{"id":"https://openalex.org/W2950750253","doi":"https://doi.org/10.1371/journal.pcbi.1006878","title":"Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network","display_name":"Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network","publication_year":2019,"publication_date":"2019-04-26","ids":{"openalex":"https://openalex.org/W2950750253","doi":"https://doi.org/10.1371/journal.pcbi.1006878","mag":"2950750253","pmid":"https://pubmed.ncbi.nlm.nih.gov/31026276"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006878","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006878&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006878&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052340671","display_name":"Peter M.U. Ung","orcid":"https://orcid.org/0000-0002-6849-5252"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter M. U. Ung","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6849-5252","affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038177398","display_name":"Masahiro Sonoshita","orcid":"https://orcid.org/0000-0003-2890-336X"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiro Sonoshita","raw_affiliation_strings":["Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108693561","display_name":"Alex Scopton","orcid":null},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex P. Scopton","raw_affiliation_strings":["Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033817692","display_name":"Arvin C. Dar","orcid":"https://orcid.org/0000-0003-0318-4848"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arvin C. Dar","raw_affiliation_strings":["Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025899246","display_name":"Ross Cagan","orcid":"https://orcid.org/0000-0001-5297-450X"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ross L. Cagan","raw_affiliation_strings":["Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048927341","display_name":"Avner Schlessinger","orcid":"https://orcid.org/0000-0003-4007-7814"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Avner Schlessinger","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-4007-7814","affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5025899246","https://openalex.org/A5048927341"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4148,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83519822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"15","issue":"4","first_page":"e1006878","last_page":"e1006878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9771999716758728,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9685999751091003,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.7119768261909485},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.630854606628418},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6278946399688721},{"id":"https://openalex.org/keywords/transformation","display_name":"Transformation (genetics)","score":0.605746865272522},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5112000107765198},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila (subgenus)","score":0.48364293575286865},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47184136509895325},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.4569568634033203},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3992078900337219},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3508882522583008},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2426724135875702},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23117902874946594},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19005897641181946},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15231412649154663}],"concepts":[{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.7119768261909485},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.630854606628418},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6278946399688721},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.605746865272522},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5112000107765198},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.48364293575286865},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47184136509895325},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4569568634033203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3992078900337219},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3508882522583008},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2426724135875702},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23117902874946594},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19005897641181946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15231412649154663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018278","descriptor_name":"Carcinoma, Neuroendocrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1006878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006878","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006878&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:31026276","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31026276","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.gla.ac.uk:218288","is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/view/author/54460.