{"id":"https://openalex.org/W2979118233","doi":"https://doi.org/10.1371/journal.pcbi.1006993","title":"Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations","display_name":"Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations","publication_year":2019,"publication_date":"2019-10-07","ids":{"openalex":"https://openalex.org/W2979118233","doi":"https://doi.org/10.1371/journal.pcbi.1006993","mag":"2979118233","pmid":"https://pubmed.ncbi.nlm.nih.gov/31589597"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006993","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006993&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006993&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073405188","display_name":"Carmichael Ong","orcid":"https://orcid.org/0000-0002-0589-5347"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carmichael F. Ong","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0589-5347","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085265756","display_name":"Thomas Geijtenbeek","orcid":"https://orcid.org/0000-0001-8352-8107"},"institutions":[{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Thomas Geijtenbeek","raw_affiliation_strings":["Department of Biomechatronics & Human-Machine Control, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomechatronics & Human-Machine Control, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064748489","display_name":"Jennifer L. Hicks","orcid":"https://orcid.org/0000-0002-2516-9334"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jennifer L. Hicks","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-2516-9334","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044061507","display_name":"Scott L. Delp","orcid":"https://orcid.org/0000-0002-9643-7551"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott L. Delp","raw_affiliation_strings":["Department of Bioengineering, Stanford University, Stanford, California, United States of America","Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America","Department of Orthopaedic Surgery, Stanford University, Stanford, California, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9643-7551","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044061507","https://openalex.org/A5064748489","https://openalex.org/A5073405188","https://openalex.org/A5085265756"],"corresponding_institution_ids":["https://openalex.org/I97018004","https://openalex.org/I98358874"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.3367,"has_fulltext":true,"cited_by_count":195,"citation_normalized_percentile":{"value":0.98200363,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"15","issue":"10","first_page":"e1006993","last_page":"e1006993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11097","display_name":"Cerebral Palsy and Movement Disorders","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11023","display_name":"Prosthetics and Rehabilitation Robotics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gait","display_name":"Gait","score":0.8033586740493774},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.7043792009353638},{"id":"https://openalex.org/keywords/ankle","display_name":"Ankle","score":0.6647233366966248},{"id":"https://openalex.org/keywords/gait-analysis","display_name":"Gait analysis","score":0.6223961114883423},{"id":"https://openalex.org/keywords/contracture","display_name":"Contracture","score":0.619668185710907},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"Muscle weakness","score":0.547474205493927},{"id":"https://openalex.org/keywords/cerebral-palsy","display_name":"Cerebral palsy","score":0.5347662568092346},{"id":"https://openalex.org/keywords/kinematics","display_name":"Kinematics","score":0.5174544453620911},{"id":"https://openalex.org/keywords/ground-reaction-force","display_name":"Ground reaction force","score":0.5039662718772888},{"id":"https://openalex.org/keywords/joint-contracture","display_name":"Joint Contracture","score":0.4619048237800598},{"id":"https://openalex.org/keywords/preferred-walking-speed","display_name":"Preferred walking speed","score":0.45763519406318665},{"id":"https://openalex.org/keywords/weakness","display_name":"Weakness","score":0.434388667345047},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38643190264701843},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.35615313053131104},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18329590559005737},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.14001601934432983},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.10116025805473328}],"concepts":[{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.8033586740493774},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.7043792009353638},{"id":"https://openalex.org/C2778640784","wikidata":"https://www.wikidata.org/wiki/Q168002","display_name":"Ankle","level":2,"score":0.6647233366966248},{"id":"https://openalex.org/C173906292","wikidata":"https://www.wikidata.org/wiki/Q1493441","display_name":"Gait analysis","level":3,"score":0.6223961114883423},{"id":"https://openalex.org/C2776937108","wikidata":"https://www.wikidata.org/wiki/Q1480291","display_name":"Contracture","level":2,"score":0.619668185710907},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.547474205493927},{"id":"https://openalex.org/C2779421357","wikidata":"https://www.wikidata.org/wiki/Q210427","display_name":"Cerebral palsy","level":2,"score":0.5347662568092346},{"id":"https://openalex.org/C39920418","wikidata":"https://www.wikidata.org/wiki/Q11476","display_name":"Kinematics","level":2,"score":0.5174544453620911},{"id":"https://openalex.org/C96332660","wikidata":"https://www.wikidata.org/wiki/Q5610971","display_name":"Ground reaction force","level":3,"score":0.5039662718772888},{"id":"https://openalex.org/C2909908917","wikidata":"https://www.wikidata.org/wiki/Q1480291","display_name":"Joint