{"id":"https://openalex.org/W2949723271","doi":"https://doi.org/10.1371/journal.pcbi.1006849","title":"Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size","display_name":"Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size","publication_year":2019,"publication_date":"2019-04-12","ids":{"openalex":"https://openalex.org/W2949723271","doi":"https://doi.org/10.1371/journal.pcbi.1006849","mag":"2949723271","pmid":"https://pubmed.ncbi.nlm.nih.gov/30978183"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006849","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006849","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006849&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006849&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018345025","display_name":"Daniel I. S. Rosenbloom","orcid":"https://orcid.org/0000-0003-1413-3907"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel I. S. Rosenbloom","raw_affiliation_strings":["Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America","Department of Systems Biology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Systems Biology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058779674","display_name":"Peter Bacchetti","orcid":"https://orcid.org/0000-0002-9323-2972"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Bacchetti","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054359071","display_name":"Mars Stone","orcid":"https://orcid.org/0000-0001-5619-2767"},"institutions":[{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mars Stone","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103323463","display_name":"Xutao Deng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xutao Deng","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029030800","display_name":"Ronald J. Bosch","orcid":"https://orcid.org/0000-0002-1774-4140"},"institutions":[{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald J. Bosch","raw_affiliation_strings":["Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210101190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073322790","display_name":"Douglas D. Richman","orcid":"https://orcid.org/0000-0003-0962-9254"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas D. Richman","raw_affiliation_strings":["University of California San Diego, La Jolla, California, United States of America","Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America"],"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014454124","display_name":"Janet D. Siliciano","orcid":"https://orcid.org/0000-0001-6712-3775"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet D. Siliciano","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038307269","display_name":"John W. Mellors","orcid":"https://orcid.org/0000-0002-3737-9742"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Mellors","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063704053","display_name":"Steven G. Deeks","orcid":"https://orcid.org/0000-0001-6371-747X"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven G. Deeks","raw_affiliation_strings":["Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004932382","display_name":"Roger G. Ptak","orcid":"https://orcid.org/0000-0002-8492-3085"},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger G. Ptak","raw_affiliation_strings":["Southern Research, Frederick, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Southern Research, Frederick, Maryland, United States of America","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033146175","display_name":"Rebecca Hoh","orcid":"https://orcid.org/0000-0001-5112-4220"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Hoh","raw_affiliation_strings":["Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059924108","display_name":"Sheila M. Keating","orcid":"https://orcid.org/0000-0002-8324-3694"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila M. Keating","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, United States of America","Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I4210093991"]},{"raw_affiliation_string":"Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I2803209242","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065310725","display_name":"Melanie Dimapasoc","orcid":"https://orcid.org/0000-0003-0328-315X"},"institutions":[{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Dimapasoc","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I4210093991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075692086","display_name":"Marta Massanella","orcid":"https://orcid.org/0000-0002-3326-151X"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marta Massanella","raw_affiliation_strings":["University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044128554","display_name":"Jun Lai","orcid":"https://orcid.org/0009-0008-6435-2888"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Lai","raw_affiliation_strings":["Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I2799853436","https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056315528","display_name":"Michele D. Sobolewski","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele D. Sobolewski","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058858155","display_name":"Deanna A. Kulpa","orcid":"https://orcid.org/0000-0002-0411-7295"},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deanna A. Kulpa","raw_affiliation_strings":["Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America","Southern