{"id":"https://openalex.org/W2807174788","doi":"https://doi.org/10.1371/journal.pcbi.1006186","title":"Minimal model of interictal and ictal discharges \u201cEpileptor-2\u201d","display_name":"Minimal model of interictal and ictal discharges \u201cEpileptor-2\u201d","publication_year":2018,"publication_date":"2018-05-31","ids":{"openalex":"https://openalex.org/W2807174788","doi":"https://doi.org/10.1371/journal.pcbi.1006186","mag":"2807174788","pmid":"https://pubmed.ncbi.nlm.nih.gov/29851959"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006186","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006186","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006186&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006186&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077603985","display_name":"Anton V. Chizhov","orcid":"https://orcid.org/0000-0002-7993-6770"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]},{"id":"https://openalex.org/I95568926","display_name":"Ioffe Institute","ror":"https://ror.org/05dkdaa55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I95568926"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Anton V. Chizhov","raw_affiliation_strings":["Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7993-6770","affiliations":[{"raw_affiliation_string":"Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I95568926"]},{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026291245","display_name":"Artyom V. Zefirov","orcid":null},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]},{"id":"https://openalex.org/I95568926","display_name":"Ioffe Institute","ror":"https://ror.org/05dkdaa55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I95568926"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Artyom V. Zefirov","raw_affiliation_strings":["Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I95568926"]},{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054408516","display_name":"Dmitry V. Amakhin","orcid":"https://orcid.org/0000-0002-7098-4768"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry V. Amakhin","raw_affiliation_strings":["Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111716073","display_name":"Elena Y. Smirnova","orcid":null},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]},{"id":"https://openalex.org/I95568926","display_name":"Ioffe Institute","ror":"https://ror.org/05dkdaa55","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210096333","https://openalex.org/I95568926"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena Yu. Smirnova","raw_affiliation_strings":["Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Physics Laboratory, Ioffe Institute, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I95568926"]},{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054294231","display_name":"Aleksey V. Zaitsev","orcid":"https://orcid.org/0000-0002-4503-0647"},"institutions":[{"id":"https://openalex.org/I163234304","display_name":"Institute of Evolutionary Physiology and Biochemistry","ror":"https://ror.org/02vf4sk45","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I163234304","https://openalex.org/I4210115279"]},{"id":"https://openalex.org/I3018698992","display_name":"Federal Almazov North-West Medical Research Centre","ror":"https://ror.org/03qepc107","country_code":"RU","type":"facility","lineage":["https://openalex.org/I3018698992"]},{"id":"https://openalex.org/I4210126033","display_name":"Institute of Experimental Medicine","ror":"https://ror.org/0344x6030","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126033"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aleksey V. Zaitsev","raw_affiliation_strings":["Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia","Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia"],"raw_orcid":"https://orcid.org/0000-0002-4503-0647","affiliations":[{"raw_affiliation_string":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I3018698992","https://openalex.org/I4210126033"]},{"raw_affiliation_string":"Laboratory of Molecular Mechanisms of Neural Interactions, Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg, Russia","institution_ids":["https://openalex.org/I163234304"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5077603985"],"corresponding_institution_ids":["https://openalex.org/I163234304","https://openalex.org/I95568926"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.4429,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.95763192,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"5","first_page":"e1006186","last_page":"e1006186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.7327141761779785},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.628244161605835},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.49401599168777466},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.4780885875225067},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.47354382276535034},{"id":"https://openalex.org/keywords/bursting","display_name":"Bursting","score":0.4360452890396118},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40418750047683716},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3964079022407532},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3894440531730652},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.37949854135513306},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.34842753410339355},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17012730240821838}],"concepts":[{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.7327141761779785},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.628244161605835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49401599168777466},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.4780885875225067},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.47354382276535034},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.4360452890396118},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40418750047683716},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3964079022407532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3894440531730652},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.37949854135513306},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.34842753410339355},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17012730240821838},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1006186","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006186","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006186&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:29851959","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29851959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1006186","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006186","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c54790d300a845b48d6b1a35da73d757","is_oa":true,"landing_page_url":"https://doaj.org/article/c54790d300a845b48d6b1a35da73d757","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 5, p e1006186 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4965938","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6005638","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6005638","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6005638","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006186","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006186","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006186&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7165367222","display_name":null,"funder_award_id":"16-15-10201","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2807174788.pdf","grobid_xml":"https://content.openalex.org/works/W2807174788.