{"id":"https://openalex.org/W2898908651","doi":"https://doi.org/10.1371/journal.pcbi.1006552","title":"Modeling and subtleties of K-Ras and Calmodulin interaction","display_name":"Modeling and subtleties of K-Ras and Calmodulin interaction","publication_year":2018,"publication_date":"2018-10-30","ids":{"openalex":"https://openalex.org/W2898908651","doi":"https://doi.org/10.1371/journal.pcbi.1006552","mag":"2898908651","pmid":"https://pubmed.ncbi.nlm.nih.gov/30376570"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006552","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006552","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006552&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006552&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103824488","display_name":"Eduardo Garrido","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095713","display_name":"Departament de Salut","ror":"https://ror.org/00nyrjc53","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210095713"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160192","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Garrido","raw_affiliation_strings":["Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain","Department of Materials Science and Physical Chemistry, Universitat de Barcelona, Institut de Recerca en Qu\u00edmica Te\u00f2rica i Computacional (IQTCUB), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095713","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Department of Materials Science and Physical Chemistry, Universitat de Barcelona, Institut de Recerca en Qu\u00edmica Te\u00f2rica i Computacional (IQTCUB), Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074804240","display_name":"Juan Jos\u00e9 L\u00e1zaro","orcid":"https://orcid.org/0000-0002-2324-7159"},"institutions":[{"id":"https://openalex.org/I4210095713","display_name":"Departament de Salut","ror":"https://ror.org/00nyrjc53","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210095713"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160192","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan L\u00e1zaro","raw_affiliation_strings":["Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2324-7159","affiliations":[{"raw_affiliation_string":"Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095713","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072030091","display_name":"Montserrat Jaumot","orcid":"https://orcid.org/0000-0003-2864-357X"},"institutions":[{"id":"https://openalex.org/I4210095713","display_name":"Departament de Salut","ror":"https://ror.org/00nyrjc53","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210095713"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160192","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Montserrat Jaumot","raw_affiliation_strings":["Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095713","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085683692","display_name":"Neus Agell","orcid":"https://orcid.org/0000-0002-1205-6074"},"institutions":[{"id":"https://openalex.org/I4210095713","display_name":"Departament de Salut","ror":"https://ror.org/00nyrjc53","country_code":"ES","type":"government","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210095713"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160192","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Neus Agell","raw_affiliation_strings":["Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1205-6074","affiliations":[{"raw_affiliation_string":"Department de Biomedicina, Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, IDIBAPS, Barcelona, Spain","institution_ids":["https://openalex.org/I4210095713","https://openalex.org/I4210160192","https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100748660","display_name":"J. Rubio","orcid":"https://orcid.org/0000-0002-5529-2325"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jaime Rubio-Martinez","raw_affiliation_strings":["Department of Materials Science and Physical Chemistry, Universitat de Barcelona, Institut de Recerca en Qu\u00edmica Te\u00f2rica i Computacional (IQTCUB), Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5529-2325","affiliations":[{"raw_affiliation_string":"Department of Materials Science and Physical Chemistry, Universitat de Barcelona, Institut de Recerca en Qu\u00edmica Te\u00f2rica i Computacional (IQTCUB), Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085683692","https://openalex.org/A5100748660"],"corresponding_institution_ids":["https://openalex.org/I4210095713","https://openalex.org/I4210160192","https://openalex.org/I71999127"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1500,"currency":"EUR","value_usd":1617},"fwci":0.6598,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.67433611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"10","first_page":"e1006552","last_page":"e1006552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"Calmodulin","score":0.9180335998535156},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5583265423774719},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.5492513179779053},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5397338271141052},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4691169559955597},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.45770856738090515},{"id":"https://openalex.org/keywords/hypervariable-region","display_name":"Hypervariable