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:314c6675ac5d4158a1dd1b291006b7e2","is_oa":true,"landing_page_url":"https://doaj.org/article/314c6675ac5d4158a1dd1b291006b7e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 4, p e1006878 (2019)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/8048432","is_oa":true,"landing_page_url":"https://figshare.com/articles/Integrated_computational_and_i_Drosophila_i_cancer_model_platform_captures_previously_unappreciated_chemicals_perturbing_a_kinase_network/8048432","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6506148","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6506148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006878","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006878&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1494627400","display_name":null,"funder_award_id":"W81XWH-15-1-0539","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G1709813350","display_name":null,"funder_award_id":"R01-CA109730","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1950558302","display_name":null,"funder_award_id":"U54OD020353","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4294856372","display_name":null,"funder_award_id":"W81XWH-15-1","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5278611676","display_name":null,"funder_award_id":"W81XWH-15-1-0111","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5617865838","display_name":null,"funder_award_id":"R01-CA170495","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6302996500","display_name":null,"funder_award_id":"R01-GM108911","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6566535030","display_name":null,"funder_award_id":"DP2 CA186570-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320309658","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950750253.pdf","grobid_xml":"https://content.openalex.org/works/W2950750253.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W989816459","https://openalex.org/W1757990252","https://openalex.org/W1809628153","https://openalex.org/W1972577475","https://openalex.org/W1975053800","https://openalex.org/W1992945955","https://openalex.org/W2005499874","https://openalex.org/W2027482274","https://openalex.org/W2027516869","https://openalex.org/W2028415754","https://openalex.org/W2030205108","https://openalex.org/W2043209972","https://openalex.org/W2043509228","https://openalex.org/W2049482339","https://openalex.org/W2061865181","https://openalex.org/W2063083610","https://openalex.org/W2065283382","https://openalex.org/W2071500926","https://openalex.org/W2075005660","https://openalex.org/W2085423858","https://openalex.org/W2096735709","https://openalex.org/W2107998520","https://openalex.org/W2121134652","https://openalex.org/W2124662474","https://openalex.org/W2144362290","https://openalex.org/W2146928870","https://openalex.org/W2155255760","https://openalex.org/W2156373035","https://openalex.org/W2162011385","https://openalex.org/W2163840257","https://openalex.org/W2171651199","https://openalex.org/W2178993379","https://openalex.org/W2222507697","https://openalex.org/W2261053929","https://openalex.org/W2274656763","https://openalex.org/W2317863386","https://openalex.org/W2332884773","https://openalex.org/W2416642098","https://openalex.org/W2506485288","https://openalex.org/W2752135966","https://openalex.org/W2778979773","https://openalex.org/W2784561120","https://openalex.org/W2805916097","https://openalex.org/W2806290811","https://openalex.org/W2898073106","https://openalex.org/W3020863653","https://openalex.org/W4211075026"],"related_works":["https://openalex.org/W2059230675","https://openalex.org/W2376003823","https://openalex.org/W2594726310","https://openalex.org/W2355193834","https://openalex.org/W2043558654","https://openalex.org/W2017996710","https://openalex.org/W4225792090","https://openalex.org/W2090863707","https://openalex.org/W4385741417","https://openalex.org/W4285201319"],"abstract_inverted_index":{"Drosophila":[0,40,54],"provides":[1,116],"an":[2],"inexpensive":[3],"and":[4,42],"quantitative":[5],"platform":[6,35,48,115],"for":[7,72,79],"measuring":[8],"whole":[9,140],"animal":[10],"drug":[11],"response.":[12],"A":[13],"complementary":[14],"approach":[15],"is":[16],"virtual":[17,80],"screening,":[18],"where":[19],"chemical":[20,129],"libraries":[21],"can":[22],"be":[23],"efficiently":[24,120],"screened":[25],"against":[26],"protein":[27],"target(s).":[28],"Here,":[29],"we":[30],"present":[31],"a":[32,53,63,105,117],"unique":[33,84],"discovery":[34],"integrating":[36],"structure-based":[37],"modeling":[38],"with":[39,98,108],"biology":[41],"organic":[43],"synthesis.":[44],"We":[45,91],"demonstrate":[46],"this":[47],"by":[49,62,67],"developing":[50],"chemicals":[51],"targeting":[52],"model":[55],"of":[56,100,111,126],"Medullary":[57],"Thyroid":[58],"Cancer":[59],"(MTC)":[60],"characterized":[61],"transformation":[64],"network":[65],"activated":[66],"oncogenic":[68],"dRetM955T.":[69],"Structural":[70],"models":[71],"kinases":[73],"relevant":[74],"to":[75,82,103,119],"MTC":[76],"were":[77],"generated":[78],"screening":[81],"identify":[83],"preliminary":[85],"hits":[86,97],"that":[87,131],"suppressed":[88],"dRetM955T-induced":[89],"transformation.":[90,113],"then":[92],"combined":[93],"features":[94],"from":[95],"our":[96],"those":[99],"known":[101],"inhibitors":[102,124],"create":[104],"'hybrid'":[106],"molecule":[107],"improved":[109],"suppression":[110],"dRetM955T":[112],"Our":[114],"framework":[118],"explore":[121],"novel":[122],"kinase":[123],"outside":[125],"explored":[127],"inhibitor":[128],"space":[130],"are":[132],"effective":[133],"in":[134],"inhibiting":[135],"cancer":[136],"networks":[137],"while":[138],"minimizing":[139],"body":[141],"toxicity.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}