Research, Frederick, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Southern Research, Frederick, Maryland, United States of America","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062975649","display_name":"Michael P. Busch","orcid":"https://orcid.org/0000-0002-1446-125X"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210093991","display_name":"Blood Systems Research Institute","ror":"https://ror.org/01ekg2j77","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093991"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael P. Busch","raw_affiliation_strings":["Blood Systems Research Institute, San Francisco, California, United States of America","Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Blood Systems Research Institute, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I4210093991"]},{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5062975649"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210093991"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2014,"currency":"EUR","value_usd":2172},"fwci":2.3744,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89161511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"4","first_page":"e1006849","last_page":"e1006849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9733999967575073,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.972000002861023,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repeatability","display_name":"Repeatability","score":0.7680313587188721},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.5203784704208374},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.307064950466156},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.23910930752754211},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.188232421875},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.16950368881225586}],"concepts":[{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.7680313587188721},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5203784704208374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.307064950466156},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23910930752754211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.188232421875},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.16950368881225586}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006849","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006849","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006849&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30978183","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30978183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1006849","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006849","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b5955aac1a054bdaae557617f2bee089","is_oa":true,"landing_page_url":"https://doaj.org/article/b5955aac1a054bdaae557617f2bee089","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 4, p e1006849 (2019)","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt43s3w2hw","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/43s3w2hw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 15, iss 4","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7990625","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Assessing_intra-lab_precision_and_inter-lab_repeatability_of_outgrowth_assays_of_HIV-1_latent_reservoir_size/7990625","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:6481870","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6481870","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006849","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006849","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006849&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5799999833106995,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1128133788","display_name":null,"funder_award_id":"Gates","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G1305528480","display_name":null,"funder_award_id":"NIH/NIAID","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1420584630","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G1831472140","display_name":null,"funder_award_id":"UM1AI126619","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2447801239","display_name":null,"funder_award_id":"1UM1AI126619","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3654102266","display_name":null,"funder_award_id":"Staff","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4301310916","display_name":null,"funder_award_id":"38619","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G4591225809","display_name":null,"funder_award_id":"1UM1Al126620","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5903061775","display_name":null,"funder_award_id":"NIAID","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6090955224","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G6611422108","display_name":null,"funder_award_id":"HHSN272201500017C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7368976211","display_name":null,"funder_award_id":"1UM1AI126619","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7527697664","display_name":null,"funder_award_id":"AI306214","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7634912203","display_name":null,"funder_award_id":"1UM1Al126620","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7694659302","display_name":null,"funder_award_id":"UM1AI126619","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7833669176","display_name":null,"funder_award_id":"109511-61-RKRL","funder_id":"https://openalex.org/F4320306342","funder_display_name":"amfAR, The Foundation for AIDS Research"},{"id":"https://openalex.org/G8587926129","display_name":null,"funder_award_id":"UCSD CFAR (AI306214)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320306342","display_name":"amfAR, The Foundation for AIDS Research","ror":"https://ror.org/02jesmk44"},{"id":"https://openalex.org/F4320311932","display_name":"James B. Pendleton Charitable Trust","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949723271.pdf","grobid_xml":"https://content.openalex.org/works/W2949723271.