region","score":0.44957080483436584},{"id":"https://openalex.org/keywords/globular-protein","display_name":"Globular protein","score":0.44629722833633423},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3819122612476349},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.375919908285141},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35763391852378845},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35111331939697266},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.28367558121681213},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.2773745357990265},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22461169958114624},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10350817441940308},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.0963616669178009}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.9180335998535156},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5583265423774719},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5492513179779053},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5397338271141052},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4691169559955597},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45770856738090515},{"id":"https://openalex.org/C81566733","wikidata":"https://www.wikidata.org/wiki/Q1047544","display_name":"Hypervariable region","level":3,"score":0.44957080483436584},{"id":"https://openalex.org/C105168689","wikidata":"https://www.wikidata.org/wiki/Q901969","display_name":"Globular protein","level":2,"score":0.44629722833633423},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3819122612476349},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.375919908285141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35763391852378845},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35111331939697266},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.28367558121681213},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.2773745357990265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22461169958114624},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10350817441940308},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0963616669178009},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1006552","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006552","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006552&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30376570","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30376570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:diposit.ub.edu:2445/148426","is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/148426","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Articles publicats en revistes (Biomedicina)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:recercat.cat:2072/369050","is_oa":true,"landing_page_url":"http://hdl.handle.net/2445/148426","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1006552","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006552","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bac767f675814a54b3e844e753c2454f","is_oa":true,"landing_page_url":"https://doaj.org/article/bac767f675814a54b3e844e753c2454f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 10, p e1006552 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5202700","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6226203","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6226203","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6226203","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006552","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006552","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006552&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3288897321","display_name":null,"funder_award_id":"2017-SGR","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"},{"id":"https://openalex.org/G3511371131","display_name":null,"funder_award_id":"2017SGR-1033","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G5554424168","display_name":null,"funder_award_id":"2017SGR","funder_id":"https://openalex.org/F4320334830","funder_display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca"},{"id":"https://openalex.org/G696704950","display_name":null,"funder_award_id":"2017SGR1033","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320323428","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57"},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2898908651.pdf","grobid_xml":"https://content.openalex.org/works/W2898908651.