{"id":"https://openalex.org/W2807802914","doi":"https://doi.org/10.1371/journal.pcbi.1006221","title":"3D morphology-based clustering and simulation of human pyramidal cell dendritic spines","display_name":"3D morphology-based clustering and simulation of human pyramidal cell dendritic spines","publication_year":2018,"publication_date":"2018-06-13","ids":{"openalex":"https://openalex.org/W2807802914","doi":"https://doi.org/10.1371/journal.pcbi.1006221","mag":"2807802914","pmid":"https://pubmed.ncbi.nlm.nih.gov/29897896"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006221","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006221","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1006221/2/pcbi.1006221.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132431Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1006221/2/pcbi.1006221.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132431Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058981758","display_name":"Sergio Luengo-S\u00e1nchez","orcid":"https://orcid.org/0000-0001-8537-1879"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Sergio Luengo-Sanchez","raw_affiliation_strings":["Computational Intelligence Group, Departamento de Inteligencia Artificial, Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8537-1879","affiliations":[{"raw_affiliation_string":"Computational Intelligence Group, Departamento de Inteligencia Artificial, Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031020971","display_name":"Isabel Fernaud-Espinosa","orcid":null},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel Fernaud-Espinosa","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain","Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082"]},{"raw_affiliation_string":"Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010920098","display_name":"Concha Bielza","orcid":"https://orcid.org/0000-0001-7109-2668"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Concha Bielza","raw_affiliation_strings":["Computational Intelligence Group, Departamento de Inteligencia Artificial, Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Intelligence Group, Departamento de Inteligencia Artificial, Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026777668","display_name":"Ruth Benavides\u2010Piccione","orcid":"https://orcid.org/0000-0003-3288-9820"},"institutions":[{"id":"https://openalex.org/I2184545","display_name":"Instituto Cajal","ror":"https://ror.org/012gwbh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I2184545"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ruth Benavides-Piccione","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain","Departamento de Neurobiolog\u00eda Funcional y de Sistemas, Instituto Cajal (CSIC), Madrid, Spain","Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082"]},{"raw_affiliation_string":"Departamento de Neurobiolog\u00eda Funcional y de Sistemas, Instituto Cajal (CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I2184545"]},{"raw_affiliation_string":"Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049812833","display_name":"Pedro Larra\u00f1aga","orcid":"https://orcid.org/0000-0003-0652-9872"},"institutions":[{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pedro Larra\u00f1aga","raw_affiliation_strings":["Computational Intelligence Group, Departamento de Inteligencia Artificial, Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Intelligence Group, Departamento de Inteligencia Artificial, Escuela T\u00e9cnica Superior de Ingenieros Inform\u00e1ticos, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040552736","display_name":"Javier DeFelipe","orcid":"https://orcid.org/0000-0001-5484-0660"},"institutions":[{"id":"https://openalex.org/I2184545","display_name":"Instituto Cajal","ror":"https://ror.org/012gwbh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I2184545"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I88060688","display_name":"Universidad Polit\u00e9cnica de Madrid","ror":"https://ror.org/03n6nwv02","country_code":"ES","type":"education","lineage":["https://openalex.org/I88060688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier DeFelipe","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain","Departamento de Neurobiolog\u00eda Funcional y de Sistemas, Instituto Cajal (CSIC), Madrid, Spain","Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210115082"]},{"raw_affiliation_string":"Departamento de Neurobiolog\u00eda Funcional y de Sistemas, Instituto Cajal (CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I2184545"]},{"raw_affiliation_string":"Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, Campus Montegancedo, Madrid, Spain","institution_ids":["https://openalex.org/I88060688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058981758"],"corresponding_institution_ids":["https://openalex.org/I88060688"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3482,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89294067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"14","issue":"6","first_page":"e1006221","last_page":"e1006221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12536","display_name":"Topological and Geometric Data Analysis","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spine","display_name":"Dendritic spine","score":0.9316458702087402},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5307913422584534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5042978525161743},{"id":"https://openalex.org/keywords/morphology","display_name":"Morphology (biology)","score":0.5042234659194946},{"id":"https://openalex.org/keywords/dendritic-filopodia","display_name":"Dendritic filopodia","score":0.4786452054977417},{"id":"https://openalex.org/keywords/pyramidal-cell","display_name":"Pyramidal cell","score":0.46346157789230347},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3551814556121826},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.12598532438278198},{"id":"https://openalex.org/keywords/zoology","display_name":"Zoology","score":0.06665050983428955}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.9316458702087402},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5307913422584534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5042978525161743},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.5042234659194946},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.4786452054977417},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.46346157789230347},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3551814556121826},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.12598532438278198},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.06665050983428955},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1006221","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006221","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1006221/2/pcbi.1006221.