{"id":"https://openalex.org/W2920495229","doi":"https://doi.org/10.1371/journal.pcbi.1006213","title":"The genetic basis for adaptation of model-designed syntrophic co-cultures","display_name":"The genetic basis for adaptation of model-designed syntrophic co-cultures","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2920495229","doi":"https://doi.org/10.1371/journal.pcbi.1006213","mag":"2920495229","pmid":"https://pubmed.ncbi.nlm.nih.gov/30822347"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006213","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006213","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006213&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006213&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008123229","display_name":"Colton J. Lloyd","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colton J. Lloyd","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-6556-6345","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075454403","display_name":"Zachary A. King","orcid":"https://orcid.org/0000-0003-1238-1499"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary A. King","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1238-1499","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048081015","display_name":"Troy E. Sandberg","orcid":"https://orcid.org/0000-0003-3240-3659"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy E. Sandberg","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072991489","display_name":"Ying Hefner","orcid":"https://orcid.org/0000-0003-3092-2914"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Hefner","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028654663","display_name":"Connor A. Olson","orcid":"https://orcid.org/0000-0003-3681-0446"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor A. Olson","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3681-0446","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073232270","display_name":"Patrick V. Phaneuf","orcid":"https://orcid.org/0000-0002-4122-6589"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick V. Phaneuf","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4122-6589","affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051432302","display_name":"Edward J. O\u2019Brien","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. O\u2019Brien","raw_affiliation_strings":["Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069073018","display_name":"Jon G. Sanders","orcid":"https://orcid.org/0000-0001-6077-4014"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon G. Sanders","raw_affiliation_strings":["Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, United States of America","Department of Pediatrics, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, United States of America","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022020022","display_name":"Rodolfo A. Salido","orcid":"https://orcid.org/0000-0003-0631-2817"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodolfo A. Salido","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0631-2817","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002373415","display_name":"Karenina Sanders","orcid":"https://orcid.org/0000-0002-6793-5770"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karenina Sanders","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-6793-5770","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066195302","display_name":"Caitriona Brennan","orcid":"https://orcid.org/0000-0003-3943-6701"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitriona Brennan","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-3943-6701","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082559708","display_name":"Gregory Humphrey","orcid":"https://orcid.org/0000-0003-3930-1663"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Humphrey","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033881627","display_name":"Rob Knight","orcid":"https://orcid.org/0000-0002-0975-9019"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob Knight","raw_affiliation_strings":["Center for Microbiome Innovation, University of California, San Diego, La Jolla, United States of America","Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","Department of Computer Science and Engineering, University of California, San Diego, La Jolla, United States of America","Department of Pediatrics, University of California, San Diego, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062042072","display_name":"Adam M. Feist","orcid":"https://orcid.org/0000-0002-8630-4800"},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","US"],"is_corresponding":true,"raw_author_name":"Adam M. Feist","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8630-4800","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, United States of America","institution_ids":["https://openalex.org/I4210133661","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5062042072"],"corresponding_institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I36258959","https://openalex.org/I4210133661","https://openalex.org/I96673099"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.282,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.79638606,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"15","issue":"3","first_page":"e1006213","last_page":"e1006213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.6790308952331543},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4913105070590973},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48297062516212463},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48167550563812256},{"id":"https://openalex.org/keywords/basis","display_name":"Basis (linear algebra)","score":0.4503239691257477},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.0960473120212555}],"concepts":[{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6790308952331543},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4913105070590973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48297062516212463},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48167550563812256},{"id":"https://openalex.org/C12426560","wikidata":"https://www.wikidata.org/wiki/Q189569","display_name":"Basis (linear