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1852817901","https://openalex.org/W1968877074","https://openalex.org/W1970856032","https://openalex.org/W1974718066","https://openalex.org/W1984392577","https://openalex.org/W1987195331","https://openalex.org/W1994652208","https://openalex.org/W1998604110","https://openalex.org/W1999441881","https://openalex.org/W1999981814","https://openalex.org/W2005912172","https://openalex.org/W2007667377","https://openalex.org/W2022920832","https://openalex.org/W2032937845","https://openalex.org/W2034063805","https://openalex.org/W2034454731","https://openalex.org/W2038391076","https://openalex.org/W2040723945","https://openalex.org/W2042160897","https://openalex.org/W2043282329","https://openalex.org/W2050367572","https://openalex.org/W2050730580","https://openalex.org/W2052366943","https://openalex.org/W2054414022","https://openalex.org/W2057227729","https://openalex.org/W2067156067","https://openalex.org/W2068971291","https://openalex.org/W2069537707","https://openalex.org/W2083695927","https://openalex.org/W2084344997","https://openalex.org/W2087060337","https://openalex.org/W2091991032","https://openalex.org/W2105101128","https://openalex.org/W2108592410","https://openalex.org/W2120118591","https://openalex.org/W2120385383","https://openalex.org/W2123350288","https://openalex.org/W2131654094","https://openalex.org/W2131993341","https://openalex.org/W2133362776","https://openalex.org/W2135184154","https://openalex.org/W2145428487","https://openalex.org/W2164555150","https://openalex.org/W2203187780","https://openalex.org/W2210900834","https://openalex.org/W2262231476","https://openalex.org/W2298480233","https://openalex.org/W2363054795","https://openalex.org/W2465160262","https://openalex.org/W2511010414","https://openalex.org/W2561607790","https://openalex.org/W2571240151","https://openalex.org/W2625829283","https://openalex.org/W2783664968","https://openalex.org/W4210373712","https://openalex.org/W4211204946","https://openalex.org/W6697697848"],"related_works":["https://openalex.org/W2079436230","https://openalex.org/W2416011990","https://openalex.org/W2390452488","https://openalex.org/W2091829542","https://openalex.org/W939296483","https://openalex.org/W1977447152","https://openalex.org/W1972645610","https://openalex.org/W2072932710","https://openalex.org/W2055841700","https://openalex.org/W949903301"],"abstract_inverted_index":{"K-Ras,":[0,115,243],"one":[1],"of":[2,8,27,62,114,123,132,137,141,152,186,196,211,215,233,242],"the":[3,9,16,25,46,70,107,111,127,130,138,147,161,170,184,197,205,209,212,231,234,239],"most":[4],"common":[5],"small":[6,33],"GTPases":[7],"cell,":[10],"still":[11],"presents":[12],"many":[13,245],"riddles,":[14],"despite":[15],"intense":[17],"efforts":[18],"to":[19,119,126,182,201,223,281,287],"unveil":[20],"its":[21,28,38,53,274,278],"mysteries.":[22],"Such":[23],"is":[24,222],"case":[26],"interaction":[29,47,64,77,148,206,210,235,284],"with":[30,105,121,149,169,207,217,267],"Calmodulin,":[31,208],"a":[32,41,60,98,117,150,165,259],"acidic":[34],"protein":[35],"known":[36],"for":[37,146,204],"role":[39],"as":[40,244],"calcium":[42],"ion":[43],"sensor.":[44],"Although":[45],"between":[48],"these":[49],"two":[50],"proteins":[51,162],"and":[52,88,110,135,277],"biological":[54],"implications":[55],"have":[56,92,177],"been":[57,67,93,178],"widely":[58],"studied,":[59],"model":[61,99,261],"their":[63],"has":[65],"not":[66],"performed.":[68],"In":[69],"present":[71,258],"work":[72],"we":[73],"analyse":[74],"this":[75],"intriguing":[76],"by":[78],"computational":[79,175],"means.":[80],"To":[81],"do":[82],"so,":[83],"both":[84,106,273],"conventional":[85],"molecular":[86,90],"dynamics":[87,91],"scaled":[89],"used.":[94],"Our":[95,189],"simulations":[96,228,257],"suggest":[97],"in":[100,164,250,254,262],"which":[101,263],"Calmodulin":[102,218,268],"would":[103,143,236],"interact":[104,120,266],"hypervariable":[108,240,279],"region":[109,241,280],"globular":[112,139,213,275],"domain":[113,140,214,276],"using":[116,180,272],"lobe":[118,151],"each":[122],"them.":[124],"According":[125],"presented":[128],"model,":[129],"interface":[131,199],"helixes":[133],"\u03b14":[134],"\u03b15":[136],"K-Ras":[142,216,264],"be":[144,202,224],"relevant":[145,203],"Calmodulin.":[153],"These":[154],"results":[155,176,190],"were":[156],"also":[157],"obtained":[158],"when":[159,193],"bringing":[160],"together":[163],"step":[166],"wise":[167],"manner":[168],"umbrella":[171],"sampling":[172],"methodology.":[173],"The":[174],"validated":[179],"SPR":[181],"determine":[183],"relevance":[185],"certain":[187],"residues.":[188],"demonstrate":[191],"that,":[192],"mutating":[194],"residues":[195],"\u03b14-\u03b15":[198],"described":[200],"diminishes.":[219],"However,":[220],"it":[221],"considered":[225],"that":[226,230,285],"our":[227,256],"indicate":[229],"bulk":[232],"fall":[237],"on":[238],"more":[246],"interactions":[247],"are":[248],"identified":[249],"said":[251],"region.":[252],"All":[253],"all":[255],"suitable":[260],"could":[265],"at":[269],"membrane":[270],"level":[271],"stablish":[282],"an":[283,288],"leads":[286],"altered":[289],"signalling.":[290]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-08-05T07:39:15.569665","created_date":"2025-10-10T00:00:00"}