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132431Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29897896","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29897896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:hispana.mcu.es:35438876","is_oa":false,"landing_page_url":"https://oa.upm.es/54566/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"PLOS Computational Biology, ISSN 1553-7358, 2018, Vol. 14, No. 6","raw_type":"PeerReviewed"},{"id":"pmh:oai:RePEc:plo:pcbi00:1006221","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006221","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:dnet:archivodigit::eea18bbf2e47b82b1cb454502eaa10cd","is_oa":true,"landing_page_url":"http://oa.upm.es/54566/","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, ISSN 1553-7358, 2018, Vol. 14, No. 6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:dda99d766df04acd909840fa86223a46","is_oa":true,"landing_page_url":"https://doaj.org/article/dda99d766df04acd909840fa86223a46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 6, p e1006221 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5030690","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6060563","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/6512828","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/3D_morphology-based_clustering_and_simulation_of_human_pyramidal_cell_dendritic_spines/6512828","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006221","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006221","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1006221/2/pcbi.1006221.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T132431Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7900000214576721}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2807802914.pdf"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W126840538","https://openalex.org/W151176851","https://openalex.org/W1482113029","https://openalex.org/W1499375857","https://openalex.org/W1507905035","https://openalex.org/W1587505135","https://openalex.org/W1607939528","https://openalex.org/W1670263352","https://openalex.org/W1680392829","https://openalex.org/W1829970718","https://openalex.org/W1972815737","https://openalex.org/W1974719053","https://openalex.org/W1976738367","https://openalex.org/W1983553517","https://openalex.org/W1986909933","https://openalex.org/W1991444801","https://openalex.org/W1992402718","https://openalex.org/W1997524269","https://openalex.org/W1997624050","https://openalex.org/W2000214666","https://openalex.org/W2001528712","https://openalex.org/W2011832962","https://openalex.org/W2023056405","https://openalex.org/W2033087539","https://openalex.org/W2033125075","https://openalex.org/W2035761443","https://openalex.org/W2049633694","https://openalex.org/W2056930330","https://openalex.org/W2058497941","https://openalex.org/W2060412165","https://openalex.org/W2070524933","https://openalex.org/W2074728660","https://openalex.org/W2082398846","https://openalex.org/W2090043895","https://openalex.org/W2090490936","https://openalex.org/W2091354315","https://openalex.org/W2099347739","https://openalex.org/W2100174069","https://openalex.org/W2117664079","https://openalex.org/W2119060960","https://openalex.org/W2122895127","https://openalex.org/W2133990480","https://openalex.org/W2137979527","https://openalex.org/W2148143831","https://openalex.org/W2154838123","https://openalex.org/W2156678388","https://openalex.org/W2160983643","https://openalex.org/W2164811687","https://openalex.org/W2165939338","https://openalex.org/W2166698530","https://openalex.org/W2168175751","https://openalex.org/W2229412420","https://openalex.org/W2406566318","https://openalex.org/W2411925630","https://openalex.org/W2437223354","https://openalex.org/W2495797471","https://openalex.org/W2529356830","https://openalex.org/W2531563875","https://openalex.org/W2561494620","https://openalex.org/W2760721217","https://openalex.org/W2795998755","https://openalex.org/W2977466517","https://openalex.org/W6664635345"],"related_works":["https://openalex.org/W2153083261","https://openalex.org/W2039508969","https://openalex.org/W4200170201","https://openalex.org/W2091097296","https://openalex.org/W1990976327","https://openalex.org/W2152832754","https://openalex.org/W2045957364","https://openalex.org/W2127861262","https://openalex.org/W2029971296","https://openalex.org/W2054116827"],"abstract_inverted_index":{"The":[0],"dendritic":[1,40,53,62,75,143],"spines":[2,54,63,110],"of":[3,9,22,35,73,88,96,109,116,134,142],"pyramidal":[4,58,136],"neurons":[5,59,137],"are":[6],"the":[7,14,32,80,85,113,131,140],"targets":[8],"most":[10],"excitatory":[11],"synapses":[12],"in":[13,45],"cerebral":[15],"cortex.":[16],"They":[17],"have":[18],"a":[19,94,124],"wide":[20],"variety":[21],"morphologies,":[23],"and":[24],"their":[25],"morphology":[26,141],"appears":[27],"to":[28,60],"be":[29],"critical":[30],"from":[31,55],"functional":[33,132],"point":[34],"view.":[36],"To":[37,77],"further":[38],"characterize":[39],"spine":[41],"geometry,":[42],"we":[43],"used":[44],"this":[46],"paper":[47],"over":[48],"7,000":[49],"individually":[50],"3D":[51,106],"reconstructed":[52],"human":[56,74,135],"cortical":[57],"group":[61,90],"using":[64],"model-based":[65],"clustering.":[66],"This":[67,119],"approach":[68,121],"uncovered":[69],"six":[70],"separate":[71],"groups":[72],"spines.":[76,144],"better":[78],"understand":[79],"differences":[81],"between":[82],"these":[83],"groups,":[84],"discriminative":[86],"characteristics":[87],"each":[89,117],"were":[91],"identified":[92],"as":[93],"set":[95],"rules.":[97],"Model-based":[98],"clustering":[99],"was":[100],"also":[101],"useful":[102,125],"for":[103,127],"simulating":[104],"accurate":[105],"virtual":[107],"representations":[108],"that":[111],"matched":[112],"morphological":[114],"definitions":[115],"cluster.":[118],"mathematical":[120],"could":[122],"provide":[123],"tool":[126],"theoretical":[128],"predictions":[129],"on":[130,139],"features":[133],"based":[138]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
