{"id":"https://openalex.org/W2884992538","doi":"https://doi.org/10.1371/journal.pcbi.1006276","title":"Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study","display_name":"Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study","publication_year":2018,"publication_date":"2018-07-16","ids":{"openalex":"https://openalex.org/W2884992538","doi":"https://doi.org/10.1371/journal.pcbi.1006276","mag":"2884992538","pmid":"https://pubmed.ncbi.nlm.nih.gov/30011279"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006276&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031474542","display_name":"Tanmay Gokhale","orcid":"https://orcid.org/0000-0002-9436-2058"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanmay A. Gokhale","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-9436-2058","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015078783","display_name":"Huda Asfour","orcid":"https://orcid.org/0000-0003-1968-1881"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huda Asfour","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071285358","display_name":"Shravan Verma","orcid":"https://orcid.org/0000-0002-6202-170X"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shravan Verma","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037872393","display_name":"Nenad Bursac","orcid":"https://orcid.org/0000-0002-5688-6061"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nenad Bursac","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5688-6061","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016723450","display_name":"Craig S. Henriquez","orcid":"https://orcid.org/0000-0002-5395-3767"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig S. Henriquez","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-5395-3767","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5016723450","https://openalex.org/A5037872393"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3942,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.83303879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"14","issue":"7","first_page":"e1006276","last_page":"e1006276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermal-conduction","display_name":"Thermal conduction","score":0.8375452756881714},{"id":"https://openalex.org/keywords/microscale-chemistry","display_name":"Microscale chemistry","score":0.7929830551147461},{"id":"https://openalex.org/keywords/wavefront","display_name":"Wavefront","score":0.6620274186134338},{"id":"https://openalex.org/keywords/curvature","display_name":"Curvature","score":0.6019185185432434},{"id":"https://openalex.org/keywords/anisotropy","display_name":"Anisotropy","score":0.47495269775390625},{"id":"https://openalex.org/keywords/isotropy","display_name":"Isotropy","score":0.44197148084640503},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.43102091550827026},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.4128269553184509},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.330743670463562},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.26586541533470154},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.14634692668914795},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09336844086647034}],"concepts":[{"id":"https://openalex.org/C172100665","wikidata":"https://www.wikidata.org/wiki/Q7465774","display_name":"Thermal conduction","level":2,"score":0.8375452756881714},{"id":"https://openalex.org/C179428855","wikidata":"https://www.wikidata.org/wiki/Q1069216","display_name":"Microscale chemistry","level":2,"score":0.7929830551147461},{"id":"https://openalex.org/C165699331","wikidata":"https://www.wikidata.org/wiki/Q461533","display_name":"Wavefront","level":2,"score":0.6620274186134338},{"id":"https://openalex.org/C195065555","wikidata":"https://www.wikidata.org/wiki/Q214881","display_name":"Curvature","level":2,"score":0.6019185185432434},{"id":"https://openalex.org/C85725439","wikidata":"https://www.wikidata.org/wiki/Q466686","display_name":"Anisotropy","level":2,"score":0.47495269775390625},{"id":"https://openalex.org/C184050105","wikidata":"https://www.wikidata.org/wiki/Q273163","display_name":"Isotropy","level":2,"score":0.44197148084640503},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.43102091550827026},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4128269553184509},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.330743670463562},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.26586541533470154},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.14634692668914795},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09336844086647034},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016880","descriptor_name":"Anisotropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1006276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30011279","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30011279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:15a640c4e7994c5581fb00a8b1ce1679","is_oa":false,"landing_page_url":"https://doaj.org/article/15a640c4e7994c5581fb00a8b1ce1679","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 7, p e1006276 