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1536497620","https://openalex.org/W1771860521","https://openalex.org/W2011208161","https://openalex.org/W2030844138","https://openalex.org/W2060829964","https://openalex.org/W2090646713","https://openalex.org/W2108123317","https://openalex.org/W2115580899","https://openalex.org/W2120515100","https://openalex.org/W2125468126","https://openalex.org/W2135925682","https://openalex.org/W2139250164","https://openalex.org/W2144549163","https://openalex.org/W2144697720","https://openalex.org/W2150847344","https://openalex.org/W2203714058","https://openalex.org/W2205289348","https://openalex.org/W2263928028","https://openalex.org/W2302202015","https://openalex.org/W2470126287","https://openalex.org/W2512878063","https://openalex.org/W2577537660","https://openalex.org/W2609863249","https://openalex.org/W2625382334","https://openalex.org/W2772359964","https://openalex.org/W2895792705","https://openalex.org/W2949712484","https://openalex.org/W3041246300","https://openalex.org/W3041863265","https://openalex.org/W3123421154","https://openalex.org/W4247539597"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2774752550","https://openalex.org/W4288084846","https://openalex.org/W2893816048","https://openalex.org/W3168747143","https://openalex.org/W2315867670","https://openalex.org/W2119695867","https://openalex.org/W1968795594","https://openalex.org/W2237675924"],"abstract_inverted_index":{"Quantitative":[0],"viral":[1,210],"outgrowth":[2,211],"assays":[3,33,200],"(QVOA)":[4],"use":[5,237,249],"limiting":[6],"dilutions":[7],"of":[8,16,78,89,92,99,126,133,159,184,226,238,243,250,259,273],"CD4+":[9],"T":[10],"cells":[11,137,240],"to":[12,24,28,75,95,175,186,236,253,268,281,289],"measure":[13],"the":[14,17,30,90,97,100,157,178,199],"size":[15,39,84,98],"latent":[18,105],"HIV-1":[19],"reservoir,":[20],"a":[21,49,122,182,195,283],"major":[22],"obstacle":[23],"curing":[25],"HIV-1.":[26],"Efforts":[27],"reduce":[29],"reservoir":[31,53,83,165,285],"require":[32],"that":[34,169,221,270],"can":[35],"reliably":[36],"quantify":[37],"its":[38,59],"in":[40,209,233],"blood":[41,135],"and":[42,61,156,203,213,224,256,275],"tissues.":[43],"Although":[44],"QVOA":[45,127,234],"is":[46,56],"regarded":[47],"as":[48,87],"\"gold":[50],"standard\"":[51],"for":[52],"measurement,":[54],"little":[55],"known":[57],"about":[58,64,111],"accuracy":[60],"precision":[62,155],"or":[63,69,189],"how":[65],"cell":[66,161,215],"storage":[67,162,225,252],"conditions":[68],"laboratory-specific":[70],"practices":[71],"affect":[72],"results.":[73],"Owing":[74],"this":[76,116],"lack":[77],"knowledge,":[79],"confidence":[80],"intervals":[81],"around":[82],"estimates-as":[85],"well":[86],"judgments":[88],"ability":[91],"therapeutic":[93],"interventions":[94],"alter":[96],"replication-competent":[101],"but":[102],"transcriptionally":[103],"inactive":[104],"reservoir-rely":[106],"on":[107,129,163],"theoretical":[108],"statistical":[109,124],"assumptions":[110],"dilution":[112],"assays.":[113],"To":[114],"address":[115],"gap,":[117],"we":[118,262],"have":[119],"carried":[120],"out":[121],"Bayesian":[123],"analysis":[125,258,272],"reliability":[128],"75":[130],"split":[131],"samples":[132,227,277],"peripheral":[134],"mononuclear":[136],"(PBMC)":[138],"from":[139,177],"5":[140],"antiretroviral":[141],"therapy":[142],"(ART)-suppressed":[143],"participants,":[144],"measured":[145],"using":[146],"four":[147],"different":[148],"QVOAs":[149],"at":[150],"separate":[151],"labs,":[152],"estimating":[153],"assay":[154,171,192],"effect":[158],"frozen":[160,251],"estimated":[164],"size.":[166],"We":[167,218],"found":[168,220],"typical":[170],"results":[172],"are":[173],"expected":[174],"differ":[176],"true":[179],"value":[180],"by":[181,287],"factor":[183],"1.6":[185],"1.9":[187],"up":[188],"down.":[190],"Systematic":[191],"differences":[193,208,232],"comprised":[194],"24-fold":[196],"range":[197],"between":[198],"with":[201],"highest":[202],"lowest":[204],"scales,":[205],"likely":[206],"reflecting":[207],"readout":[212],"input":[214],"stimulation":[216],"protocols.":[217],"also":[219],"controlled-rate":[222],"freezing":[223],"did":[228],"not":[229],"cause":[230],"substantial":[231],"compared":[235],"fresh":[239],"(95%":[241],"probability":[242],"<":[244],"2-fold":[245],"change),":[246],"supporting":[247],"continued":[248],"allow":[254],"transport":[255],"batched":[257,271],"samples.":[260],"Finally,":[261],"simulated":[263],"an":[264],"early-phase":[265],"clinical":[266],"trial":[267],"demonstrate":[269],"pre-":[274],"post-therapy":[276],"may":[278],"increase":[279],"power":[280],"detect":[282],"three-fold":[284],"reduction":[286],"15":[288],"24":[290],"percentage":[291],"points.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
