{"id":"https://openalex.org/W2951001909","doi":"https://doi.org/10.1371/journal.pcbi.1006412","title":"Maintaining maximal metabolic flux by gene expression control","display_name":"Maintaining maximal metabolic flux by gene expression control","publication_year":2018,"publication_date":"2018-09-20","ids":{"openalex":"https://openalex.org/W2951001909","doi":"https://doi.org/10.1371/journal.pcbi.1006412","mag":"2951001909","pmid":"https://pubmed.ncbi.nlm.nih.gov/30235207"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006412","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006412","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006412&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006412&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004505914","display_name":"Robert Planqu\u00e9","orcid":"https://orcid.org/0000-0002-0489-5425"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Robert Planqu\u00e9","raw_affiliation_strings":["Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-0489-5425","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110069380","display_name":"Josephus Hulshof","orcid":null},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Josephus Hulshof","raw_affiliation_strings":["Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070958079","display_name":"Bas Teusink","orcid":"https://orcid.org/0000-0003-3929-0423"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bas Teusink","raw_affiliation_strings":["Systems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044142462","display_name":"Johannes C. Hendriks","orcid":null},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johannes C. Hendriks","raw_affiliation_strings":["Systems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047855050","display_name":"Frank J. Bruggeman","orcid":"https://orcid.org/0000-0002-0255-4766"},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank J. Bruggeman","raw_affiliation_strings":["Systems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Bioinformatics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004505914"],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9922,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76089747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"14","issue":"9","first_page":"e1006412","last_page":"e1006412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.6131390333175659},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5592373609542847},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4603739380836487},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4234240651130676},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4118598401546478},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3869059681892395},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3528149724006653},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22262915968894958}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6131390333175659},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5592373609542847},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4603739380836487},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4234240651130676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4118598401546478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3869059681892395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3528149724006653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22262915968894958},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001669","descriptor_name":"Biochemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1006412","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006412","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006412&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30235207","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30235207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:research.vu.nl:openaire_cris_publications/cc1864b9-0172-4d4f-8a1f-906550af5056","is_oa":true,"landing_page_url":"https://research.vu.nl/en/publications/cc1864b9-0172-4d4f-8a1f-906550af5056","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planqu\u00e9, R, Hulshof, J, Teusink, B, Hendriks, J C & Bruggeman, F J 2018, 'Maintaining maximal metabolic flux by gene expression control', PLoS Computational Biology, vol. 14, no. 9, e1006412, pp. 1-20. https://doi.org/10.1371/journal.pcbi.1006412","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1006412","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006412","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:66255b5bc4de4b739fcdf705c66c8044","is_oa":true,"landing_page_url":"https://doaj.org/article/66255b5bc4de4b739fcdf705c66c8044","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 9, p e1006412 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5138291","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6168163","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/7111964","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Maintaining_maximal_metabolic_flux_by_gene_expression_control/7111964","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:research.vu.nl:openaire/cc1864b9-0172-4d4f-8a1f-906550af5056","is_oa":true,"landing_page_url":"https://hdl.handle.net/1871.1/cc1864b9-0172-4d4f-8a1f-906550af5056","pdf_url":null,"source":{"id":"https://openalex.org/S4306401107","display_name":"VU Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Planqu\u00e9, R, Hulshof, J, Teusink, B, Hendriks, J