Contracture","level":3,"score":0.4619048237800598},{"id":"https://openalex.org/C70770792","wikidata":"https://www.wikidata.org/wiki/Q7239848","display_name":"Preferred walking speed","level":2,"score":0.45763519406318665},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.434388667345047},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38643190264701843},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.35615313053131104},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18329590559005737},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.14001601934432983},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.10116025805473328},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077107","descriptor_name":"Gait Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000077107","descriptor_name":"Gait Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000077107","descriptor_name":"Gait Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000842","descriptor_name":"Ankle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000842","descriptor_name":"Ankle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000842","descriptor_name":"Ankle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005544","descriptor_name":"Forecasting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016138","descriptor_name":"Walking","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016138","descriptor_name":"Walking","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016138","descriptor_name":"Walking","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018908","descriptor_name":"Muscle Weakness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018908","descriptor_name":"Muscle Weakness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018908","descriptor_name":"Muscle Weakness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006993","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006993&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31589597","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31589597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1006993","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006993","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7d1d62ec971849e986528644de72c1a9","is_oa":true,"landing_page_url":"https://doaj.org/article/7d1d62ec971849e986528644de72c1a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 10, p e1006993 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/9946175","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Predicting_gait_adaptations_due_to_ankle_plantarflexor_muscle_weakness_and_contracture_using_physics-based_musculoskeletal_simulations/9946175","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6797212","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6797212","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:tudelft.nl:uuid:9b5c9a0c-fd4f-4965-90aa-d3cf521028f6","is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:9b5c9a0c-fd4f-4965-90aa-d3cf521028f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006993","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006993&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.4099999964237213},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"awards":[{"id":"https://openalex.org/G2570834467","display_name":null,"funder_award_id":"P2CHD065690","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4233645168","display_name":null,"funder_award_id":"P2C HD065690","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6968819193","display_name":null,"funder_award_id":"U54 EB020405","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G850793847","display_name":null,"funder_award_id":"U54 EB020405","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320312638","display_name":"Thomas and Stacey Siebel Foundation","ror":null},{"id":"https://openalex.org/F4320315933","display_name":"Siebel Scholars Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333063","display_name":"Stanford Bio-X","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320334432","display_name":"Stanford Research Computing Center, Stanford University","ror":null},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2979118233.pdf","grobid_xml":"https://content.openalex.org/works/W2979118233.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W136388122","https://openalex.org/W1482601876","https://openalex.org/W1490104269","https://openalex.org/W1569163094","https://openalex.org/W1578361709","https://openalex.org/W1598234728","https://openalex.org/W1605438009","https://openalex.org/W1826216865","https://openalex.org/W1826404855","https://openalex.org/W1964835671","https://openalex.org/W1966082194","https://openalex.org/W1969317593","https://openalex.org/W1971122356","https://openalex.org/W1972148528","https://openalex.org/W1972745519","https://openalex.org/W1973299365","https://openalex.org/W1974078030","https://openalex.org/W1974558909","https://openalex.org/W1979953919","https://openalex.org/W1991240629","https://openalex.org/W1997362977","https://openalex.org/W2005153477","https://openalex.org/W2009460222","https://openalex.org/W2015299659","https://openalex.org/W2019904259","https://openalex.org/W2027192020","https://openalex.org/W2031805060","https://openalex.org/W2034579881","https://openalex.org/W2036407851","https://openalex.org/W2036826589","https://openalex.org/W2043362413","https://openalex.org/W2053518639","https://openalex.org/W2053628882","https://openalex.org/W2055823563","https://openalex.org/W2057190935","https://openalex.org/W2059366099","https://openalex.org/W2067905539","https://openalex.org/W2073205720","https://openalex.org/W2074638502","https://openalex.org/W2077002165","https://openalex.org/W2078370135","https://openalex.org/W2084399