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5025667","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6062105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6820940","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Microheterogeneity-induced_conduction_slowing_and_wavefront_collisions_govern_macroscopic_conduction_behavior_A_computational_and_experimental_study/6820940","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.44999998807907104,"id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G1551183187","display_name":null,"funder_award_id":"HL126193","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5121146239","display_name":null,"funder_award_id":"T32GM007171","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7068961528","display_name":null,"funder_award_id":"HL126193","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7359505883","display_name":null,"funder_award_id":"HL132389","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8041012589","display_name":null,"funder_award_id":"HL126524","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8138459457","display_name":null,"funder_award_id":"HL093711","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8221289633","display_name":null,"funder_award_id":"HL132389","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8587395089","display_name":null,"funder_award_id":"T32GM007171","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8913398276","display_name":null,"funder_award_id":"HL126524","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2884992538.pdf","grobid_xml":"https://content.openalex.org/works/W2884992538.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W138295271","https://openalex.org/W1591748712","https://openalex.org/W1969025266","https://openalex.org/W1969068892","https://openalex.org/W1980066231","https://openalex.org/W1988370860","https://openalex.org/W1988674900","https://openalex.org/W1991649249","https://openalex.org/W1998955714","https://openalex.org/W2009283119","https://openalex.org/W2009507063","https://openalex.org/W2014661756","https://openalex.org/W2026610396","https://openalex.org/W2030576951","https://openalex.org/W2036437780","https://openalex.org/W2051797955","https://openalex.org/W2067860260","https://openalex.org/W2069058079","https://openalex.org/W2070158545","https://openalex.org/W2070722083","https://openalex.org/W2070955119","https://openalex.org/W2072146711","https://openalex.org/W2072770548","https://openalex.org/W2074992357","https://openalex.org/W2082556734","https://openalex.org/W2089124742","https://openalex.org/W2102184100","https://openalex.org/W2102289558","https://openalex.org/W2107306408","https://openalex.org/W2109440496","https://openalex.org/W2109707676","https://openalex.org/W2112091653","https://openalex.org/W2116781723","https://openalex.org/W2121809463","https://openalex.org/W2124128466","https://openalex.org/W2129917210","https://openalex.org/W2133041530","https://openalex.org/W2137265949","https://openalex.org/W2143182748","https://openalex.org/W2149811857","https://openalex.org/W2150866578","https://openalex.org/W2153144629","https://openalex.org/W2153191620","https://openalex.org/W2158589206","https://openalex.org/W2165006299","https://openalex.org/W2333046529","https://openalex.org/W2573973927","https://openalex.org/W2743121473","https://openalex.org/W2747687017","https://openalex.org/W2796321602","https://openalex.org/W2918598742","https://openalex.org/W6605662211","https://openalex.org/W6647346523","https://openalex.org/W6658195084","https://openalex.org/W7046029206"],"related_works":["https://openalex.org/W1979808816","https://openalex.org/W2378045033","https://openalex.org/W2465699412","https://openalex.org/W2381864073","https://openalex.org/W2092867183","https://openalex.org/W4286285965","https://openalex.org/W4226399849","https://openalex.org/W4304701261","https://openalex.org/W3036150537","https://openalex.org/W2779296998"],"abstract_inverted_index":{"The":[0],"incidence":[1],"of":[2,18,43,53,65,69,77,89,114,163,174,201,210],"cardiac":[3],"arrhythmias":[4],"is":[5],"known":[6],"to":[7,61,92,102,131,145,152,157,159,167,179,208],"be":[8],"associated":[9],"with":[10],"tissue":[11],"heterogeneities":[12,21,203],"including":[13,140],"fibrosis.":[14],"However,":[15],"the":[16,63,78,86,199],"impact":[17,200],"microscopic":[19,184,202],"structural":[20],"on":[22,183,204],"conduction":[23,40,99,142,149,169],"in":[24,55,58,74,97,108,117,121,126,198],"excitable":[25],"tissues":[26],"remains":[27],"poorly":[28],"understood.":[29],"In":[30],"this":[31],"study,":[32],"we":[33],"investigated":[34],"how":[35],"acellular":[36],"microheterogeneities":[37],"affect":[38],"macroscopic":[39,135,160,205],"under":[41],"conditions":[42],"normal":[44],"and":[45,57,104,125,148,171,186,191],"reduced":[46,164],"excitability":[47,165],"by":[48],"utilizing":[49],"a":[50,105,112,172],"novel":[51],"platform":[52,193],"paired":[54],"vitro":[56],"silico":[59],"studies":[60],"examine":[62],"mechanisms":[64],"conduction.":[66],"Regular":[67],"patterns":[68],"nonconductive":[70],"micro-obstacles":[71],"were":[72,129,155],"created":[73],"confluent":[75],"monolayers":[76],"previously":[79],"described":[80],"engineered-excitable":[81],"Ex293":[82],"cell":[83],"line.":[84],"Increasing":[85],"relative":[87],"ratio":[88],"obstacle":[90],"size":[91],"intra-obstacle":[93],"strand":[94],"width":[95],"resulted":[96],"significant":[98,106],"slowing":[100,143,170,185],"up":[101],"23.6%":[103],"increase":[107],"wavefront":[109,118,153,175],"curvature":[110,176],"anisotropy,":[111],"measure":[113],"spatial":[115],"variation":[116],"shape.":[119],"Changes":[120],"bulk":[122],"electrical":[123],"conductivity":[124],"path":[127],"tortuosity":[128],"insufficient":[130],"explain":[132],"these":[133],"observed":[134],"changes.":[136],"Rather,":[137],"microscale":[138,146],"behaviors":[139],"local":[141],"due":[144,151,178],"branching,":[147],"acceleration":[150],"merging":[154],"shown":[156],"contribute":[158],"phenomena.":[161],"Conditions":[162],"led":[166],"further":[168],"reversal":[173],"anisotropy":[177],"spatially":[180],"non-uniform":[181],"effects":[182],"acceleration.":[187],"This":[188],"unique":[189],"experimental":[190],"computation":[192],"provided":[194],"critical":[195],"mechanistic":[196],"insights":[197],"conduction,":[206],"pertinent":[207],"settings":[209],"fibrotic":[211],"heart":[212],"disease.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
