{"id":"https://openalex.org/W2887479833","doi":"https://doi.org/10.1371/journal.pcbi.1006170","title":"Exploring of the feature space of de novo developed post-transcriptional riboregulators","display_name":"Exploring of the feature space of de novo developed post-transcriptional riboregulators","publication_year":2018,"publication_date":"2018-08-17","ids":{"openalex":"https://openalex.org/W2887479833","doi":"https://doi.org/10.1371/journal.pcbi.1006170","mag":"2887479833","pmid":"https://pubmed.ncbi.nlm.nih.gov/30118473"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1006170","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006170","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006170&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006170&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030921206","display_name":"Gert Peters","orcid":null},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Gert Peters","raw_affiliation_strings":["Centre for Synthetic Biology, Ghent University, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Synthetic Biology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109337938","display_name":"Jo Maertens","orcid":null},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jo Maertens","raw_affiliation_strings":["Centre for Synthetic Biology, Ghent University, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Synthetic Biology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064200316","display_name":"Jeroen Lammertyn","orcid":"https://orcid.org/0000-0001-8143-6794"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeroen Lammertyn","raw_affiliation_strings":["BIOSYST-MeBioS, KU Leuven, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-8143-6794","affiliations":[{"raw_affiliation_string":"BIOSYST-MeBioS, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026523298","display_name":"Marjan De Mey","orcid":"https://orcid.org/0000-0002-8134-9436"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Marjan De Mey","raw_affiliation_strings":["Centre for Synthetic Biology, Ghent University, Ghent, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-8134-9436","affiliations":[{"raw_affiliation_string":"Centre for Synthetic Biology, Ghent University, Ghent, Belgium","institution_ids":["https://openalex.org/I32597200"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026523298"],"corresponding_institution_ids":["https://openalex.org/I32597200"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3608,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.59612363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"8","first_page":"e1006170","last_page":"e1006170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychological-repression","display_name":"Psychological repression","score":0.7412189245223999},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.6812400817871094},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6528062224388123},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6011461019515991},{"id":"https://openalex.org/keywords/protein-biosynthesis","display_name":"Protein biosynthesis","score":0.5410093665122986},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5346179604530334},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4862760305404663},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.48448440432548523},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4844539165496826},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.4583349823951721},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.45746666193008423},{"id":"https://openalex.org/keywords/untranslated-region","display_name":"Untranslated region","score":0.43780145049095154},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33423709869384766},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3097391426563263}],"concepts":[{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.7412189245223999},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6812400817871094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6528062224388123},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6011461019515991},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5410093665122986},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5346179604530334},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4862760305404663},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.48448440432548523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4844539165496826},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4583349823951721},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45746666193008423},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.43780145049095154},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33423709869384766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3097391426563263}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1006170","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006170","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006170&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:30118473","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30118473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/645116","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/645116","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Plos Computational Biology, vol. 14 (8), Art.No. ARTN e1006170","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1006170","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006170","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:archive.ugent.be:8571262","is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-8571262","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1553-7358","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:a49bada8530f411aa1c3657c4a621cb5","is_oa":false,"landing_page_url":"https://doaj.org/article/a49bada8530f411aa1c3657c4a621cb5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 14, Iss 8, p e1006170 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5087772","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6114898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1006170","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1006170","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006170&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2133747316","display_name":null,"funder_award_id":"BOF16/IOP/040","funder_id":"https://openalex.org/F4320335227","funder_display_name":"Bijzonder Onderzoeksfonds UGent"},{"id":"https://openalex.org/G5014186260","display_name":"Microfabricated inspection devices for cellomics.","funder_award_id":"121353","funder_id":"https://openalex.org/F4320321732","funder_display_name":"Agentschap voor Innovatie door Wetenschap en Technologie"},{"id":"https://openalex.org/G6610966632","display_name":null,"funder_award_id":"BOF16/IOP/040","funder_id":"https://openalex.org/F4320322603","funder_display_name":"Universiteit Gent"}],"funders":[{"id":"https://openalex.org/F4320321732","display_name":"Agentschap voor Innovatie door Wetenschap en Technologie","ror":"https://ror.org/01antkr91"},{"id":"https://openalex.org/F4320322603","display_name":"Universiteit Gent","ror":"https://ror.org/00cv9y106"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320335227","display_name":"Bijzonder Onderzoeksfonds UGent","ror":"https://ror.org/00cv9y106"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887479833.pdf","grobid_xml":"https://content.openalex.org/works/W2887479833.