{"id":"https://openalex.org/W2909293488","doi":"https://doi.org/10.1371/journal.pcbi.1006704","title":"Protein\u2014protein binding supersites","display_name":"Protein\u2014protein binding supersites","publication_year":2019,"publication_date":"2019-01-07","ids":{"openalex":"https://openalex.org/W2909293488","doi":"https://doi.org/10.1371/journal.pcbi.1006704","mag":"2909293488","pmid":"https://pubmed.ncbi.nlm.nih.gov/30615604"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006704","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006704","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006704&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006704&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059630523","display_name":"R. Viswanathan","orcid":"https://orcid.org/0000-0003-0709-4604"},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raji Viswanathan","raw_affiliation_strings":["Department of Chemistry, Yeshiva University, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Yeshiva University, New York, NY, United States of America","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061268807","display_name":"Eduardo Fajardo","orcid":null},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Fajardo","raw_affiliation_strings":["Departments of Systems & Computational Biology, and Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Systems & Computational Biology, and Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076009005","display_name":"Gabriel Steinberg","orcid":null},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Steinberg","raw_affiliation_strings":["Department of Chemistry, Yeshiva University, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Yeshiva University, New York, NY, United States of America","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030191395","display_name":"Matthew Haller","orcid":"https://orcid.org/0000-0003-3536-8270"},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Haller","raw_affiliation_strings":["Department of Chemistry, Yeshiva University, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Yeshiva University, New York, NY, United States of America","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040379692","display_name":"Andr\u00e1s Fiser","orcid":"https://orcid.org/0000-0003-0085-5335"},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andras Fiser","raw_affiliation_strings":["Departments of Systems & Computational Biology, and Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0085-5335","affiliations":[{"raw_affiliation_string":"Departments of Systems & Computational Biology, and Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040379692"],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5065,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89967548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"e1006704","last_page":"e1006704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.7418497800827026},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.6535664796829224},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6339964270591736},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.5741191506385803},{"id":"https://openalex.org/keywords/obligate","display_name":"Obligate","score":0.5336229205131531},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5266777276992798},{"id":"https://openalex.org/keywords/cognate","display_name":"Cognate","score":0.5243642330169678},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.46795380115509033},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.45363977551460266},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4422702193260193},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.43559199571609497},{"id":"https://openalex.org/keywords/a-site","display_name":"A-site","score":0.4216502010822296},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24446004629135132}],"concepts":[{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.7418497800827026},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.6535664796829224},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6339964270591736},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5741191506385803},{"id":"https://openalex.org/C24990904","wikidata":"https://www.wikidata.org/wiki/Q7075144","display_name":"Obligate","level":2,"score":0.5336229205131531},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5266777276992798},{"id":"https://openalex.org/C2777392089","wikidata":"https://www.wikidata.org/wiki/Q690548","display_name":"Cognate","level":2,"score":0.5243642330169678},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.46795380115509033},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.45363977551460266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4422702193260193},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.43559199571609497},{"id":"https://openalex.org/C96267730","wikidata":"https://www.wikidata.org/wiki/Q4647010","display_name":"A-site","level":3,"score":0.4216502010822296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24446004629135132},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1006704","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006704","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006704&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30615604","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30615604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1006704","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006704","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:de5ca3523ca14cd9a4c4f0a3f0032247","is_oa":true,"landing_page_url":"https://doaj.org/article/de5ca3523ca14cd9a4c4f0a3f0032247","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 1, p e1006704 