C & Bruggeman, F J 2018, 'Maintaining maximal metabolic flux by gene expression control', PLoS Computational Biology, vol. 14, no. 9, e1006412, pp. 1-20. https://doi.org/10.1371/journal.pcbi.1006412","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006412","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006412","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006412&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.47999998927116394,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G4168079753","display_name":null,"funder_award_id":"864-11-011","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5970844481","display_name":"Cellular change management: how cells adapt to dynamic and uncertain conditions","funder_award_id":"865.14.005","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2951001909.pdf","grobid_xml":"https://content.openalex.org/works/W2951001909.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W114979488","https://openalex.org/W1492559113","https://openalex.org/W1576919957","https://openalex.org/W1603287594","https://openalex.org/W1670869534","https://openalex.org/W1763161027","https://openalex.org/W1966507944","https://openalex.org/W1969192398","https://openalex.org/W1976569548","https://openalex.org/W1984251647","https://openalex.org/W1985039493","https://openalex.org/W1985161570","https://openalex.org/W1993004545","https://openalex.org/W2003677440","https://openalex.org/W2010824267","https://openalex.org/W2027257502","https://openalex.org/W2039230661","https://openalex.org/W2044463066","https://openalex.org/W2046760236","https://openalex.org/W2048243530","https://openalex.org/W2058713700","https://openalex.org/W2061659241","https://openalex.org/W2068872007","https://openalex.org/W2072447727","https://openalex.org/W2076477598","https://openalex.org/W2078355959","https://openalex.org/W2090167557","https://openalex.org/W2091793452","https://openalex.org/W2092309107","https://openalex.org/W2095935008","https://openalex.org/W2102041830","https://openalex.org/W2103331163","https://openalex.org/W2107275175","https://openalex.org/W2111354165","https://openalex.org/W2111436192","https://openalex.org/W2117056464","https://openalex.org/W2117597548","https://openalex.org/W2128168915","https://openalex.org/W2133254839","https://openalex.org/W2162712351","https://openalex.org/W2164200677","https://openalex.org/W2167900930","https://openalex.org/W2168360074","https://openalex.org/W2170298003","https://openalex.org/W2293244428","https://openalex.org/W2312280072","https://openalex.org/W2416065856","https://openalex.org/W2508698766","https://openalex.org/W2561548155","https://openalex.org/W2571702114","https://openalex.org/W2759254532","https://openalex.org/W2765912798","https://openalex.org/W6634365307","https://openalex.org/W6673047230"],"related_works":["https://openalex.org/W2803323662","https://openalex.org/W3032874291","https://openalex.org/W2005057264","https://openalex.org/W2363156284","https://openalex.org/W2415025170","https://openalex.org/W3151254369","https://openalex.org/W2613929436","https://openalex.org/W2347793859","https://openalex.org/W46113340","https://openalex.org/W2016183850"],"abstract_inverted_index":{"One":[0],"of":[1,4,10,35,53,84,90,100,105,121,130,164],"the":[2,7,91,101,106,119,128,162],"marvels":[3],"biology":[5],"is":[6,93,134],"phenotypic":[8],"plasticity":[9],"microorganisms.":[11],"It":[12],"allows":[13],"them":[14],"to":[15,138,144],"maintain":[16],"high":[17],"growth":[18],"rates":[19,157],"across":[20,60],"conditions.":[21,61],"Studies":[22],"suggest":[23],"that":[24,56,94,111,151],"cells":[25],"can":[26,115,154],"express":[27],"metabolic":[28,58,85,107,113,159],"enzymes":[29],"at":[30,135],"tuned":[31],"concentrations":[32],"through":[33],"adjustment":[34],"gene":[36],"expression.":[37],"The":[38,87,140],"associated":[39],"transcription":[40],"factors":[41],"are":[42],"often":[43],"regulated":[44],"by":[45,74],"intracellular":[46],"metabolites.":[47],"Here":[48],"we":[49],"study":[50],"metabolite-mediated":[51],"regulation":[52],"metabolic-gene":[54],"expression":[55],"maximises":[57],"fluxes":[59],"We":[62,109,149],"developed":[63],"an":[64],"adaptive":[65],"control":[66],"theory,":[67],"qORAC":[68],"(for":[69],"'Specific":[70],"Flux":[71],"(q)":[72],"Optimization":[73],"Robust":[75],"Adaptive":[76],"Control'),":[77],"and":[78],"illustrate":[79],"it":[80,95],"with":[81],"several":[82],"examples":[83],"pathways.":[86],"key":[88],"feature":[89],"theory":[92],"does":[96],"not":[97],"require":[98,145],"knowledge":[99],"regulatory":[102],"network,":[103],"only":[104,126],"part.":[108],"derive":[110],"maximal":[112,156],"flux":[114],"be":[116],"maintained":[117],"in":[118,158,161],"face":[120,163],"varying":[122],"N":[123],"environmental":[124,165],"parameters":[125],"if":[127],"number":[129],"transcription-factor":[131],"binding":[132],"metabolites":[133],"least":[136],"equal":[137],"N.":[139],"controlling":[141],"circuits":[142],"appear":[143],"simple":[146],"biochemical":[147],"kinetics.":[148],"conclude":[150],"microorganisms":[152],"likely":[153],"achieve":[155],"pathways,":[160],"changes.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}