algebra)","level":2,"score":0.4503239691257477},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0960473120212555},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pcbi.1006213","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006213","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006213&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30822347","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30822347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt49t371kv","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/49t371kv","pdf_url":"https://escholarship.org/uc/item/49t371kv","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology, vol 15, iss 3","raw_type":"article"},{"id":"pmh:ark:/13030/qt49t371kv","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:0b08cea9e4384dfd9328432a74685e89","is_oa":true,"landing_page_url":"https://doaj.org/article/0b08cea9e4384dfd9328432a74685e89","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 15, Iss 3, p e1006213 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5424960","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6415869","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/7793660","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_genetic_basis_for_adaptation_of_model-designed_syntrophic_co-cultures/7793660","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:osti.gov:1497437","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1497437","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1499215","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1499215","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1530862","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1530862","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pure.atira.dk:publications/70939dd1-e067-4f9c-a538-affd50e45197","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/70939dd1-e067-4f9c-a538-affd50e45197","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lloyd , C J , King , Z A , Sandberg , T E , Hefner , Y , Olson , C A , Phaneuf , P V , O'Brien , E J , Sanders , J G , Salido , R A , Sanders , K , Brennan , C , Humphrey , G , Knight , R &amp; Feist , A M 2019 , ' The genetic basis for adaptation of model-designed syntrophic co-cultures ' , PLOS Computational Biology , vol. 15 , no. 3 , e1006213 . https://doi.org/10.1371/journal.pcbi.1006213","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006213","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006213","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006213&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1286236842","display_name":null,"funder_award_id":"-AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1495466395","display_name":null,"funder_award_id":"NIH R01 GM057089","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1540404058","display_name":null,"funder_award_id":"R01 GM057089","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1677143136","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320317220","funder_display_name":"National Energy Research Scientific Computing Center"},{"id":"https://openalex.org/G2503023272","display_name":null,"funder_award_id":"Contract No. DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2539837713","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2675982406","display_name":null,"funder_award_id":"R01 GM057089","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3083819904","display_name":null,"funder_award_id":"05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3638305810","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4026863680","display_name":null,"funder_award_id":"1144086","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4109252005","display_name":null,"funder_award_id":"GM057089","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4501827968","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4565140552","display_name":null,"funder_award_id":"-AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G4785396660","display_name":null,"funder_award_id":"U01AI124316","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G5076365615","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320317220","funder_display_name":"National Energy Research Scientific Computing Center"},{"id":"https://openalex.org/G5296923526","display_name":null,"funder_award_id":"Contract No. DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320317220","funder_display_name":"National Energy Research Scientific Computing Center"},{"id":"https://openalex.org/G5417901379","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G6160741424","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320323153","funder_display_name":"Danmarks Tekniske Universitet"},{"id":"https://openalex.org/G6348972864","display_name":null,"funder_award_id":"AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6373098069","display_name":null,"funder_award_id":"U01AI124316","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6553254277","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6558272803","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7233692708","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7368046788","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7538560101","display_name":null,"funder_award_id":"DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7555623405","display_name":null,"funder_award_id":"DGE-1144086","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7672463193","display_name":null,"funder_award_id":"No. DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G7701966108","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G805243471","display_name":null,"funder_award_id":"Contract No. DE-AC02-05CH11231","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G8055720154","display_name":null,"funder_award_id":"GM057089","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8972364257","display_name":null,"funder_award_id":"NNF10CC1016517","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320317220","display_name":"National Energy Research Scientific Computing Center","ror":"https://ror.org/05v3mvq14"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323153","display_name":"Danmarks Tekniske Universitet","ror":"https://ror.org/04qtj9h94"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2920495229.pdf","grobid_xml":"https://content.openalex.org/works/W2920495229.