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W416630258","https://openalex.org/W1484977481","https://openalex.org/W1552277675","https://openalex.org/W1561818412","https://openalex.org/W1575874727","https://openalex.org/W1576838367","https://openalex.org/W1617948373","https://openalex.org/W1623815617","https://openalex.org/W1977198123","https://openalex.org/W1979787136","https://openalex.org/W1982588549","https://openalex.org/W1986910593","https://openalex.org/W1987594947","https://openalex.org/W1999647352","https://openalex.org/W2000690216","https://openalex.org/W2009332732","https://openalex.org/W2011125340","https://openalex.org/W2017791457","https://openalex.org/W2019137683","https://openalex.org/W2027322435","https://openalex.org/W2028216578","https://openalex.org/W2028756092","https://openalex.org/W2034457899","https://openalex.org/W2046686563","https://openalex.org/W2052394872","https://openalex.org/W2059602156","https://openalex.org/W2076462587","https://openalex.org/W2090046827","https://openalex.org/W2103081445","https://openalex.org/W2105003565","https://openalex.org/W2105752803","https://openalex.org/W2109611921","https://openalex.org/W2117469172","https://openalex.org/W2129341187","https://openalex.org/W2133100820","https://openalex.org/W2148654448","https://openalex.org/W2153955459","https://openalex.org/W2155965080","https://openalex.org/W2157338202","https://openalex.org/W2158645550","https://openalex.org/W2164472144","https://openalex.org/W2164493064","https://openalex.org/W2164653071","https://openalex.org/W2170437301","https://openalex.org/W2184272066","https://openalex.org/W2219448291","https://openalex.org/W2495482469","https://openalex.org/W2530677564","https://openalex.org/W2547104198","https://openalex.org/W2554698846","https://openalex.org/W2555532477","https://openalex.org/W2615262201","https://openalex.org/W2749494937","https://openalex.org/W2758730336","https://openalex.org/W2761540508","https://openalex.org/W2950195476","https://openalex.org/W4322701228"],"related_works":["https://openalex.org/W2080788537","https://openalex.org/W3181055709","https://openalex.org/W2002830460","https://openalex.org/W2064213689","https://openalex.org/W2036451364","https://openalex.org/W3195397619","https://openalex.org/W4243975172","https://openalex.org/W2130293530","https://openalex.org/W2165689100","https://openalex.org/W2090649048"],"abstract_inverted_index":{"Seizures":[0],"occur":[1],"in":[2,78,119,153,215,240,257,264],"a":[3,26,54,86,154,213,265,269,273,279,294,298],"recurrent":[4],"manner":[5],"with":[6],"intermittent":[7],"states":[8,52],"of":[9,28,39,42,61,80,90,171,178,212,218,243,251,260,283,304],"interictal":[10],"and":[11,15,20,33,92,126,132,187,201,209,225,286],"ictal":[12],"discharges":[13,44],"(IIDs":[14],"IDs).":[16],"The":[17,115,182,207,227,254],"transitions":[18,50],"to":[19,100,112,149,168,300],"from":[21,164,297],"IDs":[22,93,255],"are":[23,235,246],"determined":[24],"by":[25,69,142,196,248],"set":[27],"processes,":[29],"including":[30],"synaptic":[31,134],"interaction":[32],"ionic":[34,252,284],"dynamics.":[35],"Although":[36],"mathematical":[37,59,228],"models":[38],"separate":[40],"types":[41],"epileptic":[43],"have":[45],"been":[46,67],"developed,":[47],"modeling":[48,303],"the":[49,103,106,113,143,162,165,169,189,194,198,204,221,232,241,258,289],"between":[51],"remains":[53],"challenge.":[55],"A":[56,137],"simple":[57,99,299],"generic":[58],"model":[60,89,108,116,140,217,223,290],"seizure":[62],"dynamics":[63,285],"(Epileptor)":[64],"has":[65],"recently":[66],"proposed":[68,95],"Jirsa":[70],"et":[71],"al.":[72],"(2014);":[73],"however,":[74],"it":[75],"is":[76,94,97,117,147,176],"formulated":[77],"terms":[79],"abstract":[81],"variables.":[82,114,136],"In":[83,157],"this":[84],"paper,":[85],"minimal":[87,280],"population-type":[88],"IIDs":[91],"that":[96,231],"as":[98,102,293],"use":[101],"Epileptor,":[104],"but":[105],"suggested":[107],"attributes":[109],"physical":[110],"meaning":[111],"expressed":[118],"ordinary":[120],"differential":[121],"equations":[122],"for":[123,272],"extracellular":[124],"potassium":[125,159,199,262],"intracellular":[127],"sodium":[128,183],"concentrations,":[129],"membrane":[130],"potential,":[131],"short-term":[133],"depression":[135],"quadratic":[138],"integrate-and-fire":[139],"driven":[141],"population":[144],"input":[145],"current":[146],"used":[148],"reproduce":[150],"spike":[151],"trains":[152],"representative":[155],"neuron.":[156],"simulations,":[158],"accumulation":[160],"governs":[161],"transition":[163],"silent":[166],"state":[167,170],"an":[172],"ID.":[173],"Each":[174],"ID":[175,195,244],"composed":[177],"clustered":[179],"IID-like":[180,233],"events.":[181],"accumulates":[184],"during":[185],"discharge":[186],"activates":[188],"sodium-potassium":[190],"pump,":[191],"which":[192,239],"terminates":[193],"restoring":[197],"gradient":[200],"thus":[202],"polarizing":[203],"neuronal":[205],"membranes.":[206],"whole-cell":[208],"cell-attached":[210],"recordings":[211],"4-AP-based":[214],"vitro":[216],"epilepsy":[219],"confirmed":[220],"primary":[222],"assumptions":[224],"predictions.":[226],"analysis":[229],"revealed":[230],"events":[234],"large-amplitude":[236],"stochastic":[237],"oscillations,":[238],"case":[242],"generation":[245],"controlled":[247],"slow":[249],"oscillations":[250],"concentrations.":[253],"originate":[256],"conditions":[259],"elevated":[261],"concentrations":[263],"bath":[266],"solution":[267],"via":[268],"saddle-node-on-invariant-circle-like":[270],"bifurcation":[271],"non-smooth":[274],"dynamical":[275],"system.":[276],"By":[277],"providing":[278],"biophysical":[281],"description":[282],"network":[287],"interactions,":[288],"may":[291],"serve":[292],"hierarchical":[295],"base":[296],"more":[301],"complex":[302],"seizures.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}