{"id":"https://openalex.org/W2950448148","doi":"https://doi.org/10.1371/journal.pcbi.1006256","title":"Proteome-scale relationships between local amino acid composition and protein fates and functions","display_name":"Proteome-scale relationships between local amino acid composition and protein fates and functions","publication_year":2018,"publication_date":"2018-09-24","ids":{"openalex":"https://openalex.org/W2950448148","doi":"https://doi.org/10.1371/journal.pcbi.1006256","mag":"2950448148","pmid":"https://pubmed.ncbi.nlm.nih.gov/30248088"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006256","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006256","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006256&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006256&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087578611","display_name":"Sean M. Cascarina","orcid":"https://orcid.org/0000-0002-3054-2332"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sean M. Cascarina","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3054-2332","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066681016","display_name":"Eric D. Ross","orcid":"https://orcid.org/0000-0002-6473-9977"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric D. Ross","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6473-9977","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, United States of America","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066681016","https://openalex.org/A5087578611"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3175,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.8076353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"9","first_page":"e1006256","last_page":"e1006256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.7442666292190552},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.7433722019195557},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6485424041748047},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.6198464035987854},{"id":"https://openalex.org/keywords/organelle","display_name":"Organelle","score":0.599966824054718},{"id":"https://openalex.org/keywords/three-domain-system","display_name":"Three-domain system","score":0.58733069896698},{"id":"https://openalex.org/keywords/composition","display_name":"Composition (language)","score":0.5630670785903931},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4766286611557007},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.43715018033981323},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24175256490707397},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.15989622473716736},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11378985643386841}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7442666292190552},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7433722019195557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6485424041748047},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6198464035987854},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.599966824054718},{"id":"https://openalex.org/C188880781","wikidata":"https://www.wikidata.org/wiki/Q2430501","display_name":"Three-domain system","level":4,"score":0.58733069896698},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.5630670785903931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4766286611557007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43715018033981323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24175256490707397},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15989622473716736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11378985643386841},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1006256","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006256","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006256&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30248088","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30248088","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:5138571","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6171957","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:aff29ae5de4c4ac982d847eac0c75bbb","is_oa":true,"landing_page_url":"https://doaj.org/article/aff29ae5de4c4ac982d847eac0c75bbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 9, p e1006256 (2018)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/7123412","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Proteome-scale_relationships_between_local_amino_acid_composition_and_protein_fates_and_functions/7123412","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006256","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006256","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006256&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2857694185","display_name":null,"funder_award_id":"R01 GM105991","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5069142550","display_name":"The determinants of aggregation and toxicity of prion-like domains","funder_award_id":"5r01gm105991-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8306284039","display_name":null,"funder_award_id":"GM105991","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8576523328","display_name":"Formation and biological activity of functional protein aggregates","funder_award_id":"1517231","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950448148.pdf","grobid_xml":"https://content.openalex.org/works/W2950448148.