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5331292","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6336348","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/7556414","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Protein_protein_binding_supersites/7556414","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006704","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006704","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006704&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2377436203","display_name":null,"funder_award_id":"GM118709","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3177227261","display_name":null,"funder_award_id":"GM118709","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3338472867","display_name":null,"funder_award_id":"ACI-1053575","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4081026042","display_name":null,"funder_award_id":"R01 AI141816","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4737709065","display_name":null,"funder_award_id":"ACI-1053575","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6778350887","display_name":"XSEDE: eXtreme Science and Engineering Discovery Environment","funder_award_id":"1053575","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7085535245","display_name":null,"funder_award_id":"R01 GM118709","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8292484374","display_name":null,"funder_award_id":"AI141816","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8425617111","display_name":null,"funder_award_id":"R35 GM136357","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2909293488.pdf","grobid_xml":"https://content.openalex.org/works/W2909293488.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W173634131","https://openalex.org/W1030883578","https://openalex.org/W1570448133","https://openalex.org/W1926568554","https://openalex.org/W1967638691","https://openalex.org/W1979598348","https://openalex.org/W1981869064","https://openalex.org/W1984753195","https://openalex.org/W1985222378","https://openalex.org/W1985481261","https://openalex.org/W1996253840","https://openalex.org/W1998490996","https://openalex.org/W2000383223","https://openalex.org/W2006481713","https://openalex.org/W2008421309","https://openalex.org/W2013863297","https://openalex.org/W2025120281","https://openalex.org/W2030154259","https://openalex.org/W2031772330","https://openalex.org/W2039063819","https://openalex.org/W2039473152","https://openalex.org/W2046407284","https://openalex.org/W2048682054","https://openalex.org/W2050228834","https://openalex.org/W2055905702","https://openalex.org/W2057849368","https://openalex.org/W2064514012","https://openalex.org/W2075770210","https://openalex.org/W2080653934","https://openalex.org/W2086224494","https://openalex.org/W2092189515","https://openalex.org/W2099173559","https://openalex.org/W2103210604","https://openalex.org/W2104760790","https://openalex.org/W2109228802","https://openalex.org/W2109872885","https://openalex.org/W2110720709","https://openalex.org/W2114306742","https://openalex.org/W2114394047","https://openalex.org/W2116211618","https://openalex.org/W2118795098","https://openalex.org/W2130479394","https://openalex.org/W2136525667","https://openalex.org/W2137780217","https://openalex.org/W2141627824","https://openalex.org/W2142843496","https://openalex.org/W2151550848","https://openalex.org/W2152521138","https://openalex.org/W2158100564","https://openalex.org/W2160690759","https://openalex.org/W2166814967","https://openalex.org/W2264362083","https://openalex.org/W2419023253","https://openalex.org/W2552119722","https://openalex.org/W2722005050","https://openalex.org/W2754800853","https://openalex.org/W2757108520","https://openalex.org/W2773938469"],"related_works":["https://openalex.org/W4255644844","https://openalex.org/W2768732437","https://openalex.org/W1992223954","https://openalex.org/W1511994447","https://openalex.org/W2075580221","https://openalex.org/W2375209783","https://openalex.org/W2110486604","https://openalex.org/W2144344817","https://openalex.org/W1985222378","https://openalex.org/W2369527822"],"abstract_inverted_index":{"The":[0,150,167],"lack":[1],"of":[2,6,27,53,88,111,126,131,136,145,152,169,171,192],"a":[3,85,98,112,160,181],"deep":[4],"understanding":[5],"how":[7],"proteins":[8],"interact":[9],"remains":[10],"an":[11],"important":[12],"roadblock":[13],"in":[14,76,122,162,180],"advancing":[15],"efforts":[16],"to":[17,43,104,106,117,120,158],"identify":[18],"binding":[19,109,132,137,176],"partners":[20],"and":[21,47,139,142,147],"uncover":[22],"the":[23,28,51,77,107,143,153,164,175,193],"corresponding":[24],"regulatory":[25],"mechanisms":[26],"functions":[29],"they":[30],"mediate.":[31],"Understanding":[32],"protein-protein":[33],"interactions":[34],"is":[35,97],"also":[36],"essential":[37],"for":[38,63,73,101],"designing":[39],"specific":[40],"chemical":[41],"modifications":[42],"develop":[44],"new":[45],"reagents":[46],"therapeutics.":[48],"We":[49],"explored":[50],"hypothesis":[52],"whether":[54],"protein":[55,65,90,128],"interaction":[56,170],"sites":[57,62,75],"serve":[58],"as":[59,68],"generic":[60],"biding":[61],"non-cognate":[64,102,127],"ligands,":[66],"just":[67],"it":[69],"has":[70],"been":[71],"observed":[72],"small-molecule-binding":[74],"past.":[78],"Using":[79],"extensive":[80],"computational":[81],"docking":[82,123,154],"experiments":[83],"on":[84],"test":[86],"set":[87],"241":[89],"complexes,":[91],"we":[92],"found":[93],"that":[94,185],"indeed":[95],"there":[96],"strong":[99],"preference":[100],"ligands":[103],"bind":[105],"cognate":[108],"site":[110],"receptor.":[113],"This":[114],"observation":[115],"appears":[116,157],"be":[118],"robust":[119],"variations":[121],"programs,":[124],"types":[125],"probes,":[129],"sizes":[130,135],"patches,":[133],"relative":[134],"patches":[138],"full-length":[140],"proteins,":[141],"exploration":[144],"obligate":[146],"non-obligate":[148],"complexes.":[149],"accuracy":[151,187],"scoring":[155],"function":[156],"play":[159],"role":[161],"defining":[163],"correct":[165],"site.":[166],"frequency":[168],"unrelated":[172],"probes":[173],"recognizing":[174],"interface":[177],"was":[178],"utilized":[179],"simple":[182],"prediction":[183],"algorithm":[184],"showed":[186],"competitive":[188],"with":[189],"other":[190],"state":[191],"art":[194],"methods.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5}],"updated_date":"2026-07-14T08:27:34.040176","created_date":"2025-10-10T00:00:00"}