420","https://openalex.org/W2093458054","https://openalex.org/W2095661097","https://openalex.org/W2095869453","https://openalex.org/W2107898313","https://openalex.org/W2111214570","https://openalex.org/W2112943033","https://openalex.org/W2115455197","https://openalex.org/W2116951991","https://openalex.org/W2117368777","https://openalex.org/W2121028962","https://openalex.org/W2123564531","https://openalex.org/W2130281033","https://openalex.org/W2130909945","https://openalex.org/W2132296211","https://openalex.org/W2133220762","https://openalex.org/W2135027471","https://openalex.org/W2148501183","https://openalex.org/W2149298912","https://openalex.org/W2150513221","https://openalex.org/W2151906934","https://openalex.org/W2156472821","https://openalex.org/W2160294605","https://openalex.org/W2160382929","https://openalex.org/W2162583443","https://openalex.org/W2164481873","https://openalex.org/W2166779744","https://openalex.org/W2169036624","https://openalex.org/W2169387736","https://openalex.org/W2170622141","https://openalex.org/W2170832171","https://openalex.org/W2171491071","https://openalex.org/W2174178059","https://openalex.org/W2289112630","https://openalex.org/W2326676816","https://openalex.org/W2337344967","https://openalex.org/W2341999992","https://openalex.org/W2406423433","https://openalex.org/W2422865232","https://openalex.org/W2469455623","https://openalex.org/W2470342634","https://openalex.org/W2498621863","https://openalex.org/W2726187156","https://openalex.org/W2795755662","https://openalex.org/W2801995417","https://openalex.org/W2809366744","https://openalex.org/W2884696611","https://openalex.org/W2950152359","https://openalex.org/W3102715269","https://openalex.org/W4237651028","https://openalex.org/W4245318618","https://openalex.org/W4254128450","https://openalex.org/W4256615025","https://openalex.org/W6674003258"],"related_works":["https://openalex.org/W2091018600","https://openalex.org/W2289862099","https://openalex.org/W4221084513","https://openalex.org/W3151244334","https://openalex.org/W2142440282","https://openalex.org/W2981898805","https://openalex.org/W2071244081","https://openalex.org/W29220401","https://openalex.org/W2895733092","https://openalex.org/W4362474256"],"abstract_inverted_index":{"Deficits":[0],"in":[1,13,240],"the":[2,42,51,206,221,247,266],"ankle":[3],"plantarflexor":[4,284],"muscles,":[5],"such":[6,15,106],"as":[7,16,107],"weakness":[8,54,201,245,285],"and":[9,24,46,55,66,89,115,117,131,140,159,167,180,196,219,275,286],"contracture,":[10,56],"occur":[11],"commonly":[12],"conditions":[14],"cerebral":[17],"palsy,":[18],"stroke,":[19],"muscular":[20],"dystrophy,":[21],"Charcot-Marie-Tooth":[22],"disease,":[23],"sarcopenia.":[25],"While":[26],"these":[27,77,215],"deficits":[28,61],"likely":[29],"contribute":[30,289],"to":[31,41,71,76,93,204,223,233,249,290],"observed":[32,137,291],"gait":[33,73,149,239,271,292],"pathologies,":[34],"determining":[35],"cause-effect":[36],"relationships":[37],"is":[38],"difficult":[39],"due":[40,75],"often":[43],"co-occurring":[44],"biomechanical":[45],"neural":[47],"deficits.":[48,78],"To":[49],"elucidate":[50],"effects":[52],"of":[53,69,87,110,174,199,214,257],"we":[57,102,192],"systematically":[58],"introduced":[59],"isolated":[60],"into":[62],"a":[63,81,96,148,226,237,251,269],"musculoskeletal":[64],"model":[65,83,222,230,248,267],"generated":[67,123,147],"simulations":[68],"walking":[70,152],"predict":[72],"adaptations":[74],"We":[79,121,145],"trained":[80],"planar":[82],"containing":[84],"9":[85],"degrees":[86],"freedom":[88],"18":[90],"musculotendon":[91],"actuators":[92],"walk":[94,224],"using":[95],"custom":[97],"optimization":[98],"framework":[99],"through":[100],"which":[101],"imposed":[103],"simple":[104],"objectives,":[105],"minimizing":[108],"cost":[109],"transport":[111],"while":[112],"avoiding":[113],"falling":[114],"injury,":[116],"maintaining":[118],"head":[119],"stability.":[120],"first":[122],"gaits":[124],"at":[125,150,225],"prescribed":[126],"speeds":[127],"between":[128,156],"0.50":[129],"m/s":[130,133],"2.00":[132],"that":[134],"reproduced":[135],"experimentally":[136],"kinematic,":[138],"kinetic,":[139],"metabolic":[141],"trends":[142],"for":[143,162,186],"walking.":[144],"then":[146],"self-selected":[151,227],"speed;":[153],"quantitative":[154],"comparisons":[155],"our":[157],"simulation":[158],"experimental":[160],"data":[161],"joint":[163,165,188],"angles,":[164],"moments,":[166],"ground":[168],"reaction":[169],"forces":[170],"showed":[171],"root-mean-squared":[172],"errors":[173],"less":[175],"than":[176],"1.6":[177],"standard":[178],"deviations":[179],"normalized":[181],"cross-correlations":[182],"above":[183],"0.8":[184],"except":[185],"knee":[187,276],"moment":[189],"trajectories.":[190],"Finally,":[191],"applied":[193],"mild,":[194],"moderate,":[195],"severe":[197],"levels":[198],"muscle":[200],"or":[202,209,212,260],"contracture":[203,256,287],"either":[205],"soleus":[207],"(SOL)":[208],"gastrocnemius":[210],"(GAS)":[211],"both":[213,261],"major":[216],"plantarflexors":[217],"(PF)":[218],"retrained":[220],"speed.":[228],"The":[229],"was":[231],"robust":[232],"all":[234,241],"deficits,":[235],"finding":[236],"stable":[238],"cases.":[242],"Severe":[243,255],"PF":[244,262],"caused":[246],"adopt":[250],"slower,":[252],"\"heel-walking\"":[253],"gait.":[254],"only":[258],"SOL":[259],"yielded":[263],"similar":[264],"results:":[265],"adopted":[268],"\"toe-walking\"":[270],"with":[272],"excessive":[273],"hip":[274],"flexion":[277],"during":[278],"stance.":[279],"These":[280],"results":[281],"highlight":[282],"how":[283],"may":[288],"patterns.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":39},{"year":2021,"cited_by_count":32},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":1}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}