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1497984091","https://openalex.org/W1513332069","https://openalex.org/W1553492626","https://openalex.org/W1789686293","https://openalex.org/W1854281301","https://openalex.org/W1894813487","https://openalex.org/W1952608303","https://openalex.org/W1965286266","https://openalex.org/W1966778471","https://openalex.org/W1972097354","https://openalex.org/W1972376083","https://openalex.org/W1974279135","https://openalex.org/W1985217551","https://openalex.org/W1995385480","https://openalex.org/W2009603911","https://openalex.org/W2012385113","https://openalex.org/W2013460486","https://openalex.org/W2036792148","https://openalex.org/W2044341390","https://openalex.org/W2046231927","https://openalex.org/W2051916497","https://openalex.org/W2053780937","https://openalex.org/W2059704674","https://openalex.org/W2066688961","https://openalex.org/W2080457513","https://openalex.org/W2089431713","https://openalex.org/W2100383597","https://openalex.org/W2104412724","https://openalex.org/W2107804881","https://openalex.org/W2109281577","https://openalex.org/W2114850508","https://openalex.org/W2116592258","https://openalex.org/W2118058166","https://openalex.org/W2119651404","https://openalex.org/W2120156669","https://openalex.org/W2122581451","https://openalex.org/W2123178347","https://openalex.org/W2127745643","https://openalex.org/W2131323825","https://openalex.org/W2132121416","https://openalex.org/W2134280519","https://openalex.org/W2137529106","https://openalex.org/W2139565054","https://openalex.org/W2140794408","https://openalex.org/W2143069387","https://openalex.org/W2150860983","https://openalex.org/W2153391836","https://openalex.org/W2154610073","https://openalex.org/W2159457776","https://openalex.org/W2161409639","https://openalex.org/W2164954378","https://openalex.org/W2168639701","https://openalex.org/W2236156346","https://openalex.org/W2253933438","https://openalex.org/W2271817176","https://openalex.org/W2300912113","https://openalex.org/W2410790038","https://openalex.org/W2410952036","https://openalex.org/W2467565876","https://openalex.org/W2487117808","https://openalex.org/W2557247385","https://openalex.org/W2565793933","https://openalex.org/W2597816781","https://openalex.org/W2604909829","https://openalex.org/W2748311674","https://openalex.org/W2749545656","https://openalex.org/W2755517617","https://openalex.org/W2785428883","https://openalex.org/W2792129356","https://openalex.org/W2810866092","https://openalex.org/W6698110427"],"related_works":["https://openalex.org/W1979374213","https://openalex.org/W2042187600","https://openalex.org/W2093785836","https://openalex.org/W4387354525","https://openalex.org/W1973959357","https://openalex.org/W2360158017","https://openalex.org/W2418253448","https://openalex.org/W4242384374","https://openalex.org/W2977626908","https://openalex.org/W2011585419"],"abstract_inverted_index":{"Proteins":[0],"with":[1,33,84,115],"low-complexity":[2,18,28,53,132,151],"domains":[3,19,29],"continue":[4],"to":[5,35,61,183],"emerge":[6],"as":[7,150,187],"key":[8],"players":[9],"in":[10,86,158],"both":[11],"normal":[12],"and":[13,49,70,96,121,157,209,220],"pathological":[14],"cellular":[15,47],"processes.":[16],"Although":[17],"are":[20,139],"often":[21],"grouped":[22],"into":[23,212],"a":[24,58,102,206],"single":[25],"class,":[26],"individual":[27],"can":[30],"differ":[31],"substantially":[32],"respect":[34],"amino":[36,65,110,142,163,215],"acid":[37,66,143,164,216],"composition.":[38],"These":[39],"differences":[40,85],"may":[41,173],"strongly":[42],"influence":[43],"the":[44,124,159,188],"physical":[45],"properties,":[46],"regulation,":[48],"molecular":[50,97],"functions":[51,98],"of":[52,99,108,126,131,136,161,180,190],"domains.":[54,133],"Therefore,":[55],"we":[56],"developed":[57],"bioinformatic":[59],"approach":[60],"explore":[62],"relationships":[63,213],"between":[64,128,214],"composition,":[67,217],"protein":[68,71,80,119,218,221],"metabolism,":[69,219],"function.":[72],"We":[73],"find":[74],"that":[75,167],"local":[76,106],"compositional":[77],"enrichment":[78,107],"within":[79],"sequences":[81],"is":[82,112],"associated":[83,114],"translation":[87],"efficiency,":[88],"abundance,":[89],"half-life,":[90],"protein-protein":[91],"interaction":[92],"promiscuity,":[93],"subcellular":[94],"localization,":[95],"proteins":[100],"on":[101,118],"proteome-wide":[103],"scale.":[104],"However,":[105],"related":[109,200],"acids":[111],"sometimes":[113],"opposite":[116],"effects":[117,138],"regulation":[120],"function,":[122],"highlighting":[123],"importance":[125],"distinguishing":[127],"different":[129],"types":[130],"Furthermore,":[134],"many":[135],"these":[137,203],"discernible":[140],"at":[141],"compositions":[144],"below":[145],"those":[146],"required":[147],"for":[148,198],"classification":[149],"or":[152],"statistically-biased":[153],"by":[154,170],"traditional":[155],"methods":[156,172],"absence":[160],"homopolymeric":[162],"repeats,":[165],"indicating":[166],"thresholds":[168],"employed":[169],"classical":[171],"not":[174],"reflect":[175],"biologically":[176],"relevant":[177],"criteria.":[178],"Application":[179],"our":[181],"analyses":[182],"composition-driven":[184],"processes,":[185],"such":[186],"formation":[189],"membraneless":[191],"organelles,":[192],"reveals":[193],"distinct":[194],"composition":[195],"profiles":[196],"even":[197],"closely":[199],"organelles.":[201],"Collectively,":[202],"results":[204],"provide":[205],"unique":[207],"perspective":[208],"detailed":[210],"insights":[211],"functions.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}