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1543796220","https://openalex.org/W1579030151","https://openalex.org/W1784951239","https://openalex.org/W1828349382","https://openalex.org/W1860911392","https://openalex.org/W1877265446","https://openalex.org/W1966645118","https://openalex.org/W1978119727","https://openalex.org/W1980348663","https://openalex.org/W1982492875","https://openalex.org/W1989295284","https://openalex.org/W1989351173","https://openalex.org/W1990226486","https://openalex.org/W1993154270","https://openalex.org/W1998334766","https://openalex.org/W2004161015","https://openalex.org/W2011081257","https://openalex.org/W2016667239","https://openalex.org/W2022186026","https://openalex.org/W2029999943","https://openalex.org/W2038922280","https://openalex.org/W2045295945","https://openalex.org/W2045958990","https://openalex.org/W2045991415","https://openalex.org/W2047360542","https://openalex.org/W2051777566","https://openalex.org/W2074565201","https://openalex.org/W2079044374","https://openalex.org/W2080151858","https://openalex.org/W2080233018","https://openalex.org/W2085444284","https://openalex.org/W2086440427","https://openalex.org/W2086561953","https://openalex.org/W2088631531","https://openalex.org/W2104152588","https://openalex.org/W2107523606","https://openalex.org/W2109727090","https://openalex.org/W2113616421","https://openalex.org/W2113949169","https://openalex.org/W2117431427","https://openalex.org/W2119340328","https://openalex.org/W2120498503","https://openalex.org/W2120831623","https://openalex.org/W2122062614","https://openalex.org/W2122683100","https://openalex.org/W2129706781","https://openalex.org/W2132922290","https://openalex.org/W2132963003","https://openalex.org/W2137003403","https://openalex.org/W2140959043","https://openalex.org/W2145531823","https://openalex.org/W2146883833","https://openalex.org/W2146958608","https://openalex.org/W2147438894","https://openalex.org/W2155752821","https://openalex.org/W2156252266","https://openalex.org/W2160051211","https://openalex.org/W2164112899","https://openalex.org/W2165612309","https://openalex.org/W2165706975","https://openalex.org/W2168059482","https://openalex.org/W2169440322","https://openalex.org/W2273190468","https://openalex.org/W2282184745","https://openalex.org/W2302443832","https://openalex.org/W2313697469","https://openalex.org/W2338350425","https://openalex.org/W2344729676","https://openalex.org/W2395549144","https://openalex.org/W2501525611","https://openalex.org/W2950851734","https://openalex.org/W2952362992","https://openalex.org/W4232421753"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W1543402492","https://openalex.org/W2101501829","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2060263731","https://openalex.org/W2117627298","https://openalex.org/W391093122","https://openalex.org/W1985297433"],"abstract_inverted_index":{"Metabolic":[0],"engineering":[1,258],"increasingly":[2],"depends":[3],"upon":[4],"RNA":[5,144,169,227,267],"technology":[6],"to":[7,12,58,77,104,111,164,171,184,220,229],"customly":[8],"rewire":[9],"the":[10,25,65,68,84,166,177,187,222,266],"metabolism":[11],"maximize":[13],"production.":[14],"To":[15,205],"this":[16,48,79,141,233],"end,":[17],"pure":[18,174,247,261],"riboregulators":[19,100,147,175,228],"allow":[20,206],"dynamic":[21],"gene":[22,230,244,270],"repression":[23,182,245],"without":[24],"need":[26],"of":[27,71,74,81,86,124,179,186,224,259],"a":[28,151,199,210,252],"potentially":[29],"burdensome":[30],"coexpressed":[31],"protein":[32,189],"like":[33],"typical":[34],"Hfq":[35],"binding":[36],"small":[37],"RNAs":[38,91],"and":[39,67,106,119,154,157,218,237],"clustered":[40],"regularly":[41],"interspaced":[42],"short":[43],"palindromic":[44],"repeats":[45],"technology.":[46],"Despite":[47],"clear":[49,52],"advantage,":[50],"no":[51],"general":[53],"design":[54,153,178],"principles":[55],"are":[56,92],"available":[57],"de":[59,97,255],"novo":[60,98,256],"develop":[61],"repressing":[62,87],"riboregulators,":[63,88,262],"limiting":[64],"availability":[66],"reliable":[69,207,254],"development":[70],"these":[72],"type":[73],"riboregulators.":[75,248],"Here,":[76],"overcome":[78],"lack":[80],"knowledge":[82],"on":[83],"functionality":[85],"translation":[89,112,142,167,225],"inhibiting":[90,143,168,226],"developed":[93,99],"from":[94,133],"scratch.":[95],"These":[96],"explore":[101],"features":[102,121,127,170,239],"related":[103],"thermodynamical":[105],"structural":[107,118,236],"factors":[108],"previously":[109],"attributed":[110],"initiation":[113],"modulation.":[114,272],"In":[115,232],"total,":[116],"12":[117],"thermodynamic":[120,238],"were":[122,128,148,240],"defined":[123],"which":[125,192,263],"six":[126],"retained":[129],"after":[130],"removing":[131],"correlations":[132],"an":[134],"in":[135,176],"silico":[136],"generated":[137],"riboregulator":[138],"library.":[139],"From":[140],"library,":[145],"18":[146],"selected":[149],"using":[150],"experimental":[152],"subsequently":[155],"constructed":[156,217],"co-expressed":[158],"with":[159],"two":[160],"target":[161],"untranslated":[162],"regions":[163],"link":[165,221],"functionality.":[172],"The":[173],"experiments":[180],"showed":[181],"down":[183],"6%":[185],"original":[188],"expression":[190,271],"levels,":[191],"could":[193],"only":[194],"be":[195],"partially":[196],"explained":[197],"by":[198,246],"ordinary":[200],"least":[201,212],"squares":[202,213],"regression":[203,214],"model.":[204],"forward":[208,257],"engineering,":[209],"partial":[211],"model":[215,234],"was":[216],"validated":[219],"properties":[223],"repression.":[231],"both":[235],"important":[241],"for":[242,269],"efficient":[243],"This":[249],"approach":[250],"enables":[251],"more":[253],"effective":[260],"further":[264],"expands":[265],"toolbox":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}