[61],"conformational":[62],"change":[63],"within":[64],"network":[67],"model,":[68],"and":[69,87,165],"this":[76,84],"leads":[78,130],"correlations":[80],"among":[81],"residues.":[82],"For":[83],"concrete":[85],"example":[86],"more":[88],"generally,":[89],"demonstrate":[91,153],"main":[94],"signature":[95],"sectors":[98,118,159],"lies":[99],"small-eigenvalue":[102],"modes":[103],"covariance":[106],"matrix":[107],"sequences.":[111],"However,":[112],"secondary":[113],"signatures":[114],"these":[116,157],"also":[119],"exist":[120],"extensively-studied":[123],"large-eigenvalue":[124],"modes.":[125],"Our":[126],"simple,":[127],"general":[128],"model":[129],"us":[131],"propose":[133],"principled":[135],"method":[136],"identify":[138],"sectors,":[140],"along":[141],"with":[142],"magnitudes":[144],"mutational":[146],"effects,":[147],"from":[148],"sequence":[149],"data.":[150],"We":[151],"further":[152],"robustness":[155,167],"various":[161],"forms":[162],"selection,":[164],"our":[169],"approach":[170],"identification":[173],"multiple":[175],"traits.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-10-10T00:00:00"}