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W1509674904","https://openalex.org/W1535567480","https://openalex.org/W1546232003","https://openalex.org/W1602357967","https://openalex.org/W1628821170","https://openalex.org/W1824535033","https://openalex.org/W1828505669","https://openalex.org/W1832792590","https://openalex.org/W1889289315","https://openalex.org/W1893986342","https://openalex.org/W1955448153","https://openalex.org/W1958250075","https://openalex.org/W1964832282","https://openalex.org/W1967677046","https://openalex.org/W1968033606","https://openalex.org/W1970559599","https://openalex.org/W1974662378","https://openalex.org/W1975597731","https://openalex.org/W1982013068","https://openalex.org/W1984445372","https://openalex.org/W1991509434","https://openalex.org/W1998240064","https://openalex.org/W2005931802","https://openalex.org/W2022616740","https://openalex.org/W2022720960","https://openalex.org/W2028974656","https://openalex.org/W2029403511","https://openalex.org/W2029764374","https://openalex.org/W2029945156","https://openalex.org/W2038168681","https://openalex.org/W2041500621","https://openalex.org/W2047389560","https://openalex.org/W2048465561","https://openalex.org/W2048950596","https://openalex.org/W2056747353","https://openalex.org/W2060566975","https://openalex.org/W2076393137","https://openalex.org/W2085661494","https://openalex.org/W2090971499","https://openalex.org/W2097113949","https://openalex.org/W2107349404","https://openalex.org/W2108234281","https://openalex.org/W2108595206","https://openalex.org/W2108656223","https://openalex.org/W2109251637","https://openalex.org/W2111967267","https://openalex.org/W2113497222","https://openalex.org/W2113651242","https://openalex.org/W2114064051","https://openalex.org/W2114270359","https://openalex.org/W2121427573","https://openalex.org/W2122093325","https://openalex.org/W2122860350","https://openalex.org/W2124737787","https://openalex.org/W2126175129","https://openalex.org/W2126999541","https://openalex.org/W2128710055","https://openalex.org/W2129087744","https://openalex.org/W2129890743","https://openalex.org/W2130335772","https://openalex.org/W2132473766","https://openalex.org/W2142026735","https://openalex.org/W2146134224","https://openalex.org/W2148520571","https://openalex.org/W2149001103","https://openalex.org/W2152625710","https://openalex.org/W2154139219","https://openalex.org/W2163949203","https://openalex.org/W2167708455","https://openalex.org/W2170298003","https://openalex.org/W2170551349","https://openalex.org/W2181523240","https://openalex.org/W2224056471","https://openalex.org/W2271440286","https://openalex.org/W2290768068","https://openalex.org/W2293953879","https://openalex.org/W2397950241","https://openalex.org/W2402388476","https://openalex.org/W2416065856","https://openalex.org/W2521256720","https://openalex.org/W2538527935","https://openalex.org/W2541638185","https://openalex.org/W2545368672","https://openalex.org/W2559597060","https://openalex.org/W2561317414","https://openalex.org/W2568053875","https://openalex.org/W2598066557","https://openalex.org/W2609618150","https://openalex.org/W2616621860","https://openalex.org/W2764202526","https://openalex.org/W2767593460","https://openalex.org/W2780989829","https://openalex.org/W2787668501","https://openalex.org/W2794647037","https://openalex.org/W2833943491","https://openalex.org/W2898448106","https://openalex.org/W2903357856","https://openalex.org/W2913984908","https://openalex.org/W3098462215","https://openalex.org/W3101329979","https://openalex.org/W4233120011","https://openalex.org/W4240165350"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2061542922"],"abstract_inverted_index":{"Understanding":[0],"the":[1,25,32,58,129,150,165,173,182,201],"fundamental":[2,170],"characteristics":[3,171],"of":[4,34,93,101,156,172,203],"microbial":[5],"communities":[6,53],"could":[7],"have":[8],"far":[9],"reaching":[10],"implications":[11],"for":[12,147],"human":[13],"health":[14],"and":[15,28,119,142,158,169,190],"applied":[16],"biotechnology.":[17],"Despite":[18],"this,":[19],"much":[20],"is":[21],"still":[22],"unknown":[23],"regarding":[24],"genetic":[26,130,183],"basis":[27],"evolutionary":[29],"strategies":[30,184],"underlying":[31,185],"formation":[33,189],"viable":[35,49,186],"synthetic":[36],"communities.":[37,175,205],"By":[38],"pairing":[39],"auxotrophic":[40,77,109],"mutants":[41],"in":[42],"co-culture,":[43],"it":[44],"has":[45],"been":[46],"demonstrated":[47],"that":[48,79,97,199],"nascent":[50,187],"E.":[51,75],"coli":[52,76],"can":[54],"be":[55],"established":[56],"where":[57],"mutant":[59],"strains":[60,78],"are":[61],"metabolically":[62],"coupled.":[63],"A":[64,153],"novel":[65,94],"algorithm,":[66],"OptAux,":[67],"was":[68,161],"constructed":[69],"to":[70,84,136,149,163,195],"design":[71],"61":[72],"unique":[73],"multi-knockout":[74],"require":[80],"significant":[81],"metabolite":[82],"uptake":[83],"grow.":[85],"These":[86],"predicted":[87,107],"knockouts":[88],"included":[89],"a":[90,191],"diverse":[91,111],"set":[92],"non-specific":[95,108],"auxotrophs":[96],"result":[98],"from":[99],"inhibition":[100],"major":[102],"biosynthetic":[103],"subsystems.":[104],"Three":[105],"OptAux":[106],"strains-with":[110],"metabolic":[112,197],"deficiencies-were":[113],"co-cultured":[114],"with":[115],"an":[116],"L-histidine":[117],"auxotroph":[118],"optimized":[120],"via":[121],"adaptive":[122],"laboratory":[123],"evolution":[124],"(ALE).":[125],"Time-course":[126],"sequencing":[127],"revealed":[128],"changes":[131,198],"employed":[132],"by":[133],"each":[134],"strain":[135],"achieve":[137],"higher":[138],"community":[139,154,167,188],"growth":[140],"rates":[141],"provided":[143],"insight":[144,180],"into":[145,181],"mechanisms":[146],"adapting":[148],"syntrophic":[151],"niche.":[152],"model":[155],"metabolism":[157],"gene":[159],"expression":[160],"utilized":[162],"predict":[164],"relative":[166],"composition":[168],"evolved":[174],"This":[176],"work":[177],"presents":[178],"new":[179],"cutting-edge":[192],"computational":[193],"method":[194],"elucidate":[196],"empower":[200],"creation":[202],"cooperative":[204]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3}],"updated_date":"2026-05-09T13:55:54.758798","created_date":"2025-10-10T00:00:00"}
